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    产品编号 CFN90256
    CAS编号 60976-49-0
    分子式 = 分子量 C41H28O27 = 952.64
    产品纯度 >=98%
    物理属性 Powder
    化合物类型 Phenols
    植物来源 The herbs of Phyllanthus urinaria L.
    产品名称 产品编号 CAS编号 包装 QQ客服
    老鹳草素 CFN90256 60976-49-0 10mg QQ客服:1457312923
    老鹳草素 CFN90256 60976-49-0 20mg QQ客服:1457312923
    老鹳草素 CFN90256 60976-49-0 50mg QQ客服:1457312923
    老鹳草素 CFN90256 60976-49-0 100mg QQ客服:1457312923
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    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.

    PMID: 30417089
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  • 生物活性
    Description: Geraniin is a TNF-α releasing inhibitor with numerous activities including anticancer, anti-inflammatory, has anti-oxidant , and anti-hyperglycemic activities, with an IC50 of 43 μM. Geraniin presents radioprotective effects by regulating DNA damage on splenocytes, exerting immunostimulatory capacities and inhibiting apoptosis of radiosensitive immune cells and jejunal crypt cells. Geraniin induces Nrf2-mediated expression of antioxidant enzymes HO-1 and NQO1, presumably via PI3K/AKT and ERK1/2 signaling pathways, thereby protecting cells from H2O2-induced oxidative cell death.
    Targets: NF-kB | ERK | Nrf2 | PI3K | Akt | NADPH-oxidase | HO-1 | ROS | MMP(e.g.TIMP) | p53 | NQO1 | TNF-α
    In vitro:
    Exp Cell Res. 2015 Jan 1;330(1):91-101.
    Geraniin suppresses RANKL-induced osteoclastogenesis in vitro and ameliorates wear particle-induced osteolysis in mouse model.[Pubmed: 25016282]
    Wear particle-induced osteolysis and subsequent aseptic loosening remains the most common complication that limits the longevity of prostheses. Wear particle-induced osteoclastogenesis is known to be responsible for extensive bone erosion that leads to prosthesis failure. Thus, inhibition of osteoclastic bone resorption may serve as a therapeutic strategy for the treatment of wear particle induced osteolysis.
    In this study, we demonstrated for the first time that geraniin, an active natural compound derived from Geranium thunbergii, ameliorated particle-induced osteolysis in a Ti particle-induced mouse calvaria model in vivo. We also investigated the mechanism by which geraniin exerts inhibitory effects on osteoclasts. Geraniin inhibited RANKL-induced osteoclastogenesis in a dose-dependent manner, evidenced by reduced osteoclast formation and suppressed osteoclast specific gene expression. Specially, geraniin inhibited actin ring formation and bone resorption in vitro. Further molecular investigation demonstrated geraniin impaired osteoclast differentiation via the inhibition of the RANKL-induced NF-κB and ERK signaling pathways, as well as suppressed the expression of key osteoclast transcriptional factors NFATc1 and c-Fos.
    Collectively, our data suggested that geraniin exerts inhibitory effects on osteoclast differentiation in vitro and suppresses Ti particle-induced osteolysis in vivo. Geraniin is therefore a potential natural compound for the treatment of wear particle induced osteolysis in prostheses failure.
    Can J Physiol Pharmacol. 2013 Dec;91(12):1016-24.
    Geraniin induces apoptotic cell death in human lung adenocarcinoma A549 cells in vitro and in vivo.[Pubmed: 24289071]
    Geraniin has previously been reported to possess extensive biological activity. In this study, we reported that geraniin is an inhibitor of tumor activity in vitro and in vivo.
