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  • 罗通定

    Rotundine

    罗通定
    产品编号 CFN99195
    CAS编号 10097-84-4
    分子式 = 分子量 C21H25NO4 = 355.42
    产品纯度 >=98%
    物理属性 White powder
    化合物类型 Alkaloids
    植物来源 The root of Stephania tetrandra S. Moore
    ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用
    提供自定义包装
    产品名称 产品编号 CAS编号 包装 QQ客服
    罗通定 CFN99195 10097-84-4 10mg QQ客服:3257982914
    罗通定 CFN99195 10097-84-4 20mg QQ客服:3257982914
    罗通定 CFN99195 10097-84-4 50mg QQ客服:3257982914
    罗通定 CFN99195 10097-84-4 100mg QQ客服:3257982914
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    ChemFaces的产品在许多优秀和顶级科学期刊中被引用

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.
    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.
    IF=12.804(2019)

    PMID: 30417089
    我们的产品现已经出口到下面的研究机构与大学,并且还在增涨
  • University of Leipzig (Germany)
  • Aveiro University (Portugal)
  • Universit?t Basel (Switzerland)
  • University of Cincinnati (USA)
  • Rio de Janeiro State University (Brazil)
  • National Chung Hsing University (Taiwan)
  • University of Maryland School of Medicine (USA)
  • Calcutta University (India)
  • Molecular Biology Institute of Barcelona (IBMB)-CSIC (Spain)
  • Cancer Research Initatives Foundation(CARIF) (Malaysia)
  • National Hellenic Research Foundation (Greece)
  • Seoul National University (Korea)
  • Deutsches Krebsforschungszentrum (Germany)
  • Ateneo de Manila University (Philippines)
  • More...
  • 国外学术期刊发表的引用ChemFaces产品的部分文献
  • Curr Issues Mol Biol.2023, 45(3):2136-2156.
  • Pharmacogn J.2022, 14(2):350-357
  • Korean Journal of Pharmacognosy2019, 50(4):285-290
  • BMC Plant Biol.2021, 21(1):60.
  • Applied Physics B2021, 127(92).
  • J AOAC Int.2023, 106(1):56-64.
  • Antioxidants (Basel).2021, 10(11): 1802.
  • Biomol Ther (Seoul).2023, 31(1):40-47.
  • J Ethnopharmacol.2020, 260:112988.
  • The Malaysian journal of pathology2019, 41(3):243-251
  • Elife.2021, 10:e68058.
  • J Pharm Biomed Anal.2017, 140:274-280
  • J Cancer.2019, 10(23):5843-5851
  • J of L. Chroma.&Related Tech2017, 252-258
  • J Pharmaceut Biomed2020, 182:113110
  • Sci Rep. 2017, 12953(7)
  • Processes2021, 9(5),831.
  • Plant J.2017, 90(3):535-546
  • Evid Based Complement Alternat Med.2017, 2017:1583185
  • Cancer Manag Res.2019, 11:483-500
  • Food Chem.2022, 373(Pt B):131364.
  • Int J Mol Sci.2020, 21(22):8816.
  • Antioxidants (Basel).2019, 8(8):E307
  • ...
  • 生物活性
    Description: Rotundine provides remarkable protection against cerebral ischemia reperfusion damage, its mechanisms may be through its influence on NO、ET 1 and energy metabolism. Rotundine injection can ameliorate the damages by modulating the activities of different types of NOS. It combined with methadone treatment may be a better therapeutic method in treatment of heroin dependence.
    Targets: NOS | NO
    In vivo:
    Chinese Journal of Drug Abuse Prevention & Treatment, 2006, 12(5):270-1.
    Therapeutic Effects of Rotundine Combined with Methadone in Treatment of Heroin Dependence[Reference: WebLink]
    To explore the therapeutic effects of rotundine combined with methadone in treatment of heroin dependence.
    METHODS AND RESULTS:
    Methods: Sixty heroin addicts were randomly divided into two groups. Group A were treated with rotundine plus methadone and group B were treated with methadone alone. Results: The effective rate of group A was significantly higher than that of group B (96.67% and 73.33%, respectively, P 0.05). The total dose of methadone and the days of treatment in group A (275±21.2 mg and 8±2.3 d, respectively) was significantly lower than that of group B (415±31.2 mg and 12±2.5 d, respectively, P 0.01 and P 0.05, respectively).
    CONCLUSIONS:
    Conclusion: Rotundine combined with methadone treatment may be a better therapeutic method in treatment of heroin dependence.
    Journal of Emergenoy Medicine, 2000, 9(6):379-81.
    Influence of rotundine on NO、ET-1 and energy metabolism after acute brain injury resulted from complete cerebral ischemia reperfusion in the rats[Reference: WebLink]

    METHODS AND RESULTS:
    To find the influence of Rotundine(L THP) on NO、ET 1、ATP and Lactate in rat brain tissues after the global ischemia reperfusion and to investigate protective effects of L THP.Methods:The four vessel occlusion model was made as described by Pulsinelli Brierlog in Sprange Daweley rats.The influences of L THP on NO、ET 1 and energy metabolism during the reperfusion period was observed.Results:L THP can suppress the marked increase of NO、ET 1 and lactate in the early stage of reperfusion,and also improve the contents of ATP.
    CONCLUSIONS:
    L THP provides remarkable protection against cerebral ischemia reperfusion damage.Its mechanisms may be through its influence on NO、ET 1 and energy metabolism.
    制备储备液(仅供参考)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 2.8136 mL 14.0679 mL 28.1357 mL 56.2715 mL 70.3393 mL
    5 mM 0.5627 mL 2.8136 mL 5.6271 mL 11.2543 mL 14.0679 mL
    10 mM 0.2814 mL 1.4068 mL 2.8136 mL 5.6271 mL 7.0339 mL
    50 mM 0.0563 mL 0.2814 mL 0.5627 mL 1.1254 mL 1.4068 mL
    100 mM 0.0281 mL 0.1407 mL 0.2814 mL 0.5627 mL 0.7034 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    部分图片展示
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    罗通定; Rotundine CFN99195 10097-84-4 C21H25NO4 = 355.42 20mg QQ客服:1457312923
    四氢帕马丁; Tetrahydropalmatine CFN99553 2934-97-6 C21H25NO4 = 355.42 20mg QQ客服:2056216494
    延胡索乙素 N氧化物; Corynoxidine CFN96484 57906-85-1 C21H25NO5 = 371.4 10mg QQ客服:3257982914
    Epicorynoxidine; Epicorynoxidine CFN89271 58000-48-9 C21H25NO5 = 371.43 5mg QQ客服:1413575084
    N-甲基紫堇达明碱; N-Methylcorydalmine CFN95204 81010-29-9 C21H25NO4 = 355.4 5mg QQ客服:215959384
    右旋四氢巴马汀; D-Tetrahydropalmatine CFN90188 3520-14-7 C21H25NO4 = 355.41 20mg QQ客服:215959384
    四氢黄连碱,人血草碱; Tetrahydrocoptisine CFN90416 7461-02-1 C19H17NO4 = 323.12 20mg QQ客服:1457312923
    盐酸人血草碱; Stylopine hydrochloride CFN96656 96087-21-7 C19H18ClNO4 = 359.81 5mg QQ客服:2056216494
    左旋千金藤啶碱; L-Stepholidine CFN90457 16562-13-3 C19H21NO4 = 327.37 20mg QQ客服:3257982914
    (S)-金黄紫堇碱; Scoulerine CFN96330 6451-73-6 C19H21NO4 = 327.4 5mg QQ客服:2159513211

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