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  • 去甲基蟛蜞内酯

    Demethylwedelolactone

    去甲基蟛蜞内酯
    产品编号 CFN90521
    CAS编号 6468-55-9
    分子式 = 分子量 C15H8O7 = 300.21
    产品纯度 >=98%
    物理属性 Yellow powder
    化合物类型 Coumarins
    植物来源 The herbs of Eclipta prostrata
    ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用
    提供自定义包装
    产品名称 产品编号 CAS编号 包装 QQ客服
    去甲基蟛蜞内酯 CFN90521 6468-55-9 10mg QQ客服:215959384
    去甲基蟛蜞内酯 CFN90521 6468-55-9 20mg QQ客服:215959384
    去甲基蟛蜞内酯 CFN90521 6468-55-9 50mg QQ客服:215959384
    去甲基蟛蜞内酯 CFN90521 6468-55-9 100mg QQ客服:215959384
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    ChemFaces的产品在许多优秀和顶级科学期刊中被引用

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.
    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.
    IF=12.804(2019)

    PMID: 30417089
    我们的产品现已经出口到下面的研究机构与大学,并且还在增涨
  • University of Minnesota (USA)
  • Georgia Institute of Technology (USA)
  • Shanghai University of TCM (China)
  • Aveiro University (Portugal)
  • Instituto de Investigaciones Agropecuarias (Chile)
  • Charles Sturt University (Denmark)
  • Institute of Bioorganic Chemistry Polish Academy of Sciences (Poland)
  • Universidad Miguel Hernández (Spain)
  • Johannes Gutenberg University Mainz (JGU) (Germany)
  • University of Cincinnati (USA)
  • Washington State University (USA)
  • Calcutta University (India)
  • University of Padjajaran (Indonesia)
  • Univerzita Karlova v Praze (Czech Republic)
  • More...
  • 国外学术期刊发表的引用ChemFaces产品的部分文献
  • Drug Des Devel Ther.2020, 14:61-71
  • Int J Mol Med.2015, 35(5):1237-45
  • Inflammation.2015, 38(4):1502-16
  • Anal Biochem.2019, 569:10-15
  • Current Pharmaceutical Analysis2017, 13(5)
  • Biol Pharm Bull.2017, 40(6):797-806
  • Antioxidants (Basel).2020, 9(2):E99
  • Molecules.2021, 26(3):695.
  • Int J Mol Sci.2018, 19(9):E2825
  • Antioxidants (Basel).2021, 10(10):1620.
  • Nutrients.2021, 13(10):3414.
  • Tumour Biol.2015, 36(9):7027-34
  • Front Pharmacol.2022, 13:972825.
  • Plants (Basel).2020, 9(11):1535.
  • Plant Cell Physiol.2018, 59(1):128-141
  • Food Chem.2022, 373(Pt B):131364.
  • Journal of Ginseng Research2022, j.jgr.2022.09.005.
  • Int J Immunopathol Pharmacol.2019, 33:2058738419857537
  • Evid Based Complement Alternat Med.2018, 2018:1073509
  • Inflammation.2020, 43(5):1716-1728.
  • Int J Mol Med.2019, 43(6):2516-2522
  • J Hepatocell Carcinoma.2022, 9:327-341.
  • Pharmaceutics.2021, 13(7):1028.
  • ...
  • 生物活性
    Description: Demethylwedelolactone has trypsin inhibitory effect, it exerts anti-invasive growth effect on breast cancer cells.
    Targets: NF-kB | IkB | MEK | ERK | MMP(e.g.TIMP) | IKK
    In vitro:
    Phytother Res. 2003 Apr;17(4):420-1.
    Trypsin inhibitory effect of wedelolactone and demethylwedelolactone.[Pubmed: 12722155]
    Wedelolactone (WL) and demethylwedelolactone (DWL) isolated from Eclipta alba were tested in the trypsin inhibition bioassay (in vitro).
    METHODS AND RESULTS:
    Both compounds showed potent activity. IC(50) values of WL and DWL were found to be 2.9 and 3.0 microg/mL respectively.
    Eur J Med Chem. 2012 Oct;56:361-7.
    Demethylwedelolactone derivatives inhibit invasive growth in vitro and lung metastasis of MDA-MB-231 breast cancer cells in nude mice.[Pubmed: 22926226]
    The anticancer properties of Demethylwedelolactone (DWEL) and wedelolactone (WEL), which are naturally occurring coumestans, have not been well characterized. In this study, we investigated the anti-invasive effects of synthetic WEL and Demethylwedelolactone on human MDA-MB-231 breast cancer cells.
    METHODS AND RESULTS:
    We found that WEL and Demethylwedelolactone inhibited the anchorage-independent growth and also suppressed cell motility and cell invasion of MDA-MB-231 cells. In addition, WEL and Demethylwedelolactone reduced the activity and expression of matrix metalloproteinases (MMPs) involved in blocking the IκB-α/NFκB and MEK/ERK signaling pathways in MDA-MB-231 cells. Furthermore, Demethylwedelolactone suppressed the metastasis and lung colonization of the tumor cells in the nude mice.
    CONCLUSIONS:
    Altogether, these data suggest that Demethylwedelolactone derivatives exert anti-invasive growth effect on breast cancer cells.
    制备储备液(仅供参考)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 3.331 mL 16.655 mL 33.31 mL 66.62 mL 83.275 mL
    5 mM 0.6662 mL 3.331 mL 6.662 mL 13.324 mL 16.655 mL
    10 mM 0.3331 mL 1.6655 mL 3.331 mL 6.662 mL 8.3275 mL
    50 mM 0.0666 mL 0.3331 mL 0.6662 mL 1.3324 mL 1.6655 mL
    100 mM 0.0333 mL 0.1666 mL 0.3331 mL 0.6662 mL 0.8328 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    部分图片展示
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    甘草香豆素; Glycycoumarin CFN89408 94805-82-0 C21H20O6 = 368.37 10mg QQ客服:1457312923
    格里西轮; Glycyrin CFN89404 66056-18-6 C22H22O6 = 382.40 5mg QQ客服:215959384
    甘草吡喃香豆素; Licopyranocoumarin CFN92918 117038-80-9 C21H20O7 = 384.38 5mg QQ客服:3257982914
    甘草芳香豆素; Licoarylcoumarin CFN95072 125709-31-1 C21H20O6 = 368.4 5mg QQ客服:215959384
    考迈斯托醇; Coumestrol CFN96040 479-13-0 C15H8O5 = 268.2 10mg QQ客服:2056216494
    4'-甲氧基香豆雌酚 ; 4'-O-Methylcoumestrol CFN96922 1690-62-6 C16H10O5 = 282.25 5mg QQ客服:1457312923
    去甲基蟛蜞内酯; Demethylwedelolactone CFN90521 6468-55-9 C15H8O7 = 300.21 20mg QQ客服:3257982914
    蟛蜞菊内脂; Wedelolactone CFN98857 524-12-9 C16H10O7 = 314.3 20mg QQ客服:2056216494
    异去甲蟛蜞菊内脂; Isodemethylwedelolacton CFN90625 350681-33-3 C15H8O7 = 300.22 20mg QQ客服:1457312923
    补骨脂定; Psoralidin CFN98592 18642-23-4 C20H16O5 = 336.34 20mg QQ客服:1457312923

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