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    N-对反式香豆酰酪胺

    N-p-trans-Coumaroyltyramine

    N-对反式香豆酰酪胺
    产品编号 CFN98494
    CAS编号 36417-86-4
    分子式 = 分子量 C17H17NO3 = 283.3
    产品纯度 >=98%
    物理属性 Powder
    化合物类型 Phenylpropanoids
    植物来源 The herbs of Exochorda racemosa.
    ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用
    提供自定义包装
    产品名称 产品编号 CAS编号 包装 QQ客服
    N-对反式香豆酰酪胺 CFN98494 36417-86-4 1mg QQ客服:2932563308
    N-对反式香豆酰酪胺 CFN98494 36417-86-4 5mg QQ客服:2932563308
    N-对反式香豆酰酪胺 CFN98494 36417-86-4 10mg QQ客服:2932563308
    N-对反式香豆酰酪胺 CFN98494 36417-86-4 20mg QQ客服:2932563308
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    ChemFaces的产品在许多优秀和顶级科学期刊中被引用

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.
    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.
    IF=12.804(2019)

    PMID: 30417089
    我们的产品现已经出口到下面的研究机构与大学,并且还在增涨
  • University of Oslo (Norway)
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  • Monash University Sunway Campus (Malaysia)
  • University of Toulouse (France)
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  • Kyoto University (Japan)
  • Charles Sturt University (Denmark)
  • Imperial College London (United Kingdom)
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  • Medizinische Universit?t Wien (Austria)
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  • More...
  • 国外学术期刊发表的引用ChemFaces产品的部分文献
  • J Breast Cancer.2015, 18(2):112-118
  • Phytomedicine.2015, 22(14):1262-8
  • Acta Physiologiae Plantarum2015, 37:1736
  • J Agric Food Chem.2015, 63(44):9869-78
  • Molecules.2016, 21(10)
  • J Basic Clin Physiol Pharmacol.2016, 27(1):1-8
  • Vojnosanit Pregl2016, 75(00):391-391
  • Universidade Estadual Paulista2017, 11449
  • Molecules.2017, 22(11)
  • Nat Prod Communications2018, 10.1177
  • Int J Biol Macromol.2018, 112:1093-1103
  • Molecules.2018, 23(7):E1659
  • Bio-protocol2018, 9(14):e3301
  • Int J Mol Sci.2019, 20(3):E651
  • Molecules.2019, 24(2):E343
  • Int J Mol Med.2019, 43(6):2516-2522
  • J Food Sci Technol.2019, 56(5):2712-2720
  • Front Immunol.2020, 11:598556.
  • Biomed Pharmacother.2020, 128:110318.
  • Evid Based Complement Alternat Med.2020, 2020:8582318.
  • Rev. Chim.2020, 71(3),558-564
  • J of Pharmaceutical Analysis2020, doi: 10.1016
  • Chung Shan Medical University2020, US20200323790A1
  • ...
  • 生物活性
    Description: N-p-trans-Coumaroyltyramine is an inhibitor on acetylcholinesterase (AChE), it inhibits AChE activity in a dose-dependent manner with IC50 value of 34.5 microg/mL (122 microM). It exhibits potent inhibition of cell proliferation, platelet aggregation, and shows antioxidant activity. N-trans-p-coumaroyltyramine shows activity against Trypanosoma brucei rhodesiense (IC50s ranging from 2.2 to 13.3 microM).
    Targets: AChR
    In vitro:
    Arch. Pharm. Res.,2003, 26(9):735-8.
    Inhibitory effect of trans-N-p-coumaroyl tryamine from the twigs of Celtis chinensis on the acetylcholinesterase.[Pubmed: 14560923]

