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  • 去甲基烟碱

    Nornicotine

    去甲基烟碱
    产品编号 CFN80056
    CAS编号 494-97-3
    分子式 = 分子量 C9H12N2 = 148.10
    产品纯度 >=98%
    物理属性 Powder
    化合物类型 Alkaloids
    植物来源 The herbs of Nicotiana tabacum.
    ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用
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    产品名称 产品编号 CAS编号 包装 QQ客服
    去甲基烟碱 CFN80056 494-97-3 1mg QQ客服:215959384
    去甲基烟碱 CFN80056 494-97-3 5mg QQ客服:215959384
    去甲基烟碱 CFN80056 494-97-3 10mg QQ客服:215959384
    去甲基烟碱 CFN80056 494-97-3 20mg QQ客服:215959384
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    ChemFaces的产品在许多优秀和顶级科学期刊中被引用

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.
    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.
    IF=12.804(2019)

    PMID: 30417089
    我们的产品现已经出口到下面的研究机构与大学,并且还在增涨
  • Ateneo de Manila University (Philippines)
  • Pennsylvania State University (USA)
  • Kyoto University (Japan)
  • Universidade Católica Portuguesa (Portugal)
  • Macau University of Science and Technology (China)
  • Universidade Federal de Goias (UFG) (Brazil)
  • Universiti Kebangsaan Malaysia (Malaysia)
  • Max Rubner-Institut (MRI) (Germany)
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  • Ain Shams University (Egypt)
  • National Cancer Institute (USA)
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  • Calcutta University (India)
  • Sri Ramachandra University (India)
  • More...
  • 国外学术期刊发表的引用ChemFaces产品的部分文献
  • J Chromatogr Sci.2015, 53(5):824-9
  • Free Radic Biol Med.2017, 112:191-199
  • J Separation Science & Technology2016, 51:1579-1588
  • Journal of Third Military Medical University2018, 40(12):1073-1078
  • Nat Commun.2019, 10(1):5169
  • J Microbiol Immunol Infect.2021, S1684-1182(21)00142-0.
  • Molecules.2019, 24(10):E1930
  • Evid Based Complement Alternat Med.2016, 2016:1230294
  • Korea Institute of Oriental Medicine2020, doi: 10.21203.
  • Phytomedicine.2022, 110:154597.
  • Int J Mol Sci.2022, 23(21):12816.
  • Anticancer Res.2022, 42(9):4403-4410.
  • Microb Pathog.2019, 131:128-134
  • Universitat Stuttgart2022, opus-12200.
  • JOTCSA.2023, 10(4); 893-902.
  • J.Acta Agriculturae Scandinavica2017, 571-575
  • Vietnam Journal of Food Control.2022, 5(2): 115-128.
  • Research on Crops.2017, 18(2)
  • Plants2022, 11(3),294.
  • Int J Mol Sci.2020, 21(7):2530.
  • Front Plant Sci.2021, 12:673337.
  • Appl. Sci.2020, 10(8),2804
  • Int J Mol Sci.2022, 23(21):13112.
  • ...
  • 生物活性
    Description: Nornicotine serves as the direct precursor in the synthesis of N'-nitrosonornicotine, a potent carcinogen in laboratory animals. Nornicotine and nicotine can promote endothelial cellular proliferation, migration and tube formation of HUVECs in vitro.Nornicotine and nicotine each produced a dose-dependent decrease in nicotine self-administration, nornicotine may be an effective treatment for tobacco dependence. S(-)-Nornicotine may be of value, either alone or in combination with an opioid, for treatment of a broad-spectrum of pain (i.e. nociceptive, neuropathic, and mixed pain).Nornicotine inhibits striatal dopamine transporter (DAT) function via a nicotinic receptor (nAChR) -mediated mechanism.
    Targets: P450 (e.g. CYP17) | AChR | VEGFR
    In vitro:
    Ophthalmic Res. 2015;55(1):1-9.
    Nornicotine and Nicotine Induced Neovascularization via Increased VEGF/PEDF Ratio.[Pubmed: 26536586]
    The purpose of the current study was to evaluate the influences of Nornicotine and nicotine (NT) in cigarette smoke on the expression of vascular endothelial growth factor (VEGF) and pigment epithelium-derived factor (PEDF) in retinal pigment epithelium cells and human umbilical vein endothelial cells (HUVECs). Furthermore, the angiogenic behaviors of endothelial cells under Nornicotine and NT treatment were assessed by using in vitro methods.
    METHODS AND RESULTS:
    ARPE-19 cells and HUVECs were treated with different concentrations of either Nornicotine or NT for different periods of time. The cell proliferative effect was investigated by using the method of MTT analysis. HUVEC migration and tube formation were assessed by using the scratch assay and Matrigel models. The expressions of VEGF and PEDF gene and protein in both types of cells were examined by real-time RT-PCR and Western blot. There was no proliferation of ARPE-19 cells following treatment with various concentrations of Nornicotine or NT. In contrast, Nornicotine or NT significantly stimulated HUVEC proliferation, migration and tube formation. Nornicotine and NT upregulated the expression of VEGF but suppressed the expression of PEDF at both mRNA and protein levels in a dose- and time-dependent manner in ARPE-19 cells and HUVECs.
