剑麻皂苷元； 剑麻皂甙元； 剑麻皂素
Tigogenin
| 产品名称 |
产品编号 |
CAS编号 |
包装 |
QQ客服 |
| 剑麻皂苷元； 剑麻皂甙元； 剑麻皂素 |
CFN98501 |
77-60-1 |
10mg |
QQ客服：2056216494 |
| 剑麻皂苷元； 剑麻皂甙元； 剑麻皂素 |
CFN98501 |
77-60-1 |
20mg |
QQ客服：2056216494 |
| 剑麻皂苷元； 剑麻皂甙元； 剑麻皂素 |
CFN98501 |
77-60-1 |
50mg |
QQ客服：2056216494 |
| 剑麻皂苷元； 剑麻皂甙元； 剑麻皂素 |
CFN98501 |
77-60-1 |
100mg |
QQ客服：2056216494 |
1. 在您收到产品后请检查产品。如无问题，请将产品存入冰霜并且样品瓶保持密封，产品可以存放长达24个月（2-8摄氏度）。
2. 只要有可能，产品溶解后，您应该在同一天应用于您的实验。 但是，如果您需要提前做预实验，或者需要全部溶解，我们建议您将溶液以等分试样的形式存放在-20℃的密封小瓶中。 通常，这些可用于长达两周。 使用前，打开样品瓶前，我们建议您将产品平衡至室温至少1小时。
3. 需要更多关于溶解度，使用和处理的建议？ 请发送电子邮件至：service@chemfaces.com
订购流程
1. 在线订购
请联系我们QQ客服
2. 电话订购
请拨打电话：
027-84237683 或 027-84237783
3. 邮件或传真订购
发送电子邮件到: manager@chemfaces.com 或
发送传真到：027-84254680
提供订购信息
为了方便客户的订购，请需要订购ChemFaces产品的客户，在下单的时候请提供下列信息，以供我们快速为您建立发货信息。
1. 产品编号（CAS No.或产品名称）
2. 发货地址
3. 联系方法 (联系人，电话）
4. 开票抬头 (如果需要发票的客户）
5. 发票地址（发货地址与发票地址不同）
发货时间
1. 付款方式为100%预付款客户，我们将在确认收到货款后当天或1-3个工作日发货。
2. 付款方式为月结的客户，我们承诺在收到订单后当天或1-3个工作日内发货。
3. 如果客户所需要的产品，需要重新生产，我们有权告知客户，交货时间需要延期。
ChemFaces的产品在许多优秀和顶级科学期刊中被引用
Cell. 2018 Jan 11;172(1-2):249-261.e12. doi: 10.1016/j.cell.2017.12.019.
IF=36.216(2019)PMID: 29328914
Cell Metab. 2020 Mar 3;31(3):534-548.e5. doi: 10.1016/j.cmet.2020.01.002.
IF=22.415(2019)PMID: 32004475
Mol Cell. 2017 Nov 16;68(4):673-685.e6. doi: 10.1016/j.molcel.2017.10.022.
IF=14.548(2019)PMID: 29149595
ACS Nano. 2018 Apr 24;12(4): 3385-3396. doi: 10.1021/acsnano.7b08969.
IF=13.903(2019)PMID: 29553709
Nature Plants. 2016 Dec 22;3: 16206. doi: 10.1038/nplants.2016.205.
IF=13.297(2019)PMID: 28005066
Sci Adv. 2018 Oct 24;4(10): eaat6994. doi: 10.1126/sciadv.aat6994.
IF=12.804(2019)PMID: 30417089
我们的产品现已经出口到下面的研究机构与大学，并且还在增涨
Universit?t Basel (Switzerland)
Martin Luther University of Halle-Wittenberg (Germany)
Molecular Biology Institute of Barcelona (IBMB)-CSIC (Spain)
Semmelweis Unicersity (Hungary)
University of Vigo (Spain)
Indian Institute of Science (India)
Chinese University of Hong Kong (China)
Charles University in Prague (Czech Republic)
Universidade Federal de Goias (UFG) (Brazil)
Macau University of Science and Technology (China)
Universitas islam negeri Jakarta (Indonesia)
University of Beira Interior (Portugal)
Uniwersytet Medyczny w ?odzi (Poland)
Copenhagen University (Denmark)
More...
