酸浆苦味H

Physalin H

	产品编号	CFN92937
	CAS编号	70241-09-7
	分子式 = 分子量	C₂₈H₃₁ClO₁₀ = 562.99
	产品纯度	>=98%
	物理属性	Powder
	化合物类型	Steroids
	植物来源	The herbs of Physalis alkekengi.
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产品名称	产品编号	CAS编号	包装	QQ客服
酸浆苦味H	CFN92937	70241-09-7	1mg	QQ客服：1457312923
酸浆苦味H	CFN92937	70241-09-7	5mg	QQ客服：1457312923
酸浆苦味H	CFN92937	70241-09-7	10mg	QQ客服：1457312923
酸浆苦味H	CFN92937	70241-09-7	20mg	QQ客服：1457312923

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Description:

Physalin H is an Hh signaling inhibitor blocks GLI1-DNA-complex formation, it also strong quinone reductase induction activity with IR (Induction ratio, QR induction activity) value of 3.74±0.02. Physalin H shows immunosuppressive effects on T cells both in vitro and in vivo, and the immunosuppressive activity might be attributed to the suppression of T cell activation and proliferation, the modulation of Th1/Th2 cytokine balance and the induction of HO-1 in T cells. Physalin H shows significant in vitro leishmanicidal activities (0.92-19.4 microg/ml) against promastigotes of Leishmania major.Physalin H shows cytotoxic activity against a panel of human and murine cancer cell lines.

Targets:

HO-1 | gp120/CD4 | Antifection

In vitro:

Steroids. 2014 Oct;88:60-5.

Unprecedent aminophysalin from Physalis angulata.[Pubmed: 24973634 ]

METHODS AND RESULTS:
The 95% ethanol extract of the whole plant of Physalis angulata Linn. afforded one new skeletal physalin named aminophysalin A (1) and one new naturally occurring 5β-hydroxy-6a-chloro-5,6-dihydrophysalin B (2), together with five known physalins (3-7). Their structures were elucidated through MS, IR, NMR spectroscopy analyses and X-ray crystallography. Aminophysalin A (1) had an absolutely unusual structural feature in the chemistry of physalins with a nitrogen atom. Compounds 1-7 were evaluated for quinone reductase activities in hepa 1c1c7 cells.
CONCLUSIONS:
Physalin H (6) showed strong quinone reductase induction activity with IR (Induction ratio, QR induction activity) value of 3.74±0.02, using 4-bromoflavone as a positive control substance (2.17±0.01, 10 μg/mL), while compounds 1, 2, 3, 5 showed weak quinone reductase induction activity.

Beilstein J Org Chem. 2014 Jan 13;10:134-40.

Physalin H from Solanum nigrum as an Hh signaling inhibitor blocks GLI1-DNA-complex formation.[Pubmed: 24454566 ]

Hedgehog (Hh) signaling plays an important role in embryonic development, cell maintenance and cell proliferation. Moreover, Hh signaling contributes to the growth of cancer cells. Physalins are highly oxidized natural products with a complex structure.
METHODS AND RESULTS:
Physalins (1-7) were isolated from Solanum nigrum (Solanaceae) collected in Bangladesh by using our cell-based assay. The isolated physalins included the previously reported Hh inhibitors 5 and 6. Compounds 1 and 4 showed strong inhibition of GLI1 transcriptional activity, and exhibited cytotoxicity against cancer cell lines with an aberrant activation of Hh signaling. Compound 1 inhibited the production of the Hh-related proteins patched (PTCH) and BCL2.
CONCLUSIONS:
Analysis of the structures of different physalins showed that the left part of the physalins was important for Hh inhibitory activity. Interestingly, Physalin H (1) disrupted GLI1 binding to its DNA binding domain, while the weak inhibitor physalin G (2) did not show inhibition of GLI1-DNA complex formation.

Chem Biodivers. 2005 Sep;2(9):1164-73.

Antileishmanial physalins from Physalis minima.[Pubmed: 17193198 ]

METHODS AND RESULTS:
Three new physalins (1-3) and a new withanolide 7 have been isolated from the whole plant of Physalis minima, along with three known physalins: Physalin H (4), isophysalin B (5), and 5beta,6beta-epoxyphysalin B (6). Their structures were deduced on the basis of in-depth spectroscopic analyses.
CONCLUSIONS:
Compounds 1-6 showed significant in vitro leishmanicidal activities (0.92-19.4 microg/ml) against promastigotes of Leishmania major.

