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    酸浆苦味素G

    Physalin G

    酸浆苦味素G
    产品编号 CFN95104
    CAS编号 76045-38-0
    分子式 = 分子量 C28H30O10 = 526.5
    产品纯度 >=98%
    物理属性 Powder
    化合物类型 Steroids
    植物来源 The herbs of Physalis alkekengi
    ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用
    提供自定义包装
    产品名称 产品编号 CAS编号 包装 QQ客服
    酸浆苦味素G CFN95104 76045-38-0 1mg QQ客服:2159513211
    酸浆苦味素G CFN95104 76045-38-0 5mg QQ客服:2159513211
    酸浆苦味素G CFN95104 76045-38-0 10mg QQ客服:2159513211
    酸浆苦味素G CFN95104 76045-38-0 20mg QQ客服:2159513211
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    ChemFaces的产品在许多优秀和顶级科学期刊中被引用

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.
    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.
    IF=12.804(2019)

    PMID: 30417089
    我们的产品现已经出口到下面的研究机构与大学,并且还在增涨
  • Monash University (Australia)
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  • University of Stirling (United Kingdom)
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  • 国外学术期刊发表的引用ChemFaces产品的部分文献
  • J Biol Chem.2014, 289(3):1723-31
  • Int J Mol Sci.2015, 16(1):1232-51
  • Arch Pharm Res.2015, 38(6):1080-9
  • FEBS Lett.2015, 589(1):182-7
  • Mediators Inflamm.2016, 2016:7216912
  • Phytochem Anal.2016, 27(5):296-303
  • Acta Chromatographica2016, 29(3)
  • Mol Immunol. 2016, 78:121-132
  • Invest New Drugs.2017, 35(2):166-179
  • Aquaculture2017, 481:94-102
  • The Pharmaceutical Society of Japan2018, 138(4):571-579
  • BMC Pharmacol Toxicol.2018, 19(1):5
  • J Cell Mol Med.2018, 22(9):4236-4242
  • Front Microbiol.2019, 10:2806
  • Int J Mol Sci.2019, 20(3):E651
  • J Ethnopharmacol.2019, 228:132-141
  • Molecules.2019, 24(4):E744
  • Molecules.2019, 24(6):E1155
  • Food Chem.2019, 290:286-294
  • J Food Biochem.2019, 43(9):e12970
  • Phytomedicine.2019, 62:152962
  • Chem Pharm Bull (Tokyo).2019, 67(11):1242-1247
  • J of Ana. Chem.2019, 74(11):1113-1121
  • ...
  • 生物活性
    Description: Physalin G has antinociceptive property.
    In vitro:
    Pharmacogn Mag. 2016 May;12(Suppl 2):S231-6.
    Chemopreventive Agents from Physalis minima Function as Michael Reaction Acceptors.[Pubmed: 27279713]
    The fruits of some varieties of genus Physalis have been used as delicious fruits and functional food in the Northeast of China.
    METHODS AND RESULTS:
    To reveal the functional material basis, we performed bioactivity-guided phytochemical research and chemopreventive effect assay of the constituents from Physalis minima. It was demonstrated that the ethyl acetate extract of P. minima L. (EEPM) had potential quinone reductase (QR) inducing activity with induction ratio (IR, QR induction activity) value of 1.47 ± 0.24, and glutathione binding property as potential Michael reaction acceptors (with an α, β-unsaturated ketone moiety). Furthermore, bioactivity-guided phytochemical research led eight compounds (1-8), which were elucidated as 3-isopropyl-5-acetoxycyclohexene-2-one-1 (1), isophysalin B (2), physalin G (3), physalin D (4), physalin I (5), physordinose B (6), stigmasterol-3-O-β-D-glucopyranoside (7) and 5α-6β-dihydroxyphysalin R (8) on the basis of nuclear magnetic resonance spectroscopy analyses and HRESIMS. Then, isophysalin B (2) and physordinose B (6) showed significant QR inducing activity with IR value of 2.80 ± 0.19 and 2.38 ± 0.46, respectively. An ultra-performance liquid chromatographic method with glutathione as the substrate was used to detect the Michael reaction acceptors in extracts of Physalis minima (EPM).We investigated the chemical constituents of EPM guided by biological activity methodIsophysalin B (1) and physordinose B (6) showed strong quinone reductase inducing activity with induction ratio values of 2.80 ± 0.19 and 2.38 ± 0.46.
