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  • 细叶远志苷 A

    Tenuifoliside A

    细叶远志苷 A
    产品编号 CFN90770
    CAS编号 139726-35-5
    分子式 = 分子量 C31H38O17 = 682.6
    产品纯度 >=98%
    物理属性 Powder
    化合物类型 Phenylpropanoids
    植物来源 The roots of Polygala tenuifolia.
    ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用
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    产品名称 产品编号 CAS编号 包装 QQ客服
    细叶远志苷 A CFN90770 139726-35-5 10mg QQ客服:2056216494
    细叶远志苷 A CFN90770 139726-35-5 20mg QQ客服:2056216494
    细叶远志苷 A CFN90770 139726-35-5 50mg QQ客服:2056216494
    细叶远志苷 A CFN90770 139726-35-5 100mg QQ客服:2056216494
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    ChemFaces的产品在许多优秀和顶级科学期刊中被引用

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.
    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.
    IF=12.804(2019)

    PMID: 30417089
    我们的产品现已经出口到下面的研究机构与大学,并且还在增涨
  • Universidad de Buenos Aires (Argentina)
  • Worcester Polytechnic Institute (USA)
  • University of Wollongong (Australia)
  • Periyar University (India)
  • Hamdard University (India)
  • Centrum Menselijke Erfelijkheid (Belgium)
  • Kamphaengphet Rajabhat University (Thailand)
  • Biotech R&D Institute (USA)
  • Gyeongsang National University (Korea)
  • Institute of Chinese Materia Medica (China)
  • University of Zurich (Switzerland)
  • China Medical University (Taiwan)
  • Universitas Airlangga (Indonesia)
  • University of Melbourne (Australia)
  • More...
  • 国外学术期刊发表的引用ChemFaces产品的部分文献
  • Molecules.2017, 22(11)
  • Environ Toxicol.2023, 23929.
  • Natural Product Communications2023, 18(9).
  • Food Funct.2022, 13(13):6923-6933.
  • Food Chem.2021, 360:130063.
  • J Biol Chem.2014, 289(3):1723-31
  • Univerzita Karlova2022, 228192.
  • Int J Mol Sci.2023, 24(5):4505.
  • Org Biomol Chem.2017, 15(31):6483-6492
  • Curr Issues Mol Biol.2022, 44(10):5106-5116.
  • Molecules2022, 27(9):2613.
  • Auburn University2015, 1-58
  • Vietnam Journal of Food Control.2022, 5(2): 115-128.
  • J. Korean Wood Sci. Technol.2022, 50(5):338-352.
  • Int J Immunopathol Pharmacol.2019, 33:2058738419857537
  • Cancers (Basel).2023, 15(1):37.
  • Food Chem.2019, 275:746-753
  • J Food Sci Technol.2019, 56(5):2712-2720
  • Res Rep Urol.2022, 14:313-326.
  • Cancer Lett. 2023, 18:216584.
  • Appl Biochem Biotechnol.2022, s12010-022-04166-2.
  • Cell.2018, 172(1-2):249-261
  • Molecules.2020, 25(9):2081.
  • ...
  • 生物活性
    Description: Tenuifoliside A has anti-apoptotic,neuroprotective,and anti-inflammatory effects, it inhibits the NF-κB and MAPK pathways.
    Targets: NO | NOS | PGE | COX | TNF-α | p65 | NF-kB | IkB | MAPK | JNK | ERK | PI3K | Akt | IKK
    In vitro:
    Eur J Pharmacol. 2013 Dec 5;721(1-3):267-76.
    The inhibition of JNK MAPK and NF-κB signaling by tenuifoliside A isolated from Polygala tenuifolia in lipopolysaccharide-induced macrophages is associated with its anti-inflammatory effect.[Pubmed: 24076326]
    The root of Polygala tenuifolia Willd. (Polygalaceae) is well known for its use in the treatment of neurasthenia, amnesia, and inflammation.
    METHODS AND RESULTS:
    In this study, we isolated phenyl propanoid type metabolite Tenuifoliside A, one of the phenylpropanoids from P. tenuifolia, and investigated its anti-inflammatory effects in lipopolysaccharide (LPS)-stimulated RAW264.7 and murine peritoneal macrophages. The results showed that Tenuifoliside A inhibited the production of nitric oxide (NO), inducible nitric oxide synthase (iNOS), prostaglandin E2 (PG E2), and cyclooxygenase (COX)-2. In addition, Tenuifoliside A suppressed the production of pro-inflammatory cytokines, such as tumor necrosis factor (TNF)-α and interleukin (IL)-1β. We also evaluated the effects of Tenuifoliside A on the activation of nuclear factor-kappaB (NF-κB). Tenuifoliside A inhibited the translocation of the NF-κB subunit p65 into the nucleus by interrupting the phosphorylation and degradation of inhibitor kappa B (IκB)-α in LPS-stimulated murine peritoneal macrophages. Moreover, we confirmed that the suppression of the inflammatory process by Tenuifoliside A was mediated through the mitogen-activated protein kinases (MAPKs) pathway based on the fact that Tenuifoliside A significantly decreased p-c-Jun N-terminal kinase (p-JNK) protein expression in LPS-stimulated murine peritoneal macrophages. Taken together, the anti-inflammatory effects of Tenuifoliside A were mediated by the inhibition of the NF-κB and MAPK pathways.
    CONCLUSIONS:
    This study is the first report on the anti-inflammatory effects of Tenuifoliside A, and the strong anti-inflammatory effects of Tenuifoliside A provide potential compound to be developed as therapeutic for inflammatory diseases.
    Rev Neurosci. 2015;26(3):305-21.
