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  • 海柯吉宁

    Hecogenin

    海柯吉宁
    产品编号 CFN98586
    CAS编号 467-55-0
    分子式 = 分子量 C27H42O4 = 430.62
    产品纯度 >=98%
    物理属性 Powder
    化合物类型 Steroids
    植物来源 The roots of Aconitum carmichaeli Debx
    ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用
    提供自定义包装
    产品名称 产品编号 CAS编号 包装 QQ客服
    海柯吉宁 CFN98586 467-55-0 10mg QQ客服:2056216494
    海柯吉宁 CFN98586 467-55-0 20mg QQ客服:2056216494
    海柯吉宁 CFN98586 467-55-0 50mg QQ客服:2056216494
    海柯吉宁 CFN98586 467-55-0 100mg QQ客服:2056216494
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    ChemFaces的产品在许多优秀和顶级科学期刊中被引用

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.
    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.
    IF=12.804(2019)

    PMID: 30417089
    我们的产品现已经出口到下面的研究机构与大学,并且还在增涨
  • University of Eastern Finland (Finland)
  • Medical University of Gdansk (Poland)
  • VIB Department of Plant Systems Biology, UGent (PSB) (Belgium)
  • Copenhagen University (Denmark)
  • Technical University of Denmark (Denmark)
  • Subang Jaya Medical Centre (Malaysia)
  • National Chung Hsing University (Taiwan)
  • Shanghai Institute of Organic Chemistry (China)
  • Universidade Católica Portuguesa (Portugal)
  • Molecular Biology Institute of Barcelona (IBMB)-CSIC (Spain)
  • Universidad de Buenos Aires (Argentina)
  • Instytut Nawozów Sztucznych w Pu?awach (Poland)
  • The Ohio State University (USA)
  • University of Hawaii Cancer Center (USA)
  • More...
  • 国外学术期刊发表的引用ChemFaces产品的部分文献
  • Food Chem.2020, 327:126992.
  • Food Sci Nutr.2023, 11(9):5532-5542.
  • Oncotarget.2017, 8(64):108006-108019
  • LWT-Food Science and Technology2017, 75:488-496
  • Int J Mol Sci.2020, 21(9):3392.
  • Inflammation2015, 38(1):445-55
  • Mol Immunol. 2016, 78:121-132
  • Sci Rep.2020, 10:4495(2020)
  • Asian Pac J Tropical Bio.2020, 10(6):239-247
  • Nutrients.2018, 10(12):E1998
  • Hum Exp Toxicol.2022, 41:9603271221143713.
  • LWT2021, 147:111620.
  • Pharmaceutics.2021, 13(7):1028.
  • Plant Physiol Biochem.2023, 202:107913.
  • Int J Mol Sci.2022, 23(23):14826.
  • Nutrients.2022, 14(23):4997.
  • Toxins (Basel).2021, 13(9):593.
  • ACS Omega.2022, 7(44):40009-40020.
  • Food Chem.2016, 191:81-90
  • Int J Vitam Nutr Res.2022, doi: 10.1024.
  • Plant Methods.2017, 13:108
  • Journal of Food Composition and Analysis2021, 100:103905.
  • Food Chem.2020, 313:126079
  • ...
  • 生物活性
    Description: Hecogenin, a steroid saponin isolated from Agave sisalana, is a potent and highly selective inhibitor of UGT1A4 with an IC50 value of 1.5 μM. Hecogenin has anti-cancer, antiproliferative,antioxidant and anti-inflammatory effects, it can protect gastro by K⁺(ATP) channels opening and the COX-2/PG pathway. Hecogenin has inhibition of human rheumatoid arthritis synovial cell survival, the effect is associated with increased apoptosis, p38 mitogen-activated protein kinase activity and upregulation of cyclooxygenase-2.
    Targets: ERK | MMP(e.g.TIMP) | COX | ATPase | Potassium Channel | p38MAPK | NO | TRPV | TNF-α | PGE | IL Receptor | PPAR | NF-kB | JNK
    In vitro:
    Anticancer Agents Med Chem. 2014;14(8):1128-35.
    Hecogenin acetate inhibits reactive oxygen species production and induces cell cycle arrest and senescence in the A549 human lung cancer cell line.[Pubmed: 25115457]
    Cellular and molecular mechanisms related to lung cancer have been extensively studied in recent years, but the availability of effective treatments is still scarce. Hecogenin acetate, a natural saponin presenting a wide spectrum of reported pharmacological activities, has been previously evaluated for its anticancer/antiproliferative activity in some in vivo and in vitro models.
    METHODS AND RESULTS:
    Here, we investigated the effects of hecogenin acetate in a human lung cancer cell line. A549 non-small lung cancer cells were exposed to different concentrations of hecogenin acetate and reactive species production, ERK1/2 activation, matrix metalloproteinase expression, cell cycle arrest and cell senescence parameters were evaluated. Hecogenin acetate significantly inhibited increase in intracellular reactive species production induced by H2O2. In addition, hecogenin acetate blocked ERK1/2 phosphorylation and inhibited the increase in MMP-2 caused by H2O2. Treatment with hecogenin acetate induced G0/G1-phase arrest at two concentrations (75 and 100 μM, 74% and 84.3% respectively), and increased the staining of senescence-associated β -galactosidase positive cells.
    CONCLUSIONS:
    These data indicate that hecogenin acetate is able to exert anti-cancer effects by modulating reactive species production, inducing cell cycle arrest and senescence and also modulating ERK1/2 phosphorylation and MMP-2 production.
    Int J Mol Med. 2007 Oct;20(4):451-60.
    Inhibition of human rheumatoid arthritis synovial cell survival by hecogenin and tigogenin is associated with increased apoptosis, p38 mitogen-activated protein kinase activity and upregulation of cyclooxygenase-2.[Pubmed: 17786275]
