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  • 二氢丹参酮I

    Dihydrotanshinone I

    二氢丹参酮I
    产品编号 CFN97435
    CAS编号 87205-99-0
    分子式 = 分子量 C18H14O3 = 278.3
    产品纯度 >=98%
    物理属性 Red powder
    化合物类型 Diterpenoids
    植物来源 The roots of Salvia miltiorrhiza Bge.
    ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用
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    二氢丹参酮I CFN97435 87205-99-0 10mg QQ客服:215959384
    二氢丹参酮I CFN97435 87205-99-0 20mg QQ客服:215959384
    二氢丹参酮I CFN97435 87205-99-0 50mg QQ客服:215959384
    二氢丹参酮I CFN97435 87205-99-0 100mg QQ客服:215959384
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    ChemFaces的产品在许多优秀和顶级科学期刊中被引用

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.
    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.
    IF=12.804(2019)

    PMID: 30417089
    我们的产品现已经出口到下面的研究机构与大学,并且还在增涨
  • Universitas Airlangga (Indonesia)
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  • 国外学术期刊发表的引用ChemFaces产品的部分文献
  • Molecules.2017, 22(3)
  • Nutrients.2019, 12(1):E40
  • Front Pharmacol.2022, 13:906763.
  • J.the Korean Socie. Food Sci.&Nut.2023; 52(1):26-39.
  • J Neuroinflammation.2020, 17(1):75.
  • Pharmacognosy Journal2019, 11(2): 369-373
  • An Acad Bras Cienc.2023, 95(3):e20220672
  • Anticancer Res.2018, 38(4):2127-2135
  • Food Res Int.2022, 157:111397.
  • Antioxidants (Basel).2022, 11(12):2327.
  • Toxicol Rep.2021, 8:1131-1142.
  • Drug Test Anal.2018, 10(10):1579-1589
  • J of L. Chroma.&Related Tech2017, 252-258
  • Crystals2020, 10(3), 206.
  • Molecules.2019, 24(6):E1177
  • The Korea Journal of Herbology2020, 35(3):33-45.
  • J of Health Science and Alternative Medicine2019, 1(1)
  • Front Pharmacol.2019, 10:1226
  • Antioxidants (Basel).2020, 9(6):544.
  • Antioxidants (Basel).2020, 9(7):581.
  • Phytochem Anal.2013, 24(5):493-503
  • Front Plant Sci.2020, 11:630.
  • Yakugaku Zasshi.2018, 138(4):571-579
  • ...
  • 生物活性
    Description: Dihydrotanshinone I is a potent inhibitor of the HuR:RNA interaction, it exhibits strong inhibition towards human liver microsome (HLM)-catalyzed propofol glucuronidation, and UDP-glucuronosyltransferase (UGT) 1A7. Dihydrotanshinone I has antibacterial, anti-cancer, anti-angiogenic, and cytotoxic activities, it induces caspase and ROS dependent apoptosis and autophagy.
    Targets: TNF-α | NF-kB | p65 | COX | MMP(e.g.TIMP) | VEGFR | IL Receptor | ERK | p38MAPK | JNK | p21 | Caspase | ROS | Autophagy | Antifection | AChR
    In vitro:
    Biosci Biotechnol Biochem. 1999 Dec;63(12):2236-9.
    Antibacterial activities of cryptotanshinone and dihydrotanshinone I from a medicinal herb, Salvia miltiorrhiza Bunge.[Pubmed: 10664860 ]
    Cryptotanshinone and dihydrotanshinone I, constituents of a medicinal plant, Salvia miltiorrhiza Bunge, had antibacterial activity against a broad range of Gram positive bacteria.
    METHODS AND RESULTS:
    These compounds generated superoxide radicals in Bacillus subtilis lysates. A recombination-deficient mutant strain of B. subtilis was 2- to 8-fold more sensitive than a wild strain, and this hypersensitivity was reduced in the presence of dithiothreitol as an antioxidant. DNA, RNA, and protein syntheses in B. subtilis were non-selectively inhibited by these compounds.
    CONCLUSIONS:
    These results suggest that superoxide radicals are important in the antibacterial actions of the agents.
    Acta Biochim Biophys Sin (Shanghai). 2008 Jan;40(1):1-6.
    Dihydrotanshinone I inhibits angiogenesis both in vitro and in vivo.[Pubmed: 18180848]
    Dihydrotanshinone I (DI), a naturally occurring compound extracted from Salvia miltiorrhiza Bunge, has been reported to have cytotoxicity to a variety of tumor cells. In this study, we investigated its anti-angiogenic capacity in human umbilical vein endothelial cells.
