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    葛花苷

    Kakkalide

    葛花苷
    产品编号 CFN95052
    CAS编号 58274-56-9
    分子式 = 分子量 C28H32O15 = 608.6
    产品纯度 >=98%
    物理属性 Powder
    化合物类型 Flavonoids
    植物来源 The roots of Pueraria lobata
    ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用
    提供自定义包装
    产品名称 产品编号 CAS编号 包装 QQ客服
    葛花苷 CFN95052 58274-56-9 1mg QQ客服:3257982914
    葛花苷 CFN95052 58274-56-9 5mg QQ客服:3257982914
    葛花苷 CFN95052 58274-56-9 10mg QQ客服:3257982914
    葛花苷 CFN95052 58274-56-9 20mg QQ客服:3257982914
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    ChemFaces的产品在许多优秀和顶级科学期刊中被引用

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.
    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.
    IF=12.804(2019)

    PMID: 30417089
    我们的产品现已经出口到下面的研究机构与大学,并且还在增涨
  • National Hellenic Research Foundation (Greece)
  • University of Wuerzburg (Germany)
  • The Institute of Cancer Research (United Kingdom)
  • Max Rubner-Institut (MRI) (Germany)
  • University of Virginia (USA)
  • Sapienza University of Rome (Italy)
  • University of East Anglia (United Kingdom)
  • Universiti Putra Malaysia(UPM) (Malaysia)
  • Universidad Veracuzana (Mexico)
  • Cancer Research Initatives Foundation(CARIF) (Malaysia)
  • University of Wollongong (Australia)
  • Worcester Polytechnic Institute (USA)
  • The Vancouver Prostate Centre (VPC) (Canada)
  • Universite de Lille1 (France)
  • More...
  • 国外学术期刊发表的引用ChemFaces产品的部分文献
  • BMC Complement Altern Med.2016, 16:213
  • Research on Crops.2017, 18(2)
  • J Ethnopharmacol.2017, 206:73-77
  • Universidade Estadual Paulista2017, 42785
  • Korean J of Food Science&Technology 2017, 49(2):146-150
  • Biochem Biophys Res Commun.2017, 494(3-4):587-593
  • Pharm Biol.2017, 55(1):360-366
  • J Nat Med.2017, 71(4):745-756
  • Molecules.2018, 23(2)
  • Nat Commun.2019, 10(1):2745
  • J of the Korean Society of Cosmetics and Cosmetology2019, 225-231
  • FASEB J.2019, 33(2):2026-2036
  • Biochem Biophys Res Commun.2019, 518(4):732-738
  • Toxicol In Vitro.2019, 59:161-178
  • Sci Rep.2019, 9(1):6429
  • J Sep Sci.2020, 201901140
  • Molecules2020, 25(4):892
  • Biochem Biophys Res Commun.2020, 522(4):1052-1058
  • Antioxidants (Basel).2020, 9(2):E99
  • Front Pharmacol.2020, 11:566490.
  • Evid Based Complement Alternat Med.2020, 2020:9416962.
  • Neurotox Res.2020, 38(1):163-174.
  • Environ Toxicol.2020, doi: 10.1002
  • ...
  • 生物活性
    Description: Kakkalide is a potent lactate dehydrogenase (LDH) inhibitor, it has anti-inflammatory effects. Kakkalide can inhibit ROS-associated inflammation and ameliorated insulin-resistant endothelial dysfunction by beneficial effects on IRS-1 function.Kakkalide attenuates ethanol-induced gastric injury in mice by inhibiting the infiltration of neutrophils, it also shows protective effects on ethanol-induced lethality and hepatic injury are dependent on its biotransformation by human intestinal microflora.
    Targets: IL Receptor | NF-kB | ROS | Akt | PI3K | IkB | NO | PGE | COX | TNF-α | IKK | LDH
    In vitro:
    J Diabetes. 2013 Mar;5(1):13-24.
    Kakkalide ameliorates endothelial insulin resistance by suppressing reactive oxygen species-associated inflammation.[Pubmed: 23190749 ]
    Kakkalide is the predominant isoflavone derived from the flowers of Pueraria lobata (Willd.) Ohwi. The aim of the present study was to investigate the effects of kakkalide on insulin resistance in the endothelium.
    METHODS AND RESULTS:
    Human umbilical vein endothelial cells (HUVEC) were stimulated with 100 μmol/L palmitate (PA) for 30 min and the effects of 30 min pretreatment with 0.1-10 μmol/L kakkalide on reactive oxygen species (ROS)-associated inflammation in cells were evaluated by western blot analysis and reverse transcription-polymerase chain reaction. Furthermore, we investigated the biomodulation of insulin signaling by kakkalide along the insulin receptor substrate (IRS)-1/Akt/endothelial nitric oxide synthase (eNOS) pathway. We also determined the effects of 30 min pretreatment with 0.1-10 μmol/L kakkalide on insulin-mediated endothelium-dependent vasodilation of rat aorta in vitro following stimulation with 100 μmol/L PA. Kakkalide inhibited ROS overproduction and effectively restored mitochondrial membrane potential, demonstrating its chemoprotection of mitochondrial function. In addition, kakkalide inhibited ROS-associated inflammation in the endothelium by inhibiting tumor necrosis factor-α and interleukin-6 production and gene expression, as well as suppressing the phosphorylation of c-Jun N-terminal kinase and IκB kinase β/nuclear factor-κB. Inflammation impaired insulin phosphatidylinositol 3-kinase (PI3K) signaling and reduced insulin-mediated NO production in endothelial cells. Kakkalide facilitated PI3K signaling by positively regulating serine/tyrosine phosphorylation of IRS-1.
    CONCLUSIONS:
    Kakkalide inhibited ROS-associated inflammation and ameliorated insulin-resistant endothelial dysfunction by beneficial effects on IRS-1 function.
    In vivo:
    Mol Nutr Food Res. 2017 Feb;61(2).
    Irisolidone attenuates ethanol-induced gastric injury in mice by inhibiting the infiltration of neutrophils.[Pubmed: 27546737]
    This study was designed to determine whether irisolidone and its glycoside kakkalide, which are the major constituents of the flower of Pueraria lobata (Kudzu) can attenuate ethanol-induced gastritic injury in mice.
    METHODS AND RESULTS:
    Irisolidone and kakkalide inhibited IL-8 secretion and NF-κB activation in lipopolysaccharide-stimulated KATO III cells. Therefore, we investigated their protective effects against ethanol-induced gastric injury in mice. Pretreatment with kakkalide or irisolidone decreased the area of hemorrhagic ulcerative lesions caused by ethanol and suppressed stomach myeloperoxidase activity, CXCL4 secretion, and NF-κB activation. The ameliorating effect of irisolidone was more potent than that of kakkalide.
    CONCLUSIONS:
    Irisolidone may attenuate ethanol-induced gastritis by inhibiting the infiltration of immune cells, particularly neutrophils, through the regulation of CXCL-4 or IL-8 secretion.
    J Pharmacol Sci. 2003 Nov;93(3):331-6.
    Protective effects of kakkalide from Flos puerariae on ethanol-induced lethality and hepatic injury are dependent on its biotransformation by human intestinal microflora.[Pubmed: 14646251]

