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  • 甘草芳香豆素

    Licoarylcoumarin

    甘草芳香豆素
    产品编号 CFN95072
    CAS编号 125709-31-1
    分子式 = 分子量 C21H20O6 = 368.4
    产品纯度 >=98%
    物理属性 Powder
    化合物类型 Coumarins
    植物来源 The roots of Glycyrrhiza uralensis.
    ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用
    提供自定义包装
    产品名称 产品编号 CAS编号 包装 QQ客服
    甘草芳香豆素 CFN95072 125709-31-1 1mg QQ客服:215959384
    甘草芳香豆素 CFN95072 125709-31-1 5mg QQ客服:215959384
    甘草芳香豆素 CFN95072 125709-31-1 10mg QQ客服:215959384
    甘草芳香豆素 CFN95072 125709-31-1 20mg QQ客服:215959384
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    ChemFaces的产品在许多优秀和顶级科学期刊中被引用

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.
    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.
    IF=12.804(2019)

    PMID: 30417089
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  • 国外学术期刊发表的引用ChemFaces产品的部分文献
  • PLoS One.2015, 10(5):e0127060
  • J. Soc. Cosmet. Sci. Korea2016, 163-171
  • J Ethnopharmacol.2016, 192:370-381
  • Pharmacognosy Magazine2017, 13(52):868-874
  • J.Acta Agriculturae Scandinavica2017, 571-575
  • Integr Med Res.2017, 6(4):395-403
  • Korean j.of Pharm.2017, 70-76
  • International Food Research Journal2018, 25(6):2560-2571
  • Sci Adv.2018, 4(10)
  • The Japan Society for Analytical Chemistry2018, 67(4):201-206
  • Clin Transl Oncol.2019, 10.1007
  • Front Aging Neurosci.2019, 11:230
  • BMC Microbiol.2019, 19(1):78
  • J Ethnopharmacol.2019, 236:31-41
  • Exp Biol Med (Maywood).2019, 244(18):1665-1679
  • Journal of Third Military Medical University2019, 41(2):110-115
  • The Malaysian journal of pathology2019, 41(3):243-251
  • J Food Biochem.2019, 43(9):e12970
  • Phytomedicine.2019, 59:152785
  • Phytomedicine.2019, 67:153159
  • Antioxidants (Basel).2019, 8(8):E307
  • TCI CO.2019, US20190151281A1
  • J Pharmaceut Biomed2020, 182:113110
  • ...
  • 生物活性
    Description: Licoarylcoumarin is a strong inhibitor of adenosine 3',5'-cyclic monophosphate (cAMP) phosphodiesterase. Licoarylcoumarin has antibacterial effects on the VRE strains; it has anti-HIV activity, and it has inhibitory effects on xanthine oxidase.
    Targets: cAMP | HIV | Antifection
    In vitro:
    Molecules. 2014 Mar 28;19(4):3883-97.
    Structures of two new flavonoids and effects of licorice phenolics on vancomycin-resistant Enterococcus species.[Pubmed: 24686577]
    Since our previous study revealed that several licorice phenolics have antibacterial effects on methicillin-resistant Staphylococcus aureus (MRSA), and suppressive effects on the oxacillin resistance of MRSA, we further investigated effectiveness of licorice constituents on vancomycin-resistant Enterococcus (VRE) bacteria, and purified 32 phenolic compounds.
    METHODS AND RESULTS:
    Two flavonoids among them were characterized structurally, and identified their structures as demethylglycyrol (31) and 5,7-di-O-methylluteone (32), respectively. Examination of antibacterial effects of licorice phenolics showed that 3-arylcoumarins such as licoarylcoumarin (9) and glycycoumarin (26), and 2-arylcoumarones such as gancaonin I (17), have moderate to potent antibacterial effects on the VRE strains used in this study.
    Chem Pharm Bull (Tokyo). 1989 Nov;37(11):3005-9.
    Phenolic constituents of licorice. II. Structures of licopyranocoumarin, licoarylcoumarin and glisoflavone, and inhibitory effects of licorice phenolics on xanthine oxidase.[Pubmed: 2632045]

    METHODS AND RESULTS:
    An anti-HIV (human immunodeficiency virus) phenolic constituent, licopyranocoumarin (4), and two other new phenolics named licoarylcoumarin (5) and glisoflavone (6) were isolated from Si-pei licorice (a commercial licorice; root and stolon of Glycyrrhiza sp. from the north-western region of China) using droplet countercurrent chromatography and centrifugal partition chromatography, and their structures were assigned based on chemical and spectroscopic data. Kaempferol 3-O-methyl ether (7) and licocoumarone (8) were also isolated from the licorice.
    CONCLUSIONS:
    The inhibitory effects of ten licorice phenolics on xanthine oxidase were examined. Licochalcone B (1), glycyrrhisoflavone (2), 8 and licochalcone A (19) showed 50% inhibition at the concentration of 1.3-5.6 x 10(-5) M.
    制备储备液(仅供参考)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 2.7144 mL 13.5722 mL 27.1444 mL 54.2888 mL 67.861 mL
    5 mM 0.5429 mL 2.7144 mL 5.4289 mL 10.8578 mL 13.5722 mL
    10 mM 0.2714 mL 1.3572 mL 2.7144 mL 5.4289 mL 6.7861 mL
    50 mM 0.0543 mL 0.2714 mL 0.5429 mL 1.0858 mL 1.3572 mL
    100 mM 0.0271 mL 0.1357 mL 0.2714 mL 0.5429 mL 0.6786 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    部分图片展示
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    异去甲蟛蜞菊内脂; Isodemethylwedelolacton CFN90625 350681-33-3 C15H8O7 = 300.22 10mg QQ客服:1148253675
    补骨脂定; Psoralidin CFN98592 18642-23-4 C20H16O5 = 336.34 20mg QQ客服:1148253675
    新甘草酚; Neoglycyrol CFN90792 23013-84-5 C21H18O6 = 366.4 10mg QQ客服:2932563308
    甘草香豆素; Glycycoumarin CFN89408 94805-82-0 C21H20O6 = 368.37 10mg QQ客服:1413575084
    格里西轮; Glycyrin CFN89404 66056-18-6 C22H22O6 = 382.40 5mg QQ客服:215959384
    甘草吡喃香豆素; Licopyranocoumarin CFN92918 117038-80-9 C21H20O7 = 384.38 5mg QQ客服:215959384
    甘草芳香豆素; Licoarylcoumarin CFN95072 125709-31-1 C21H20O6 = 368.4 5mg QQ客服:215959384
    考迈斯托醇; Coumestrol CFN96040 479-13-0 C15H8O5 = 268.2 5mg QQ客服:2932563308
    4'-甲氧基香豆雌酚 ; 4'-O-Methylcoumestrol CFN96922 1690-62-6 C16H10O5 = 282.25 5mg QQ客服:1413575084
    去甲基蟛蜞内酯; Demethylwedelolactone CFN90521 6468-55-9 C15H8O7 = 300.21 20mg QQ客服:1413575084

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