    We conducted our study to assess the antiproliferative and proapoptotic potential of hecogenin and tigogenin, two saponins which are structurally similar to diosgenin. We particularly focused our attention on mitogen-activated protein kinase (MAPK) activation in relation to apoptosis but also with the COX-2 expression and activity. Rheumatoid arthritis (RA) synoviocytes were isolated from fresh synovial biopsies obtained from five RA patients undergoing hip arthroplasty.
    METHODS AND RESULTS:
    Measurement of cell proliferation was determined using the MTT assay. Apoptosis was evaluated by studying caspase-8, caspase-9 and caspase-3 activities but also by quantification of DNA fragmentation. Quantification of human phospho-MAPKs was realized by ELISA. COX-2 expression was demonstrated by Western blot analysis and COX-2 activity by assay of endogenous prostaglandin E2 (PGE2) production. Tigogenin was more effective than hecogenin in inducing apoptosis in human RA fibroblast-like synoviocytes (FLS) which was caspase dependent but poly(ADP-ribose) polymerase independent and characterized by DNA fragmentation. Our results demonstrated hecogenin- and tigogenin-induced apoptosis through activation of p38 without affecting the JNK and ERK pathways. Indeed, pretreatment with a p38 inhibitor decreased saponin-induced apoptosis with a significant decrease in DNA fragmentation. Furthermore, the rate of apoptosis induced by hecogenin or tigogenin was associated with overexpression of COX-2 correlated with overproduction of endogenous PGE2.
    CONCLUSIONS:
    These new results provide strong evidence that a family of structurally similar plant steroids is capable of inducing apoptosis in human RA FLS with different rates and different signalling pathways. This study also confirms the discussed appearance of the downregulation or upregulation of COX-2 in cell apoptosis as a function of cell type.
    In vivo:
    Molecules. 2014 Jun 19;19(6):8303-16.
    Evidence for the involvement of spinal cord-inhibitory and cytokines-modulatory mechanisms in the anti-hyperalgesic effect of hecogenin acetate, a steroidal sapogenin-acetylated, in mice.[Pubmed: 24950436]
    Hecogenin is a steroidal sapogenin largely drawn from the plants of the genus Agave, commonly known as 'sisal', and is one of the important precursors used by the pharmaceutical industry for the synthesis of steroid hormones. Hecogenin acetate (HA) is a steroidal sapogenin-acetylated that produces antinociceptive activity. Thus, we evaluate the antihyperalgesic profile of HA in mice in inflammatory models, as well as its possible involvement with c-fos expression on spinal cord area and cytokines to produces analgesic profile.
    METHODS AND RESULTS:
    Acute pretreatment with HA (5, 10, or 20 mg/kg; i.p.) inhibited the development of mechanical hyperalgesia induced by carrageenan, TNF-α, dopamine and PGE2. Additionally, the immunofluorescence data demonstrated that acute pretreatment with HA, at all doses tested, significantly inhibited Fos-like expression in the spinal cord dorsal horn normally observed after carrageenan-inflammation. Moreover, HA did not affect the motor performance of the mice as tested in the Rota rod test. This antinociceptive profile seems to be related, at least in part, to a reduction of pro-inflammatory cytokines, as IL-1β.
    CONCLUSIONS:
    The present results suggest that HA attenuates mechanical hyperalgesia by blocking the neural transmission of pain at the spinal cord levels and by cytokines-inhibitory mechanisms.
    制备储备液(仅供参考)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 2.3222 mL 11.6112 mL 23.2223 mL 46.4447 mL 58.0558 mL
    5 mM 0.4644 mL 2.3222 mL 4.6445 mL 9.2889 mL 11.6112 mL
    10 mM 0.2322 mL 1.1611 mL 2.3222 mL 4.6445 mL 5.8056 mL
    50 mM 0.0464 mL 0.2322 mL 0.4644 mL 0.9289 mL 1.1611 mL
    100 mM 0.0232 mL 0.1161 mL 0.2322 mL 0.4644 mL 0.5806 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    部分图片展示
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    菝葜皂苷元; 菝葜皂甙元; Sarsasapogenin CFN99779 126-19-2 C27H44O3 = 416.64 20mg QQ客服:215959384
    剑麻皂苷元; 剑麻皂甙元; 剑麻皂素; Tigogenin CFN98501 77-60-1 C27H44O3 = 416.64 20mg QQ客服:2159513211
    剑麻皂苷元乙酸酯; Tigogenin acetate CFN91164 2530-07-6 C29H46O4 = 458.7 10mg QQ客服:2056216494
    薯蓣皂苷元; Diosgenin CFN99515 512-04-9 C27H42O3 = 414.63 20mg QQ客服:3257982914
    偏诺皂苷元; Pennogenin CFN90706 507-89-1 C27H42O4 = 430.62 5mg QQ客服:2056216494
    海柯吉宁; Hecogenin CFN98586 467-55-0 C27H42O4 = 430.62 20mg QQ客服:1457312923
    蒺藜苷元; (25R)-Spirost-4-ene-3,12-dione CFN91702 6875-60-1 C27H38O4 = 426.6 5mg QQ客服:1457312923
    吉托皂苷元; Gitogenin CFN93779 511-96-6 C27H44O4 = 432.6 5mg QQ客服:215959384
    绿莲皂甙元; Chlorogenin CFN91558 562-34-5 C27H44O4 = 432.6 5mg QQ客服:1457312923

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