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    N-反式阿魏酰酪胺

    N-trans-Feruloyltyramine

    N-反式阿魏酰酪胺
    产品编号 CFN97135
    CAS编号 66648-43-9
    分子式 = 分子量 C18H19NO4 = 313.4
    产品纯度 >=98%
    物理属性 Powder
    化合物类型 Phenylpropanoids
    植物来源 The herbs of Cannabis sativa L.
    ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用
    提供自定义包装
    产品名称 产品编号 CAS编号 包装 QQ客服
    N-反式阿魏酰酪胺 CFN97135 66648-43-9 1mg QQ客服:2056216494
    N-反式阿魏酰酪胺 CFN97135 66648-43-9 5mg QQ客服:2056216494
    N-反式阿魏酰酪胺 CFN97135 66648-43-9 10mg QQ客服:2056216494
    N-反式阿魏酰酪胺 CFN97135 66648-43-9 20mg QQ客服:2056216494
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    ChemFaces的产品在许多优秀和顶级科学期刊中被引用

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.
    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.
    IF=12.804(2019)

    PMID: 30417089
    我们的产品现已经出口到下面的研究机构与大学,并且还在增涨
  • University of Lodz (Poland)
  • Calcutta University (India)
  • Universiti Putra Malaysia(UPM) (Malaysia)
  • Medical University of Gdansk (Poland)
  • University of Queensland (Australia)
  • Molecular Biology Institute of Barcelona (IBMB)-CSIC (Spain)
  • Technical University of Denmark (Denmark)
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  • Instituto de Investigaciones Agropecuarias (Chile)
  • University of Hull (United Kingdom)
  • Shanghai University of TCM (China)
  • Univerzita Karlova v Praze (Czech Republic)
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  • University of Fribourg (Switzerland)
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  • 国外学术期刊发表的引用ChemFaces产品的部分文献
  • HortTechnology2016, 26(6):816-819
  • The Korea Journal of Herbology2016, 29-35
  • Pharmacognosy Magazine2017, 13(52):868-874
  • Evid Based Complement Alternat Med.2017, 2017:1401279
  • Hum Exp Toxicol.2017, 36(11):1169-1176
  • J Food Compos Anal2017, 62:197-204
  • Nat Prod Communications2018, 10.1177
  • The Pharmaceutical Society of Japan2018, 138(4):571-579
  • Journal of functional foods2018, 171-182
  • Exp Parasitol.2018, 194:67-78
  • Phytomedicine.2018, 40:37-47
  • Biochem Biophys Res Commun.2018, 495(1):1271-1277
  • Front Immunol.2018, 9:2091
  • Microb Pathog.2019, 131:128-134
  • Exp Ther Med.2019, 18(6):4388-4396
  • Evid Based Complement Alternat Med.2019, 2019:2135351
  • Int J Cosmet Sci.2019, 41(1):12-20
  • Biomed Chromatogr.2019, 8:e4774
  • Pharmaceutics.2020, 12(9):845.
  • Phytother Res.2020, 34(4):788-795.
  • J Agric Food Chem.2020, 68(43):12164-12172.
  • Antimicrob Agents Chemother.2020, AAC.01921-20.
  • Evid Based Complement Alternat Med.2021, 8707280.
  • ...
  • 生物活性
    Description: N-trans-Feruloyltyramine(NTF) is a platelet aggregation inhibitor, which has hepatoprotective, and antioxidative effects, NTF is likely to inhibit COX enzymes, thereby suppressing P-selectin expression on platelets;NTF inhibits melanogenesis in a dose-dependent manner.
    Targets: NO | PGE | AP-1 | NOS | COX | TNF-α | JNK | Beta Amyloid | Caspase
    In vitro:
    Chem Biol Interact. 2015 Jun 25;235:56-62.
    N-trans-feruloyltyramine inhibits LPS-induced NO and PGE2 production in RAW 264.7 macrophages: Involvement of AP-1 and MAP kinase signalling pathways.[Pubmed: 25843058]
    Mitogen-activated protein kinase (MAPK) signalling pathway can regulate inflammatory and immune responses. N-trans-feruloyltyramine (FLA) is an active phenylpropanoid compound. It possesses antioxidant, antimicrobial, anti-melanogenesis, and anticancer activities. However, the precise molecular mechanisms underlying FLA modulation of cytokine expression in LPS-stimulated RAW 264.7 macrophages have not been fully investigated. In this study, we examined the mechanisms underlying the immunomodulative effects of FLA isolated from Arcangelisia gusanlung.
