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  • 大车前苷

    Plantamajoside

    大车前苷
    产品编号 CFN99522
    CAS编号 104777-68-6
    分子式 = 分子量 C29H36O16 = 640.6
    产品纯度 >=98%
    物理属性 White powder
    化合物类型 Phenylpropanoids
    植物来源 The herbs of Plantago depressa Willd.
    ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用
    提供自定义包装
    产品名称 产品编号 CAS编号 包装 QQ客服
    大车前苷 CFN99522 104777-68-6 10mg QQ客服:1457312923
    大车前苷 CFN99522 104777-68-6 20mg QQ客服:1457312923
    大车前苷 CFN99522 104777-68-6 50mg QQ客服:1457312923
    大车前苷 CFN99522 104777-68-6 100mg QQ客服:1457312923
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    ChemFaces的产品在许多优秀和顶级科学期刊中被引用

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.
    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.
    IF=12.804(2019)

    PMID: 30417089
    我们的产品现已经出口到下面的研究机构与大学,并且还在增涨
  • Sanford Burnham Prebys Medical Discovery Institute (USA)
  • Shanghai Institute of Organic Chemistry (China)
  • Calcutta University (India)
  • Auburn University (USA)
  • Universita' Degli Studi Di Cagliari (Italy)
  • Technical University of Denmark (Denmark)
  • Chiang Mai University (Thailand)
  • University of Lodz (Poland)
  • Sanford Burnham Medical Research Institute (USA)
  • Universidade da Beira Interior (Germany)
  • Nicolaus Copernicus Uniwersity (Poland)
  • Korea Food Research Institute(KFRI) (Korea)
  • Center for protein Engineering (CIP) (Belgium)
  • Colorado State University (USA)
  • More...
  • 国外学术期刊发表的引用ChemFaces产品的部分文献
  • Heliyon.2023, e12778.
  • Cell Biochem Funct.2018, 36(6):303-311
  • Phytomedicine.2019, 55:229-237
  • Biochem Biophys Res Commun.2018, 505(4):1148-1153
  • JMSACL2023, 09.002
  • Evid Based Complement Alternat Med.2021, 8855980.
  • Nutrients.2023, 15(3):753.
  • J Sep Sci.2022, 45(18):3556-3566.
  • J Nat Prod.2018, 81(4):966-975
  • J of the Society of Cosmetic Scientists of Korea2018, 44(4):407-417
  • Int J Mol Sci.2020, 21(8):2790.
  • Int J Med Sci.2020, 17(5):626-631
  • Biomolecules.2019, 9(11):E696
  • J Korean Med Ophthalmol Otolaryngol Dermatol2023, 36(1):1-20.
  • Mol Plant Pathol.2022, 10.1111:mpp.13280.
  • Applied Biological Chemistry 2022, 65,5(2022).
  • Molecules.2020, 25(17):3783.
  • Key Engineering Materials2022, 931(47-53).
  • J Sep Sci.2020, 43(22):4148-4161.
  • Korean Herb. Med. Inf.2020, 8(2):205-213
  • Phytother Res.2019, 33(5):1490-1500
  • J Cell Mol Med . 2023, jcmm.17954.
  • Sci Rep.2021, 11(1):14180.
  • ...
  • 生物活性
    Description: Plantamajoside has antibacterial, antioxidant, anti-tumor, anti-inflammatory and anti-skin photoaging effects, it has protective activities against Cadmium-induced renal injury. Plantamajoside ameliorates lipopolysaccharide-induced acute lung injury via suppressing NF-κB and MAPK activation, it can inhibit UVB and advanced glycation end products‐induced MMP-1 Expression by suppressing the MAPK and NF‐ĸB pathways in HaCaT cells, and attenuate the upregulation of receptor for AGEs (RAGE) by glycer-AGEs with UVB irradiation.
    Targets: NF-kB | p38MAPK | MMP(e.g.TIMP) | ROS | TLR | IkB | p65 | JNK | ERK | IL Receptor | IKK
    In vitro:
    Photochem Photobiol. 2016 Sep;92(5):708-19.
    Plantamajoside Inhibits UVB and Advanced Glycation End Products-Induced MMP-1 Expression by Suppressing the MAPK and NF-κB Pathways in HaCaT Cells.[Pubmed: 27346084]
    Photoaging and glycation stress are major causes of skin deterioration. Oxidative stress caused by ultraviolet B (UVB) irradiation can upregulate matrix metalloprotease 1 (MMP-1), a major enzyme responsible for collagen damage in the skin. Advanced glycation end products (AGEs) accumulate via gradual formation from skin proteins, especially from long-lived proteins such as dermal elastin and collagen. Plantamajoside (PM), isolated from Plantago asiatica, has various biological effects including anti-inflammatory and antioxidant effects.