    METHODS AND RESULTS:
    DI induced a potent cytotoxicity to human umbilical vein endothelial cells, with an IC(50) value of approximately 1.28 microg/ml. At 0.25-1 microg/ml, DI dose-dependently suppressed human umbilical vein endothelial cell migration, invasion, and tube formation detected by wound healing, Transwell invasion and Matrigel tube formation assays, respectively. Moreover, DI showed significant in vivo anti-angiogenic activity in chick embryo chorioallantoic membrane assay. DI induced a 61.1% inhibitory rate of microvessel density at 0.2 microg/egg.
    CONCLUSIONS:
    Taken together, our results showed that DI could inhibit angiogenesis through suppressing endothelial cell proliferation, migration, invasion and tube formation, indicating that DI has a potential to be developed as a novel anti-angiogenic agent.
    Mol Cell Biochem. 2012 Apr;363(1-2):191-202.
    Combination treatment with dihydrotanshinone I and irradiation enhances apoptotic effects in human cervical cancer by HPV E6 down-regulation and caspases activation.[Pubmed: 22147199 ]
    The aim of this study was to investigate the effect of dihydrotanshinone I (DI) in inhibiting the growth of human cervical cancer cells both in vitro and in vivo, and molecular targets in HeLa cells when treated by DI or irradiation with or without being combined. In this study, MTT, clonogenic assay, flow cytometry, and Western blotting were performed to assess the effect of treatment on cells.
    METHODS AND RESULTS:
    After treatment with IR, DI, and DI + IR, the apoptosis was 5.8, 13.3 and 22.5% (P < 0.05 vs. control), respectively. Clonogenic assay revealed that the survival of irradiated HeLa cell was significantly reduced by DI treatment. Combination treatment with IR and DI could down-regulate HPV E6 gene expression. Effect of DI on up-regulation of p21 expression and down-regulation of cyclin B1, p34(cdc2) expression in irradiated HeLa cell was concomitant with cell cycle arrest in G(2) phase. The significant increase in caspase-3 activity was also observed in the combination treatment. When HeLa cells were grown as xenografts in nude mice, combination treatment with DI and IR induced a significant decrease in tumor growth, and without signs of general or organ toxicity.
    CONCLUSIONS:
    These data suggest DI should be tested as the radiosensitizer in vitro and in vivo, which has potential in the treatment of human cervical cancer.
    Front Pharmacol . 2016 Nov 8;7:418.
    Dihydrotanshinone I Attenuates Atherosclerosis in ApoE-Deficient Mice: Role of NOX4/NF-κB Mediated Lectin-Like Oxidized LDL Receptor-1 (LOX-1) of the Endothelium[Pubmed: 27891092]
    Abstract Dihydrotanshinone I (DHT) is a natural compound extracted from Salvia miltiorrhiza Bunge which has been widely used for treating cardiovascular diseases. However, its role in atherosclerosis remains unclear. In this study, the effect of DHT on atherosclerosis were investigated using apolipoprotein E-deficient (ApoE-/-) mice and endothelial cells. In lipopolysaccharide (LPS)-stimulated human umbilical vein endothelial cells (HUVECs), DHT (10 nM) decreased lectin-like ox-LDL receptor-1 (LOX-1) and NADPH oxidase 4 (NOX4) expression, reactive oxygen species (ROS) production, NF-κB nuclear translocation, ox-LDL endocytosis and monocytes adhesion. Silence NOX4 inhibited LPS-induced LOX-1 expression, NF-κB nuclear translocation, ox-LDL endocytosis and monocytes adhesion. In ApoE-/- mice fed with an atherogenic diet, DHT (10 and 25 mg kg-1) significantly attenuated atherosclerotic plaque formation, altered serum lipid profile, decreased oxidative stress and shrunk necrotic core areas. The enhanced expression of LOX-1, NOX4, and NF-κB in aorta was also dramatically inhibited by DHT. In conclusion, these results suggested that DHT showed anti-atherosclerotic activity through inhibition of LOX-1 mediated by NOX4/NF-κB signaling pathways both in vitro and in vivo. This finding suggested that DHT might be used as a potential vascular protective candidate for the treatment of atherosclerosis. Keywords: LOX-1; ROS; atherosclerosis; dihydrotanshinone I; lipopolysaccharide.
