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  • 三粒小麦黄酮

    Tricetin

    三粒小麦黄酮
    产品编号 CFN70392
    CAS编号 520-31-0
    分子式 = 分子量 C15H10O7 = 302.2
    产品纯度 >=98%
    物理属性 Powder
    化合物类型 Flavonoids
    植物来源 The herbs of Avena sativa
    ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用
    提供自定义包装
    产品名称 产品编号 CAS编号 包装 QQ客服
    三粒小麦黄酮 CFN70392 520-31-0 1mg QQ客服:2159513211
    三粒小麦黄酮 CFN70392 520-31-0 5mg QQ客服:2159513211
    三粒小麦黄酮 CFN70392 520-31-0 10mg QQ客服:2159513211
    三粒小麦黄酮 CFN70392 520-31-0 20mg QQ客服:2159513211
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    ChemFaces的产品在许多优秀和顶级科学期刊中被引用

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.
    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.
    IF=12.804(2019)

    PMID: 30417089
    我们的产品现已经出口到下面的研究机构与大学,并且还在增涨
  • Chiang Mai University (Thailand)
  • Macau University of Science and Technology (China)
  • Mahatma Gandhi University (India)
  • Osmania University (India)
  • China Medical University (Taiwan)
  • Julius Kühn-Institut (Germany)
  • Leibniz Institute of Plant Biochemistry (Germany)
  • Tokyo Woman's Christian University (Japan)
  • Center for protein Engineering (CIP) (Belgium)
  • Universite Libre de Bruxelles (Belgium)
  • University of Bordeaux (France)
  • Universidad de Antioquia (Colombia)
  • The University of Newcastle (Australia)
  • University of Otago (New Zealand)
  • More...
  • 国外学术期刊发表的引用ChemFaces产品的部分文献
  • Korean J. Medicinal Crop Sci2021, 10:345-352.
  • Food Chem.2017, 221:1135-1144
  • Pharmacol Res.2020, 161:105205.
  • Inflammation.2020, 43(5):1716-1728.
  • Journal of Life Science2017, 233-240
  • Molecules.2022, 27(2):451.
  • Enzyme Microb Technol.2019, 122:64-73
  • Chemistry of Plant Raw Materials2022, 20220210569.
  • Biosci Rep.2020, 40(8):BSR20201219.
  • J Korean Med Obes Res.2023, 23:10-7
  • Nutrients.2018, 10(7)
  • Food Chem.2023, 404(Pt A):134517.
  • Biochem Pharmacol.2020, 178:114083
  • Int J Mol Sci.2018, 19(2)
  • Nutrients.2020, 12(3):595.
  • Front Pharmacol.2019, 10:1025
  • LWT - Food Science and Technology2022, 164:113627
  • J Chromatogr Sci.2015, 53(5):824-9
  • Industrial Crops and Products2020, 146:112186
  • Vietnam Journal of Science2022, 64(2), 69-75.
  • The Malaysian journal of pathology2019, 41(3):243-251
  • Antioxidants.2022, 11(3):491.
  • J Nat Prod.2023, 86(2):264-275.
  • ...
  • 生物活性
    Description: Tricetin, a dietary flavonoid, inhibits proliferation of human breast adenocarcinoma mcf-7 cells by blocking cell cycle progression and inducing apoptosis. It possesses the anti-metastatic activity of osteosarcoma cells by transcriptionally repressing MMP-9 via p38 and Akt signaling pathways. Tricetin also may be a promising chemopreventive agent against human breast cancer.
    Targets: MMP-9 | p38MAPK | Akt | p53 | Caspase | Chk | CDK | ERK | JNK | Bcl-2/Bax
    In vitro:
    Journal of Agricultural & Food Chemistry, 2009, 57(18):8688-8695.
    Tricetin, a dietary flavonoid, inhibits proliferation of human breast adenocarcinoma mcf-7 cells by blocking cell cycle progression and inducing apoptosis.[Reference: WebLink]
