腺嘌呤

Adenine

	产品编号	CFN89041
	CAS编号	73-24-5
	分子式 = 分子量	C₅H₅N₅ = 135.13
	产品纯度	>=98%
	物理属性	Powder
	化合物类型	Alkaloids
	植物来源	The seeds of Plantago depressa Wild.
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产品名称	产品编号	CAS编号	包装	QQ客服
腺嘌呤	CFN89041	73-24-5	10mg	QQ客服：1457312923
腺嘌呤	CFN89041	73-24-5	20mg	QQ客服：1457312923
腺嘌呤	CFN89041	73-24-5	50mg	QQ客服：1457312923
腺嘌呤	CFN89041	73-24-5	100mg	QQ客服：1457312923

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Description:

Adenine is a purine derivative and a nucleobase with a variety of roles in biochemistry. Adenine, an AMP-activated protein kinase (AMPK) activator, can accelerate the diabetic wound healing by PPAR delta and angiogenic regulation; it also can increase the inhibitory activity of human interferon against encephalomyocarditis virus. Adenine can act as an efficient radiation-protecting agent at low concentration (2 micromol) and also inhibit cytostatic properties with regard to cancer cells at higher concentration.

Targets:

AMPK | PPAR

In vitro:

Antimicrob Agents Chemother. 1986 Jul;30(1):192-5.

Potentiation by levamisole, methisoprinol, and adenine or adenosine of the inhibitory activity of human interferon against encephalomyocarditis virus.[Pubmed: 2428301 ]

METHODS AND RESULTS:
The antiviral action of different human interferons against encephalomyocarditis virus in HeLa cell cultures was analyzed. Cell treatment with levamisole (200 micrograms/ml), methisoprinol (1 mg/ml), or adenine or adenosine (33 or 100 micrograms/ml, respectively) potentiated the anti-encephalomyocarditis virus activity of human interferon by 8- to 32-fold.
CONCLUSIONS:
A higher level of potentiation (256-fold) was achieved either by combined treatments with levamisole plus methisoprinol or by treatment with one of these compounds plus adenine or adenosine.

Anticancer Res. 2006 Jul-Aug;26(4B):3005-10.

Radiation-induced effect of adenine (vitamin B4) on mitomycin C activity. In vitro experiments.[Pubmed: 16886627]

METHODS AND RESULTS:
The radiation-induced biological behavior of adenine (vitamin B4) was investigated in vitro under various conditions, implementing breast cancer cells (MCF-7 line) as a model. In aerated media (46% OH and 54% O2*-) at pH=7.4, adenine at low concentration (2 micromol) acted as an efficient radiation-protecting agent. At higher concentration, however, it inhibited cytostatic properties with regard to cancer cells. This double-track activity is based on its chemical structure. Similar features of adenine were also observed in air-free (46% OH, 44% e- aq, 10% H) as well as in media saturated with N2O (90% OH, 10% H), but with different efficiencies. In the presence of mitomycin C (MMC), adenine retained its double-track behavior.
CONCLUSIONS:
Hence, adenine and MMC compete for the e- aq, but the electronically excited adenine molecules can transfer electrons to MMC, leading to the additional formation of active MMC-. By implementation of formate for the conversion of OH and H into the transient *COO-, which subsequently transfers electron to MMC, a highest efficiency of MMC- was obtained.

In vivo:

Eur J Pharmacol. 2017 Nov 21;818:569-577.

Adenine accelerated the diabetic wound healing by PPAR delta and angiogenic regulation.[Pubmed: 29162431 ]

Wound healing is one of the major complications of diabetes, and problems with wound healing in diabetics often lead to amputation and even death. AMP-activated protein kinase (AMPK) is a protein involved in intracellular metabolism. Activated AMPK can reduce visceral fat and cholesterol synthesis and even inhibit hepatic gluconeogenesis. Activation of AMPK has been widely used in the treatment of type II diabetes.
METHODS AND RESULTS:
We applied an AMPK activator (Adenine) to human fibroblasts and to the wounds of streptozotocin-induced diabetic mice. We applied Adenine ointment to the wounds on 7 consecutive days and observed the healing status as well as activation of AMPK and angiogenic factors. Based on the appearance of the wounds, the results showed that after 7 days of treatment the wound area was smaller in the Adenine-treated group relative to the control group.
CONCLUSIONS:
The results for tissue protein expression showed that, compared to the control group, angiogenic related protein, PPARδ were increased and receptor for advanced glycation endproducts (RAGE) was decreased in the Adenine-treated group. Our studies indicate that Adenine has the potential to become a useful drug in the treatment of diabetic wound healing.

产品名称	产品编号	CAS编号	分子式 = 分子量	位单	联系QQ
咖啡因; Caffeine	CFN99004	58-08-2	C₈H₁₀N₄O₂ = 194.2	20mg	QQ客服：2159513211
1,3,9-三甲基尿酸; 1,3,9-Trimethyluric acid	CFN89099	7464-93-9	C₈H₁₀N₄O₃ = 210.19	5mg	QQ客服：215959384
肌苷酸二钠盐; 5'-IMPdisodium salt	CFN80067	4691-65-0	C₁₀H₁₁N₄Na₂O₈P = 392.17	5mg	QQ客服：3257982914
巴豆苷；异鸟苷; Crotonoside	CFN99524	1818-71-9	C₁₀H₁₃N₅O₅ = 283.24	20mg	QQ客服：2159513211
次黄嘌呤 ; Hypoxanthine	CFN96592	68-94-0	C₅H₄N₄O = 136.11	20mg	QQ客服：215959384
3-甲基黄嘌呤; 3-Methylxanthine	CFN95087	1076-22-8	C₆H₆N₄O₂ = 166.1	20mg	QQ客服：3257982914
可可碱; Theobromine	CFN99737	83-67-0	C₇H₈N₄O₂ = 180.16	20mg	QQ客服：2159513211
茶碱; Theophylline	CFN99768	58-55-9	C₇H₈N₄O₂ = 180.16	20mg	QQ客服：215959384
腺嘌呤; Adenine	CFN89041	73-24-5	C₅H₅N₅ = 135.13	20mg	QQ客服：2056216494
S-(5'-腺苷基)-L-氯化蛋氨酸; S-(5'-Adenosyl)-L-methionine chloride	CFN90073	24346-00-7	C₁₅H₂₃ClN₆O₅S = 434.9	10mg	QQ客服：3257982914

	1 mg	5 mg	10 mg	20 mg	25 mg
1 mM	7.4003 mL	37.0014 mL	74.0028 mL	148.0056 mL	185.007 mL
5 mM	1.4801 mL	7.4003 mL	14.8006 mL	29.6011 mL	37.0014 mL
10 mM	0.74 mL	3.7001 mL	7.4003 mL	14.8006 mL	18.5007 mL
50 mM	0.148 mL	0.74 mL	1.4801 mL	2.9601 mL	3.7001 mL
100 mM	0.074 mL	0.37 mL	0.74 mL	1.4801 mL	1.8501 mL

腺嘌呤

Adenine

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