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  • 1,2,3,6-四-O-没食子酰-β-D-葡萄糖

    1,2,3,6-Tetragalloylglucose

    1,2,3,6-四-O-没食子酰-β-D-葡萄糖
    产品编号 CFN00447
    CAS编号 79886-50-3
    分子式 = 分子量 C34H28O22 = 788.57
    产品纯度 >=98%
    物理属性 Powder
    化合物类型 Phenols
    植物来源 The peels of Punica granatum L.
    ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用
    提供自定义包装
    产品名称 产品编号 CAS编号 包装 QQ客服
    1,2,3,6-四-O-没食子酰-β-D-葡萄糖 CFN00447 79886-50-3 1mg QQ客服:2159513211
    1,2,3,6-四-O-没食子酰-β-D-葡萄糖 CFN00447 79886-50-3 5mg QQ客服:2159513211
    1,2,3,6-四-O-没食子酰-β-D-葡萄糖 CFN00447 79886-50-3 10mg QQ客服:2159513211
    1,2,3,6-四-O-没食子酰-β-D-葡萄糖 CFN00447 79886-50-3 20mg QQ客服:2159513211
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    Cell. 2018 Jan 11;172(1-2):249-261.e12.
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    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

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    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
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    IF=12.804(2019)

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  • 国外学术期刊发表的引用ChemFaces产品的部分文献
  • Chemistry of Plant Materials.2016, 33-46
  • Pamukkale Medical Journal2022, 15(4):796-803.
  • Chemistry of Natural Compounds2018, 204-206
  • Molecules.2021, 26(4):816.
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  • ...
  • 生物活性
    Description: 1,2,3,6-Tetragalloylglucose has antioxidative activity, it also shows the most potent anticomplement activity (IC(50), 34 microM).
    Targets: LDL
    In vitro:
    Biosci Biotechnol Biochem. 2008 Aug;72(8):2158-63.
    Antioxidative activities of galloyl glucopyranosides from the stem-bark of Juglans mandshurica.[Pubmed: 18685223]

    METHODS AND RESULTS:
    Two phenolics, 1,2,6-trigalloylglucose (1) and 1,2,3,6-Tetragalloylglucose (2), isolated from the stem-bark of Juglans mandshurica were evaluated for their antioxidative activities. The results showed that compounds 1 and 1,2,3,6-Tetragalloylglucose exhibited strong scavenging activities against 1,1'-diphenyl-1-picrylhydrazyl (DPPH), 2,2'-azino-bis-(3-ethylbenzenthiazoline-6-sulphonic) acid (ABTS(*+)), and superoxide radicals (O(2)(*-)), and also had a significant inhibitory effect on lipid peroxidation and low-density lipoprotein (LDL) oxidation.
    CONCLUSIONS:
    The strong superoxide radical scavenging of 1 and 1,2,3,6-Tetragalloylglucose resulted from the potential competitive inhibition with xanthine at the active site of xanthine oxidase (OX). In addition, compounds 1 and 1,2,3,6-Tetragalloylglucose displayed significant lipoxygenase inhibitory activity, the mode of inhibition also being identified as competitive. In comparison, the antioxidative activities of compounds 1 and 1,2,3,6-Tetragalloylglucose, together with gallic acid, indicated that the number of galloyl moieties could play an important role in the antioxidative activity.
    Biol Pharm Bull. 2003 Jul;26(7):1042-4.
    Anti-complement activity of constituents from the stem-bark of Juglans mandshurica.[Pubmed: 12843637 ]