    This study is the first to investigate the anticancer effect of tricetin in human breast adenocarcinoma MCF-7 cells.
    METHODS AND RESULTS:
    Results reveal that tricetin inhibits MCF-7 cells by blocking cell cycle progression in the G2/M phase and inducing apoptosis. Cell cycle blockade is associated with increased activation of ataxia telangiectasia-mutated (ATM). Activation of ATM by tricetin phosphorylated p53 at serine 15, resulting in increased stability of p53 by decreasing p53 and murine double minute-2 (MDM2) interaction. In addition, tricetin-mediated G2/M phase arrest was also associated with decreases in the amounts of cyclin B, cyclin A, cdc2 and cdc25C, and increases in the phosphorylation of Chk2, cdc25C and cdc2. The specific ATM inhibitor caffeine significantly decreased tricetin-mediated G2/M arrest by inhibiting the phosphorylation of p53 (serine 15) and Chk2. Tricetin-induced apoptotic cell death is associated with changes in the expression of Bax and Bak, decreasing levels of Bcl-2 and Bcl-X(L), and subsequently triggering the mitochondrial apoptotic pathway. In addition, pretreatment of cells with caspase-9 inhibitor blocked tricetin-induced apoptosis, indicating that caspase-9 activation is involved in tricetin-mediated MCF-7 cell apoptosis.
    CONCLUSIONS:
    These findings suggest that tricetin may be a promising chemopreventive agent against human breast cancer.
    制备储备液(仅供参考)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 3.3091 mL 16.5453 mL 33.0907 mL 66.1813 mL 82.7267 mL
    5 mM 0.6618 mL 3.3091 mL 6.6181 mL 13.2363 mL 16.5453 mL
    10 mM 0.3309 mL 1.6545 mL 3.3091 mL 6.6181 mL 8.2727 mL
    50 mM 0.0662 mL 0.3309 mL 0.6618 mL 1.3236 mL 1.6545 mL
    100 mM 0.0331 mL 0.1655 mL 0.3309 mL 0.6618 mL 0.8273 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    部分图片展示
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    半枝莲种素; Rivularin CFN92217 70028-59-0 C18H16O7 = 344.3 5mg QQ客服:3257982914
    黄芩黄酮II; Skullcapflavone II CFN92216 55084-08-7 C19H18O8 = 374.4 10mg QQ客服:2159513211
    3',5,5',7-四羟基-4',6-二甲氧基黄酮; 3',5,5',7-Tetrahydroxy-4',6-dimethoxyflavone CFN99369 125537-92-0 C17H14O8 = 346.3 5mg QQ客服:1457312923
    5,7,3'-三羟基-6,4',5'-三甲氧基黄酮; 5,7,3'-Trihydroxy-6,4',5'-trimethoxyflavone CFN90939 78417-26-2 C18H16O8 = 360.3 5mg QQ客服:2159513211
    3'-Hydroxy-5,7,4',5'-Tetramethoxyflavone; 3'-Hydroxy-5,7,4',5'-Tetramethoxyflavone CFN95397 29976-51-0 C19H18O7 = 358.4 5mg QQ客服:2159513211
    三粒小麦黄酮; Tricetin CFN70392 520-31-0 C15H10O7 = 302.2 10mg QQ客服:2159513211
    苜蓿素; Tricin CFN98841 520-32-1 C17H14O7 = 330.3 10mg QQ客服:1457312923
    4',5-二羟基-3',5',6,7-四甲氧基黄酮; 4',5-Dihydroxy-3',5',6,7-tetramethoxyflavone CFN97322 83133-17-9 C19H18O8 = 374.4 5mg QQ客服:1413575084
    5,3'-二羟基-6,7,4',5'-四甲氧基黄酮; 3',5-Dihydroxy-4',5',6,7-tetramethoxyflavone CFN99214 111537-41-8 C19H18O8 = 374.4 5mg QQ客服:2056216494
    5,7-二羟基-3',4',5'-三甲氧基黄酮; 5,7-Dihydroxy-3',4',5'-trimethoxyflavone CFN96493 18103-42-9 C18H16O7 = 344.32 5mg QQ客服:2056216494

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