    METHODS AND RESULTS:
    In this study, we assessed the protective effects of PM on a human keratinocyte cell line (HaCaT) and primary human dermal fibroblasts (HDF) against stress caused by glyceraldehyde-induced AGEs (glycer-AGEs) with UVB irradiation. We found that PM attenuated UVB- and-glycer-AGEs-induced MMP-1 expression in HaCaT and HDF cells and proinflammatory cytokines expression by inhibiting the phosphorylation of mitogen-activated protein kinases (MAPKs) activated by reactive oxygen species. Specific inhibitors of NF-κB and MAPKs attenuated the induced expression of MMP-1. PM also inhibited the phosphorylation of IκBα, and reduced nuclear translocation of NF-κB in these cells. Furthermore, PM attenuated the upregulation of receptor for AGEs (RAGE) by glycer-AGEs with UVB irradiation.
    CONCLUSIONS:
    Therefore, our findings strongly suggest that PM is a promising inhibitor of skin photoaging.
    In vivo:
    Environ Toxicol Pharmacol. 2015 Jan;39(1):125-36.
    Nephroprotection of plantamajoside in rats treated with cadmium.[Pubmed: 25499790]
    Cadmium (Cd), an environmental and industrial pollutant, generates free radicals responsible for oxidative stress. Cd can also lead to various renal toxic damage such as the proximal tubules and glomerulus dysfunction. Plantamajoside (PMS), a major compound of Plantago asiatica (PA), was reported to have the antioxidant effects.
    METHODS AND RESULTS:
    In this study, we investigated the protective effects of PMS on Cd-induced renal damage in the NRK-52E cell and rat kidney tissue. Cd exposure increased the ROS generation, lipid peroxidation, serum biochemical values of renal damage, and mRNA and protein expressions of KIM-1 in vitro and in vivo. The significant reduction in glutathione (GSH)/glutathione disulfide (GSSG) ratio and activities of antioxidant enzymes were also observed in the rats treated with Cd. PMS significantly decreased the ROS generation and lipid peroxidation, thus enhancing GSH/GSSG ratio, antioxidant enzyme activities in the cells and rats, and improved histochemical appearances.
    CONCLUSIONS:
    Indicating that PMS has protective activities against Cd-induced renal injury.
    Phytother Res. 2007 Dec;21(12):1118-23.
    A 90 day repeated oral toxicity study on plantamajoside concentrate from Plantago asiatica.[Pubmed: 17622978 ]
    Plantago asiatica is distributed widely in East Asia. Since ancient times it has been used as a diuretic to treat acute urinary infections, and as an antiinflammatory, antiasthmatic, antioxidant, antibacterial, antihyperlipidemic and antihepatitis drug. The major compound, plantamajoside from P. asiatica, which is used as a marker compound in chemotaxonomic studies, was reported to have antibacterial activity, inhibition activity against cAMP phosphodiesterase and 5-lipoxygenase and antioxidant activity. However, there are no reports on the safety of plantamajoside.
    METHODS AND RESULTS:
    This study assessed the toxic effects of plantamajoside concentrate (PC), the purity of which was above 80%, in rats following administration at dose levels of 0, 500, 1000 and 2000 mg/kg body weight/day for 13 weeks, as recommended by the OECD guidelines. The results showed that there were no differences in body weight, food intake, water consumption, relative organ weight or the hematological and serum biochemical values among the different dosage groups. No death or abnormal clinical signs were observed during the experimental period.