国外学术期刊发表的引用ChemFaces产品的部分文献
| Description: |
Tigogenin is one of steroidal sapogenins which is widely used for synthesizing steroid drugs. It might have protective effect on bone and be helpful in preventing the development of osteoporosis.Tigogenin induces apoptosis, associated with overexpression of COX-2 correlated with overproduction of endogenous PGE2. Tigogenin inhibited of PPARgamma and via p38 MAPK pathway.
|
| Targets: |
COX | PGE | PPAR | p38MAPK |
| In vitro: |
| Int J Mol Med. 2007 Oct;20(4):451-60. | | Inhibition of human rheumatoid arthritis synovial cell survival by hecogenin and tigogenin is associated with increased apoptosis, p38 mitogen-activated protein kinase activity and upregulation of cyclooxygenase-2.[Pubmed: 17786275] | We conducted our study to assess the antiproliferative and proapoptotic potential of hecogenin and tigogenin, two saponins which are structurally similar to diosgenin.
METHODS AND RESULTS:
We particularly focused our attention on mitogen-activated protein kinase (MAPK) activation in relation to apoptosis but also with the COX-2 expression and activity. Rheumatoid arthritis (RA) synoviocytes were isolated from fresh synovial biopsies obtained from five RA patients undergoing hip arthroplasty. Measurement of cell proliferation was determined using the MTT assay. Apoptosis was evaluated by studying caspase-8, caspase-9 and caspase-3 activities but also by quantification of DNA fragmentation. Quantification of human phospho-MAPKs was realized by ELISA. COX-2 expression was demonstrated by Western blot analysis and COX-2 activity by assay of endogenous prostaglandin E2 (PGE2) production. Tigogenin was more effective than hecogenin in inducing apoptosis in human RA fibroblast-like synoviocytes (FLS) which was caspase dependent but poly(ADP-ribose) polymerase independent and characterized by DNA fragmentation. Our results demonstrated hecogenin- and tigogenin-induced apoptosis through activation of p38 without affecting the JNK and ERK pathways. Indeed, pretreatment with a p38 inhibitor decreased saponin-induced apoptosis with a significant decrease in DNA fragmentation. Furthermore, the rate of apoptosis induced by hecogenin or tigogenin was associated with overexpression of COX-2 correlated with overproduction of endogenous PGE2.
CONCLUSIONS:
These new results provide strong evidence that a family of structurally similar plant steroids is capable of inducing apoptosis in human RA FLS with different rates and different signalling pathways. This study also confirms the discussed appearance of the downregulation or upregulation of COX-2 in cell apoptosis as a function of cell type. |
|
|
1 mg |
5 mg |
10 mg |
20 mg |
25 mg |
| 1 mM |
2.4002 mL |
12.0008 mL |
24.0015 mL |
48.0031 mL |
60.0038 mL |
| 5 mM |
0.48 mL |
2.4002 mL |
4.8003 mL |
9.6006 mL |
12.0008 mL |
| 10 mM |
0.24 mL |
1.2001 mL |
2.4002 mL |
4.8003 mL |
6.0004 mL |
| 50 mM |
0.048 mL |
0.24 mL |
0.48 mL |
0.9601 mL |
1.2001 mL |
| 100 mM |
0.024 mL |
0.12 mL |
0.24 mL |
0.48 mL |
0.6 mL |
* Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
部分图片展示
联系方式
电机：027-84237783
传真：027-84254680
在线QQ: 1413575084
E-Mail：manager@chemfaces.com
湖北省武汉沌口经济技术开区车城南路83号1号楼第三层厂房
ChemFaces为科学家，科研人员与企业提供快速的产品递送。我们通过瑞士SGS ISO 9001:2008质量体系认证
天然化合物与对照品的研发和生产。
