(-)-白藏属脑

(-)-Heraclenol

	产品编号	CFN89405
	CAS编号	139079-42-8
	分子式 = 分子量	C₁₆H₁₆O₆ = 304.29
	产品纯度	>=98%
	物理属性	Powder
	化合物类型	Coumarins
	植物来源	The aerial parts of Incarvillea younghusbandii.
ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用

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产品名称	产品编号	CAS编号	包装	QQ客服
(-)-白藏属脑	CFN89405	139079-42-8	1mg	QQ客服：2056216494
(-)-白藏属脑	CFN89405	139079-42-8	5mg	QQ客服：2056216494
(-)-白藏属脑	CFN89405	139079-42-8	10mg	QQ客服：2056216494
(-)-白藏属脑	CFN89405	139079-42-8	20mg	QQ客服：2056216494

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ChemFaces的产品在许多优秀和顶级科学期刊中被引用

Cell. 2018 Jan 11;172(1-2):249-261.e12.
doi: 10.1016/j.cell.2017.12.019.
IF=36.216(2019)

PMID: 29328914

Cell Metab. 2020 Mar 3;31(3):534-548.e5.
doi: 10.1016/j.cmet.2020.01.002.
IF=22.415(2019)

PMID: 32004475

Mol Cell. 2017 Nov 16;68(4):673-685.e6.
doi: 10.1016/j.molcel.2017.10.022.
IF=14.548(2019)

PMID: 29149595

ACS Nano. 2018 Apr 24;12(4): 3385-3396.
doi: 10.1021/acsnano.7b08969.
IF=13.903(2019)

PMID: 29553709

Nature Plants. 2016 Dec 22;3: 16206.
doi: 10.1038/nplants.2016.205.
IF=13.297(2019)

PMID: 28005066

Sci Adv. 2018 Oct 24;4(10): eaat6994.
doi: 10.1126/sciadv.aat6994.
IF=12.804(2019)

PMID: 30417089

Warszawski Uniwersytet Medyczny (Poland)

Leibniz-Institut für Pflanzenbiochemie (IPB) (Germany)

University of the Basque Country (Spain)

Johannes Gutenberg University Mainz (JGU) (Germany)

University of Vigo (Spain)

Biotech R&D Institute (USA)

Max-Planck-Insitut (Germany)

Universidad Industrial de Santander (Colombia)

Utah State University (USA)

National Hellenic Research Foundation (Greece)

Aarhus University (Denmark)

Srinakharinwirot University (Thailand)

Gyeongsang National University (Korea)

University of Limpopo (South Africa)

More...

Description:

(-)-Heraclenol shows in vitro anti-plasmodial activity against chloroquine-sensitive and chloroquine-resistant strains of Plasmodium falciparum.(-)-Heraclenol has moderate antibacterial and antifungal activities.

Targets:

Antifection

In vitro:

Current Science, 2011, 100(11):1706-1711.

Microbial transformation of (+)-heraclenin by Aspergillus niger and evaluation of its antiplasmodial and antimicrobial activities[Reference: WebLink]

METHODS AND RESULTS:
Microbial transformation of (+)-heraclenin (1) by Aspergillus niger was studied in growth media to assess its antiplasmodial and antimicrobial activities. It was transformed to (-)-Heraclenol (2) as the sole product in a stereospecific manner. The in vitro antiplasmodial activity of compounds 1 and 2 was tested with chloroquine-sensitive and chloroquine-resistant strains of Plasmodium falciparum. Further, the in vitro antibacterial activity of 1 and 2 against three Grampositive bacteria, Bacillus subtilis, Bacillus sphaericus and Staphylococcus aureus, and three Gram-negative bacteria, Pseudomonas aeruginosa, Escherichia coli and Chromobacterium violaceum was analysed using agar-plate diffusion assay. The same method was employed for the evaluation of antifungal activity against five pathogenic strains of fungi, A. niger, Rhizopus oryzae, Aspergillus flavus, Candida albicans and Saccharomyces cerevisiae.
CONCLUSIONS:
Both furanocoumarins 1 and 2 displayed significant levels of antiplasmodial and moderate levels of antimicrobial activities against the tested pathogenic strains. Compound 2 exhibited two-fold less potent antiplasmodial activity (IC50 = 6.0 μg/ml) than the parent compound 1 (IC50 = 2.5 μg/ml), whereas no difference was observed in the antimicrobial activity of both furanocoumarins. The oxirane ring was found to be beneficial in terms of antiplasmodial activity.

产品名称	产品编号	CAS编号	分子式 = 分子量	位单	联系QQ
欧前胡素; Imperatorin	CFN98758	482-44-0	C₁₆H₁₄O₄ = 270.3	20mg	QQ客服：2056216494
独活素; Heraclenin	CFN98354	2880-49-1	C₁₆H₁₄O₅ = 286.3	5mg	QQ客服：215959384
异栓翅芹醇; Isogosferol	CFN98890	53319-52-1	C₁₆H₁₄O₅ = 286.3	5mg	QQ客服：2159513211
异石当归素; Isosaxalin	CFN98929	55481-86-2	C₁₆H₁₅ClO₅ = 322.7	5mg	QQ客服：2056216494
白芷属脑; Heraclenol	CFN98402	31575-93-6	C₁₆H₁₆O₆ = 304.3	10mg	QQ客服：1413575084
(-)-白藏属脑; (-)-Heraclenol	CFN89405	139079-42-8	C₁₆H₁₆O₆ = 304.29	5mg	QQ客服：1457312923
独活属醇缩丙酮; Heraclenol acetonide	CFN97112	64790-68-7	C₁₉H₂₀O₆ = 344.4	5mg	QQ客服：3257982914
3'-O-BETA-D-吡喃葡萄糖苷白芷属脑酯; Heraclenol 3'-O-beta-D-glucopyranoside	CFN98410	32207-10-6	C₂₂H₂₆O₁₁ = 466.4	5mg	QQ客服：2056216494
Heraclenol 3'-O-[beta-D-apiofuranosyl-(1-6)-beta-D-glucopyranoside]; Heraclenol 3'-O-[beta-D-apiofuranosyl-(1-6)-beta-D-glucopyranoside]	CFN97243	765316-44-7	C₂₇H₃₄O₁₅ = 598.6	5mg	QQ客服：2159513211
Rivulobirin E; Rivulobirin E	CFN98247	237407-59-9	C₃₂H₃₀O₁₁ = 590.6	5mg	QQ客服：1413575084

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	1 mg	5 mg	10 mg	20 mg	25 mg
1 mM	3.2863 mL	16.4317 mL	32.8634 mL	65.7268 mL	82.1585 mL
5 mM	0.6573 mL	3.2863 mL	6.5727 mL	13.1454 mL	16.4317 mL
10 mM	0.3286 mL	1.6432 mL	3.2863 mL	6.5727 mL	8.2158 mL
50 mM	0.0657 mL	0.3286 mL	0.6573 mL	1.3145 mL	1.6432 mL
100 mM	0.0329 mL	0.1643 mL	0.3286 mL	0.6573 mL	0.8216 mL