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  • 色醇,吲哚-3-乙醇

    Tryptophol

    色醇,吲哚-3-乙醇
    产品编号 CFN98866
    CAS编号 526-55-6
    分子式 = 分子量 C10H11NO = 161.2
    产品纯度 >=98%
    物理属性 Powder
    化合物类型 Alkaloids
    植物来源 From Zygosaccharomyces priorianus.
    ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用
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    产品名称 产品编号 CAS编号 包装 QQ客服
    色醇,吲哚-3-乙醇 CFN98866 526-55-6 10mg QQ客服:3257982914
    色醇,吲哚-3-乙醇 CFN98866 526-55-6 20mg QQ客服:3257982914
    色醇,吲哚-3-乙醇 CFN98866 526-55-6 50mg QQ客服:3257982914
    色醇,吲哚-3-乙醇 CFN98866 526-55-6 100mg QQ客服:3257982914
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    ChemFaces的产品在许多优秀和顶级科学期刊中被引用

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.
    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
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    IF=12.804(2019)

    PMID: 30417089
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  • 国外学术期刊发表的引用ChemFaces产品的部分文献
  • Current Traditional Medicine, 2021, 7:326-335(10).
  • ACS Chem Biol.2019, 14(5):873-881
  • J of Health Science and Alternative Medicine2019, 1(1)
  • Front Immunol.2017, 8:1542
  • J Ethnopharmacol.2020, 269:113752.
  • Molecules.2020, 25(23):5556.
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  • Nutrients.2019, 11(6):E1380
  • Front Cell Dev Biol.2021, 9:638174.
  • Food Research2021, 5(1):65-71
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  • Acta Pharm Sin B.2015, 5(4):323-9.
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  • ...
  • 生物活性
    Description: Tryptophol is an aromatic alcohol found as a secondary product of alcoholic fermentation that induces sleep in humans. Tryptophol can inhibit the infection/replication of GVE2 by interacting with the host's Clp protease. Tryptophol can inhibit the proliferation of U937 cells by inducing apoptosis via a pathway involving caspase-8 followed by caspase-3. Tryptophol induces apoptosis through Death Receptor (DR) 5 and that the resistance of peripheral blood lymphocytes (PBL) to tryptophol-induced apoptosis might be due to competition from decoy receptor (DcR).
    Targets: PARP | Caspase
    In vitro:
    Biosci Biotechnol Biochem. 2007 Aug;71(8):2065-8.
    Tryptophol induces death receptor (DR) 5-mediated apoptosis in U937 cells.[Pubmed: 17690453]
    Tryptophol is a natural component isolated from vinegar produced from the boiled extract of black soybean. We have reported that tryptophol induces apoptosis in U937 cells via activation of caspase-8 followed by caspase-3. Tryptophol, however, did not affect human peripheral blood lymphocytes (PBL).
    METHODS AND RESULTS:
    In this study, we found that tryptophol enhances formation of a death-inducing signaling complex including death receptor (DR) 5. Cell viability and induction of apoptosis by tryptophol was reduced by transfection with decoy receptor (DcR) 1.
    CONCLUSIONS:
    These results indicate that tryptophol induces apoptosis through DR5 and that the resistance of PBL to tryptophol-induced apoptosis might be due to competition from DcR1.
    Basic Clin Pharmacol Toxicol. 2008 May;102(5):443-52.
    Genotoxicity of tryptophol in a battery of short-term assays on human white blood cells in vitro.[Pubmed: 18248512]

    METHODS AND RESULTS:
    The genotoxic effects of Tryptophol (indole-3-ethanol), an aromatic alcohol and known secondary metabolite of the opportunistic yeast Candida albicans and other Candida spp. The results obtained suggest cytotoxic, cytostatic and genotoxic effects of the Tryptophol treatment in vitro that were mainly dose-dependent. The type and the extent of DNA lesions detected in Tryptophol-treated samples indicate the possibility that observed damage is mediated by highly reactive aldehyde metabolite and/or free radicals produced by treatment. The results show that mortality of lymphocytes in Tryptophol-treated samples was primarily caused by apoptosis. The generation of additional DNA strand breaks and cytogenetic consequences (chromosome aberrations, sister chromatid exchanges and micronuclei), as observed in this study, sustain the possibility that Tryptophol toxicity is mediated by the formation of DNA cross-links and aldehyde-protein adducts.
    CONCLUSIONS:
    In conclusion, this preliminary study elucidates only a part of Tryptophol toxicity to human cells. Because current evidence is not sufficient to obtain information relevant for human risk assessment, further in vitro and in vivo studies are essential in order to clarify remaining issues, especially to elucidate the exact mechanisms and nature of the damage produced following treatment as well to estimate possible interindividual variability in genotoxic responses to the chemical.
    Experientia. 1976 May 15;32(5):645-7.
    The effects of tryptophol on immune responses and it implications toward trypanosome-induced immunosuppression.[Pubmed: 776647]

