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  • 茯苓酸B

    Poricoic acid B

    茯苓酸B
    产品编号 CFN95050
    CAS编号 137551-39-4
    分子式 = 分子量 C30H44O5 = 484.7
    产品纯度 >=98%
    物理属性 Powder
    化合物类型 Triterpenoids
    植物来源 The roots of Wolfiporia cocos (Schw.) Ryv.
    ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用
    提供自定义包装
    产品名称 产品编号 CAS编号 包装 QQ客服
    茯苓酸B CFN95050 137551-39-4 1mg QQ客服:3257982914
    茯苓酸B CFN95050 137551-39-4 5mg QQ客服:3257982914
    茯苓酸B CFN95050 137551-39-4 10mg QQ客服:3257982914
    茯苓酸B CFN95050 137551-39-4 20mg QQ客服:3257982914
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    ChemFaces的产品在许多优秀和顶级科学期刊中被引用

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.
    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.
    IF=12.804(2019)

    PMID: 30417089
    我们的产品现已经出口到下面的研究机构与大学,并且还在增涨
  • Korea Institute of Oriental Medicine (Korea)
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  • More...
  • 国外学术期刊发表的引用ChemFaces产品的部分文献
  • The Korea Society of Pha.2014, 300-314
  • Phytomedicine.2015, 22(4):498-503
  • Mol Immunol. 2016, 78:121-132
  • Current Pharmaceutical Analysis2017, 13(5)
  • Sci Rep. 2017, 17332(7)
  • The Japan Society for Analy. Chem.2017, 66(8):613-617
  • Food Res Int.2018, 106:909-919
  • J Hematol Oncol.2018, 11(1):112
  • Int J Mol Sci.2018, 19(2)
  • Int J Mol Sci.2018, 19(9):E2601
  • Food Chem.2018, 262:78-85
  • Toxicol In Vitro.2018, 52:94-105
  • Korean J. Crop Sci.2018, 63(2):131-139
  • Pharmacol Rep.2018, 70(6):1195-1201
  • J Chromatogr B Analyt Technol Biomed Life Sci.2019, 1113:1-13
  • J of Physics Conference Series2019, 1349(1)
  • Evid Based Complement Alternat Med.2019, 2019:2135351
  • J Asian Nat Prod Res.2019, 5:1-17
  • Korean Journal of Pharmacognosy2019, 50(4):285-290
  • Phytomedicine.2019, 56:48-56
  • Phytomedicine.2019, 57:95-104
  • Environ Toxicol Pharmacol.2019, 66:109-115
  • Neurochem Int.2020, 133:104629
  • ...
  • 生物活性
    Description: Poricoic acid B shows inhibitory activity against TPA-induced ear inflammatory oedema, it also shows potent inhibitory effects on Epstein-Barr virus early antigen (EBV-EA) activation induced by the tumor promoter 12-O-tetradecanoylphorbol-13-acetate (TPA).
    In vitro:
    J Nat Prod. 2002 Apr;65(4):462-5.
    Inhibition of tumor-promoting effects by poricoic acids G and H and other lanostane-type triterpenes and cytotoxic activity of poricoic acids A and G from Poria cocos.[Pubmed: 11975480]
    The structures of two novel 3,4-seco-lanostane-type triterpenes isolated from the sclerotium of Poria cocos were established to be 16alpha-hydroxy-3,4-seco-lanosta-4(28),8,24-triene-3,21-dioic acid (1; poricoic acid G) and 16alpha-hydroxy-3,4-seco-24-methyllanosta-4(28),8,24(24(1))-triene-3,21-dioic acid (2; poricoic acid H) on the basis of spectroscopic methods.
    METHODS AND RESULTS:
