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    • 松苓新酸

    Dehydrotrametenolic acid

    松苓新酸
    		产品编号 CFN90577
    CAS编号 29220-16-4
    分子式 = 分子量 C30H46O3 = 454.69
    产品纯度 >=98%
    物理属性 Powder
    化合物类型 Triterpenoids
    植物来源 The roots of Wolfiporia cocos (Schw.) Ryv.
    ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用
    提供自定义包装
    产品名称 产品编号 CAS编号 包装 QQ客服
    松苓新酸 CFN90577 29220-16-4 10mg QQ客服：215959384
    松苓新酸 CFN90577 29220-16-4 20mg QQ客服：215959384
    松苓新酸 CFN90577 29220-16-4 50mg QQ客服：215959384
    松苓新酸 CFN90577 29220-16-4 100mg QQ客服：215959384
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    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
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    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
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    IF=12.804(2019)

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    • 国外学术期刊发表的引用ChemFaces产品的部分文献
  • Malaysian J of Fundamental and Applied Sciences 2018, 14(3):368-373
  • Molecules.2020, 25(23):5556.
  • J Pharmaceut Biomed2020, 182:113110
  • J Biol Chem.2014, 289(3):1723-31
  • J Biochem Mol Toxicol.2017, 31(9)
  • Phytomedicine.2016, 23(4):331-9
  • Molecules.2016, 21(10)
  • J of Engineering Science&Technology2018, 13(9):2820-2828
  • VNU Journal of Science2023, No. 20.
  • Appl. Sci. 2021, 11(8),3437.
  • Molecules.2021, 26(19):6032.
  • BMC Plant Biol.2021, 21(1):60.
  • Molecules.2020, 25(3):734
  • Pak J Pharm Sci.2019, 32(6)
  • Cell Physiol Biochem.2017, 43(4):1425-1435
  • J. Food Composition and Analysis2022, 114:104731
  • Int J Mol Sci.2018, 19(2)
  • Korean Herb. Med. Inf.2020, 8(2):243-254.
  • Nutrients2020, 12(2):488
  • iScience.2023, 26(9):107602.
  • Chemistry of Plant Raw Materials2019, 4:135-147
  • Front Immunol.2018, 9:2655
  • Industrial Crops and Products2021, 163:113313.
  • ...
    • 生物活性
    Description: Dehydrotrametenolic acid is a promising candidate for a new type of insulin-sensitizing drug; it can be a potential anticancer agent against H-ras transformed tumor.
    Targets: PARP | Caspase | Akt | ERK | PPAR
    In vitro:
    Life Sci. 2006 Jan 2;78(6):607-13.
    Dehydrotrametenolic acid selectively inhibits the growth of H-ras transformed rat2 cells and induces apoptosis through caspase-3 pathway.[Pubmed: 16112686]
    The screening of natural products that preferentially inhibit growth of H-ras transformed rat2 cells vs. rat2 cells was performed to identify H-ras specific growth inhibitor.
    METHODS AND RESULTS:
    A lanostane-type triterpene acid, dehydrotrametenolic acid (3beta-hydroxylanosta-7,9(11),24-trien-21-oic acid), was isolated from the sclerotium of Poria cocos (Polyporaceae). Dehydrotrametenolic acid selectively inhibited the growth of H-ras transformed cells with a GI(50) value of 40 microM. FACS analysis indicated that the compound exerted its anti-proliferation effects through cell cycle arrest at G2/M phase and accumulation of sub-G1 population. Dehydrotrametenolic acid-induced apoptosis was further confirmed with chromosomal DNA fragmentation, caspase-3 activation, and degradation of PARP and Lamin A/C degradation. The compound also regulated the expression of H-ras, Akt and Erk, which are the downstream proteins of H-ras signaling pathways.
    CONCLUSIONS:
    The results suggest that dehydrotrametenolic acid can be a potential anticancer agent against H-ras transformed tumor.
    In vivo:
    Biol Pharm Bull. 2002 Jan;25(1):81-6.
    Dehydrotrametenolic acid induces preadipocyte differentiation and sensitizes animal models of noninsulin-dependent diabetes mellitus to insulin.[Pubmed: 11824563]
    We recently discovered that the triterpene acid compound dehydrotrametenolic acid promotes adipocyte differentiation in vitro and acts as an insulin sensitizer in vivo. This natural product has been isolated from dried sclerotia of Poria cocos WOLF (Polyporaceae), a well-known traditional Chinese medicinal plant.
    METHODS AND RESULTS:
    We examined the effects of dehydrotrametenolic acid on plasma glucose concentration in obese hyperglycemic db/db mice. Dehydrotrametenolic acid can reduce hyperglycemia in mouse models of noninsulin-dependent diabetes mellitus (NIDDM) and act as an insulin sensitizer as indicated by the results of the glucose tolerance test. These terpenoids and thiazolidine type of antidiabetic agents such as Ciglitazone, although structurally unrelated, share many biological activities: both induce adipose conversion, activate peroxisome proliferator-activated receptor gamma (PPAR gamma) in vitro, and reduce hyperglycemia in animal models of NIDDM. Dehydrotrametenolic acid is a promising candidate for a new type of insulin-sensitizing drug.
    CONCLUSIONS:
    This finding is very important for the development of insulin sensitizers that are not of the thiazolidine type.
    制备储备液(仅供参考)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 2.1993 mL 10.9965 mL 21.993 mL 43.986 mL 54.9825 mL
    5 mM 0.4399 mL 2.1993 mL 4.3986 mL 8.7972 mL 10.9965 mL
    10 mM 0.2199 mL 1.0997 mL 2.1993 mL 4.3986 mL 5.4983 mL
    50 mM 0.044 mL 0.2199 mL 0.4399 mL 0.8797 mL 1.0997 mL
    100 mM 0.022 mL 0.11 mL 0.2199 mL 0.4399 mL 0.5498 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    部分图片展示
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    金钱松呋喃酸; Pseudolarifuroic acid CFN91924 130825-79-5 C30H42O4 = 466.65 5mg QQ客服：2056216494
    3-氧代甘遂-7,24-二烯-21-酸; 3-Oxotirucalla-7,24-dien-21-oic acid CFN97609 82464-35-5 C30H46O3 = 454.69 5mg QQ客服：2056216494
    苦楝萜酸甲酯; Methyl kulonate CFN92975 22611-37-6 C31H48O4 = 484.71 5mg QQ客服：215959384
    帕克醇; Parkeol CFN92825 514-45-4 C30H50O = 426.7 5mg QQ客服：2056216494
    葫芦二烯醇; Cucurbitadienol CFN92378 35012-08-9 C30H50O = 426.7 5mg QQ客服：1413575084
    桦褐孔菌醇; Inotodiol CFN92367 35963-37-2 C30H50O2 = 442.7 5mg QQ客服：2159513211
    3beta-羟基羊毛甾-8,24-二烯-21-醛; 3beta-Hydroxylanosta-8,24-diene-21-al CFN92365 96574-03-7 C30H48O2 = 440.7 5mg QQ客服：1457312923
    3β-羟基-羊毛甾-8,24-二烯-21-酸; Trametenolic acid CFN92366 24160-36-9 C30H48O3 = 456.7 10mg QQ客服：1457312923
    Tsugaric acid A; Tsugaric acid A CFN90990 174391-64-1 C32H50O4 = 498.8 5mg QQ客服：3257982914
    榄香酮酸; Beta-Elemonic acid CFN90991 28282-25-9 C30H46O3 = 454.7 20mg QQ客服：2056216494

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