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  • 五味子酯甲

    Schisantherin A

    五味子酯甲
    产品编号 CFN99925
    CAS编号 58546-56-8
    分子式 = 分子量 C30H32O9 = 536.56
    产品纯度 >=98%
    物理属性 Cryst.
    化合物类型 Lignans
    植物来源 The seeds of Schisandra chinensis (Turcz.) Baill.
    ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用
    提供自定义包装
    产品名称 产品编号 CAS编号 包装 QQ客服
    五味子酯甲 CFN99925 58546-56-8 10mg QQ客服:2159513211
    五味子酯甲 CFN99925 58546-56-8 20mg QQ客服:2159513211
    五味子酯甲 CFN99925 58546-56-8 50mg QQ客服:2159513211
    五味子酯甲 CFN99925 58546-56-8 100mg QQ客服:2159513211
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    ChemFaces的产品在许多优秀和顶级科学期刊中被引用

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.
    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.
    IF=12.804(2019)

    PMID: 30417089
    我们的产品现已经出口到下面的研究机构与大学,并且还在增涨
  • Universidade de Franca (Brazil)
  • University of Maryland School of Medicine (USA)
  • Kyushu University (Japan)
  • Uniwersytet Medyczny w ?odzi (Poland)
  • Seoul National University (Korea)
  • University of Wisconsin-Madison (USA)
  • Georgia Institute of Technology (USA)
  • Chang Gung University (Taiwan)
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  • University of Maryland (USA)
  • University of Brasilia (Brazil)
  • Gyeongsang National University (Korea)
  • University of Medicine and Pharmacy (Romania)
  • University of Liège (Belgium)
  • More...
  • 国外学术期刊发表的引用ChemFaces产品的部分文献
  • J Immunol.2023, ji2200727.
  • J of Essential Oil Research2019, 1677272
  • Phytomedicine.2018, 41:62-66
  • Antioxidants (Basel).2021, 10(11):1831.
  • J Agric Food Chem.2021, 69(46):14037-14047.
  • Plants (Basel).2021, 10(11):2317.
  • Evid Based Complement Alternat Med.2017, 2017:6360836
  • Preprints2021, doi:10.20944
  • PLoS One.2021, 16(9):e0257243.
  • J Control Release.2021, 336:159-168.
  • Int J Mol Sci.2019, 20(14):E3538
  • Nutrients.2020, 12(12):3607.
  • Biotechnol Bioeng.2020, 117(7):2198-2208.
  • Functional Ecology2020, doi: 10.1111.
  • FASEB J.2019, 33(2):2026-2036
  • Molecules.2022, 27(7):2360.
  • United States Patent Application2020, 20200038363
  • Int J Mol Sci.2022, 23(21):13112.
  • Biomol Ther (Seoul).2023, 31(1):40-47.
  • Daru.2022, 30(2):273-288.
  • Front Pharmacol.2023, 14:1095083.
  • Nutrients.2019, 11(4):E936
  • Univerzita Karlova2022, 228192.
  • ...
  • 生物活性
    Description: Schisantherin A exhibits anti-tussive, sedative, anti-inflammatory, antioxidant, anti-osteoporotic, neuroprotective, cognition enhancing, and cardioprotective activities. Schisantherin A can significantly attenuate Aβ1-42-induced learning and memory impairment and noticeably improve the histopathological changes in the hippocampus. Schisantherin A exhibits neuroprotection against 1-methyl-4-phenylpyridinium ion (MPP(+)) through the regulation of two distinct pathways including increasing CREB-mediated Bcl-2 expression and activating PI3K/Akt survival signaling.
    Targets: ROS | NO | NOS | MAPK | PI3K | GSK-3 | IL Receptor | PGE | TNF-α | COX | ERK | p38MAPK | JNK | NF-kB | Beta Amyloid | Akt
    In vivo:
    PLoS One. 2013 Apr 19;8(4):e61590.
    Protective role of deoxyschizandrin and schisantherin A against myocardial ischemia-reperfusion injury in rats.[Pubmed: 23620773]

