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  • Volvaltrate B

    Volvaltrate B

    Volvaltrate B
    产品编号 CFN96443
    CAS编号 1181224-13-4
    分子式 = 分子量 C27H41ClO11 = 577.06
    产品纯度 >=98%
    物理属性 Powder
    化合物类型 Iridoids
    植物来源 The herbs of Valeriana jatamansi
    ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用
    提供自定义包装
    产品名称 产品编号 CAS编号 包装 QQ客服
    Volvaltrate B CFN96443 1181224-13-4 1mg QQ客服:1413575084
    Volvaltrate B CFN96443 1181224-13-4 5mg QQ客服:1413575084
    Volvaltrate B CFN96443 1181224-13-4 10mg QQ客服:1413575084
    Volvaltrate B CFN96443 1181224-13-4 20mg QQ客服:1413575084
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    ChemFaces的产品在许多优秀和顶级科学期刊中被引用

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.
    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.
    IF=12.804(2019)

    PMID: 30417089
    我们的产品现已经出口到下面的研究机构与大学,并且还在增涨
  • University of Queensland (Australia)
  • University of Lodz (Poland)
  • University of Minnesota (USA)
  • The University of Newcastle (Australia)
  • National Research Council of Canada (Canada)
  • University Medical Center Mainz (Germany)
  • Kyung Hee University (Korea)
  • University of Maryland School of Medicine (USA)
  • Institute of Tropical Disease Universitas Airlangga (Indonesia)
  • University of Oslo (Norway)
  • Cornell University (USA)
  • Colorado State University (USA)
  • Tokyo Woman's Christian University (Japan)
  • Universidad Industrial de Santander (Colombia)
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  • 国外学术期刊发表的引用ChemFaces产品的部分文献
  • J Vet Sci.2020, 21(3):e39.
  • Korean Journal of Pharmacognosy2018, 49(4):349-361
  • Pharmaceutics.2021, 13(2):187.
  • Front Cell Dev Biol.2021, 9:588093.
  • Rev. Chim.2020, 71(3),558-564
  • J Pharmaceutical Research Int.2021, 33(41A):275-284.
  • Drug Invention Today2019, 12(6):1303-1306
  • Int. Conference on Med. Sci. and Bio.2017, 17973
  • Int J Mol Sci.2020, 21(9):3144.
  • Journal of Ginseng Research2021, 3 June.
  • Phytomedicine Plus2022, 2(1):100207.
  • Front Pharmacol.2021, 12:690113.
  • J Enzyme Inhib Med Chem.2019, 34(1):134-143
  • J Chem Inf Model.2021, 61(11):5708-5718.
  • Mol Cells.2015, 38(9):765-72
  • University of Central Lancashire2017, 20472
  • University of Guelph2021, 12.
  • Nutrients.2018, 10(12):E1998
  • J Pharm Anal.2016, 6(6):363-373
  • Nutrients.2018, 10(10)
  • Chem Biol Interact.2020, 328:109200.
  • LWT-Food Science and Technology2017, 75:488-496
  • Food Funct.2021, 12(4):1469-1481.
  • ...
  • 生物活性
    Description: Volvaltrate B shows cytotoxic activity against the lung adenocarcinoma (A549), metastatic prostate cancer (PC-3M), colon cancer (HCT-8), and hepatoma (Bel7402) cell lines, with IC50 values of 8.5, 2.0, 3.2, and 6.1 uM, respectively.
    In vitro:
    J Nat Prod. 2010 Oct 22;73(10):1723-6.
    Revision of the Structures of 1,5-Dihydroxy-3,8-epoxyvalechlorine, Volvaltrate B, and Valeriotetrate C from Valeriana jatamansi and V. officinalis.[Pubmed: 20853876 ]

    METHODS AND RESULTS:
    The structures of 1,5-dihydroxy-3,8-epoxyvalechlorine (1a) and volvaltrate B (6a), two new chlorinated iridoids isolated from Valeriana jatamansi and V. officinalis, respectively, were originally assigned on the basis of spectroscopic methods. Reinvestigation using X-ray analysis and chemical transformation revealed that the original assignment of H-7 in 1a and OH-8 in 6a should be inverted and that the structures should be revised to 1 and 6, respectively. Correspondingly, the structure of valeriotetrate C (7a) should be revised to 7.
    CONCLUSIONS:
    Volvaltrate B (6) showed cytotoxic activity against the lung adenocarcinoma (A549), metastatic prostate cancer (PC-3M), colon cancer (HCT-8), and hepatoma (Bel7402) cell lines, with IC50 values of 8.5, 2.0, 3.2, and 6.1 μM, respectively.
    制备储备液(仅供参考)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 1.7329 mL 8.6646 mL 17.3292 mL 34.6584 mL 43.3231 mL
    5 mM 0.3466 mL 1.7329 mL 3.4658 mL 6.9317 mL 8.6646 mL
    10 mM 0.1733 mL 0.8665 mL 1.7329 mL 3.4658 mL 4.3323 mL
    50 mM 0.0347 mL 0.1733 mL 0.3466 mL 0.6932 mL 0.8665 mL
    100 mM 0.0173 mL 0.0866 mL 0.1733 mL 0.3466 mL 0.4332 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    部分图片展示
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    Valeriotetrate C; Valeriotetrate C CFN96459 904891-20-9 C37H58O15 = 742.85 5mg QQ客服:3257982914
    Jatamanvaltrate B ; Jatamanvaltrate B CFN96826 1134138-66-1 C32H50O13 = 642.73 5mg QQ客服:1148253675
    氯化缬草素; Valechlorine CFN90622 51771-49-4 C22H31ClO8 = 458.93 5mg QQ客服:1148253675
    Valeriandoid B; Valeriandoid B CFN96460 1380399-57-4 C24H33ClO10 = 516.97 5mg QQ客服:1148253675
    Volvaltrate B; Volvaltrate B CFN96443 1181224-13-4 C27H41ClO11 = 577.06 5mg QQ客服:215959384
    氯戊曲酯 K ; Chlorovaltrate K CFN96824 96801-92-2 C22H33ClO8 = 460.94 5mg QQ客服:2159513211
    栀子醛; Cerbinal CFN97119 65597-42-4 C11H8O4 = 204.2 5mg QQ客服:3257982914
    环戊并[C]吡喃-4,7-二羧酸 4-甲酯; Cerberic acid CFN97120 65597-44-6 C11H8O5 = 220.2 5mg QQ客服:2932563308
    戊曲酯,缬草三酯; Valepotriate CFN90205 18296-44-1 C22H30NO8 = 422.47 20mg QQ客服:2159513211
    地戊曲酯; Didrovaltrate CFN96822 18296-45-2 C22H32O8 = 424.49 5mg QQ客服:3257982914

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