N-对反式香豆酰酪胺

N-p-trans-Coumaroyltyramine

	产品编号	CFN98494
	CAS编号	36417-86-4
	分子式 = 分子量	C₁₇H₁₇NO₃ = 283.3
	产品纯度	>=98%
	物理属性	Powder
	化合物类型	Phenylpropanoids
	植物来源	The herbs of Exochorda racemosa.
ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用

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产品名称	产品编号	CAS编号	包装	QQ客服
N-对反式香豆酰酪胺	CFN98494	36417-86-4	1mg	QQ客服：1413575084
N-对反式香豆酰酪胺	CFN98494	36417-86-4	5mg	QQ客服：1413575084
N-对反式香豆酰酪胺	CFN98494	36417-86-4	10mg	QQ客服：1413575084
N-对反式香豆酰酪胺	CFN98494	36417-86-4	20mg	QQ客服：1413575084

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ChemFaces的产品在许多优秀和顶级科学期刊中被引用

Cell. 2018 Jan 11;172(1-2):249-261.e12.
doi: 10.1016/j.cell.2017.12.019.
IF=36.216(2019)

PMID: 29328914

Cell Metab. 2020 Mar 3;31(3):534-548.e5.
doi: 10.1016/j.cmet.2020.01.002.
IF=22.415(2019)

PMID: 32004475

Mol Cell. 2017 Nov 16;68(4):673-685.e6.
doi: 10.1016/j.molcel.2017.10.022.
IF=14.548(2019)

PMID: 29149595

ACS Nano. 2018 Apr 24;12(4): 3385-3396.
doi: 10.1021/acsnano.7b08969.
IF=13.903(2019)

PMID: 29553709

Nature Plants. 2016 Dec 22;3: 16206.
doi: 10.1038/nplants.2016.205.
IF=13.297(2019)

PMID: 28005066

Sci Adv. 2018 Oct 24;4(10): eaat6994.
doi: 10.1126/sciadv.aat6994.
IF=12.804(2019)

PMID: 30417089

University of Bordeaux (France)

University of Oslo (Norway)

Shanghai Institute of Organic Chemistry (China)

University of Auckland (New Zealand)

Korea Intitute of Science and Technology (KIST) (Korea)

Yale University (USA)

Medical University of South Carolina (USA)

Auburn University (USA)

Uniwersytet Medyczny w ?odzi (Poland)

University of Toulouse (France)

Medizinische Universit?t Wien (Austria)

Kyoto University (Japan)

National Cancer Center Research Institute (Japan)

Florida International University (USA)

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Description:

N-p-trans-Coumaroyltyramine is an inhibitor on acetylcholinesterase (AChE), it inhibits AChE activity in a dose-dependent manner with IC50 value of 34.5 microg/mL (122 microM). It exhibits potent inhibition of cell proliferation, platelet aggregation, and shows antioxidant activity. N-trans-p-coumaroyltyramine shows activity against Trypanosoma brucei rhodesiense (IC50s ranging from 2.2 to 13.3 microM).

Targets:

AChR

In vitro:

Arch. Pharm. Res.,2003, 26(9):735-8.

Inhibitory effect of trans-N-p-coumaroyl tryamine from the twigs of Celtis chinensis on the acetylcholinesterase.[Pubmed: 14560923]

METHODS AND RESULTS:
The methanolic extract of the twigs of Celtis chinensis was found to show inhibitory activity on acetylcholinesterase (AChE), an enzyme that plays a role in the metabolic hydrolysis of ACh. Bioassay-guided fractionation of the methanolic extract resulted in the isolation of N-p-trans-Coumaroyltyramine, as an inhibitor on AChE.
CONCLUSIONS:
This compound inhibited AChE activity in a dose-dependent manner, and the IC50 value of N-p-trans-Coumaroyltyramine was 34.5 microg/mL (122 microM).

Nat Prod Commun. 2012 Jun;7(6):753-5.

