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  • 酸浆苦素L

    Physalin L

    酸浆苦素L
    产品编号 CFN90166
    CAS编号 113146-74-0
    分子式 = 分子量 C28H32O10 = 528.55
    产品纯度 >=98%
    物理属性 White powder
    化合物类型 Steroids
    植物来源 The herbs of Physalis alkekengi
    ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用
    提供自定义包装
    产品名称 产品编号 CAS编号 包装 QQ客服
    酸浆苦素L CFN90166 113146-74-0 1mg QQ客服:215959384
    酸浆苦素L CFN90166 113146-74-0 5mg QQ客服:215959384
    酸浆苦素L CFN90166 113146-74-0 10mg QQ客服:215959384
    酸浆苦素L CFN90166 113146-74-0 20mg QQ客服:215959384
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    ChemFaces的产品在许多优秀和顶级科学期刊中被引用

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.
    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.
    IF=12.804(2019)

    PMID: 30417089
    我们的产品现已经出口到下面的研究机构与大学,并且还在增涨
  • University of East Anglia (United Kingdom)
  • University of Queensland (Australia)
  • Universidad de La Salle (Mexico)
  • Seoul National University of Science and Technology (Korea)
  • Weizmann Institute of Science (Israel)
  • Universidade do Porto (Portugal)
  • Sant Gadge Baba Amravati University (India)
  • Funda??o Universitária de Desenvolvimento (Brazil)
  • University of Auckland (New Zealand)
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  • The Vancouver Prostate Centre (VPC) (Canada)
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  • Universidade de Franca (Brazil)
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  • 国外学术期刊发表的引用ChemFaces产品的部分文献
  • Nutrients.2021, 13(3):978.
  • Phytochemistry.2021, 181:112539.
  • Appl Biochem Biotechnol.2022, s12010-022-04166-2.
  • Current Pharmaceutical Analysis2017, 13(5)
  • Front Aging Neurosci.2019, 11:230
  • Molecules.2019, 24(2):E343
  • J Ethnopharmacol.2022, 282:114574.
  • Applied Biological Chemistry2022, 65(77).
  • Key Engineering Materials2022, 931(47-53).
  • J Anal Methods Chem.2022, 2022:2229500.
  • Antibiotics.2022, 11(4), 510.
  • Molecules.2018, 23(2)
  • Molecules.2019, 24(23):E4303
  • Food Chem.2020, 332:127412
  • Int J Mol Sci.2020, 21(7):2530.
  • Data Science for Genomics2023, 107-128.
  • Chem Biol Interact.2019, 315:108910
  • Food Bioscience2023, 56:103311.
  • Front Neurosci.2019, 13:1091
  • J Chromatogr B Analyt Technol Biomed Life Sci.2018, 1080:27-36
  • Natural Product Communications2020, doi: 10.1177.
  • Mol Microbiol.2019, 112(1):317-332
  • Phytomedicine.2015, 22(11):1027-36
  • ...
  • 生物活性
    Description: Physalin L shows a distinct fluorescence spot under UV 365 nm with good separation.
    In vitro:
    Steroids. 2012 Apr;77(5):441-7.
    Physalins with anti-inflammatory activity are present in Physalis alkekengi var. franchetii and can function as Michael reaction acceptors.[Pubmed: 22197662]
    Michael reaction acceptors (MRAs) are a class of active molecules that are directly or indirectly involved in various cellular processes, including the regulation of many signaling pathways.
    METHODS AND RESULTS:
    In this study, the inducible nitric oxide synthase (iNOS) assay was used to demonstrate that the dichloromethane extract of Physalis alkekengi var. franchetii (DCEP) possesses anti-inflammatory activity that might be attributed to the modification of key cysteine residues in IKKβ by the MRAs in DCEP. To isolate these MRAs, glutathione (GSH) was employed, and a simple ultra-performance liquid chromatography/tandem mass spectrometry (UPLC-MS/MS) screening method was developed to investigate the GSH conjugates with potential MRAs. Five physalins, including one new compound isophysalin A (2), together with four known steroidal compounds, physalin A (1), physalin O (3), physalin L (4) and physalin G (5), were isolated to evaluate the GSH conjugating abilities, and it was indicated that compounds 1, 2 and 3, which had a common α,β-unsaturated ketone moiety, exhibited conjugating abilities with GSH and also showed significant nitric oxide (NO) production inhibiting activities. The anti-inflammatory activities of compounds 1, 2 and 3 might be attributed to their targeting multiple cysteine residues on IKKβ; therefore, the alkylation of IKKβ by compound 1 was further studied by micrOTOF-MS.
    CONCLUSIONS:
    The result showed that six cysteine residues (C(59), C(179), C(299), C(370), C(412), and C(618)) were alkylated, which indicated that IKKβ is a potential target for the anti-inflammatory activity of physalin A.
    制备储备液(仅供参考)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 1.892 mL 9.4598 mL 18.9197 mL 37.8394 mL 47.2992 mL
    5 mM 0.3784 mL 1.892 mL 3.7839 mL 7.5679 mL 9.4598 mL
    10 mM 0.1892 mL 0.946 mL 1.892 mL 3.7839 mL 4.7299 mL
    50 mM 0.0378 mL 0.1892 mL 0.3784 mL 0.7568 mL 0.946 mL
    100 mM 0.0189 mL 0.0946 mL 0.1892 mL 0.3784 mL 0.473 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    部分图片展示
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    异酸浆苦味素G; Isophysalin G CFN95328 152221-21-1 C28H30O10 = 526.5 5mg QQ客服:2159513211
    酸浆苦味H; Physalin H CFN92937 70241-09-7 C28H31ClO10 = 562.99 5mg QQ客服:2159513211
    4,7-二脱氢新酸浆苦素B; 4,7-Didehydroneophysalin B CFN95317 134461-76-0 C28H28O9 = 508.5 5mg QQ客服:2056216494
    酸浆苦味素X; Physalin X CFN95329 72497-31-5 C28H30O10 = 526.5 5mg QQ客服:2056216494
    根薯酮内酯A; Taccalonolide A CFN90596 108885-68-3 C36H46O14 = 702.74 10mg QQ客服:1413575084
    根薯酮内酯AJ; Taccalonolide AJ CFN90935 1349904-82-0 C34H44O14 = 676.7 5mg QQ客服:1413575084
    酸浆苦素L; Physalin L CFN90166 113146-74-0 C28H32O10 = 528.55 5mg QQ客服:1413575084
    酸浆苦味A; Physalin A CFN92940 23027-91-0 C28H30O10 = 526.5 5 mg QQ客服:2056216494
    酸浆苦素O; Physalin O CFN95097 120849-18-5 C28H32O10 = 528.55 5mg QQ客服:1413575084
    异酸浆苦味A; Isophysalin A CFN92936 1363398-67-7 C28H30O10 = 526.5 5mg QQ客服:1413575084

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