Tsugaric acid A

	产品编号	CFN90990
	CAS编号	174391-64-1
	分子式 = 分子量	C₃₂H₅₀O₄ = 498.8
	产品纯度	>=98%
	物理属性	Powder
	化合物类型	Triterpenoids
	植物来源	The sclerotium of Poria cocos (Schw.) Wolf
ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用

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产品名称	产品编号	CAS编号	包装	QQ客服
Tsugaric acid A	CFN90990	174391-64-1	1mg	QQ客服：1457312923
Tsugaric acid A	CFN90990	174391-64-1	5mg	QQ客服：1457312923
Tsugaric acid A	CFN90990	174391-64-1	10mg	QQ客服：1457312923
Tsugaric acid A	CFN90990	174391-64-1	20mg	QQ客服：1457312923

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ChemFaces的产品在许多优秀和顶级科学期刊中被引用

Cell. 2018 Jan 11;172(1-2):249-261.e12.
doi: 10.1016/j.cell.2017.12.019.
IF=36.216(2019)

PMID: 29328914

Cell Metab. 2020 Mar 3;31(3):534-548.e5.
doi: 10.1016/j.cmet.2020.01.002.
IF=22.415(2019)

PMID: 32004475

Mol Cell. 2017 Nov 16;68(4):673-685.e6.
doi: 10.1016/j.molcel.2017.10.022.
IF=14.548(2019)

PMID: 29149595

ACS Nano. 2018 Apr 24;12(4): 3385-3396.
doi: 10.1021/acsnano.7b08969.
IF=13.903(2019)

PMID: 29553709

Nature Plants. 2016 Dec 22;3: 16206.
doi: 10.1038/nplants.2016.205.
IF=13.297(2019)

PMID: 28005066

Sci Adv. 2018 Oct 24;4(10): eaat6994.
doi: 10.1126/sciadv.aat6994.
IF=12.804(2019)

PMID: 30417089

Nanjing University of Chinese Medicine (China)

Leibniz Institute of Plant Biochemistry (Germany)

National Research Council of Canada (Canada)

Korea Intitute of Science and Technology (KIST) (Korea)

Mahidol University (Thailand)

University of Malaya (Malaysia)

Kazusa DNA Research Institute (Japan)

Universidade da Beira Interior (Germany)

Imperial College London (United Kingdom)

University of Illinois (USA)

Universidad de Buenos Aires (Argentina)

Chang Gung University (Taiwan)

University of Fribourg (Switzerland)

University of Mysore (India)

More...

Description:

Tsugaric acid A can significantly inhibit superoxide anion formation in fMLP/CB-stimulated rat neutrophils, it is also able to protect human keratinocytes against damage induced by ultraviolet B (UV B) light, indicates that tsugaric acid A can protect keratinocytes from photodamage.

Targets:

NO | IFN-γ

In vitro:

Phytochemistry. 2008 Jan;69(1):234-9.

Antiinflammatory triterpenoids and steroids from Ganoderma lucidum and G. tsugae.[Pubmed: 17655889 ]

The antiinflammatory properties of triterpenoids and steroids from both Ganoderma lucidum and Ganoderma tsugae were studied.
METHODS AND RESULTS:
Twelve compounds, including ergosta-7,22-dien-3beta-ol (1), ergosta-7,22-dien-3beta-yl palmitate (2), ergosta-7,22-dien-3-one (3), ergosta-7,22-dien-2beta,3alpha,9alpha-triol (4), 5alpha,8alpha-epidioxyergosta-6,22-dien-3beta-ol (5), ganoderal A (6), ganoderal B (7), ganoderic aldehyde A (8), Tsugaric acid A (9), 3-oxo-5alpha-lanosta-8,24-dien-21-oic acid (10), 3alpha-acetoxy-5alpha-lanosta-8,24-dien-21-oic acid ester beta-d-glucoside (11), and tsugaric acid B (12), were assessed in vitro by determining their inhibitory effects on the chemical mediators released from mast cells, neutrophils, and macrophages.
CONCLUSIONS:
Compound 10 showed a significant inhibitory effect on the release of beta-glucuronidase from rat neutrophils stimulated with formyl-Met-Leu-Phe (fMLP)/cytochalasin B (CB) whereas compound 9 significantly inhibited superoxide anion formation in fMLP/CB-stimulated rat neutrophils. Compound 10 also exhibited a potent inhibitory effect on NO production in lipopolysaccharide (LPS)/interferon-gamma (IFN-gamma)-stimulated N9 microglial cells. Moreover, compound 9 was also able to protect human keratinocytes against damage induced by ultraviolet B (UV B) light, which indicated 9 could protect keratinocytes from photodamage.

产品名称	产品编号	CAS编号	分子式 = 分子量	位单	联系QQ
茯苓酸B; Poricoic acid B	CFN95050	137551-39-4	C₃₀H₄₄O₅ = 484.7	20mg	QQ客服：3257982914
茯苓酸G; Poricoic acid G	CFN95056	415724-84-4	C₃₀H₄₆O₅ = 486.7	5mg	QQ客服：2159513211
大戟二烯醇; Euphol	CFN89516	514-47-6	C₃₀H₅₀O = 426.71	10mg	QQ客服：2056216494
大戟醇; Euphorbol	CFN91600	566-14-3	C₃₁H₅₂O = 440.7	5mg	QQ客服：215959384
羊毛甾醇; Lanosterol	CFN92368	79-63-0	C₃₀H₅₀O = 426.7	20mg	QQ客服：3257982914
丁酰鲸鱼醇; Butyrospermol	CFN92376	472-28-6	C₃₀H₅₀O = 426.7	5mg	QQ客服：215959384
苦楝酮; Kulinone	CFN92977	21688-61-9	C₃₀H₄₈O₂ = 440.70	5mg	QQ客服：1413575084
Aphagranin A ; Aphagranin A	CFN96579	1318173-53-3	C₃₃H₅₄O₆ = 546.79	5mg	QQ客服：3257982914
金钱松呋喃酸; Pseudolarifuroic acid	CFN91924	130825-79-5	C₃₀H₄₂O₄ = 466.65	5mg	QQ客服：2159513211
3-氧代甘遂-7,24-二烯-21-酸; 3-Oxotirucalla-7,24-dien-21-oic acid	CFN97609	82464-35-5	C₃₀H₄₆O₃ = 454.69	5mg	QQ客服：1457312923

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	1 mg	5 mg	10 mg	20 mg	25 mg
1 mM	2.0048 mL	10.0241 mL	20.0481 mL	40.0962 mL	50.1203 mL
5 mM	0.401 mL	2.0048 mL	4.0096 mL	8.0192 mL	10.0241 mL
10 mM	0.2005 mL	1.0024 mL	2.0048 mL	4.0096 mL	5.012 mL
50 mM	0.0401 mL	0.2005 mL	0.401 mL	0.8019 mL	1.0024 mL
100 mM	0.02 mL	0.1002 mL	0.2005 mL	0.401 mL	0.5012 mL