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  • 3-甲基黄嘌呤

    3-Methylxanthine

    3-甲基黄嘌呤
    产品编号 CFN95087
    CAS编号 1076-22-8
    分子式 = 分子量 C6H6N4O2 = 166.1
    产品纯度 >=98%
    物理属性 Powder
    化合物类型 Alkaloids
    植物来源 The fruits of Theobroma cacao L.
    ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用
    提供自定义包装
    产品名称 产品编号 CAS编号 包装 QQ客服
    3-甲基黄嘌呤 CFN95087 1076-22-8 10mg QQ客服:1413575084
    3-甲基黄嘌呤 CFN95087 1076-22-8 20mg QQ客服:1413575084
    3-甲基黄嘌呤 CFN95087 1076-22-8 50mg QQ客服:1413575084
    3-甲基黄嘌呤 CFN95087 1076-22-8 100mg QQ客服:1413575084
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    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
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    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

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  • ...
  • 生物活性
    Description: 3-Methylxanthine inhibited xanthine crystallization, it could protect patients with xanthinuria from the development of renal xanthine calculi.
    In vitro:
    PLoS One. 2018 Aug 29;13(8):e0198881.
    Xanthine urolithiasis: Inhibitors of xanthine crystallization.[Pubmed: 30157195 ]
    To identify in vitro inhibitors of xanthine crystallization that have potential for inhibiting the formation of xanthine crystals in urine and preventing the development of the renal calculi in patients with xanthinuria.
    METHODS AND RESULTS:
    The formation of xanthine crystals in synthetic urine and the effects of 10 potential crystallization inhibitors were assessed using a kinetic turbidimetric system with a photometer. The maximum concentration tested for each compound was: 20 mg/L for 3-methylxanthine (3-MX); 40 mg/L for 7-methylxanthine (7-MX), 1-methylxanthine (1-MX), theobromine (TB), theophylline, paraxanthine, and caffeine; 45 mg/L for 1-methyluric acid; 80 mg/L for 1,3-dimethyluric acid; and 200 mg/L for hypoxanthine. Scanning electron microscopy was used to examine the morphology of the crystals formed when inhibitory effects were observed. Only 7-MX, 3-MX, and 1-MX significantly inhibited xanthine crystallization at the tested concentrations. Mixtures of inhibitors had an additive effect rather than a synergistic effect on crystallization.
    CONCLUSIONS:
    Two of the inhibitors identified here-7-MX and 3-MX-are major metabolites of TB. In particular, after TB consumption, 20% is excreted in the urine as TB, 21.5% as 3-MX, and 36% as 7-MX. Thus, consumption of theobromine could protect patients with xanthinuria from the development of renal xanthine calculi. Clinical trials are necessary to demonstrate these effects in vivo.
    制备储备液(仅供参考)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 6.0205 mL 30.1023 mL 60.2047 mL 120.4094 mL 150.5117 mL
    5 mM 1.2041 mL 6.0205 mL 12.0409 mL 24.0819 mL 30.1023 mL
    10 mM 0.602 mL 3.0102 mL 6.0205 mL 12.0409 mL 15.0512 mL
    50 mM 0.1204 mL 0.602 mL 1.2041 mL 2.4082 mL 3.0102 mL
    100 mM 0.0602 mL 0.301 mL 0.602 mL 1.2041 mL 1.5051 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    部分图片展示
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    茶碱; Theophylline CFN99768 58-55-9 C7H8N4O2 = 180.16 20mg QQ客服:1413575084
    腺嘌呤; Adenine CFN89041 73-24-5 C5H5N5 = 135.13 20mg QQ客服:1413575084
    S-(5'-腺苷基)-L-氯化蛋氨酸; S-(5'-Adenosyl)-L-methionine chloride CFN90073 24346-00-7 C15H23ClN6O5S = 434.9 10mg QQ客服:3257982914
    S-腺甙甲硫氨酸对甲苯磺酸盐; S-Adenosyl-L-methionine tosylate CFN90074 71914-80-2 C22H30N6O8S2 = 570.6 5mg QQ客服:2056216494
    S-腺苷蛋氨酸; S-Adenosyl-L-Methtonine CFN90075 17176-17-9 C15H22N6O5S = 398.44 20mg QQ客服:2159513211
    S-腺苷基-L-蛋氨碘盐; S-Adenosyl-L-Methionine iodide salt CFN90076 3493-13-8 C15H23IN6O5S.I = 526.3 5mg QQ客服:1413575084
    Zarzissine; Zarzissine CFN96195 160568-14-9 C5H5N5 = 135.1 5mg QQ客服:1457312923
    鸟嘌呤核苷; Guanosine CFN90925 118-00-3 C10H13N5O5 = 283.2 20mg QQ客服:215959384
    2'-脱氧鸟苷; 2'-Deoxyguanosine CFN91545 312693-72-4 C10H13N5O4 = 267.2 20mg QQ客服:215959384
    虫草素; Cordycepin CFN98566 73-03-0 C10H13N5O3 = 251.24 20mg QQ客服:3257982914

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