    In vivo:
    Phytomedicine. 2015 Nov 15;22(12):1079-87.
    Dihydrotanshinone I induced apoptosis and autophagy through caspase dependent pathway in colon cancer.[Pubmed: 26547530 ]
    Dihydrotanshinone I (DHTS) was previously reported to exhibit the most potent anti-cancer activity among several tanshinones in colon cancer cells. Its cytotoxic action was reactive oxygen species (ROS) dependent but p53 independent. To further study the anti-cancer activity of DHTS and its molecular mechanisms of action in colon cancer both in vitro and in vivo.
    METHODS AND RESULTS:
    Caspase activity was detected by fluorescence assay. Apoptosis was detected by flow cytometry and TUNEL assay. Protein levels were analyzed by western blotting. Knockdown of target gene was achieved by siRNA transfection. Formation of LC3B puncta and activation of caspase-3 were detected by confocal fluorescence microscope. In vivo anti-colon cancer activity of DHTS was observed in xenograft tumors in NOD/SCID mice. Anti-colon cancer activity of DHTS by inducing apoptosis and autophagy was observed both in vitro and in vivo. Mitochondria mediated caspase dependent pathway was essential in DHTS-induced cytotoxicity. The apoptosis induced by DHTS was suppressed by knockdown of apoptosis inducing factor (AIF), inhibition of caspase-3/9 but was increased after knockdown of caspase-2. Meantime, knockdown of caspase-2, pretreatment with Z-VAD-fmk or NAC (N-Acety-L-Cysteine) efficiently inhibited the autophagy induced by DHTS. A crosstalk between cytochrome c and AIF was also reported.
    CONCLUSIONS:
    DHTS-induced caspase and ROS dependent apoptosis and autophagy were mediated by mitochondria in colon cancer. DHTS could be a promising leading compound for the development of anti-tumor agent or be developed as an adjuvant drug for colon cancer therapy.
    制备储备液(仅供参考)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 3.5932 mL 17.9662 mL 35.9324 mL 71.8649 mL 89.8311 mL
    5 mM 0.7186 mL 3.5932 mL 7.1865 mL 14.373 mL 17.9662 mL
    10 mM 0.3593 mL 1.7966 mL 3.5932 mL 7.1865 mL 8.9831 mL
    50 mM 0.0719 mL 0.3593 mL 0.7186 mL 1.4373 mL 1.7966 mL
    100 mM 0.0359 mL 0.1797 mL 0.3593 mL 0.7186 mL 0.8983 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    部分图片展示
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    次甲二氢丹参醌; Methylenedihydrotanshinquinone CFN92249 126979-81-5 C18H16O3 = 280.3 5mg QQ客服:1413575084
    四氢丹参酮 I; Tetrahydro tanshinone I CFN90460 126979-84-8 C18H16O3 = 280.31 5mg QQ客服:3257982914
    二氢丹参酮I; Dihydrotanshinone I CFN97435 87205-99-0 C18H14O3 = 278.3 20mg QQ客服:1457312923
    15,16-二氢丹参二醇 B; 15,16-Dihydrotanshindiol B CFN92241 891854-86-7 C18H18O5 = 314.3 5mg QQ客服:215959384
    15,16-二氢丹参二醇 C; 15,16-Dihydrotanshindiol C CFN92242 891854-96-9 C18H18O5 = 314.3 5mg QQ客服:1413575084
    丹参醇 C; Danshenol C CFN96391 910856-25-6 C21H20O4 = 336.4 5mg QQ客服:2159513211
    丹参醇A; Danshenol A CFN92167 189308-08-5 C21H20O4 = 336.4 5mg QQ客服:2056216494
    15-表-丹参醇 A; 15-Epi-Danshenol-A CFN92168 216987-13-2 C21H20O4 = 336.4 5mg QQ客服:1413575084
    异丹参酮II; Isotanshinone II CFN92020 98249-39-9 C18H12O3 = 276.3 5mg QQ客服:1457312923
    二氢异丹参酮II; Dihydroisotanshinone II CFN98293 260397-58-8 C18H14O3 = 278.3 5mg QQ客服:2159513211

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