10-脱乙酰基巴卡丁 III； 10-去乙酰基巴卡亭
10-Deacetylbaccatin III
|
|
产品编号 |
CFN98421 |
| CAS编号 |
32981-86-5 |
| 分子式 = 分子量 |
C29H36O10 = 544.6 |
| 产品纯度 |
>=98% |
| 物理属性 |
Powder |
| 化合物类型 |
Diterpenoids |
| 植物来源 |
The barks of Taxus yunnanensis Cheng et L. K. Fu |
| ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用 |
|
| 产品名称 |
产品编号 |
CAS编号 |
包装 |
QQ客服 |
| 10-脱乙酰基巴卡丁 III； 10-去乙酰基巴卡亭 |
CFN98421 |
32981-86-5 |
10mg |
QQ客服：3004468091 |
| 10-脱乙酰基巴卡丁 III； 10-去乙酰基巴卡亭 |
CFN98421 |
32981-86-5 |
20mg |
QQ客服：3004468091 |
| 10-脱乙酰基巴卡丁 III； 10-去乙酰基巴卡亭 |
CFN98421 |
32981-86-5 |
50mg |
QQ客服：3004468091 |
| 10-脱乙酰基巴卡丁 III； 10-去乙酰基巴卡亭 |
CFN98421 |
32981-86-5 |
100mg |
QQ客服：3004468091 |
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ChemFaces的产品在许多优秀和顶级科学期刊中被引用
Cell. 2018 Jan 11;172(1-2):249-261.e12. doi: 10.1016/j.cell.2017.12.019.
IF=36.216(2019)PMID: 29328914
Cell Metab. 2020 Mar 3;31(3):534-548.e5. doi: 10.1016/j.cmet.2020.01.002.
IF=22.415(2019)PMID: 32004475
Mol Cell. 2017 Nov 16;68(4):673-685.e6. doi: 10.1016/j.molcel.2017.10.022.
IF=14.548(2019)PMID: 29149595
ACS Nano. 2018 Apr 24;12(4): 3385-3396. doi: 10.1021/acsnano.7b08969.
IF=13.903(2019)PMID: 29553709
Nature Plants. 2016 Dec 22;3: 16206. doi: 10.1038/nplants.2016.205.
IF=13.297(2019)PMID: 28005066
Sci Adv. 2018 Oct 24;4(10): eaat6994. doi: 10.1126/sciadv.aat6994.
IF=12.804(2019)PMID: 30417089
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国外学术期刊发表的引用ChemFaces产品的部分文献
Plant Pathology2022, 10.1111:ppa.13651.
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Processes2023, 11(2), 385。
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...
| Description: |
10-Deacetylbacccatin III is an antineoplastic agent and an anti-cancer intermediate, it can selectively inhibit the growth of L. donovani intracellular amastigotes within J774 murine macrophages in vitro at nanomolar concentrations with an IC50 value of 70 nM.
The 10-Deacetylbaccatin III-treated promastigotes were slightly arrested in the G2/M phase whereas taxol-treated cells were blocked in the G2/M phase. |
| In vitro: |
| Planta Med. 2007 Aug;73(10):1081-8. | | In vitro activity of 10-deacetylbaccatin III against Leishmania donovani promastigotes and intracellular amastigotes.[Pubmed: 17691059] | Current treatments for leishmaniasis are unsatisfactory due to their route of administration, toxicity and expense but, most importantly, to the developed resistance of Leishmania to first-line drugs.
Therefore, the identification of new effective targeted drugs is an urgent need. Since many studies have shown that medicinal plants contain compounds active against protozoa we have undertaken a study aiming to determine the antileishmanial activity of the taxoid 10-deacetylbaccatin III, isolated from dried needles and small branches of the European yew tree (Taxus baccata).
METHODS AND RESULTS:
Interestingly, 10-deacetylbaccatin III was found to selectively inhibit the growth of L. DONOVANI intracellular amastigotes within J774 murine macrophages in vitro at nanomolar concentrations with an IC(50) value of 70 nM. Concentrations of 10-deacetylbaccatin III as high as 5 microM did not affect J774 murine macrophages whereas 20 nM of taxol, used as a control, was toxic to macrophages. The compound also inhibited the growth of L. donovani promastigotes but at higher concentrations with a maximum level of inhibition of 35 %. Taxol inhibited promastigote growth at micromolar concentrations. Comparison of the effect of 10-deacetylbaccatin III to that of taxol on cell cycle progression and cellular morphology showed that their mechanisms of action are different.
METHODS AND RESULTS:
The 10-deacetylbaccatin III-treated promastigotes were slightly arrested in the G2/M phase whereas taxol-treated cells were blocked in the G2/M phase. In addition 10-deacetylbaccatin III treatment, contrary to taxol, did not affect cellular morphology. |
|
|
1 mg |
5 mg |
10 mg |
20 mg |
25 mg |
| 1 mM |
1.8362 mL |
9.1811 mL |
18.3621 mL |
36.7242 mL |
45.9053 mL |
| 5 mM |
0.3672 mL |
1.8362 mL |
3.6724 mL |
7.3448 mL |
9.1811 mL |
| 10 mM |
0.1836 mL |
0.9181 mL |
1.8362 mL |
3.6724 mL |
4.5905 mL |
| 50 mM |
0.0367 mL |
0.1836 mL |
0.3672 mL |
0.7345 mL |
0.9181 mL |
| 100 mM |
0.0184 mL |
0.0918 mL |
0.1836 mL |
0.3672 mL |
0.4591 mL |
* Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
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