    CONCLUSIONS:
    Therefore, the results suggested that no observed adverse effect level (NOAEL) of the PC in rats after oral administration is considered to be greater than 2000 mg/kg in rats under the conditions employed in this study.
    Int Immunopharmacol . 2016 Jun;35:315-322.
    Plantamajoside ameliorates lipopolysaccharide-induced acute lung injury via suppressing NF-κB and MAPK activation[Pubmed: 27089391]
    Abstract Despite developments in the knowledge and therapy of acute lung injury in recent decades, mortality remains high, and there is usually a lack of effective therapy. Plantamajoside, a major ingredient isolated from Plantago asiatica L. (Plantaginaceae), has been reported to have potent anti-inflammatory properties. However, the effect of plantamajoside on lipopolysaccharide (LPS)-induced acute lung injury (ALI) in mice has not been investigated. The present study aimed to reveal the potential mechanism responsible for the anti-inflammatory effects of plantamajoside on LPS-induced acute lung injury in mice and in RAW264.7 cells. The results of histopathological changes as well as the lung wet-to-dry ratio and myeloperoxidase (MPO) activity showed that plantamajoside ameliorated the lung injury that was induced by LPS. qPCR and ELISA assays demonstrated that plantamajoside suppressed the production of IL-1β, IL-6 and TNF-α in a dose-dependent manner. TLR4 is an important sensor in LPS infection. Molecular studies showed that the expression of TLR4 was inhibited by plantamajoside administration. Further study was conducted on nuclear factor (NF)-κB and mitogen-activated protein kinase (MAPK) using pathways using western blots. The results showed that plantamajoside inhibited the phosphorylation of IκBα, p65, p38, JNK and ERK. All results indicated that plantamajoside has protective effect on LPS-induced ALI in mice and in RAW264.7 cells. Thus, plantamajoside may be a potential therapy for the treatment of pulmonary inflammation. Keywords: Acute lung injury; Anti-inflammation; MAPK; NF-κB; Plantamajoside.
    制备储备液(仅供参考)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 1.561 mL 7.8052 mL 15.6104 mL 31.2207 mL 39.0259 mL
    5 mM 0.3122 mL 1.561 mL 3.1221 mL 6.2441 mL 7.8052 mL
    10 mM 0.1561 mL 0.7805 mL 1.561 mL 3.1221 mL 3.9026 mL
    50 mM 0.0312 mL 0.1561 mL 0.3122 mL 0.6244 mL 0.7805 mL
    100 mM 0.0156 mL 0.0781 mL 0.1561 mL 0.3122 mL 0.3903 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    部分图片展示
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    Brachynoside heptaacetate; Brachynoside heptaacetate CFN99490 144765-80-0 C45H54O22 = 946.9 5mg QQ客服:1413575084
    大车前苷; Plantamajoside CFN99522 104777-68-6 C29H36O16 = 640.6 20mg QQ客服:1457312923
    车前草苷D; Plantainoside D CFN93188 147331-98-4 C29H36O16 = 640.59 10mg QQ客服:2159513211
    贞桐苷A; Clerodenoside A CFN99691 164022-75-7 C35H44O17 = 736.7 5mg QQ客服:1413575084
    鞭打绣球苷A; Hemiphroside A CFN99697 165338-27-2 C31H40O16 = 668.7 5mg QQ客服:1457312923
    鞭打绣球苷B; Hemiphroside B CFN99698 165338-28-3 C31H38O17 = 682.6 5mg QQ客服:2159513211
    鞭打绣球苷B十乙酰酯; Hemiphroside B nonaacetate CFN89035 132302-25-1 C49H56O26 = 1060.98 5mg QQ客服:3257982914
    连翘酯苷A; Forsythoside A CFN99705 79916-77-1 C29H36O15 = 624.59 20mg QQ客服:1457312923
    连翘酯苷I; Forsythoside I CFN90988 1177581-50-8 C29H36O15 = 624.59 10mg QQ客服:1413575084
    细叶远志苷 A; Tenuifoliside A CFN90770 139726-35-5 C31H38O17 = 682.6 20mg QQ客服:1457312923

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