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  • 脯氨酸

    • 脯氨酸

    Proline

    脯氨酸
    		产品编号 CFN99612
    CAS编号 147-85-3
    分子式 = 分子量 C5H9NO2 = 115.1
    产品纯度 >=98%
    物理属性 Powder
    化合物类型 Alkaloids
    植物来源 The herbs of Gynura japonica
    ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用
    提供自定义包装
    产品名称 产品编号 CAS编号 包装 QQ客服
    脯氨酸 CFN99612 147-85-3 10mg QQ客服：2056216494
    脯氨酸 CFN99612 147-85-3 20mg QQ客服：2056216494
    脯氨酸 CFN99612 147-85-3 50mg QQ客服：2056216494
    脯氨酸 CFN99612 147-85-3 100mg QQ客服：2056216494
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    ChemFaces的产品在许多优秀和顶级科学期刊中被引用

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.
    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.
    IF=12.804(2019)

    PMID: 30417089
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    • 国外学术期刊发表的引用ChemFaces产品的部分文献
  • Int J Mol Sci.2022, 23(11):6104.
  • Chinese Pharmacological Bulletin2019, 35(8):1120-1125
  • J Appl Biol Chem2022, 65:343−348.
  • J Pharm Biomed Anal.2019, 172:268-277
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  • Antioxidants (Basel).2020, 9(2):E120
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  • Food Research International2016, 106-113
  • J Pharmaceutical and Biomedical Analysis2022, 114631.
  • Molecules.2021, 26(4):1084.
  • Food Science&Tech. Res.2022, 28(2):123-132.
  • Agronomy2020, 10(3),388.
  • J of the Korean Society of Cosmetics and Cosmetology2018, 399-406
  • Biomed Pharmacother.2023, 163:114785.
  • Cancers (Basel).2021, 13(6):1432.
  • Journal of Molecular Liquids2022, 364:120062.
  • Bioengineering2023, 10(10), 1113.
  • Pathogens.2018, 7(3):E62
  • Cells.2021, 10(10):2633.
  • ...
    • 生物活性
    Description: L-Proline is one of the twenty amino acids used in living organisms as the building blocks of proteins.Proline accumulates in many plant species in response to environmental stress, it can act as a signaling molecule to modulate mitochondrial functions, influence cell proliferation or cell death and trigger specific gene expression, which can be essential for plant recovery from stress, the engineering of proline metabolism could lead to new opportunities to improve plant tolerance of environmental stresses.
    Targets: p38MAPK | HIF
    In vitro:
    Science. 2001 Apr 20;292(5516):464-8.
    HIFalpha targeted for VHL-mediated destruction by proline hydroxylation: implications for O2 sensing.[Pubmed: 11292862 ]
    HIF (hypoxia-inducible factor) is a transcription factor that plays a pivotal role in cellular adaptation to changes in oxygen availability. In the presence of oxygen, HIF is targeted for destruction by an E3 ubiquitin ligase containing the von Hippel-Lindau tumor suppressor protein (pVHL). We found that human pVHL binds to a short HIF-derived peptide when a conserved proline residue at the core of this peptide is hydroxylated. Because proline hydroxylation requires molecular oxygen and Fe(2+), this protein modification may play a key role in mammalian oxygen sensing.
    In vivo:
    Trends Plant Sci. 2010 Feb;15(2):89-97.
    Proline: a multifunctional amino acid.[Pubmed: 20036181 ]
    Proline accumulates in many plant species in response to environmental stress. Although much is now known about proline metabolism, some aspects of its biological functions are still unclear. Here, we discuss the compartmentalization of proline biosynthesis, accumulation and degradation in the cytosol, chloroplast and mitochondria. We also describe the role of proline in cellular homeostasis, including redox balance and energy status. Proline can act as a signaling molecule to modulate mitochondrial functions, influence cell proliferation or cell death and trigger specific gene expression, which can be essential for plant recovery from stress. Although the regulation and function of proline accumulation are not yet completely understood, the engineering of proline metabolism could lead to new opportunities to improve plant tolerance of environmental stresses.
    制备储备液(仅供参考)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 8.6881 mL 43.4405 mL 86.881 mL 173.7619 mL 217.2024 mL
    5 mM 1.7376 mL 8.6881 mL 17.3762 mL 34.7524 mL 43.4405 mL
    10 mM 0.8688 mL 4.344 mL 8.6881 mL 17.3762 mL 21.7202 mL
    50 mM 0.1738 mL 0.8688 mL 1.7376 mL 3.4752 mL 4.344 mL
    100 mM 0.0869 mL 0.4344 mL 0.8688 mL 1.7376 mL 2.172 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    部分图片展示
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    5-羟基-2-吡咯烷酮; 5-Hydroxy-2-pyrrolidinone CFN97072 62312-55-4 C4H7NO2 = 101.1 5mg QQ客服：215959384
    蕨内酰胺; Pterolactam CFN98614 38072-88-7 C5H9NO2 = 115.1 5mg QQ客服：2056216494
    盐酸水苏碱; Stachydrine hydrochloride CFN98506 4136-37-2 C7H14ClNO2 = 179.64 20mg QQ客服：1457312923
    脯氨酸; Proline CFN99612 147-85-3 C5H9NO2 = 115.1 20mg QQ客服：2159513211
    去甲基烟碱; Nornicotine CFN80056 494-97-3 C9H12N2 = 148.10 5mg QQ客服：215959384
    L-尼古丁; L-Nicotine CFN99512 54-11-5 C10H14N2 = 162.23 20mg QQ客服：1457312923
    (1'S.2'S)-尼古丁1'-氧化物 ; Nicotine 1'-N-oxide CFN96582 51095-86-4 C10H14N2O = 178.23 5mg QQ客服：1457312923
    Aglain C; Aglain C CFN96309 177468-85-8 C36H42N2O8 = 630.7 5mg QQ客服：2056216494
    Aglain B; Aglain B CFN96344 177262-32-7 C36H42N2O8 = 630.7 5mg QQ客服：215959384
    Aglaxiflorin D; Aglaxiflorin D CFN96299 269739-78-8 C36H42N2O9 = 646.7 5mg QQ客服：2056216494

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