    Plant-derived natural medicines for the management of depression: an overview of mechanisms of action.[Pubmed: 25719303]
    Depression is a serious widespread psychiatric disorder that affects approximately 17% of people all over the world. Exploring the neurological mechanisms of the antidepressant activity of plant-derived agents could have a crucial role in developing natural drugs for the management of depression.
    METHODS AND RESULTS:
    The aim of the present study is to review the neurological mechanisms of action of antidepressant plants and their constituents. For this purpose, electronic databases, including PubMed, Science Direct, Scopus, and Cochrane Library, were searched from 1966 to October 2013. The results showed that several molecular mechanisms could be proposed for the antidepressant activity of medicinal plants and their constituents. Hypericum species could normalize brain serotonin level. Liquiritin and isoliquiritin from Glycyrrhiza uralensis rhizome act via the noradrenergic system. Rosmarinus officinalis and curcumin from Curcuma longa interact with D1 and D2 receptors as well as elevate the brain dopamine level. Sida tiagii and Aloysia gratissima involve γ-aminobutyric acid and N-methyl-D-aspartate receptors, respectively. Fuzi polysaccharide-1 from Aconitum carmichaeli could affect brain-derived neurotrophic factor signaling pathways. Psoralidin from Psoralea corylifolia seed modulate the hypothalamic-pituitary-adrenal axis. The total glycosides of Paeonia lactiflora demonstrate an inhibitory effect on both subtypes of monoamine oxidase. 3,6'-Di-o-sinapoyl-sucrose and tenuifoliside A from Polygala tenuifolia exhibit cytoprotective effects on neuronal cells.
    CONCLUSIONS:
    Further preclinical and clinical trials evaluating their safety, bioefficacy, and bioavailability are suggested to prove the valuable role of natural drugs in the management of depressive disorders.
    In vivo:
    Phytomedicine. 2010 Aug;17(10):794-9.
    Potential antidepressant properties of Radix Polygalae (Yuan Zhi).[Pubmed: 20541923]
    Radix Polygalae ("Yuan Zhi", the roots of Polygala tenuifolia Willd., YZ) is an important herb used in traditional Chinese medicine to mediate depression.
    METHODS AND RESULTS:
    The present study was designed to verify the antidepressant effects of the standardized YZ ethanol extract (YZE) and its four fractions YZ-30, YZ-50, YZ-70 and YZ-90 on the tail suspension (TST) and forced swimming test (FST). Furthermore, the standardization of the fractions obtained from the separation procedures was carried out by high-performance liquid chromatography (HPLC)-fingerprint. The YZ-50 fraction (Oligosaccharide esters--enriched, oral (200 mg/kg) showed a significant anti-immobility like effects. The data of YZ-50 on the corticosterone-induced injure of SH-SY5Y human neuroblastoma cell indicated that YZ-50 may have biological effects on neuroprotection. Proliferation of cell lines was assessed by dimethylthiazoldiphenyltetrazoliumbromide (MTT) and 5-bromo-2'-deoxyuridine (BrdU) incorporation assays. It was found that YZ-50 and its two bioactive compounds, 3,6'-di-o-sinapoyl-sucrose (DISS) and tenuifoliside A(TEA) showed protection activities in SY5Y cells from the lesion.
    CONCLUSIONS:
    By using bioassay-screening methods, our results indicate that the presence of oligosaccharide esters such as DISS and TEA in this herb may be responsible for the cytoprotective activity effects.
    制备储备液(仅供参考)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 1.465 mL 7.3249 mL 14.6499 mL 29.2997 mL 36.6247 mL
    5 mM 0.293 mL 1.465 mL 2.93 mL 5.8599 mL 7.3249 mL
    10 mM 0.1465 mL 0.7325 mL 1.465 mL 2.93 mL 3.6625 mL
    50 mM 0.0293 mL 0.1465 mL 0.293 mL 0.586 mL 0.7325 mL
    100 mM 0.0146 mL 0.0732 mL 0.1465 mL 0.293 mL 0.3662 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    部分图片展示
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    beta-羟基麦角甾苷; beta-Hydroxyacteoside CFN95499 109279-13-2 C29H36O16 = 640.6 10mg QQ客服:2159513211
    beta-氧化毛蕊花糖苷; beta-Oxoacteoside CFN95667 149507-92-6 C29H34O16 = 638.6 5mg QQ客服:2159513211
    厚朴苷D; Magnoloside D CFN91910 1418309-03-1 C29H36O15 = 624.59 5mg QQ客服:1457312923
    Leucosceptoside A; Leucosceptoside A CFN89166 83529-62-8 C30H38O15 = 638.61 5mg QQ客服:1457312923
    地黄苷; Martynoside CFN97159 67884-12-2 C31H40O15 = 652.7 5mg QQ客服:2056216494
    异地黄苷; Isomartynoside CFN97525 94410-22-7 C31H40O15 = 652.7 5mg QQ客服:3257982914
    连翘酯苷H; Forsythoside H CFN90987 1178974-85-0 C29H36O15 = 624.59 10mg QQ客服:1457312923
    异连翘酯苷; Isoforsythiaside CFN98591 1357910-26-9 C29H36O15 = 624.59 20mg QQ客服:2159513211
    厚朴苷A; Magnoloside A CFN99232 113557-95-2 C29H36O15 = 624.6 10mg QQ客服:3257982914
    木兰苷B; Magnoloside B CFN91539 116872-05-0 C35H46O20 = 786.7 5mg QQ客服:1457312923

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