    METHODS AND RESULTS:
    When kakkalide, which was isolated from Flos Puerariae, was incubated with human fecal bacteria, kakkalide was metabolized to irisolidone via kakkalidone. When kakkalide (250 mg/kg) was orally administered to rats, irisolidone, but not kakkalide, was detected in the blood. The mortality associated with ethanol treatment was slightly reduced when the mice were intraperitoneally treated with kakkalide. Intraperitoneally administered kakkalide and kakkalidone did not reduce alcohol toxicity. However, orally administered kakkalide and intraperitoneally administered irisolidone significantly reduced the mortality. Orally administered kakkalide and intraperitoneally injected irisolidone greatly reduced serum alanine aminotransferase and aspartate aminotransferase activities in ethanol-intoxified mice.
    CONCLUSIONS:
    Orally administered kakkalide and intraperitoneally administered irisolidone significantly lowered the level of blood ethanol. The results indicate that kakkalide is a prodrug of irisolidone in protecting against ethanol-induced lethality and hepatic injury.
    制备储备液(仅供参考)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 1.6431 mL 8.2156 mL 16.4312 mL 32.8623 mL 41.0779 mL
    5 mM 0.3286 mL 1.6431 mL 3.2862 mL 6.5725 mL 8.2156 mL
    10 mM 0.1643 mL 0.8216 mL 1.6431 mL 3.2862 mL 4.1078 mL
    50 mM 0.0329 mL 0.1643 mL 0.3286 mL 0.6572 mL 0.8216 mL
    100 mM 0.0164 mL 0.0822 mL 0.1643 mL 0.3286 mL 0.4108 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    部分图片展示
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    葛花苷; Kakkalide CFN95052 58274-56-9 C28H32O15 = 608.6 10mg QQ客服:2056216494
    鸢尾甲苷A; Iristectorin A CFN95037 37744-61-9 C23H24O12 = 492.4 10mg QQ客服:2932563308
    野鹫尾苷 ; Iridin CFN96557 491-74-7 C24H26O13 = 522.46 20mg QQ客服:2056216494
    葛根素芹菜糖苷; Mirificin CFN90643 103654-50-8 C26H28O13 = 548.49 20mg QQ客服:2932563308
    3'-羟基葛根素芹菜糖苷; 3'-Hydroxymirificin CFN95102 168035-02-7 C26H28O14 = 564.5 5mg QQ客服:2932563308
    3'-甲氧基葛根素芹菜糖苷; 3'-Methoxymirificin CFN95112 1297609-29-0 C27H30O14 = 578.5 5mg QQ客服:1413575084
    4'-O-甲氧基葛根素; 4'-Methoxypuerarin CFN90782 92117-94-7 C22H22O9 = 430.4 10mg QQ客服:2159513211
    葛根素-6''-O-木糖苷; Puerarin 6''-O-xyloside CFN90640 114240-18-5 C26H28O13 = 548.49 20mg QQ客服:3257982914
    Formononetin-8-C-beta-D-apiofuranosyl-(1→6)-O-beta-D-glucopyranoside; Formononetin-8-C-beta-D-apiofuranosyl-(1->6)-O-beta-D-glucopyranoside CFN95157 1147858-78-3 C27H30O13 = 562.5 10mg QQ客服:2932563308
    美佛辛-4'-O-葡萄糖苷; Mirificin-4'-O-glucoside CFN95091 168035-01-6 C32H38O18 = 710.6 5mg QQ客服:3257982914

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