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    4-羟基肉桂酰胺

    4-Hydroxycinnamamide

    4-羟基肉桂酰胺
    产品编号 CFN99895
    CAS编号 194940-15-3
    分子式 = 分子量 C9H9NO2 = 163.2
    产品纯度 >=98%
    物理属性 Powder
    化合物类型 Phenylpropanoids
    植物来源 The herbs of Berberis pruinosa.
    ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用
    提供自定义包装
    产品名称 产品编号 CAS编号 包装 QQ客服
    4-羟基肉桂酰胺 CFN99895 194940-15-3 1mg QQ客服:1457312923
    4-羟基肉桂酰胺 CFN99895 194940-15-3 5mg QQ客服:1457312923
    4-羟基肉桂酰胺 CFN99895 194940-15-3 10mg QQ客服:1457312923
    4-羟基肉桂酰胺 CFN99895 194940-15-3 20mg QQ客服:1457312923
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    ChemFaces的产品在许多优秀和顶级科学期刊中被引用

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.
    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.
    IF=12.804(2019)

    PMID: 30417089
    我们的产品现已经出口到下面的研究机构与大学,并且还在增涨
  • CSIRO - Agriculture Flagship (Australia)
  • Universidad Industrial de Santander (Colombia)
  • Griffith University (Australia)
  • Universidade Federal de Goias (UFG) (Brazil)
  • Technical University of Denmark (Denmark)
  • Monash University (Australia)
  • University of Helsinki (Finland)
  • Funda??o Universitária de Desenvolvimento (Brazil)
  • Aarhus University (Denmark)
  • The University of Newcastle (Australia)
  • Nicolaus Copernicus Uniwersity (Poland)
  • Universiti Putra Malaysia(UPM) (Malaysia)
  • Rio de Janeiro State University (Brazil)
  • Celltrion Chemical Research Institute (Korea)
  • More...
  • 国外学术期刊发表的引用ChemFaces产品的部分文献
  • Pharmacogn Mag.2015, 11:S585-91
  • Food Research International2016, 106-113
  • Mediators Inflamm. 2016, 2016:6189590
  • Chemistry of Plant Materials.2016, 33-46
  • Acta Physiologiae Plantarum2016, 38:7
  • Braz J Med Biol Res. 2016, 49(7)
  • Biochem Systematics and Ecology2017, 11-18
  • J Biochem Mol Toxicol.2017, 31(9)
  • Int J Biol Macromol.2018, 112:1093-1103
  • J Sep Sci.2018, 41(11):2488-2497
  • Front Immunol.2018, 9:2655
  • Nutrients.2019, 11(11):E2694
  • Chinese Pharmacological Bulletin2019, 35(8):1120-1125
  • Chemistry of Plant Raw Materials2019, 4:135-147
  • Biochem Biophys Res Commun.2019, 518(4):732-738
  • Psychopharmacology (Berl).2020, 10.1007
  • Agronomy2020, 10(10),1489
  • Metabolites.2020, 11(1):E11.
  • LWT2020, 124:109163
  • Biochem Pharmacol. 2020, 177:114014.
  • Molecules.2020, 25(21):5087.
  • J Sep Sci.2020, 43(22):4148-4161.
  • Biochem Biophys Res Commun.2021, 534:802-807.
  • ...
  • 生物活性
    Description: 4-Hydroxycinnamamide has antioxidant activity. 4-Hydroxycinnamamide derivatives are specific inhibitors of tyrosine-specific protein kinases.
    Targets: EGFR | Calcium Channel | Sodium Channel | ATPase | Potassium Channel | AMPK | p38MAPK
    In vitro:
    Cancer Res. 1989 May 1;49(9):2374-8.
    Specific inhibitors of tyrosine-specific protein kinases: properties of 4-hydroxycinnamamide derivatives in vitro.[Pubmed: 2706625]

