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  • 灵芝萜酮二醇

    Ganodermanondiol

    灵芝萜酮二醇
    产品编号 CFN99085
    CAS编号 107900-76-5
    分子式 = 分子量 C30H48O3 = 456.7
    产品纯度 >=98%
    物理属性 Powder
    化合物类型 Triterpenoids
    植物来源 The fruit body of Ganoderma lucidum.
    ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用
    提供自定义包装
    产品名称 产品编号 CAS编号 包装 QQ客服
    灵芝萜酮二醇 CFN99085 107900-76-5 1mg QQ客服:2159513211
    灵芝萜酮二醇 CFN99085 107900-76-5 5mg QQ客服:2159513211
    灵芝萜酮二醇 CFN99085 107900-76-5 10mg QQ客服:2159513211
    灵芝萜酮二醇 CFN99085 107900-76-5 20mg QQ客服:2159513211
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    ChemFaces的产品在许多优秀和顶级科学期刊中被引用

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.
    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.
    IF=12.804(2019)

    PMID: 30417089
    我们的产品现已经出口到下面的研究机构与大学,并且还在增涨
  • Almansora University (Egypt)
  • Florida International University (USA)
  • Pennsylvania State University (USA)
  • Shanghai University of TCM (China)
  • University of Amsterdam (Netherlands)
  • University of Bonn (Germany)
  • Kyung Hee University (Korea)
  • Leibniz-Institut für Pflanzenbiochemie (IPB) (Germany)
  • Complutense University of Madrid (Spain)
  • Sanford Burnham Medical Research Institute (USA)
  • The Ohio State University (USA)
  • Ain Shams University (Egypt)
  • Celltrion Chemical Research Institute (Korea)
  • Universiti Kebangsaan Malaysia (Malaysia)
  • More...
  • 国外学术期刊发表的引用ChemFaces产品的部分文献
  • Phytother Res.2015, 29(7):1088-96
  • Mediators Inflamm. 2016, 2016:6189590
  • Acta Chromatographica2016, 29(3)
  • Chemistry of Plant Materials.2016, 33-46
  • Anal Bioanal Chem. 2016, 408(15)
  • Int J Mol Sci.2017, 18(5)
  • University of Central Lancashire2017, 20472
  • Drug Test Anal.2018, 10(10):1579-1589
  • J Hematol Oncol.2018, 11(1):112
  • ACS Nano.2018, 12(4):3385-3396
  • Int J Mol Sci.2018, 19(9):E2601
  • J Ethnopharmacol.2018, 210:88-94
  • Molecules.2018, 23(12):E3103
  • Molecules.2018, 23(9):E2121
  • Anal Bioanal Chem.2018, 410(5):1561-1569
  • Biorxiv2019, 10.1101
  • J Chromatogr B Analyt Technol Biomed Life Sci.2019, 1126-1127:121743
  • Food Chem.2019, 274:345-350
  • Food Chem.2019, 279:80-87
  • Int J Mol Med.2019, 43(6):2516-2522
  • New Journal of Chemistry2019, 43:12538-12547
  • Phytomedicine.2019, 65:153089
  • Int Immunopharmacol.2019, 71:361-371
  • ...
  • 生物活性
    Description: Ganodermanondiol exhibits potent cytoprotective effects on t-BHP-induced hepatotoxicity in human liver-derived HepG2 cells, presumably through Nrf2-mediated antioxidant enzymes and AMPK. It also can significantly inhibit the proliferation of leukemic cancer cells, and it could be one of the antileukemie active constituents of Ganoderma lucidum. Ganodermanondiol shows a strong anticomplement activity against the classical pathway (CP) of the complement system with IC(50) values of 41.7 microM. It shows significant anti-human immunodeficiency virus (anti-HIV)-1 protease activity with IC50 values of 20-90 microM.
    Targets: Nrf2 | HIV | AMPK
    In vitro:
    Food Chem Toxicol. 2013 Mar;53:317-24.
    Protective effect of ganodermanondiol isolated from the Lingzhi mushroom against tert-butyl hydroperoxide-induced hepatotoxicity through Nrf2-mediated antioxidant enzymes.[Pubmed: 23266269]
    Ganodermanondiol, a biologically active compound, was isolated from the Lingzhi mushroom (Ganoderma lucidum). The present study examined the protective effects of Ganodermanondiol against tert-butyl hydroperoxide (t-BHP)-induced hepatotoxicity.