    METHODS AND RESULTS:
    Anesthetized male rats were treated once with deoxyschizandrin(DSD) and Schisantherin A(STA) (each 40 μmol/kg) through the tail vein after 45 min of ischemia, followed by 2-h reperfusion. Cardiac function, infarct size, biochemical markers, histopathology and apoptosis were measured and mRNA expression of gp91 (phox) in myocardial tissue assessed by RT-PCR. Neonatal rat cardiomyocytes were pretreated with DSD and STA and then damaged by H2O2. Cell apoptosis was tested by a flow cytometric assay. Compared with the I/R group: (i) DSD and STA could significantly reduce the abnormalities of LVSP, LVEDP, ±dp/dtmax and arrhythmias, thereby showing their protective roles in cardiac function; (ii) DSD and STA could significantly attenuate the infarct size and MDA release while increasing SOD activity, suggesting a role in reducing myocardial injury; (iii) tissue morphology and myocardial textual analysis revealed that DSD and STA mitigated changes in myocardial histopathology; (iv) DSD and STA decreased apoptosis (33.56±2.58% to 10.28±2.80% and 10.98±1.99%, respectively) and caspase-3 activity in the myocardium (0.62±0.02 OD/mg to 0.38±0.02 OD/mg and 0.32±0.02 OD/mg, respectively), showing their protective effects upon cardiomyocytes; and (v) DSD and STA had similar protective effects on I/R injury as those seen with the positive control metoprolol. In vitro, DSD and STA could significantly decrease the apoptosis of neonatal cardiomyocytes.
    CONCLUSIONS:
    These data suggest that DSD and STA can protect against myocardial I/R injury. The underlining mechanism may be related to their role in inhibiting cardiomyocyte apoptosis.
    Biochem Biophys Res Commun. 2014 Jul 4;449(3):344-50.
    Schisantherin A suppresses osteoclast formation and wear particle-induced osteolysis via modulating RANKL signaling pathways.[Pubmed: 2484538]
    Receptor activator of NF-κB ligand (RANKL) plays critical role in osteoclastogenesis. Targeting RANKL signaling pathways has been a promising strategy for treating osteoclast related bone diseases such as osteoporosis and aseptic prosthetic loosening. Schisantherin A (SA), a dibenzocyclooctadiene lignan isolated from the fruit of Schisandra sphenanthera, has been used as an antitussive, tonic, and sedative agent, but its effect on osteoclasts has been hitherto unknown.
    METHODS AND RESULTS:
    In the present study, SA was found to inhibit RANKL-induced osteoclast formation and bone resorption. The osteoclastic specific marker genes induced by RANKL including c-Src, SA inhibited OSCAR, cathepsin K and TRAP in a dose dependent manner. Further signal transduction studies revealed that SA down-regulate RANKL-induced nuclear factor-kappaB (NF-κB) signaling activation by suppressing the phosphorylation and degradation of IκBα, and subsequently preventing the NF-κB transcriptional activity. Moreover, SA also decreased the RANKL-induced MAPKs signaling pathway, including JNK and ERK1/2 posphorylation while had no obvious effects on p38 activation. Finally, SA suppressed the NF-κB and MAPKs subsequent gene expression of NFATc1 and c-Fos. In vivo studies, SA inhibited osteoclast function and exhibited bone protection effect in wear-particle-induced bone erosion model. Taken together, SA could attenuate osteoclast formation and wear particle-induced osteolysis by mediating RANKL signaling pathways.
    CONCLUSIONS:
    These data indicated that SA is a promising therapeutic natural compound for the treatment of osteoclast-related prosthesis loosening.
    制备储备液(仅供参考)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 1.8637 mL 9.3186 mL 18.6372 mL 37.2745 mL 46.5931 mL
    5 mM 0.3727 mL 1.8637 mL 3.7274 mL 7.4549 mL 9.3186 mL
    10 mM 0.1864 mL 0.9319 mL 1.8637 mL 3.7274 mL 4.6593 mL
    50 mM 0.0373 mL 0.1864 mL 0.3727 mL 0.7455 mL 0.9319 mL
    100 mM 0.0186 mL 0.0932 mL 0.1864 mL 0.3727 mL 0.4659 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    部分图片展示
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    戈米辛F; Gomisin F CFN92719 62956-47-2 C28H34O9 = 514.6 5mg QQ客服:215959384
    戈米辛G; Gomisin G CFN90123 62956-48-3 C30H32O9 = 536.6 10mg QQ客服:1457312923
    戈米辛H; Gomisin H CFN94008 66056-20-0 C23H30O7 = 418.5 10mg QQ客服:1413575084
    巴豆酰戈米辛 H; Tigloylgomisin H CFN96618 66069-55-4 C28H36O8 = 500.59 5mg QQ客服:1413575084
    苯甲酰戈米辛 H; Benzoylgomisin H CFN96939 66056-23-3 C30H34O8 = 522.59 5mg QQ客服:3257982914
    Schisphenin E ; Schisphenin E CFN95223 1311376-52-9 C24H32O7 = 432.5 5mg QQ客服:1457312923
    五味子酯戊; Schisantherin E CFN90878 64917-83-5 C30H34O9 = 538.6 10mg QQ客服:2056216494
    当归酰基戈米辛 Q ; Angeloylgomisin Q CFN96727 72561-28-5 C29H38O9 = 530.61 5mg QQ客服:2056216494
    当归酰基戈米辛H; Angeloylgomisin H CFN90710 66056-22-2 C28H36O8 = 500.58 10mg QQ客服:2159513211
    鹤庆五味子辛素; Schisanwilsonin H CFN92350 1181216-83-0 C30H32O9 = 536.6 5mg QQ客服:2159513211

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