    METHODS AND RESULTS:
    Inhibition by seven synthetic 4-Hydroxycinnamamide derivatives, ST 271, ST 280, ST 458, ST 494, ST 633, ST 638, and ST 642, of tyrosine-specific protein kinases (tyrosine kinase) of oncogene or proto-oncogene products (p130gag-v-fps, p70gag-actin-v-fgr, pp60v-src, pp60c-src) and epidermal growth factor (EGF) receptor kinase were investigated. ST 638 (alpha-cyano-3-ethoxy-4-hydroxy-5-phenylthiomethylcinnamamide) strongly inhibited more of the tyrosine kinases than any of the other compounds. The susceptibilities of these tyrosine kinases to ST 638 increased in the following order: EGF receptor greater than p70gag-actin-v-fgr greater than pp60c-src greater than p130gag-v-fps, pp60v-src, with 50% inhibitory concentration values of 1.1, 4.2, 18, 70, and 87 microM, respectively. The phosphorylation of the tyrosine residues in particulate fractions from RR1022 cells expressing pp60v-src was inhibited by ST 638 in a dose-dependent way, while it had a negligible effect on the phosphorylations of threonine and serine residues. Kinetic analysis showed that ST 638 competitively inhibited the phosphorylation of an exogenous substrate by the EGF receptor kinase with a Ki of 2.1 microM. ST 638 noncompetitively inhibited autophosphorylation by EGF receptor kinase.
    CONCLUSIONS:
    These results indicate that ST 638 is a potent and specific inhibitor of tyrosine kinases in vitro, and that its inhibitory activity is caused by competing with the substrate protein for the tyrosine kinase binding site.
    Eur J Med Chem. 2015 Jan 7;89:628-37.
    Development of 3-hydroxycinnamamide-based HDAC inhibitors with potent in vitro and in vivo anti-tumor activity.[Pubmed: 25462271]
    Inhibition of histone deacetylases (HDACs) has diverse effects on cell function, such as causing differentiation, growth arrest and apoptosis in nearly all types of tumor cell lines.
    METHODS AND RESULTS:
    In our previous work, we have designed and synthesized a novel series of 4-Hydroxycinnamamide-based and 3-hydroxycinnamamide-based HDAC inhibitors (HDACIs), among which, 3-hydroxycinnamamide-based HDACIs 1a-1c exhibited moderate inhibition against HDACs. In this article, we report the development of a more potent class of 3-hydroxycinnamamide-based HDACIs, compound 7o exhibited much higher pan-HDAC inhibitory activity than positive control SAHA. In addition, compound 7h showed excellent in vitro growth inhibitory activity against more than ten cell lines and induced U937 cells apoptosis in micromolar concentration.
    CONCLUSIONS:
    In vivo assay in U937 xenograft model identified compound 7h as a potent, orally active HDACI.
    Bioorg Med Chem Lett. 2002 Sep 16;12(18):2599-602.
    Synthesis and evaluation of 4-hydroxyphenylacetic acid amides and 4-hydroxycinnamamides as antioxidants.[Pubmed: 12182869]
    4-Hydroxyphenylacetic acid amides and 4-Hydroxycinnamamides were synthesized and their antioxidant and neuroprotective activities were evaluated.
    METHODS AND RESULTS:
    Among the prepared compounds, 8b, and exhibited potent inhibition of lipid peroxidation in rat brain homogenates, and marked DPPH radical scavenging activities. Furthermore, and exhibited neuroprotective action against the oxidative damage induced by the exposure of primary cultured rat cortical cells to H(2)O(2), xanthine/xanthine oxidase, or Fe(2+)/ascorbic acid.
    CONCLUSIONS:
    Based on these results, we found that was the most potent antioxidant among the compounds tested.
    制备储备液(仅供参考)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 6.1275 mL 30.6373 mL 61.2745 mL 122.549 mL 153.1863 mL
    5 mM 1.2255 mL 6.1275 mL 12.2549 mL 24.5098 mL 30.6373 mL
    10 mM 0.6127 mL 3.0637 mL 6.1275 mL 12.2549 mL 15.3186 mL
    50 mM 0.1225 mL 0.6127 mL 1.2255 mL 2.451 mL 3.0637 mL
    100 mM 0.0613 mL 0.3064 mL 0.6127 mL 1.2255 mL 1.5319 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    部分图片展示
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    N1,N10-双(对香豆酰)亚精胺; N1,N10-Bis(p-coumaroyl)spermidine CFN99248 114916-05-1 C25H31N3O4 = 437.5 5mg QQ客服:1457312923
    3,4-二羟基肉桂酰胺; 3,4-Dihydroxycinnamamide CFN99316 1202-41-1 C9H9NO3 = 179.2 5mg QQ客服:2932563308
    3-[3,4-双(乙酰氧基)苯基]-2-丙烯酰胺; 3,4-Diacetoxycinnamamide CFN99390 129488-34-2 C13H13NO5 = 263.3 5mg QQ客服:2932563308
    阿魏酸酰胺; Ferulamide CFN97041 61012-31-5 C10H11NO3 = 193.2 5mg QQ客服:3257982914
    印枳碱; Aegeline CFN91133 456-12-2 C18H19NO3 = 297.4 20mg QQ客服:2056216494
    N-咖啡酰O-甲基酪胺; N-Caffeoyl O-methyltyramine CFN70295 189307-47-9 C18H19NO4 = 313.4 5mg QQ客服:1413575084
    N-反式阿魏酰酪胺; N-trans-Feruloyltyramine CFN97135 66648-43-9 C18H19NO4 = 313.4 10mg QQ客服:2932563308
    N-反式-阿魏酰-3-甲氧基酪胺; N-trans-Feruloyl-3-methoxytyramine CFN97268 78510-19-7 C19H21NO5 = 343.4 5mg QQ客服:2932563308
    芥子酰酪胺; N-trans-Sinapoyltyramine CFN91137 200125-11-7 C19H21NO5 = 343.4 10mg QQ客服:1413575084
    4-羟基肉桂酰胺; 4-Hydroxycinnamamide CFN99895 194940-15-3 C9H9NO2 = 163.2 5mg QQ客服:2932563308

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