Cinnamoylphenethyl amides from Polygonum hyrcanicum possess anti-trypanosomal activity.[Pubmed: 22816300]

METHODS AND RESULTS:
A methanolic extract from aerial parts of Polygonum hyrcanicum (Polygonaceae) showed high activity against Trypanosoma brucei rhodesiense (IC50 = 3.7 microg/mL). Bioassay-guided fractionation of the extract resulted in isolation of cinnamoylphenethyl amides, including N-trans-caffeoyltyramine (1), N-p-trans-Coumaroyltyramine (7), and N-trans-feruloyltyramine (8) as the main active constituents (IC50s ranging from 2.2 to 13.3 microM). Some structurally related, but less active compounds, such as cannabisin B (2), tyrosol (3), p-coumaric acid (4), ferulic acid (5), and N-cis-feruloyltyramine (6) were also identified, along with N-trans-3,4-dimethoxycinnamoyldopamine (9).
CONCLUSIONS:
Cytotoxicity of the active compounds in L6 cells was determined, and selectivity indices (SI) of 7.9 to 33.4 were calculated.

产品名称	产品编号	CAS编号	分子式 = 分子量	位单	联系QQ
芥子酰酪胺; N-trans-Sinapoyltyramine	CFN91137	200125-11-7	C₁₉H₂₁NO₅ = 343.4	10mg	QQ客服：1457312923
N-苯甲酰酪胺; N-benzoyltyramine	CFN91563	41859-54-5	C₁₅H₁₅NO₂ = 241.3	10mg	QQ客服：1457312923
4-羟基肉桂酰胺; 4-Hydroxycinnamamide	CFN99895	194940-15-3	C₉H₉NO₂ = 163.2	5mg	QQ客服：1413575084
黄皮新肉桂酰胺B; Lansiumamide B	CFN95718	121817-37-6	C₁₈H₁₇NO = 263.3	10mg	QQ客服：2056216494
N-对反式香豆酰酪胺; N-p-trans-Coumaroyltyramine	CFN98494	36417-86-4	C₁₇H₁₇NO₃ = 283.3	10mg	QQ客服：1457312923
N-反式-对香豆酰酪胺; N-trans-p-Coumaroyltyrosine	CFN95279	77201-66-2	C₁₈H₁₇NO₅ = 327.3	10mg	QQ客服：2056216494
N-对香豆酰-N’-咖啡酰腐胺; N-p-coumaroyl-N'-caffeoylputrescine	CFN99238	1138156-77-0	C₂₂H₂₄N₂O₅ = 396.4	5mg	QQ客服：1457312923
N-反式-对香豆酰-N'-反式-阿魏酰-3-羟基-1,5-戊二胺; N-trans-p-Coumaroyl-N'-trans-feruloyl-3-hydroxy-cadaverine	CFN95637	2584997-91-9	C₂₅H₃₀N₂O₇ = 470.5	5mg	QQ客服：2056216494
N1,N10-双(对香豆酰)亚精胺; N1,N10-Bis(p-coumaroyl)spermidine	CFN99248	114916-05-1	C₂₅H₃₁N₃O₄ = 437.5	5mg	QQ客服：1413575084
3,4-二羟基肉桂酰胺; 3,4-Dihydroxycinnamamide	CFN99316	1202-41-1	C₉H₉NO₃ = 179.2	5mg	QQ客服：3257982914

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	1 mg	5 mg	10 mg	20 mg	25 mg
1 mM	3.5298 mL	17.6491 mL	35.2983 mL	70.5965 mL	88.2457 mL
5 mM	0.706 mL	3.5298 mL	7.0597 mL	14.1193 mL	17.6491 mL
10 mM	0.353 mL	1.7649 mL	3.5298 mL	7.0597 mL	8.8246 mL
50 mM	0.0706 mL	0.353 mL	0.706 mL	1.4119 mL	1.7649 mL
100 mM	0.0353 mL	0.1765 mL	0.353 mL	0.706 mL	0.8825 mL