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  • 丹参醇A

    Danshenol A

    丹参醇A
    产品编号 CFN92167
    CAS编号 189308-08-5
    分子式 = 分子量 C21H20O4 = 336.4
    产品纯度 >=98%
    物理属性 Red powder
    化合物类型 Diterpenoids
    植物来源 The roots of Salvia miltiorrhiza
    ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用
    提供自定义包装
    产品名称 产品编号 CAS编号 包装 QQ客服
    丹参醇A CFN92167 189308-08-5 1mg QQ客服:2056216494
    丹参醇A CFN92167 189308-08-5 5mg QQ客服:2056216494
    丹参醇A CFN92167 189308-08-5 10mg QQ客服:2056216494
    丹参醇A CFN92167 189308-08-5 20mg QQ客服:2056216494
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    ChemFaces的产品在许多优秀和顶级科学期刊中被引用

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
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    PMID: 32004475

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    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
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    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
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    IF=12.804(2019)

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  • 国外学术期刊发表的引用ChemFaces产品的部分文献
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  • ...
  • 生物活性
    Description: Danshenol A has strong aldose reductase (AR) inhibitory activity, has IC50 of 0.10 microM which is comparable to that of epalrestat in clinical use. Danshenol A also has antitumor activity in T-24, QGY, K562, Me180 and BIU87 cell lines, shows inhibited growth of K562 (IC50 = 0.53 μg/mL), T-24 (IC50 = 7.94 μg/mL), QGY (IC50 = 4.65 μg/mL) and Me180 (IC50 = 6.89 μg/mL) cell lines.
    Targets: Aldose reductase
    In vitro:
    Planta Med. 2006 Jan;72(1):84-6.
    Two new abietane diterpenoids from Salvia yunnanensis.[Pubmed: 16450305]

    METHODS AND RESULTS:
    Two new abietane diterpenoids, yunnannin A and danshenol C, were isolated from Salvia yunnanensis together with ten known diterpenoids, Danshenol A, przewalskin, tanshinone IIA, tanshinone I, crypotanshinone, 1,2-dihydrotanshinone, tanshinlactone, 5,6-dehydrosugiol, 12-hydroxy-6,7-seco-8,11,3-abietatriene-6,7-dial and phytol. Their structures were established based on spectroscopic data, chemical reactions and comparison with literature data.
    CONCLUSIONS:
    Compounds were tested for their antitumor activity in T-24, QGY, K562, Me180 and BIU87 cell lines. Compound showed inhibited growth of K562 (IC50=0.53 microg/mL), T-24 (IC50=7.94 microg/mL), QGY (IC50=4.65 microg/mL) and Me180 (IC50=6.89 microg/mL) cell lines while compound was inactive. Compound showed moderate inhibitory activity on QGY (IC50=16.75 microg/mL) and Me180 (IC50=5.84 microg/mL) cells.
    Chem Pharm Bull (Tokyo). 1997 Aug;45(8):1306-11.
    Aldose reductase inhibitory constituents of the root of Salvia miltiorhiza Bunge.[Pubmed: 9377780]

    METHODS AND RESULTS:
    The constituents of the MeOH extract of Salvia miltiorhiza BUNGE, which showed strong aldose reductase (AR) inhibitory activity, were examined, and two new abietane-type diterpenoids, Danshenol A (1) and danshenol B (2), were isolated together with six known ones: dihydrotanshimme I (3), cryptotanshinone (4), tanshinone I (5), tanshinone IIA (6), (-)-danshexinkun A (7), and sugiol (8). Among them, 4, 5, and 8 were weak AR inhibitors with IC50 from 4.80 to > 10.0 microM, while 1, 2, 3, 6, and 7 were strong inhibitors (IC50 from 0.10 to 1.75 microM). Danshenol A (1), the strongest inhibitor, had IC50 of 0.10 microM which is comparable to that of epalrestat in clinical use.
    CONCLUSIONS:
    Moreover, from a consideration of IC50, and yield of each compound, it was concluded that tanshinone IIA (6) is the major active constituent of the MeOH extract and Danshenol A (I) and (-)danshexinkun A(7) are the minor ones.
    制备储备液(仅供参考)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 2.9727 mL 14.8633 mL 29.7265 mL 59.453 mL 74.3163 mL
    5 mM 0.5945 mL 2.9727 mL 5.9453 mL 11.8906 mL 14.8633 mL
    10 mM 0.2973 mL 1.4863 mL 2.9727 mL 5.9453 mL 7.4316 mL
    50 mM 0.0595 mL 0.2973 mL 0.5945 mL 1.1891 mL 1.4863 mL
    100 mM 0.0297 mL 0.1486 mL 0.2973 mL 0.5945 mL 0.7432 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    部分图片展示
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    次甲二氢丹参醌; Methylenedihydrotanshinquinone CFN92249 126979-81-5 C18H16O3 = 280.3 5mg QQ客服:2056216494
    四氢丹参酮 I; Tetrahydro tanshinone I CFN90460 126979-84-8 C18H16O3 = 280.31 5mg QQ客服:3257982914
    二氢丹参酮I; Dihydrotanshinone I CFN97435 87205-99-0 C18H14O3 = 278.3 20mg QQ客服:1457312923
    15,16-二氢丹参二醇 B; 15,16-Dihydrotanshindiol B CFN92241 891854-86-7 C18H18O5 = 314.3 5mg QQ客服:215959384
    15,16-二氢丹参二醇 C; 15,16-Dihydrotanshindiol C CFN92242 891854-96-9 C18H18O5 = 314.3 5mg QQ客服:1413575084
    丹参醇 C; Danshenol C CFN96391 910856-25-6 C21H20O4 = 336.4 5mg QQ客服:3257982914
    丹参醇A; Danshenol A CFN92167 189308-08-5 C21H20O4 = 336.4 5mg QQ客服:1413575084
    15-表-丹参醇 A; 15-Epi-Danshenol-A CFN92168 216987-13-2 C21H20O4 = 336.4 5mg QQ客服:2159513211
    异丹参酮II; Isotanshinone II CFN92020 98249-39-9 C18H12O3 = 276.3 5mg QQ客服:215959384
    二氢异丹参酮II; Dihydroisotanshinone II CFN98293 260397-58-8 C18H14O3 = 278.3 5mg QQ客服:1457312923

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