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  • N-反式阿魏酰酪胺

    N-trans-Feruloyltyramine

    N-反式阿魏酰酪胺
    产品编号 CFN97135
    CAS编号 66648-43-9
    分子式 = 分子量 C18H19NO4 = 313.4
    产品纯度 >=98%
    物理属性 Powder
    化合物类型 Phenylpropanoids
    植物来源 The herbs of Cannabis sativa L.
    ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用
    提供自定义包装
    产品名称 产品编号 CAS编号 包装 QQ客服
    N-反式阿魏酰酪胺 CFN97135 66648-43-9 1mg QQ客服:1148253675
    N-反式阿魏酰酪胺 CFN97135 66648-43-9 5mg QQ客服:1148253675
    N-反式阿魏酰酪胺 CFN97135 66648-43-9 10mg QQ客服:1148253675
    N-反式阿魏酰酪胺 CFN97135 66648-43-9 20mg QQ客服:1148253675
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    ChemFaces的产品在许多优秀和顶级科学期刊中被引用

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.
    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.
    IF=12.804(2019)

    PMID: 30417089
    我们的产品现已经出口到下面的研究机构与大学,并且还在增涨
  • University of Otago (New Zealand)
  • John Innes Centre (United Kingdom)
  • Shanghai Institute of Biochemistry and Cell Biology (China)
  • Chiang Mai University (Thailand)
  • Universitas Airlangga (Indonesia)
  • Aveiro University (Portugal)
  • Yale University (USA)
  • University of Melbourne (Australia)
  • Universidade Federal de Santa Catarina (Brazil)
  • Sant Gadge Baba Amravati University (India)
  • Universita' Degli Studi Di Cagliari (Italy)
  • Ain Shams University (Egypt)
  • University of Queensland (Australia)
  • Nicolaus Copernicus Uniwersity (Poland)
  • More...
  • 国外学术期刊发表的引用ChemFaces产品的部分文献
  • Pharmacognosy Journal2019, 11(2): 369-373
  • Int J Biol Macromol.2018, 112:1093-1103
  • J Biosci.2020, 45:46.
  • Food Funct.2021, 12(13):5892-5902.
  • Molecules.2021, 26(6):1635.
  • Cells.2021, 10(11):2919.
  • Drug Des Devel Ther.2020, 14:5189-5204.
  • Institute of Food Science & Technology2021, 18 December.
  • Allergol Immunopathol (Madr).2022, 1;50(4):23-30.
  • Phytother Res.2019, 33(4):1104-1113
  • J Pharmaceutical Research Int.2021, 33(41A):275-284.
  • Plant Biotechnology Reports 2021, 15:117-124.
  • Korean Journal of Pharmacognosy2014, 113-120
  • The Journal of Phytopharmacology2020, 9(1): 1-4
  • Analytical sci. & Tech2016, 186-193
  • Applied Biological Chemistry 2021, 64(75)
  • The University of Manitoba2021, 35690.
  • Molecules.2019, 24(7):E1290
  • Mol Med Rep.2015, 12(5):7789-95
  • Journal of Functional Foods2022, 91:105019.
  • Molecules2022, 27(3),1140.
  • Virulence.2018, 9(1):588-603
  • Nutrients2022, 14(14)2929
  • ...
  • 生物活性
    Description: N-trans-Feruloyltyramine(NTF) is a platelet aggregation inhibitor, which has hepatoprotective, and antioxidative effects, NTF is likely to inhibit COX enzymes, thereby suppressing P-selectin expression on platelets;NTF inhibits melanogenesis in a dose-dependent manner.
    Targets: NO | PGE | AP-1 | NOS | COX | TNF-α | JNK | Beta Amyloid | Caspase
    In vitro:
    Chem Biol Interact. 2015 Jun 25;235:56-62.
    N-trans-feruloyltyramine inhibits LPS-induced NO and PGE2 production in RAW 264.7 macrophages: Involvement of AP-1 and MAP kinase signalling pathways.[Pubmed: 25843058]
    Mitogen-activated protein kinase (MAPK) signalling pathway can regulate inflammatory and immune responses. N-trans-feruloyltyramine (FLA) is an active phenylpropanoid compound. It possesses antioxidant, antimicrobial, anti-melanogenesis, and anticancer activities. However, the precise molecular mechanisms underlying FLA modulation of cytokine expression in LPS-stimulated RAW 264.7 macrophages have not been fully investigated. In this study, we examined the mechanisms underlying the immunomodulative effects of FLA isolated from Arcangelisia gusanlung.
    METHODS AND RESULTS:
    FLA strongly suppressed mRNA expression of inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2), but not tumor necrosis factor (TNF)-α, thereby inhibiting the production of nitric oxide (NO) and prostaglandin E2 (PGE2) in lipopolysaccharide (LPS)-stimulated RAW 264.7 cells. Furthermore, FLA also inhibited nuclear translocation of activation protein (AP)-1, and simultaneously decreased the expression and phosphorylation of the c-Jun N-terminal kinase (JNK) protein.
    CONCLUSIONS:
    These results suggest that the anti-inflammatory effects of FLA might be attributed to downregulation of COX-2 and iNOS via suppression of AP-1 and the JNK signalling pathway in RAW 264.7 macrophages.
    Fitoterapia. 2010 Mar;81(2):124-31.