In vivo:

Int Immunopharmacol. 2010 Mar;10(3):290-7.

Investigation of the immunosuppressive activity of Physalin H on T lymphocytes.[Pubmed: 19951747]

Physalis angulata is an annual herb widely used in folk medicine. It is mainly used for treating rheumatoid arthritis (RA). Following bioactivity-guided isolation, a representative immunosuppressive compound, Physalin H was been identified from this herb medicine. The purpose of this work was to assess the immunosuppressive activity of Physalin H on T cells and to explore its potential mode of action.
METHODS AND RESULTS:
The results showed that Physalin H in a dose-dependent manner significantly inhibited the proliferation of T cells induced by concanavalin A (ConA) and by the mixed lymphocyte culture reaction (MLR). This inhibitive activity was mainly due to interfering DNA replication in G1 stages. In vivo experiments showed that, administration of Physalin H dose-dependently suppressed CD4(+) T cell mediated delayed-type hypersensitivity (DTH) reactions, and suppressed antigen-specific T-cell response in ovalbumin (OVA) immunized mice. Further study indicated that Physalin H could modulate Th1/Th2 cytokine balance and induce the production of immune regulation target Heme oxygenase (HO)-1 in T-cells in vitro.
CONCLUSIONS:
In this study, we demonstrated the immunosuppressive effect of Physalin H on T cells both in vitro and in vivo, and the immunosuppressive activity might be attributed to the suppression of T cell activation and proliferation, the modulation of Th1/Th2 cytokine balance and the induction of HO-1 in T cells.

产品名称	产品编号	CAS编号	分子式 = 分子量	位单	联系QQ
酸浆苦味B; Physalin B	CFN92941	23133-56-4	C₂₈H₃₀O₉ = 510.53	5mg	QQ客服：2056216494
酸浆苦味D; Physalin D	CFN92939	54980-22-2	C₂₈H₃₂O₁₁ = 544.55	5mg	QQ客服：2159513211
酸浆苦味素F; Physalin F	CFN91811	57423-71-9	C₂₈H₃₀O₁₀ = 526.5	10mg	QQ客服：1457312923
酸浆苦味素G; Physalin G	CFN95104	76045-38-0	C₂₈H₃₀O₁₀ = 526.5	5mg	QQ客服：2159513211
异酸浆苦味素G; Isophysalin G	CFN95328	152221-21-1	C₂₈H₃₀O₁₀ = 526.5	5mg	QQ客服：2159513211
酸浆苦味H; Physalin H	CFN92937	70241-09-7	C₂₈H₃₁ClO₁₀ = 562.99	5mg	QQ客服：1457312923
4,7-二脱氢新酸浆苦素B; 4,7-Didehydroneophysalin B	CFN95317	134461-76-0	C₂₈H₂₈O₉ = 508.5	5mg	QQ客服：1413575084
酸浆苦味素X; Physalin X	CFN95329	72497-31-5	C₂₈H₃₀O₁₀ = 526.5	5mg	QQ客服：1413575084
根薯酮内酯A; Taccalonolide A	CFN90596	108885-68-3	C₃₆H₄₆O₁₄ = 702.74	10mg	QQ客服：3257982914
根薯酮内酯AJ; Taccalonolide AJ	CFN90935	1349904-82-0	C₃₄H₄₄O₁₄ = 676.7	5mg	QQ客服：3257982914

	1 mg	5 mg	10 mg	20 mg	25 mg
1 mM	1.7762 mL	8.8812 mL	17.7623 mL	35.5246 mL	44.4058 mL
5 mM	0.3552 mL	1.7762 mL	3.5525 mL	7.1049 mL	8.8812 mL
10 mM	0.1776 mL	0.8881 mL	1.7762 mL	3.5525 mL	4.4406 mL
50 mM	0.0355 mL	0.1776 mL	0.3552 mL	0.7105 mL	0.8881 mL
100 mM	0.0178 mL	0.0888 mL	0.1776 mL	0.3552 mL	0.4441 mL

酸浆苦味H

Physalin H

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