    These two, and eight other known compounds isolated from the sclerotium, Poricoic acid B (3), poricoic acid A (4), tumulosic acid (5), dehydrotumulosic acid (6), 3-epidehydrotumulosic acid (7), polyporenic acid C (8), 25-hydroxy-3-epidehydrotumulosic acid (9), and dehydroabietic acid methyl ester (10), showed potent inhibitory effects on Epstein-Barr virus early antigen (EBV-EA) activation induced by the tumor promoter 12-O-tetradecanoylphorbol-13-acetate (TPA). Evaluation of the cytotoxicity of compounds 1 and 4 against human cancer cell lines revealed that 1 was significantly cytotoxic to leukemia HL-60 cells [GI(50) (concentration that yields 50% growth) value 39.3 nM], although it showed only moderate cytotoxicity to the other cells. Compound 4 exhibited moderate cytotoxicity to all of the cancer cell lines tested.
    In vivo:
    Phytotherapy Research,1996,10(7):581-4.
    Inhibitory Effect of Poria cocos on 12-O-Tetradecanoylphorbol-13Acetate‐Induced Ear Oedema and Tumour Promotion in Mouse Skin[Reference: WebLink]
    The methanol extract from the sclerotium of Poria cocos was found to inhibit 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced tumour promotion in two-stage carcinogenesis in mouse skin.
    METHODS AND RESULTS:
    From the active fraction of the extract, eight lanostane-type triterpene acids and four 3,4-secolanostane-type triterpene acids were isolated. The isolated compounds showed inhibitory activity against TPA-induced ear inflammatory oedema. The 50% inhibitory dose of pachymic acid, 3-O-acetyl-16α-hydroxytrametenolic acid, dehydropachymic acid, dehydroeburiconic acid, 3β-hydroxylanosta-7,9(11),24-trien-21-oic acid, poricoic acid A and Poricoic acid B for TPA-induced inflammation was 17–44 μg/ear, at a grade corresponding to that of hydrocortisone.
    制备储备液(仅供参考)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 2.0631 mL 10.3157 mL 20.6313 mL 41.2626 mL 51.5783 mL
    5 mM 0.4126 mL 2.0631 mL 4.1263 mL 8.2525 mL 10.3157 mL
    10 mM 0.2063 mL 1.0316 mL 2.0631 mL 4.1263 mL 5.1578 mL
    50 mM 0.0413 mL 0.2063 mL 0.4126 mL 0.8253 mL 1.0316 mL
    100 mM 0.0206 mL 0.1032 mL 0.2063 mL 0.4126 mL 0.5158 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    部分图片展示
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    Tsugaric acid A; Tsugaric acid A CFN90990 174391-64-1 C32H50O4 = 498.8 5mg QQ客服:2932563308
    榄香酮酸; Beta-Elemonic acid CFN90991 28282-25-9 C30H46O3 = 454.7 5mg QQ客服:215959384
    16 alpha-Hydroxytrametenolic acid; 16 alpha-Hydroxytrametenolic acid CFN90803 176390-68-4 C30H48O4 = 472.7 10mg QQ客服:2932563308
    3-O-Acetyl-16 alpha-hydroxytrametenolic acid; 3-O-Acetyl-16 alpha-hydroxytrametenolic acid CFN90804 168293-13-8 C32H50O5 = 514.8 10mg QQ客服:1413575084
    松苓新酸; Dehydrotrametenolic acid CFN90577 29220-16-4 C30H46O3 = 454.69 20mg QQ客服:2932563308
    16α-羟基松苓新酸; 16alpha-Hydroxydehydrotrametenolic acid CFN90790 176390-66-2 C30H46O4 = 470.7 10mg QQ客服:1148253675
    3-O-乙酰基-16α-羟基松苓新酸; 3-O-Acetyl-16 alpha-hydroxydehydrotrametenolic acid CFN90791 168293-14-9 C32H48O5 = 512.7 10mg QQ客服:2932563308
    茯苓酸B; Poricoic acid B CFN95050 137551-39-4 C30H44O5 = 484.7 10mg QQ客服:2932563308
    茯苓酸G; Poricoic acid G CFN95056 415724-84-4 C30H46O5 = 486.7 5mg QQ客服:1148253675
    大戟二烯醇; Euphol CFN89516 514-47-6 C30H50O = 426.71 10mg QQ客服:1148253675

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