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    飞龙掌血内酯

    Toddalolactone

    飞龙掌血内酯
    产品编号 CFN90247
    CAS编号 483-90-9
    分子式 = 分子量 C16H20O6 = 308.33
    产品纯度 >=98%
    物理属性 White powder
    化合物类型 Coumarins
    植物来源 The roots of Toddalia asiatica Lam.
    ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用
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    产品名称 产品编号 CAS编号 包装 QQ客服
    飞龙掌血内酯 CFN90247 483-90-9 10mg QQ客服:3257982914
    飞龙掌血内酯 CFN90247 483-90-9 20mg QQ客服:3257982914
    飞龙掌血内酯 CFN90247 483-90-9 50mg QQ客服:3257982914
    飞龙掌血内酯 CFN90247 483-90-9 100mg QQ客服:3257982914
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    ChemFaces的产品在许多优秀和顶级科学期刊中被引用

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.
    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.
    IF=12.804(2019)

    PMID: 30417089
    我们的产品现已经出口到下面的研究机构与大学,并且还在增涨
  • Nanjing University of Chinese Medicine (China)
  • Auburn University (USA)
  • China Medical University (Taiwan)
  • University of Mysore (India)
  • Tohoku University (Japan)
  • Anna University (India)
  • Centrum Menselijke Erfelijkheid (Belgium)
  • Weizmann Institute of Science (Israel)
  • Universidad Industrial de Santander (Colombia)
  • MTT Agrifood Research Finland (Finland)
  • University of Canterbury (New Zealand)
  • Subang Jaya Medical Centre (Malaysia)
  • Texas A&M University (USA)
  • Universidade Católica Portuguesa (Portugal)
  • More...
  • 国外学术期刊发表的引用ChemFaces产品的部分文献
  • Int J Mol Sci.2015, 16(8):18396-411
  • Asian J Beauty Cosmetol2016, 14(3):249-257
  • Am J Chin Med.2016, 44(6):1255-1271
  • Sci Rep. 2017, 17332(7)
  • Evid Based Complement Alternat Med.2017, 2017:1583185
  • J Ethnopharmacol.2017, 206:327-336
  • Srinagarind Medical Journal2017, 32(1)
  • Sci Rep.2017, 7:467-479
  • Nutrients.2018, 10(10)
  • Chemistry of Natural Compounds2018, 54(3):572–576
  • Sci Rep.2018, 8:15059
  • Nutrients.2019, 11(11):E2694
  • Chemistry of Plant Materials.2019, 129-136
  • Chemistry of Plant Raw Materials2019, 4:135-147
  • Oncol Rep.2019, 41(4):2453-2463
  • Saudi Pharm J2020, 10.1016
  • J Sep Sci.2020, 201901140
  • Biomolecules.2020, 10(6):925.
  • Adaptive Medicine 2020, 12(1): 4-10
  • Nutr Res Pract.2020, 14(5):478-489.
  • Int J Mol Sci.2020, 21(9):3144.
  • Foods.2020, 9(10):1348.
  • American Association for Anatomy2020, doi: 10.1002.
  • ...
  • 生物活性
    Description: Toddalolactone, a natural coumarin, inhibits the activity of recombinant human Plasminogen activator inhibitor-1 (PAI-1) in a dose-dependent manner, yielding an IC50 value of 37.31 ± 3.23 μM.
    Targets: PAI-1
    In vitro:
    Phytother Res. 2002 May;16(3):281-2.
    Spasmolytic activity of Toddalia asiatica Var. floribunda.[Pubmed: 12164278 ]
    The spasmolytic activity of the aerial parts of Toddalia asiatica var. floribunda (family Rutaceae) was evaluated.
    METHODS AND RESULTS:
    The ethanol extract exhibited significant spasmolytic activity and was then partitioned into five fractions. The activity was found to be concentrated only in the hexane and chloroform fractions.
    CONCLUSIONS:
    This activity was shown not to be due to the coumarins, Toddalolactone and toddanone, as was previously thought.
    Front Pharmacol. 2017 Jul 21;8:489.