    METHODS AND RESULTS:
    The methanolic extract of the twigs of Celtis chinensis was found to show inhibitory activity on acetylcholinesterase (AChE), an enzyme that plays a role in the metabolic hydrolysis of ACh. Bioassay-guided fractionation of the methanolic extract resulted in the isolation of N-p-trans-Coumaroyltyramine, as an inhibitor on AChE.
    CONCLUSIONS:
    This compound inhibited AChE activity in a dose-dependent manner, and the IC50 value of N-p-trans-Coumaroyltyramine was 34.5 microg/mL (122 microM).
    Nat Prod Commun. 2012 Jun;7(6):753-5.
    Cinnamoylphenethyl amides from Polygonum hyrcanicum possess anti-trypanosomal activity.[Pubmed: 22816300]

    METHODS AND RESULTS:
    A methanolic extract from aerial parts of Polygonum hyrcanicum (Polygonaceae) showed high activity against Trypanosoma brucei rhodesiense (IC50 = 3.7 microg/mL). Bioassay-guided fractionation of the extract resulted in isolation of cinnamoylphenethyl amides, including N-trans-caffeoyltyramine (1), N-p-trans-Coumaroyltyramine (7), and N-trans-feruloyltyramine (8) as the main active constituents (IC50s ranging from 2.2 to 13.3 microM). Some structurally related, but less active compounds, such as cannabisin B (2), tyrosol (3), p-coumaric acid (4), ferulic acid (5), and N-cis-feruloyltyramine (6) were also identified, along with N-trans-3,4-dimethoxycinnamoyldopamine (9).
    CONCLUSIONS:
    Cytotoxicity of the active compounds in L6 cells was determined, and selectivity indices (SI) of 7.9 to 33.4 were calculated.
    制备储备液(仅供参考)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 3.5298 mL 17.6491 mL 35.2983 mL 70.5965 mL 88.2457 mL
    5 mM 0.706 mL 3.5298 mL 7.0597 mL 14.1193 mL 17.6491 mL
    10 mM 0.353 mL 1.7649 mL 3.5298 mL 7.0597 mL 8.8246 mL
    50 mM 0.0706 mL 0.353 mL 0.706 mL 1.4119 mL 1.7649 mL
    100 mM 0.0353 mL 0.1765 mL 0.353 mL 0.706 mL 0.8825 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    部分图片展示
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    N-反式阿魏酰酪胺; N-trans-Feruloyltyramine CFN97135 66648-43-9 C18H19NO4 = 313.4 10mg QQ客服:2056216494
    N-反式-阿魏酰-3-甲氧基酪胺; N-trans-Feruloyl-3-methoxytyramine CFN97268 78510-19-7 C19H21NO5 = 343.4 5mg QQ客服:1413575084
    芥子酰酪胺; N-trans-Sinapoyltyramine CFN91137 200125-11-7 C19H21NO5 = 343.4 10mg QQ客服:1413575084
    4-羟基肉桂酰胺; 4-Hydroxycinnamamide CFN99895 194940-15-3 C9H9NO2 = 163.2 5mg QQ客服:2932563308
    N-对反式香豆酰酪胺; N-p-trans-Coumaroyltyramine CFN98494 36417-86-4 C17H17NO3 = 283.3 10mg QQ客服:3257982914
    N-对香豆酰-N’-咖啡酰腐胺; N-p-coumaroyl-N'-caffeoylputrescine CFN99238 1138156-77-0 C22H24N2O5 = 396.4 5mg QQ客服:2056216494
    N1,N10-双(对香豆酰)亚精胺; N1,N10-Bis(p-coumaroyl)spermidine CFN99248 114916-05-1 C25H31N3O4 = 437.5 5mg QQ客服:2932563308
    3,4-二羟基肉桂酰胺; 3,4-Dihydroxycinnamamide CFN99316 1202-41-1 C9H9NO3 = 179.2 5mg QQ客服:1457312923
    3-[3,4-双(乙酰氧基)苯基]-2-丙烯酰胺; 3,4-Diacetoxycinnamamide CFN99390 129488-34-2 C13H13NO5 = 263.3 5mg QQ客服:1457312923
    阿魏酸酰胺; Ferulamide CFN97041 61012-31-5 C10H11NO3 = 193.2 5mg QQ客服:1457312923

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