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  • 三尖杉酯碱

    Harringtonine

    三尖杉酯碱
    产品编号 CFN90891
    CAS编号 26833-85-2
    分子式 = 分子量 C28H37NO9 = 531.6
    产品纯度 >=98%
    物理属性 Powder
    化合物类型 Alkaloids
    植物来源 The branches of Cephalotaxus fortunei Hook.f.
    ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用
    提供自定义包装
    产品名称 产品编号 CAS编号 包装 QQ客服
    三尖杉酯碱 CFN90891 26833-85-2 1mg QQ客服:2159513211
    三尖杉酯碱 CFN90891 26833-85-2 5mg QQ客服:2159513211
    三尖杉酯碱 CFN90891 26833-85-2 10mg QQ客服:2159513211
    三尖杉酯碱 CFN90891 26833-85-2 20mg QQ客服:2159513211
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    ChemFaces的产品在许多优秀和顶级科学期刊中被引用

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.
    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.
    IF=12.804(2019)

    PMID: 30417089
    我们的产品现已经出口到下面的研究机构与大学,并且还在增涨
  • University of Wollongong (Australia)
  • Utah State University (USA)
  • University of Malaya (Malaysia)
  • Universiti Sains Malaysia (Malaysia)
  • University of Oslo (Norway)
  • Stanford University (USA)
  • University of Limpopo (South Africa)
  • Shanghai University of TCM (China)
  • Uniwersytet Medyczny w ?odzi (Poland)
  • National Research Council of Canada (Canada)
  • University Medical Center Mainz (Germany)
  • University of Wuerzburg (Germany)
  • University of Illinois (USA)
  • Periyar University (India)
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  • 国外学术期刊发表的引用ChemFaces产品的部分文献
  • Natural Product Communications2020, doi: 10.1177.
  • Pharmaceuticals (Basel).2021, 14(10):1046.
  • Biosci Biotechnol Biochem.2021, 85(10):2153-2160.
  • Journal of Ginseng Research2021, 3 June.
  • European Journal of Integrative Medicine2018, 20:165-172
  • Food Chem.2019, 279:80-87
  • Molecules.2020, 25(9):2111.
  • Pharmaceutics.2021, 13(7):1028.
  • US20170000760 A12016, 42740
  • Molecules.2020, 25(7):1625.
  • J Korean Med Obes Res.2023, 23:10-7
  • Eur J Neurosci.2021, 53(11):3548-3560.
  • Drug Chem Toxicol.2020, 1-12.
  • Evid Based Complement Alternat Med.2018, 2018:3610494
  • Phytochemistry Letters2015, 243-247
  • Food Funct.2022, 13(13):6923-6933.
  • Anticancer Res.2020, 40(10):5529-5538.
  • Food Funct.2020, 11(2):1322-1333.
  • Sci Rep.2017, 7:40345
  • Cells.2022, 11(8), 1311.
  • Phytomedicine.2017, 24:77-86
  • J Microbiol Biotechnol.2020, 30(2):178-186.
  • APMIS.2019, 127(10):688-695
  • ...
  • 生物活性
    Description: Harringtonine , an anticancer drug with high chemotherapeutic efficiency to human chronic granulocytic/myelomonocytic leukemia, has been reported to rapidly induce apoptosis in HL-60 cells in a wide scope/range of dosage by investigators from our lab and others. Harringtonine exerts its antiviral effects by inhibiting Chikungunya virus (CHIKV) viral protein synthesis.
    Targets: Calcium Channel | Antifection
    In vitro:
    Cancer Lett. 1998 May 15;127(1-2):113-21.
    Intracellular calcium distribution in apoptosis of HL-60 cells induced by harringtonine: intranuclear accumulation and regionalization.[Pubmed: 9619866]
    Harringtonine (HT), an anticancer drug with high chemotherapeutic efficiency to human chronic granulocytic/myelomonocytic leukemia, has been reported to rapidly induce apoptosis in HL-60 cells in a wide scope/range of dosage by investigators from our lab and others.
    METHODS AND RESULTS:
    In the present studies, by using video enhancement contrast (VEC) microscopy, we dynamically analyzed changes in intracellular calcium distribution in a single HL-60 cell over the period from the initiation of apoptosis to the obvious appearance of chromatin condensation. The results from this paper demonstrated the striking distinction of intracellular calcium distribution at different time points after treatment with HT. Before treatment in normal HL-60 cells the highest [Ca2+]i accumulation was observed in the peri-nuclear area and the lowest was observed in the nucleus; after treatment with 1 microg/ml HT for 30 min intracellular calcium diffused all over the cell compartments, while intranuclear calcium increased comparatively and significantly. The phenomenon of intranuclear calcium accumulation was further confirmed by using laser scanning confocal microscopy (LSCM). In addition, co-localization of the highest calcium region with condensed chromatin in apoptotic HL-60 cells was also observed by LSCM.
    CONCLUSIONS:
    Our results suggest that two sequential alterations of intracellular calcium distribution occurred in apoptotic HL-60 cells induced by HT, i.e. (a) accumulation of calcium in the nucleus and (b) regionalization in a specific nuclear region.
    Antimicrob. Agents Chemother., 2013, 57(1): 155-67.
    Inhibition of Chikungunya Virus Replication by Harringtonine, a Novel Antiviral That Suppresses Viral Protein Expression[Reference: WebLink]
    Chikungunya virus (CHIKV) is a mosquito-transmitted virus that has reemerged as a significant public health threat in the last decade.
    METHODS AND RESULTS:
    Harringtonine, a cephalotaxine alkaloid, displayed potent inhibition of CHIKV infection (50% effective concentration [EC50] = 0.24 μM) with minimal cytotoxicity and was selected for elucidation of its antiviral mechanism. Time-of-addition studies, cotreatment assays, and direct transfection of viral genomic RNA indicated that Harringtonine inhibited an early stage of the CHIKV replication cycle which occurred after viral entry into cells. In addition, quantitative reverse transcription-PCR (qRT-PCR) and Western blot analyses indicated that Harringtonine affects CHIKV RNA production as well as viral protein expression.
    CONCLUSIONS:
    Treatment of Harringtonine against Sindbis virus, a related alphavirus, suggested that Harringtonine could inhibit other alphaviruses. This study suggests for the first time that Harringtonine exerts its antiviral effects by inhibiting CHIKV viral protein synthesis.
    制备储备液(仅供参考)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 1.8811 mL 9.4056 mL 18.8111 mL 37.6223 mL 47.0278 mL
    5 mM 0.3762 mL 1.8811 mL 3.7622 mL 7.5245 mL 9.4056 mL
    10 mM 0.1881 mL 0.9406 mL 1.8811 mL 3.7622 mL 4.7028 mL
    50 mM 0.0376 mL 0.1881 mL 0.3762 mL 0.7524 mL 0.9406 mL
    100 mM 0.0188 mL 0.0941 mL 0.1881 mL 0.3762 mL 0.4703 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    部分图片展示
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    桥氧三尖杉碱; Drupacine CFN96761 49686-57-9 C18H21NO5 = 331.36 5mg QQ客服:2056216494
    三尖杉碱; Cephalotaxine CFN90919 24316-19-6 C18H21NO4 = 315.4 20mg QQ客服:1413575084
    4-羟基三尖杉碱; 4-Hydroxycephalotaxine CFN97338 84567-08-8 C18H21NO5 = 331.4 5mg QQ客服:1457312923
    乙酰三尖杉碱; Acetylcephalotaxine CFN98255 24274-60-0 C20H23NO5 = 357.4 5mg QQ客服:2159513211
    高三尖杉酯碱; Homoharringtonine CFN98110 26833-87-4 C29H39NO9 = 545.61 20mg QQ客服:1457312923
    三尖杉酯碱; Harringtonine CFN90891 26833-85-2 C28H37NO9 = 531.6 5mg QQ客服:1457312923
    Cephalocyclidin A; Cephalocyclidin A CFN98660 421583-14-4 C17H19NO5 = 317.3 5mg QQ客服:1413575084
    去甲基三尖杉碱; Demethylcephalotaxinone CFN96766 51020-45-2 C17H17NO4 = 299.32 5mg QQ客服:3257982914
    Chilenine; Chilenine CFN89525 71700-15-7 C20H17NO7 = 383.35 5mg QQ客服:3257982914

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