    CONCLUSIONS:
    Our results demonstrate that Nornicotine and NT promoted endothelial cellular proliferation, migration and tube formation of HUVECs in vitro. These effects might be partly due to simultaneous modulation of VEGF/PEDF signaling in ARPE-19 cells and HUVECs.
    In vivo:
    Psychopharmacology (Berl). 2000 Oct;152(3):289-94.
    Nornicotine pretreatment decreases intravenous nicotine self-administration in rats.[Pubmed: 11105939]
    Nicotine has been shown to be effective as a treatment for reducing tobacco dependence. However, few studies have examined the effect of other nicotinic agonists to determine if they can also decrease nicotine self-administration. The present study determined if Nornicotine, a tobacco alkaloid and major nicotine metabolite in brain, could reduce nicotine self-administration in rats.
    METHODS AND RESULTS:
    Each rat was prepared with an indwelling jugular catheter and trained to self-administer intravenous nicotine (0.03 mg/kg per infusion). After nicotine self-administration stabilized, rats were pretreated with either (-)-nicotine (0, 0.1, 0.3, and 1.0 mg/kg free base) or (+/-)-Nornicotine (0, 1, 3, 5.6, and 10.0 mg/kg free base) and assessed for nicotine self-administration. A separate group of rats was maintained on sucrose reinforced responding and pretreated with Nornicotine to determine the specificity of the pretreatment effect. In another group of rats, the time course of the pretreatment effect of either (-)-nicotine (0.56 and 1.0 mg/kg) or (+/-)-Nornicotine (5.6 and 10.0 mg/kg) was examined. Nicotine and Nornicotine each produced a dose-dependent decrease in nicotine self-administration. Furthermore, the decrease in nicotine self-administration in response to the 5.6 mg/kg Nornicotine pretreatment was specific to nicotine self-administration, as this dose did not decrease sucrose reinforced responding in tolerant animals. In addition, within the dose range tested, the suppressant effect of Nornicotine had a two-fold longer duration than that of nicotine (120 versus 60 min).
    CONCLUSIONS:
    These results suggest that Nornicotine may be an effective treatment for tobacco dependence.
    Synapse. 2007 Mar;61(3):157-65.
    Nornicotine inhibition of dopamine transporter function in striatum via nicotinic receptor activation.[Pubmed: 17146768]
    Nornicotine, a tobacco alkaloid and N-demethylated nicotine metabolite, releases DA from superfused rat striatal slices in a mecamylamine-sensitive manner, indicating nicotinic receptor (nAChR) modulation of this response.
    METHODS AND RESULTS:
    The current study determined the effect of Nornicotine on rat striatal dopamine transporter (DAT) function using in vivo voltammetry. In a dose-related and mecamylamine-sensitive manner, Nornicotine (0.35-12.0 mg/kg, s.c.) decreased DA clearance, suggesting that Nornicotine inhibits striatal DAT function via a nAChR-mediated mechanism. Furthermore, the nAChRs mediating the Nornicotine-induced inhibition of DAT function appear to be different from those activated by nicotine which increases DA clearance.
    CONCLUSIONS:
    Understanding the actions of Nornicotine in brain may have significance for emerging therapeutics and for the management of nicotine dependence.
    制备储备液(仅供参考)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 6.7522 mL 33.761 mL 67.5219 mL 135.0439 mL 168.8049 mL
    5 mM 1.3504 mL 6.7522 mL 13.5044 mL 27.0088 mL 33.761 mL
    10 mM 0.6752 mL 3.3761 mL 6.7522 mL 13.5044 mL 16.8805 mL
    50 mM 0.135 mL 0.6752 mL 1.3504 mL 2.7009 mL 3.3761 mL
    100 mM 0.0675 mL 0.3376 mL 0.6752 mL 1.3504 mL 1.688 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    部分图片展示
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    5-羟基-2-吡咯烷酮; 5-Hydroxy-2-pyrrolidinone CFN97072 62312-55-4 C4H7NO2 = 101.1 5mg QQ客服:1413575084
    蕨内酰胺; Pterolactam CFN98614 38072-88-7 C5H9NO2 = 115.1 5mg QQ客服:215959384
    盐酸水苏碱; Stachydrine hydrochloride CFN98506 4136-37-2 C7H14ClNO2 = 179.64 20mg QQ客服:3257982914
    脯氨酸; Proline CFN99612 147-85-3 C5H9NO2 = 115.1 20mg QQ客服:215959384
    去甲基烟碱; Nornicotine CFN80056 494-97-3 C9H12N2 = 148.10 5mg QQ客服:3257982914
    L-尼古丁; L-Nicotine CFN99512 54-11-5 C10H14N2 = 162.23 20mg QQ客服:2056216494
    (1'S.2'S)-尼古丁1'-氧化物 ; Nicotine 1'-N-oxide CFN96582 51095-86-4 C10H14N2O = 178.23 5mg QQ客服:2159513211
    Aglain C; Aglain C CFN96309 177468-85-8 C36H42N2O8 = 630.7 5mg QQ客服:1413575084
    Aglain B; Aglain B CFN96344 177262-32-7 C36H42N2O8 = 630.7 5mg QQ客服:215959384
    Aglaxiflorin D; Aglaxiflorin D CFN96299 269739-78-8 C36H42N2O9 = 646.7 5mg QQ客服:2159513211

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