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    三尖杉碱

    Cephalotaxine

    三尖杉碱
    产品编号 CFN90919
    CAS编号 24316-19-6
    分子式 = 分子量 C18H21NO4 = 315.4
    产品纯度 >=98%
    物理属性 Powder
    化合物类型 Alkaloids
    植物来源 The barks of Cephalotaxus fortunei Hook. f.
    ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用
    提供自定义包装
    产品名称 产品编号 CAS编号 包装 QQ客服
    三尖杉碱 CFN90919 24316-19-6 10mg QQ客服:2159513211
    三尖杉碱 CFN90919 24316-19-6 20mg QQ客服:2159513211
    三尖杉碱 CFN90919 24316-19-6 50mg QQ客服:2159513211
    三尖杉碱 CFN90919 24316-19-6 100mg QQ客服:2159513211
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    ChemFaces的产品在许多优秀和顶级科学期刊中被引用

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.
    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.
    IF=12.804(2019)

    PMID: 30417089
    我们的产品现已经出口到下面的研究机构与大学,并且还在增涨
  • Heidelberg University (Germany)
  • Srinakharinwirot University (Thailand)
  • Sapienza University of Rome (Italy)
  • CSIRO - Agriculture Flagship (Australia)
  • University of Parma (Italy)
  • University of Fribourg (Switzerland)
  • Fraunhofer-Institut für Molekularbiologie und Angewandte ?kologie IME (Germany)
  • Rio de Janeiro State University (Brazil)
  • National Research Council of Canada (Canada)
  • China Medical University (Taiwan)
  • University of British Columbia (Canada)
  • Korea Food Research Institute(KFRI) (Korea)
  • University of Leipzig (Germany)
  • University of Vienna (Austria)
  • More...
  • 国外学术期刊发表的引用ChemFaces产品的部分文献
  • Auburn University2015, 1-58
  • Evid Based Complement Alternat Med.2016, 2016:1739760
  • J Nat Med.2017, 71(2):380-388
  • Int. J. of Food Properties2017, S108-S118
  • PLoS One.2018, 13(11):e0208055
  • Evid Based Complement Alternat Med.2018, 2018:3610494
  • Molecules.2018, 23(11):E2837
  • Cell Biochem Funct.2018, 36(6):303-311
  • Planta Med.2018, 84(15):1101-1109
  • Cell Death Dis.2019, 10(12):882
  • Saf Health Work.2019, 10(2):196-204
  • Pharmacognosy Journal2019, 11(2): 369-373
  • Drug Invention Today2019, 12(6):1303-1306
  • Asian J Beauty Cosmetol2019, 17(3):287-294
  • BMC Microbiol.2019, 19(1):78
  • J of the Korean Society of Cosmetics and Cosmetology2019, 225-231
  • Saudi Pharm J.2019, 27(1):145-153
  • FASEB J.2019, 33(2):2026-2036
  • Plos One.2020, 10.1371
  • J Chromatogr Sci.2020, 58(6):485-493.
  • Arch Biochem Biophys.2020, 687:108363.
  • Drug Dev Res.2020, doi: 10.1002
  • Natural Product Communications2020, doi: 10.1177.
  • ...
  • 生物活性
    Description: Cephalotaxine is an antiviral as well as antitumor agent. It is useless for the treatment of infection by flaviviruses, but potentially useful in combined therapy against hepatitis B.
    Targets: HBV
    In vitro:
    Planta Med. 2007 Jun;73(6):552-8.
    Effect of cantharidin, cephalotaxine and homoharringtonine on [Pubmed: 17458779 ]
    The effect as antiviral agents versus viral hepatitis B and C of three compounds purified from natural products commonly used as remedies in traditional Chinese medicine, cantharidin, cephalotaxine and homoharingtonine, was investigated.
    METHODS AND RESULTS:
    To assess the activity of these compounds against flavivirus, we used bovine viral diarrhoea virus (BVDV) as a surrogate for hepatitis C virus (HCV). Anti-BVDV activity was determined by reduction in BVDV-RNA production and protection of infected embryonic bovine trachea (EBTr) cells against the cytopathic effect of BVDV. The effect versus hepatitis B virus (HBV) was investigated by measuring HBsAg and HBV-DNA release from hepatoblastoma HepG2 2.2.15 cells infected with HBV. As positive control we used the standard anti-HBV and anti-HCV drugs, lamivudine and ribavirin, respectively. Up to 100 microM lamivudine and ribavirin did not induce cell toxicity, whereas they induced dose-dependent anti-HBV and anti-BVDV effects, respectively. In the same range, cantharidin, cephalotaxine and homoharringtonine induced toxicity in EBTr cells and had no protective effect against BVDV.
    CONCLUSIONS:
    In contrast, they were able to inhibit HBV production at concentrations 10- to 100-fold lower than those inducing cell toxicity, which suggests that they are useless for the treatment of infection by flaviviruses, but potentially useful in combined therapy against hepatitis B.
    制备储备液(仅供参考)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 3.1706 mL 15.8529 mL 31.7058 mL 63.4115 mL 79.2644 mL
    5 mM 0.6341 mL 3.1706 mL 6.3412 mL 12.6823 mL 15.8529 mL
    10 mM 0.3171 mL 1.5853 mL 3.1706 mL 6.3412 mL 7.9264 mL
    50 mM 0.0634 mL 0.3171 mL 0.6341 mL 1.2682 mL 1.5853 mL
    100 mM 0.0317 mL 0.1585 mL 0.3171 mL 0.6341 mL 0.7926 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    部分图片展示
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    桥氧三尖杉碱; Drupacine CFN96761 49686-57-9 C18H21NO5 = 331.36 5mg QQ客服:1413575084
    三尖杉碱; Cephalotaxine CFN90919 24316-19-6 C18H21NO4 = 315.4 20mg QQ客服:2159513211
    4-羟基三尖杉碱; 4-Hydroxycephalotaxine CFN97338 84567-08-8 C18H21NO5 = 331.4 5mg QQ客服:2932563308
    乙酰三尖杉碱; Acetylcephalotaxine CFN98255 24274-60-0 C20H23NO5 = 357.4 5mg QQ客服:1413575084
    高三尖杉酯碱; Homoharringtonine CFN98110 26833-87-4 C29H39NO9 = 545.61 20mg QQ客服:2932563308
    三尖杉酯碱; Harringtonine CFN90891 26833-85-2 C28H37NO9 = 531.6 20mg QQ客服:3257982914
    Cephalocyclidin A; Cephalocyclidin A CFN98660 421583-14-4 C17H19NO5 = 317.3 5mg QQ客服:2056216494
    去甲基三尖杉碱; Demethylcephalotaxinone CFN96766 51020-45-2 C17H17NO4 = 299.32 5mg QQ客服:1457312923
    Chilenine; Chilenine CFN89525 71700-15-7 C20H17NO7 = 383.35 5mg QQ客服:1413575084

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