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  • 柚木柯因

    Tectochrysin

    柚木柯因
    产品编号 CFN98840
    CAS编号 520-28-5
    分子式 = 分子量 C16H12O4 = 268.3
    产品纯度 >=98%
    物理属性 Yellow cryst.
    化合物类型 Flavonoids
    植物来源 The heartwoods of Pinus strobus L.
    ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用
    提供自定义包装
    产品名称 产品编号 CAS编号 包装 QQ客服
    柚木柯因 CFN98840 520-28-5 1mg QQ客服:1413575084
    柚木柯因 CFN98840 520-28-5 5mg QQ客服:1413575084
    柚木柯因 CFN98840 520-28-5 10mg QQ客服:1413575084
    柚木柯因 CFN98840 520-28-5 20mg QQ客服:1413575084
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    ChemFaces的产品在许多优秀和顶级科学期刊中被引用

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.
    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.
    IF=12.804(2019)

    PMID: 30417089
    我们的产品现已经出口到下面的研究机构与大学,并且还在增涨
  • Uniwersytet Medyczny w ?odzi (Poland)
  • Uniwersytet Jagielloński w Krakowie (Poland)
  • Korea Institute of Oriental Medicine (Korea)
  • Center for protein Engineering (CIP) (Belgium)
  • National Research Council of Canada (Canada)
  • FORTH-IMBB (Greece)
  • Institute of Chinese Materia Medica (China)
  • Johannes Gutenberg University Mainz (JGU) (Germany)
  • CSIRO - Agriculture Flagship (Australia)
  • Aarhus University (Denmark)
  • University of Perugia (Italy)
  • University of Dicle (Turkey)
  • Celltrion Chemical Research Institute (Korea)
  • Shanghai Institute of Organic Chemistry (China)
  • More...
  • 国外学术期刊发表的引用ChemFaces产品的部分文献
  • Evid Based Complement Alternat Med.2018, 2018:1073509
  • Drug Chem Toxicol.2020, 1-14.
  • Int J Mol Sci.2017, 19(1)
  • United States Patent Application2020, 20200038363
  • Bulletin of Health Research2016, 44(4):279-286
  • Appl. Sci.2020, 10,1304
  • Appl. Sci.2020, 10(23), 8729
  • Front Pharmacol.2016, 7:460
  • Pharmaceuticals (Basel).2022, 15(8):982.
  • J Agric Food Chem.2020, 68(51):15164-15175
  • Int J Mol Sci.2019, 21(1):E265
  • Sci Rep. 2017, 12953(7)
  • BioResources J.2020, 15(3).
  • Arch Pharm Res.2015, 38(6):1080-9
  • Heliyon.2022, 8(12):e12031.
  • Inflammation.2015, 38(4):1502-16
  • J. Korean Wood Sci. Technol.2022, 50(5):338-352.
  • Molecules.2021, 26(19):6032.
  • Journal of Apiculture2019, 34(2):131-136
  • mBio.2020, 11(3):e00686-20.
  • Phytomedicine.2022, 99:153997.
  • Eur J Pharmacol.2022, 917:174744.
  • Environ Toxicol.2021, doi: 10.1002
  • ...
  • 生物活性
    Description: Tectochrysin is a promising inhibitor for the reversal of ABCG2-mediated drug transport, it leads to apoptotic cell death in NSCLC cells through activation of DR3 and Fas expression via inhibition of STAT3 phosphorylation.Tectochrysin has antioxidant effect, it also exhibits a significant hepatoprotective activity in hepatic damage induced by CCl4-intoxication in rats.
    Targets: STAT | Caspase | Bcl-2/Bax | ATPase
    In vivo:
    Arch Pharm Res. 2003 Jan;26(1):43-6.
    In vivo anti-oxidant activities of tectochrysin.[Pubmed: 12568357]
    The anti-oxidant activities of tectochrysin, a major compound of propolis, were investigated.
    METHODS AND RESULTS:
    Tectochrysin exhibited a significant decrease in serum transaminase activities elevated by hepatic damage induced by CCl4-intoxication in rats. Tectochrysin tested exhibited a lipid peroxidation causing a significant decrease in MDA production in TBA-reactant assay. Tectochrysin was strong in the increase in the anti-oxidant enzymes such as hepatic cytosolic superoxide dismutase, catalase and glutathione peroxidase activities in CCl4-intoxicated rats.
    CONCLUSIONS:
    These results suggest that tectochrysin possess not only the anti-oxidant, but also the activities in CCl4-intoxicated rats. Especially, tectochrysin was found to cause significant increases in the rat liver cytosolic SOD, catalase, GSH-px activities as well as a significant decrease in the MDA production.
    制备储备液(仅供参考)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 3.7272 mL 18.6359 mL 37.2717 mL 74.5434 mL 93.1793 mL
    5 mM 0.7454 mL 3.7272 mL 7.4543 mL 14.9087 mL 18.6359 mL
    10 mM 0.3727 mL 1.8636 mL 3.7272 mL 7.4543 mL 9.3179 mL
    50 mM 0.0745 mL 0.3727 mL 0.7454 mL 1.4909 mL 1.8636 mL
    100 mM 0.0373 mL 0.1864 mL 0.3727 mL 0.7454 mL 0.9318 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    部分图片展示
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    5-羟基-7-乙酰氧基黄酮; 5-Hydroxy-7-acetoxyflavone CFN97139 6674-40-4 C17H12O5 = 296.3 5mg QQ客服:3257982914
    5-乙酰氧基-7-羟基黄酮; 5-Acetoxy-7-hydroxyflavone CFN99409 132351-58-7 C17H12O5 = 296.3 5mg QQ客服:3257982914
    5,7-二乙酰氧基黄酮; 5,7-Diacetoxyflavone CFN97138 6665-78-7 C19H14O6 = 338.3 5mg QQ客服:215959384
    柚木柯因; Tectochrysin CFN98840 520-28-5 C16H12O4 = 268.3 5mg QQ客服:2159513211
    柯因二甲醚; Chrysin dimethylether CFN90896 21392-57-4 C17H14O4 = 282.3 20mg QQ客服:1413575084
    去甲汉黄芩素; Norwogonin CFN92218 4443-09-8 C15H10O5 = 270.2 20mg QQ客服:2056216494
    汉黄芩素; Wogonin CFN97089 632-85-9 C16H12O5 = 284.3 20mg QQ客服:2159513211
    5-羟基-7-乙酰氧基-8-甲氧基黄酮; 5-Hydroxy-7-acetoxy-8-methoxyflavone CFN97535 95480-80-1 C18H14O6 = 326.3 5mg QQ客服:215959384
    5,7-二羟基-8-甲氧基黄酮二乙酸酯; 5,7-Diacetoxy-8-methoxyflavone CFN98240 23246-80-2 C20H16O7 = 368.3 5mg QQ客服:2056216494
    苏荠宁黄酮; 5-羟基-7,8-二甲氧基黄酮; Moslosooflavone CFN98475 3570-62-5 C17H14O5 = 298.3 20mg QQ客服:215959384

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