    METHODS AND RESULTS:
    Daily administration of tryptophol to laboratory rodents resulted in significantly depressed antibody production of heterologous red blood cell challenge, did not alter cellular-mediated responses to oxazalone.
    CONCLUSIONS:
    These results suggest that trypanosome-produced tryptophol may account for the immunodepression observed during trypanosomiasis.
    In vivo:
    Life Sci. 1970 Mar 15;9(6):323-9.
    Tryptophol, 5-hydroxytryptophol and 5-methoxytryptophol induced sleep in mice.[Reference: WebLink]

    METHODS AND RESULTS:
    Tryptophol, 5-hydroxyTryptophol and 5-methoxyTryptophol were found to induce sleep in mice. The onset of action was most rapid for Tryptophol and 5-methoxyTryptophol; 5-hydroxyTryptophol had the slowest onset, probably due to difficulty of transport across the blood-brain barrier. Sleep times were shortest for Tryptophol and 5-methoxyTryptophol and longest for 5-hydroxyTryptophol.
    CONCLUSIONS:
    It was suggested that the Tryptophols or the corresponding aldehydes may play a role in physiological sleep mechanisms.
    制备储备液(仅供参考)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 6.2035 mL 31.0174 mL 62.0347 mL 124.0695 mL 155.0868 mL
    5 mM 1.2407 mL 6.2035 mL 12.4069 mL 24.8139 mL 31.0174 mL
    10 mM 0.6203 mL 3.1017 mL 6.2035 mL 12.4069 mL 15.5087 mL
    50 mM 0.1241 mL 0.6203 mL 1.2407 mL 2.4814 mL 3.1017 mL
    100 mM 0.062 mL 0.3102 mL 0.6203 mL 1.2407 mL 1.5509 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    部分图片展示
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    2-(1H-Indole-3-carboxamido)benzoic acid; 2-(1H-Indole-3-carboxamido)benzoic acid CFN96192 171817-95-1 C16H12N2O3 = 280.3 5mg QQ客服:1148253675
    5-苄氧基吲哚-3-乙醛酰胺; Indole-3-glyoxylamide CFN96487 5548-10-7 C10H8N2O2 = 188.18 5mg QQ客服:215959384
    圆锥定A; Paniculidine A CFN97552 97399-93-4 C14H17NO2 = 231.3 5mg QQ客服:215959384
    圆锥定B; Paniculidine B CFN97553 97399-94-5 C14H19NO2 = 233.3 5mg QQ客服:1413575084
    圆锥定C; Paniculidine C CFN97554 97399-95-6 C13H17NO = 203.3 5mg QQ客服:215959384
    吲哚-3-丙烯酸甲酯; Indole-3-acrylic acid methyl ester CFN99899 19626-92-7 C12H11NO2 = 201.2 5mg QQ客服:2159513211
    3-吲哚乙酸; Indolelactic acid CFN95263 1821-52-9 C11H11NO3 = 205.2 20mg QQ客服:2932563308
    3-咔唑羧酸甲酯; Methyl 3-carbazolecarboxylate CFN97559 97931-41-4 C14H11NO2 = 225.2 5mg QQ客服:3257982914
    吲哚-3-甲酸; 1H-Indole-3-carboxylic acid CFN97256 771-50-6 C9H7NO2 = 161.2 1g QQ客服:3257982914
    吲哚-3-甲酸甲酯; Methyl 3-indolecarboxylate CFN97515 942-24-5 C10H9NO2 = 175.2 100mg QQ客服:1413575084

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