    Inhibition of PAI-1 Activity by Toddalolactone as a Mechanism for Promoting Blood Circulation and Removing Stasis by Chinese Herb Zanthoxylum nitidum var. tomentosum.[Pubmed: 28785222 ]
    Traditional Chinese medicine has been used to treat a variety of human diseases for many centuries. Zanthoxylum nitidum var. tomentosum is used as an adjuvant to promote blood circulation and remove stasis. However, the mechanisms of improving circulation and other biological activities of Z. nitidum var. tomentosum are still unclear. Plasminogen activator inhibitor-1 (PAI-1) regulates the plasminogen activation system through inhibition of tissue-type and urokinase-type plasminogen activators (tPA and uPA). PAI-1 has been linked to fibrin deposition that evolves into organ fibrosis and atherosclerosis.
    METHODS AND RESULTS:
    In the present study, we showed that ethanol extract prepared from Z. nitidum var. tomentosum exhibited PAI-1 inhibitory activity, and identified toddalolactone as the main active component that inhibited the activity of recombinant human PAI-1 with IC50 value of 37.31 ± 3.23 μM, as determined by chromogenic assay, and the effect was further confirmed by clot lysis assay. In vitro study showed that toddalolactone inhibited the binding between PAI-1 and uPA, and therefore prevented the formation of the PAI-1/uPA complex. Intraperitoneal injection of toddalolactone in mice significantly prolonged tail bleeding and reduced arterial thrombus weight in a FeCl3-induced thrombosis model. In addition, the hydroxyproline level in the plasma and the degree of liver fibrosis in mice were decreased after intraperitoneal injection of toddalolactone in CCl4-induced mouse liver fibrosis model.
    CONCLUSIONS:
    Taken together, PAI-1 inhibition exerted by toddalolactone may represent a novel molecular mechanism by which Z. nitidum var. tomentosum manifests its effect in the treatment of thrombosis and fibrosis.
    制备储备液(仅供参考)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 3.2433 mL 16.2164 mL 32.4328 mL 64.8656 mL 81.082 mL
    5 mM 0.6487 mL 3.2433 mL 6.4866 mL 12.9731 mL 16.2164 mL
    10 mM 0.3243 mL 1.6216 mL 3.2433 mL 6.4866 mL 8.1082 mL
    50 mM 0.0649 mL 0.3243 mL 0.6487 mL 1.2973 mL 1.6216 mL
    100 mM 0.0324 mL 0.1622 mL 0.3243 mL 0.6487 mL 0.8108 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    部分图片展示
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    (R)-白花前胡醇 7-O-beta-D-吡喃葡萄糖苷; Peucedanol 7-O-glucoside CFN89412 65853-04-5 C20H26O10 = 426.41 5mg QQ客服:1413575084
    Peujaponiside; Peujaponiside CFN93412 155740-16-2 C25H34O14 = 558.5 5mg QQ客服:1413575084
    当归醇A; Angelol A CFN90999 19625-17-3 C20H24O7 = 376.4 10mg QQ客服:2159513211
    当归醇M; Angelol M CFN95060 1092952-64-1 C20H24O7 = 376.4 5mg QQ客服:1413575084
    当归醇B; Angelol B CFN91000 83156-04-1 C20H24O7 = 376.4 10mg QQ客服:2056216494
    当归醇K; Angelol K CFN80136 169736-93-0 C20H24O7 = 376.15 5mg QQ客服:2056216494
    当归醇G; Angelol G CFN92988 83199-38-6 C20H24O7 = 376.40 10mg QQ客服:3257982914
    当归醇H; Angelol H CFN91925 83247-73-8 C20H24O7 = 376.40 5 mg QQ客服:1413575084
    飞龙掌血内酯; Toddaculine CFN92733 4335-12-0 C16H18O4 = 274.3 5mg QQ客服:3257982914
    飞龙掌血内酯; Toddalolactone CFN90247 483-90-9 C16H20O6 = 308.33 20mg QQ客服:1457312923

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