    METHODS AND RESULTS:
    Ganodermanondiol protected human liver-derived HepG2 cells through nuclear factor-E2-related factor 2 (Nrf2) pathway-dependent heme oxygenase-1 expressions. Moreover, Ganodermanondiol increased cellular glutathione levels and the expression of the glutamine-cysteine ligase gene in a dose-dependent manner. Furthermore, Ganodermanondiol exposure enhanced the phosphorylation of adenosine monophosphate-activated protein kinase (AMPK) and its upstream kinase activators, LKB1 and Ca(2+)/calmodulin-dependent protein kinase-II (CaMKII).
    CONCLUSIONS:
    This study indicates that Ganodermanondiol exhibits potent cytoprotective effects on t-BHP-induced hepatotoxicity in human liver-derived HepG2 cells, presumably through Nrf2-mediated antioxidant enzymes and AMPK.
    Planta Med. 2001 Dec;67(9):811-4.
    Anticomplement activity of terpenoids from the spores of Ganoderma lucidum.[Pubmed: 11745016]
    A new lanostane-type terpenoid, lucidenic acid SP1 (1), was isolated from a CHCl(3)-soluble fraction of Ganoderma lucidum spores together with four other known compounds (2 - 5). The structure of lucidenic acid SP1 was determined to be 3 beta,7 beta-dihydroxy-4,4,14 alpha-trimethyl-11,15-dioxo-5 alpha-chol-8-en-24-oic acid by spectroscopic means including 2D-NMR.
    METHODS AND RESULTS:
    Twelve triterpenes (1-12) isolated from G. lucidum spores were investigated in vitro for their anticomplementary activity. Compounds 1 - 5 were inactive, whereas ganoderiol F (8), ganodermanondiol (9) and ganodermanontriol (10) showed a strong anticomplement activity against the classical pathway (CP) of the complement system with IC(50) values of 4.8, 41.7, and 17.2 microM, respectively. The potency of these triterpene alcohols (8-10) in inhibiting CP activity was improved when the number of hydroxymethyl groups on the side chain moiety is increased. On the other hand, the ganoderic acids 1-7, which contain a carboxyl group in the side chain, and lucidumols A and B (11, 12) had little activity on this system.
    制备储备液(仅供参考)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 2.1896 mL 10.9481 mL 21.8962 mL 43.7924 mL 54.7405 mL
    5 mM 0.4379 mL 2.1896 mL 4.3792 mL 8.7585 mL 10.9481 mL
    10 mM 0.219 mL 1.0948 mL 2.1896 mL 4.3792 mL 5.4741 mL
    50 mM 0.0438 mL 0.219 mL 0.4379 mL 0.8758 mL 1.0948 mL
    100 mM 0.0219 mL 0.1095 mL 0.219 mL 0.4379 mL 0.5474 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    部分图片展示
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    灵芝醇A; Ganoderol A CFN99065 104700-97-2 C30H46O2 = 438.7 5mg QQ客服:215959384
    灵芝醇F; Ganoderiol F CFN99244 114567-47-4 C30H46O3 = 454.7 5mg QQ客服:2932563308
    灵芝萜酮二醇 ; Ganodermanondiol CFN99085 107900-76-5 C30H48O3 = 456.7 5mg QQ客服:3257982914
    灵芝醇A; Ganoderiol A CFN80461 106518-61-0 C30H50O4 = 474.37 5mg QQ客服:1148253675
    灵芝马酮; Ganodermanontriol CFN99077 106518-63-2 C30H48O4 = 472.7 5mg QQ客服:215959384
    Lucialdehyde A; Lucialdehyde A CFN90304 420781-84-6 C30H46O2 = 438.69 5mg QQ客服:2159513211
    灵芝醛A; Ganoderal A CFN90306 104700-98-3 C30H44O2 = 436.68 5mg QQ客服:3257982914
    灵芝酮A; Ganoderone A CFN90303 873061-79-1 C30H48O3 = 456.70 5mg QQ客服:2932563308
    赤芝二醇; Lucidadiol CFN96840 252351-95-4 C30H48O3 = 456.71 5mg QQ客服:2932563308
    Lucidal; Lucidal CFN92234 252351-96-5 C30H46O3 = 454.7 5mg QQ客服:215959384

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