    METHODS AND RESULTS:
    Four known flavonoids and two galloyl glucoses isolated from the stem-bark of Juglans mandshurica (Juglandaceae), namely taxifolin (1), afzelin (2), quercitrin (3), myricitrin (4), 1,2,6-trigalloylglucose (5), and 1,2,3,6-Tetragalloylglucose (6), were evaluated for their anti-complement activity against complement system. Afzelin (2) and quercitrin (3) showed inhibitory activity against complement system with 50% inhibitory concentrations (IC(50)) values of 258 and 440 microM. 1,2,6-Trigalloylglucose (5) and 1,2,3,6-Tetragalloylglucose (6) exhibited anti-complement activity with IC(50) values of 136 and 34 microM. In terms of the evaluation of the structure-activity relationship of 3,5,7-trihydroxyflavone, compounds 2, 3, and 4 were hydrolyzed with naringinase to give kaempferol (2a), quercetin (3a), and myricetin (4a) as their aglycones, and these were also tested for their anti-complement activity. Of the three aglycones, kaempferol (2a) exhibited weak anti-complement activity with an IC(50) value of 730 microM, while quercetin (3a) and myricetin (4a) were inactive in this assay system.
    CONCLUSIONS:
    Among the compounds tested, 1,2,3,6-Tetragalloylglucose (6) showed the most potent anticomplement activity (IC(50), 34 microM).
    Hum Exp Toxicol. 2011 Sep;30(9):1415-9.
    Inhibition effects of the classical pathway complement of isolated compounds from Quercus glauca.[Pubmed: 21078772]
    Species of the Quercus species is an evergreen broadleaf tree found not only in Korea but also in China, Taiwan, and Japan. Quercus species is the most commonly occurring plant among the 50 native species of the family Fagaceae in Korea, China, and Taiwan. Quercus species have been used for diarrhea, dysentery, dermatitis, and hemorrhagia in Korean folk medicine. The present study evaluated the anticomplement effect of constituents from Quercus species (Fagaceae) in classical pathway complement system.
    METHODS AND RESULTS:
    We have evaluated leaves of five species of the Quercus genus with regard to its anticomplement activity and have identified its active principles following activity-guided isolation. Bioactivity-guided fractionation of the 80% methanol extracts of the stem barks of Quercus glauca Thunberg has led to the isolation of galloyl derivatives, displaying high anticomplement activity. Four galloyl derivatives isolated from the leaves of Q. glauca, namely 6'-O-galloyl salidroside (1), methyl gallate (2), 1,2,3,6-tetragalloylglucose (3), and 1,2,6-trigalloylglucose (4). 1, 2, 3 and 4 showed inhibitory activity against complement system with 50% inhibitory concentrations (IC(50)) values of 224 μM, 362.4 μM, 32.3 μM, and 138.3 μM.
    CONCLUSIONS:
    Among the compounds tested, 3 showed the most potent anticomplement activity (IC(50), 32.3 μM). This is the first report of the isolation and anticomplement activity from Q. glauca.
    In vivo:
    Food Chem Toxicol . 2018 Oct;120:651-661.
    Identification and characterization of in vitro inhibitors against UDP-glucuronosyltransferase 1A1 in uva-ursi extracts and evaluation of in vivo uva-ursi-drug interactions[Pubmed: 30075316]
    Abstract Uva-ursi leaf is widely used to treat symptoms of lower urinary tract infections. Here, we evaluated the in vitro inhibitory effects of uva-ursi extracts on 10 major human UDP-glucuronosyltransferases (UGT) isoforms. Of the 10 tested UGT isoforms, uva-ursi extracts exerted the strongest inhibitory effect on UGT1A1-mediated β-estradiol 3-glucuronidation with the lowest IC50 value of 8.45 ± 1.56 μg/mL. To identify the components of uva-ursi extracts showing strong inhibitory effects against UGT1A1, the inhibitory effects of nine major constituents of the extracts were assessed. Among the tested compounds, gallotannin exerted the most potent inhibition on UGT1A1, followed by 1,2,3,6-tetragalloylglucose; both demonstrated competitive inhibition, with Ki values of 1.68 ± 0.150 μM and 3.55 ± 0.418 μM. We found that gallotannin and 1,2,3,6-tetragalloylglucose also inhibited another UGT1A1-specific biotransformation, SN-38-glucuronidation, showing the same order of inhibition. Thus, in vitro UGT1A1 inhibitory potentials of uva-ursi extracts might primarily result from the inhibitory activities of gallotannin and 1,2,3,6-tetragalloylglucose present in the extracts. However, in rats, co-administration with uva-ursi extracts did not alter the in vivo marker for UGT1A1 activity, expressed as the molar ratio of AUCSN-38 glucuronide/AUCSN-38, because plasma concentrations of gallotannin and 1,2,3,6-tetragalloylglucose may be too low to inhibit the UGT1A1-mediated metabolism of SN-38 in vivo. The poor oral absorption of gallotannin and 1,2,3,6-tetragalloylglucose in uva-ursi extracts might cause the poor in vitro-in vivo correlation. These findings will be helpful for the safe and effective use of uva-ursi extracts in clinical practice. Keywords: 1,2,3,6-Tetragalloylglucose; Gallotannin; In vitro UGT1A1 inhibition; In vivo herb‒drug interaction; Uva-ursi extract.
    制备储备液(仅供参考)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 1.2681 mL 6.3406 mL 12.6812 mL 25.3624 mL 31.703 mL
    5 mM 0.2536 mL 1.2681 mL 2.5362 mL 5.0725 mL 6.3406 mL
    10 mM 0.1268 mL 0.6341 mL 1.2681 mL 2.5362 mL 3.1703 mL
    50 mM 0.0254 mL 0.1268 mL 0.2536 mL 0.5072 mL 0.6341 mL
    100 mM 0.0127 mL 0.0634 mL 0.1268 mL 0.2536 mL 0.317 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    部分图片展示
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    单宁酸; Tannic acid CFN90501 1401-55-4 C76H52O46 = 1701.2 20mg QQ客服:2056216494
    柯里拉京; Corilagin CFN90176 23094-69-1 C27H22O18 = 634.45 20mg QQ客服:215959384
    诃子宁; Chebulanin CFN92294 166833-80-3 C27H24O19 = 652.5 5mg QQ客服:215959384
    乔松苷;乔松素-7-O-β-D-葡萄糖苷; Pinocembroside CFN95444 75829-43-5 C21H22O9 = 418.4 20mg QQ客服:1457312923
    赶黄草苷B; Thonningianin B CFN91481 271579-12-5 C35H30O17 = 722.6 5mg QQ客服:2159513211
    Thonningianin A; Thonningianin A CFN90633 271579-11-4 C42H34O21 = 874.7 20mg QQ客服:2159513211
    Pinocembrin 7-O-(4'',6''-hexahydroxydiphenoyl)-beta-D-glucose; Pinocembrin 7-O-(4'',6''-hexahydroxydiphenoyl)-beta-D-glucose CFN95462 1825287-22-6 C35H28O17 = 720.6 10mg QQ客服:3257982914
    Pinocembrin 7-O-(3''-galloyl-4'',6''-(S)-hexahydroxydiphenoyl)-β-D-glucose; Pinocembrin 7-O-(3''-galloyl-4'',6''-(S)-hexahydroxydiphenoyl)-beta-D-glucose CFN90881 205370-59-8 C42H32O21 = 872.7 20mg QQ客服:2159513211
    2,6-Dihydroxyacetophenone-4-O-[4',6'-(S)-hexahydroxydiphenoyl]-beta-D-glucose; 2,6-Dihydroxyacetophenone-4-O-[4',6'-(S)-hexahydroxydiphenoyl]-beta-D-glucose CFN95470 1781226-44-5 C28H24O17 = 632.5 5mg QQ客服:3257982914
    老鹳草素; Geraniin CFN90256 60976-49-0 C41H28O27 = 952.64 20mg QQ客服:3257982914

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