    CONCLUSIONS:
    This study generated useful information for consumers and many encourage researchers to utilize edible fruits from Physalis as a source of phytochemicals.
    In vivo:
    J Nat Prod. 2014 Nov 26;77(11):2397-403.
    Antinociceptive properties of physalins from Physalis angulata.[Pubmed: 25396337]
    Pain is the most common reason a patient sees a physician. Nevertheless, the use of typical painkillers is not completely effective in controlling all pain syndromes; therefore further attempts have been made to develop improved analgesic drugs. The present study was undertaken to evaluate the antinociceptive properties of physalin B (1), physalin D (2), physalin F (3), and physalin G (4) isolated from Physalis angulata in inflammatory and centrally mediated pain tests in mice.
    METHODS AND RESULTS:
    Systemic pretreatment with 1-4 produced dose-related antinociceptive effects on the writhing and formalin tests, traditional screening tools for the assessment of analgesic drugs. On the other hand, only 3 inhibited inflammatory parameters such as hyperalgesia, edema, and local production of TNF-α following induction with complete Freund's adjuvant. Treatment with 1, 3, and 4 produced an antinociceptive effect on the tail flick test, suggesting a centrally mediated antinociception. Reinforcing this idea, 2-4 enhanced the mice latency reaction time during the hot plate test. Mice treated with physalins did not demonstrate motor performance alterations.
    CONCLUSIONS:
    These results suggest that 1-4 present antinociceptive properties associated with central, but not anti-inflammatory, events and indicate a new pharmacological property of physalins.
    制备储备液(仅供参考)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 1.8993 mL 9.4967 mL 18.9934 mL 37.9867 mL 47.4834 mL
    5 mM 0.3799 mL 1.8993 mL 3.7987 mL 7.5973 mL 9.4967 mL
    10 mM 0.1899 mL 0.9497 mL 1.8993 mL 3.7987 mL 4.7483 mL
    50 mM 0.038 mL 0.1899 mL 0.3799 mL 0.7597 mL 0.9497 mL
    100 mM 0.019 mL 0.095 mL 0.1899 mL 0.3799 mL 0.4748 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    部分图片展示
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    根薯酮内酯A; Taccalonolide A CFN90596 108885-68-3 C36H46O14 = 702.74 10mg QQ客服:3257982914
    根薯酮内酯AJ; Taccalonolide AJ CFN90935 1349904-82-0 C34H44O14 = 676.7 5mg QQ客服:1413575084
    酸浆苦素L; Physalin L CFN90166 113146-74-0 C28H32O10 = 528.55 5mg QQ客服:2932563308
    酸浆苦味A; Physalin A CFN92940 23027-91-0 C28H30O10 = 526.5 5 mg QQ客服:1413575084
    酸浆苦素O; Physalin O CFN95097 120849-18-5 C28H32O10 = 528.55 5mg QQ客服:3257982914
    异酸浆苦味A; Isophysalin A CFN92936 1363398-67-7 C28H30O10 = 526.5 5mg QQ客服:1413575084
    酸浆苦味C; Physalin C CFN92938 27503-33-9 C28H30O9 = 510.53 5mg QQ客服:2932563308
    酸浆苦味B; Physalin B CFN92941 23133-56-4 C28H30O9 = 510.53 5mg QQ客服:215959384
    酸浆苦味D; Physalin D CFN92939 54980-22-2 C28H32O11 = 544.55 5mg QQ客服:1148253675
    酸浆苦味素G; Physalin G CFN95104 76045-38-0 C28H30O10 = 526.5 5mg QQ客服:1148253675

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