    METHODS AND RESULTS:
    FLA strongly suppressed mRNA expression of inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2), but not tumor necrosis factor (TNF)-α, thereby inhibiting the production of nitric oxide (NO) and prostaglandin E2 (PGE2) in lipopolysaccharide (LPS)-stimulated RAW 264.7 cells. Furthermore, FLA also inhibited nuclear translocation of activation protein (AP)-1, and simultaneously decreased the expression and phosphorylation of the c-Jun N-terminal kinase (JNK) protein.
    CONCLUSIONS:
    These results suggest that the anti-inflammatory effects of FLA might be attributed to downregulation of COX-2 and iNOS via suppression of AP-1 and the JNK signalling pathway in RAW 264.7 macrophages.
    Fitoterapia. 2010 Mar;81(2):124-31.
    Antioxidant and enzyme inhibition activities and chemical profiles of Polygonum sachalinensis F.Schmidt ex Maxim (Polygonaceae).[Pubmed: 19698767]
    Polygonum sachalinensis is a widespread invasive plant in Europe. Chemical profiles of its different organs were studied by HPLC-UV-ESI/MS.
    METHODS AND RESULTS:
    Seven major constituents quercetin-3-O-beta-D-galactopyranoside, quercetin-3-O-arabinopyranoside, lapathoside D, N-trans-feruloyltyramine, lapathoside C, hydropiperoside, and vanicoside B were isolated and identified. The free radical-scavenging, alpha/beta-glucosidase, and acetylcholinesterase inhibitory activities of crude MeOH extracts and isolated compounds were studied. The structure-activity relationships were discussed. The chemical profiles revealed flavonoids and phenylpropanoids are the major compounds of all the organs of this plant. Quercetin-3-O-arabinopyranoside, lapathoside D, N-trans-feruloyltyramine, lapathoside C and hydropiperoside were isolated from this species for the first time. In the alpha-glucosidase bioassay, quercetin-3-O-beta-D-galactopyranoside, lapathoside D and N-trans-feruloyltyramine demonstrated stronger activities than the positive reference acarbose.
    CONCLUSIONS:
    The trend in scavenging power showed no relation to enzyme inhibition in the test models.
    制备储备液(仅供参考)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 3.1908 mL 15.9541 mL 31.9081 mL 63.8162 mL 79.7703 mL
    5 mM 0.6382 mL 3.1908 mL 6.3816 mL 12.7632 mL 15.9541 mL
    10 mM 0.3191 mL 1.5954 mL 3.1908 mL 6.3816 mL 7.977 mL
    50 mM 0.0638 mL 0.3191 mL 0.6382 mL 1.2763 mL 1.5954 mL
    100 mM 0.0319 mL 0.1595 mL 0.3191 mL 0.6382 mL 0.7977 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    部分图片展示
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    N1,N10-双(对香豆酰)亚精胺; N1,N10-Bis(p-coumaroyl)spermidine CFN99248 114916-05-1 C25H31N3O4 = 437.5 5mg QQ客服:2159513211
    3,4-二羟基肉桂酰胺; 3,4-Dihydroxycinnamamide CFN99316 1202-41-1 C9H9NO3 = 179.2 5mg QQ客服:3257982914
    3-[3,4-双(乙酰氧基)苯基]-2-丙烯酰胺; 3,4-Diacetoxycinnamamide CFN99390 129488-34-2 C13H13NO5 = 263.3 5mg QQ客服:1457312923
    阿魏酸酰胺; Ferulamide CFN97041 61012-31-5 C10H11NO3 = 193.2 5mg QQ客服:3257982914
    印枳碱; Aegeline CFN91133 456-12-2 C18H19NO3 = 297.4 20mg QQ客服:2159513211
    N-咖啡酰O-甲基酪胺; N-Caffeoyl O-methyltyramine CFN70295 189307-47-9 C18H19NO4 = 313.4 5mg QQ客服:2056216494
    N-反式阿魏酰酪胺; N-trans-Feruloyltyramine CFN97135 66648-43-9 C18H19NO4 = 313.4 10mg QQ客服:1413575084
    N-反式-阿魏酰-3-甲氧基酪胺; N-trans-Feruloyl-3-methoxytyramine CFN97268 78510-19-7 C19H21NO5 = 343.4 5mg QQ客服:2932563308
    芥子酰酪胺; N-trans-Sinapoyltyramine CFN91137 200125-11-7 C19H21NO5 = 343.4 10mg QQ客服:1457312923
    4-羟基肉桂酰胺; 4-Hydroxycinnamamide CFN99895 194940-15-3 C9H9NO2 = 163.2 5mg QQ客服:2159513211

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