    Geraniin suppressed the proliferation of A549 cells in a dose- and time-dependent manner. Geraniin arrested the cell cycle in the S phase and induced a significant accumulation of reactive oxygen species (ROS), as well as an increased percentage of cells with mitochondrial membrane potential (MMP) disruption. Western blot analysis showed that geraniin inhibited Bcl-2 expression and induced Bax expression to disintegrate the outer mitochondrial membrane and cause cytochrome c release. Mitochondrial cytochrome c release was associated with the activation of caspase-9 and caspase-3 cascades. Additionally, geraniin resulted in tumor growth inhibition in A549 xenografts.
    Our results indicate cytotoxic activity of geraniin towards cancer cells in vitro and in vivo.
    In vivo:
    Bioorg Med Chem Lett. 2015 Feb 1;25(3):673-9.
    Osteoprotective effect of geraniin against ovariectomy-induced bone loss in rats.[Pubmed: 25532904]
    In the present study, we investigated the antiosteoporotic effect of geraniin on osteoporosis induced by OVX in rats.
    The analysis of biochemical parameters showed that geraniin could significantly increase serum calcium, estradiol and calcitonin levels, and decrease serum ALP, tartrate-resistant acid phosphatase, serum crosslinked C-terminal telopeptide of type I collagen, and urinary deoxypyridinoline/creatinine ratio levels, respectively. Geraniin was also found to prevent OVX-induced bone loss in bone mineral density and bone mineral content, to elevate femur weight and bone calcium content, and to enhance the bone mechanical properties as compared with OVX group. In addition, geraniin was demonstrated to improve the histomorphological parameters of OVX-induced bone loss, including bone trabecular number, thickness, and separation.
    These results indicated that geraniin have a protective effect against OVX-induced rat osteoporosis.
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 1.0497 mL 5.2486 mL 10.4971 mL 20.9943 mL 26.2429 mL
    5 mM 0.2099 mL 1.0497 mL 2.0994 mL 4.1989 mL 5.2486 mL
    10 mM 0.105 mL 0.5249 mL 1.0497 mL 2.0994 mL 2.6243 mL
    50 mM 0.021 mL 0.105 mL 0.2099 mL 0.4199 mL 0.5249 mL
    100 mM 0.0105 mL 0.0525 mL 0.105 mL 0.2099 mL 0.2624 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    1-O-没食子酰-6-O-肉桂酰葡萄糖; 1-O-galloyl-6-O-cinnamoylglucose CFN95053 115746-69-5 C22H22O11 = 462.4 5mg QQ客服:3257982914
    2-肉桂酰-1-没食子酰葡萄糖; 2-Cinnamoyl-1-galloylglucose CFN95098 56994-83-3 C22H22O11 = 462.4 5mg QQ客服:1413575084
    1,2,3,4,6-五没食子酰葡萄糖; 1,2,3,4,6-O-Pentagalloylglucose CFN90192 14937-32-7 C41H32O26 = 940.68 20mg QQ客服:1457312923
    单宁酸; Tannic acid CFN90501 1401-55-4 C76H52O46 = 1701.2 20mg QQ客服:1457312923
    柯里拉京; Corilagin CFN90176 23094-69-1 C27H22O18 = 634.45 20mg QQ客服:1457312923
    诃子宁; Chebulanin CFN92294 166833-80-3 C27H24O19 = 652.5 5mg QQ客服:2159513211
    Thonningianin A; Thonningianin A CFN90633 271579-11-4 C42H34O21 = 874.7 10mg QQ客服:3257982914
    Pinocembrin 7-O-(3''-galloyl-4'',6''-(S)-hexahydroxydiphenoyl)-β-D-glucose; Pinocembrin 7-O-(3''-galloyl-4'',6''-(S)-hexahydroxydiphenoyl)-beta-D-glucose CFN90881 205370-59-8 C42H32O21 = 872.7 10mg QQ客服:2159513211
    老鹳草素; Geraniin CFN90256 60976-49-0 C41H28O27 = 952.64 20mg QQ客服:1457312923
    诃子鞣酸; Chebulagic acid CFN92295 23094-71-5 C41H30O27 = 954.7 5mg QQ客服:3257982914





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