    Antioxidant and enzyme inhibition activities and chemical profiles of Polygonum sachalinensis F.Schmidt ex Maxim (Polygonaceae).[Pubmed: 19698767]
    Polygonum sachalinensis is a widespread invasive plant in Europe. Chemical profiles of its different organs were studied by HPLC-UV-ESI/MS.
    METHODS AND RESULTS:
    Seven major constituents quercetin-3-O-beta-D-galactopyranoside, quercetin-3-O-arabinopyranoside, lapathoside D, N-trans-feruloyltyramine, lapathoside C, hydropiperoside, and vanicoside B were isolated and identified. The free radical-scavenging, alpha/beta-glucosidase, and acetylcholinesterase inhibitory activities of crude MeOH extracts and isolated compounds were studied. The structure-activity relationships were discussed. The chemical profiles revealed flavonoids and phenylpropanoids are the major compounds of all the organs of this plant. Quercetin-3-O-arabinopyranoside, lapathoside D, N-trans-feruloyltyramine, lapathoside C and hydropiperoside were isolated from this species for the first time. In the alpha-glucosidase bioassay, quercetin-3-O-beta-D-galactopyranoside, lapathoside D and N-trans-feruloyltyramine demonstrated stronger activities than the positive reference acarbose.
    CONCLUSIONS:
    The trend in scavenging power showed no relation to enzyme inhibition in the test models.
    Inflamm Res . 2018 Jan;67(1):67-75.
    Nature is the best source of anti-inflammatory drugs: indexing natural products for their anti-inflammatory bioactivity[Pubmed: 28956064]
    Abstract Objectives: The aim was to index natural products for less expensive preventive or curative anti-inflammatory therapeutic drugs. Materials: A set of 441 anti-inflammatory drugs representing the active domain and 2892 natural products representing the inactive domain was used to construct a predictive model for bioactivity-indexing purposes. Method: The model for indexing the natural products for potential anti-inflammatory activity was constructed using the iterative stochastic elimination algorithm (ISE). ISE is capable of differentiating between active and inactive anti-inflammatory molecules. Results: By applying the prediction model to a mix set of (active/inactive) substances, we managed to capture 38% of the anti-inflammatory drugs in the top 1% of the screened set of chemicals, yielding enrichment factor of 38. Ten natural products that scored highly as potential anti-inflammatory drug candidates are disclosed. Searching the PubMed revealed that only three molecules (Moupinamide, Capsaicin, and Hypaphorine) out of the ten were tested and reported as anti-inflammatory. The other seven phytochemicals await evaluation for their anti-inflammatory activity in wet lab. Conclusion: The proposed anti-inflammatory model can be utilized for the virtual screening of large chemical databases and for indexing natural products for potential anti-inflammatory activity. Keywords: Anti-inflammatory; Bioactivity index; Chemoinformatics; Ligand-based modeling.
    制备储备液(仅供参考)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 3.1908 mL 15.9541 mL 31.9081 mL 63.8162 mL 79.7703 mL
    5 mM 0.6382 mL 3.1908 mL 6.3816 mL 12.7632 mL 15.9541 mL
    10 mM 0.3191 mL 1.5954 mL 3.1908 mL 6.3816 mL 7.977 mL
    50 mM 0.0638 mL 0.3191 mL 0.6382 mL 1.2763 mL 1.5954 mL
    100 mM 0.0319 mL 0.1595 mL 0.3191 mL 0.6382 mL 0.7977 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    部分图片展示
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    N-对反式香豆酰酪胺; N-p-trans-Coumaroyltyramine CFN98494 36417-86-4 C17H17NO3 = 283.3 10mg QQ客服:1413575084
    N-反式-对香豆酰酪胺; N-trans-p-Coumaroyltyrosine CFN95279 77201-66-2 C18H17NO5 = 327.3 10mg QQ客服:215959384
    N-对香豆酰-N’-咖啡酰腐胺; N-p-coumaroyl-N'-caffeoylputrescine CFN99238 1138156-77-0 C22H24N2O5 = 396.4 5mg QQ客服:3257982914
    N1,N10-双(对香豆酰)亚精胺; N1,N10-Bis(p-coumaroyl)spermidine CFN99248 114916-05-1 C25H31N3O4 = 437.5 5mg QQ客服:1148253675
    3,4-二羟基肉桂酰胺; 3,4-Dihydroxycinnamamide CFN99316 1202-41-1 C9H9NO3 = 179.2 5mg QQ客服:215959384
    3-[3,4-双(乙酰氧基)苯基]-2-丙烯酰胺; 3,4-Diacetoxycinnamamide CFN99390 129488-34-2 C13H13NO5 = 263.3 5mg QQ客服:2932563308
    阿魏酸酰胺; Ferulamide CFN97041 61012-31-5 C10H11NO3 = 193.2 5mg QQ客服:1413575084
    印枳碱; Aegeline CFN91133 456-12-2 C18H19NO3 = 297.4 20mg QQ客服:215959384
    N-咖啡酰O-甲基酪胺; N-Caffeoyl O-methyltyramine CFN70295 189307-47-9 C18H19NO4 = 313.4 5mg QQ客服:2159513211
    N-反式咖啡酰真蛸胺; N-trans-caffeoyloctopamine CFN95264 1378868-10-0 C17H17NO5 = 315.3 5mg QQ客服:2932563308

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