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  • 安石榴甙; 安石榴苷

    Punicalagin

    安石榴甙; 安石榴苷
    产品编号 CFN99938
    CAS编号 65995-63-3
    分子式 = 分子量 C48H28O30 = 1084.72
    产品纯度 >=98%
    物理属性 Powder
    化合物类型 Phenols
    植物来源 The peel of Punica granatum L.
    ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用
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    产品名称 产品编号 CAS编号 包装 QQ客服
    安石榴甙; 安石榴苷 CFN99938 65995-63-3 10mg QQ客服:2056216494
    安石榴甙; 安石榴苷 CFN99938 65995-63-3 20mg QQ客服:2056216494
    安石榴甙; 安石榴苷 CFN99938 65995-63-3 50mg QQ客服:2056216494
    安石榴甙; 安石榴苷 CFN99938 65995-63-3 100mg QQ客服:2056216494
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    ChemFaces的产品在许多优秀和顶级科学期刊中被引用

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.
    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.
    IF=12.804(2019)

    PMID: 30417089
    我们的产品现已经出口到下面的研究机构与大学,并且还在增涨
  • Mahidol University (Thailand)
  • Pennsylvania State University (USA)
  • Semmelweis Unicersity (Hungary)
  • University of Vienna (Austria)
  • Subang Jaya Medical Centre (Malaysia)
  • Sapienza University of Rome (Italy)
  • Hamdard University (India)
  • Sanford Burnham Medical Research Institute (USA)
  • Warszawski Uniwersytet Medyczny (Poland)
  • Universita' Degli Studi Di Cagliari (Italy)
  • National Hellenic Research Foundation (Greece)
  • Ateneo de Manila University (Philippines)
  • University of Wollongong (Australia)
  • Johannes Gutenberg University Mainz (JGU) (Germany)
  • More...
  • 国外学术期刊发表的引用ChemFaces产品的部分文献
  • Molecules.2019, 24(12):E2286
  • Heliyon2022, 8(2):e08866.
  • Food Res Int.2020, 133:109130.
  • PLoS One.2021, 16(6):e0248479.
  • Molecules.2023, 28(9):3685.
  • Molecules.2021, 26(4):1084.
  • Industrial Crops and Products2018, 353-362
  • J Chromatogr B Analyt Technol Biomed Life Sci.2018, 1080:27-36
  • Biomed Pharmacother.2020, 131:110673.
  • Chinese Journal of Hospital Pharmacy2020, 40(7)
  • Molecules.2019, 25(1):E103
  • Int J Cosmet Sci.2022, doi:10.1111/ics.12827.
  • ACS Synth Biol.2022, 11(10):3296-3304.
  • Biomolecules.2021, 11(10):1537.
  • BMC Plant Biol.2021, 21(1):60.
  • Life Sci.2021, 286:120019.
  • Huazhong Agricultural University2022, pp34.
  • Journal of Functional Foods2022, 98:105271.
  • Kor. J. Herbol.2022, 37(5): 89-96.
  • Int J Mol Sci.2022, 23(20):12516.
  • Nutrients.2021, 13(3):978.
  • Molecules.2021, 26(6):1738.
  • Int J Mol Sci.2018, 19(9):E2601
  • ...
  • 生物活性
    Description: Punicalagin has antifungal , antiviral, anti-atherosclerotic, hepatoprotective , anti-obesity., antiproliferative, anti-apoptotic, anti-inflammatory, and antioxidant effects. It can suppress the phosphorylation of MAPK including p38, c-JNK, and ERK, it also has potently inhibiting the activity of fatty acid synthase with half-inhibitory concentration values (IC 50 ) of 4.50μM.
    Targets: TNF-α | IL Receptor | Bcl-2/Bax | Caspase | gp120/CD4 | PGE | p38MAPK | p65 | JNK | ERK | NF-kB | IkB | IKK | FAS
    In vitro:
    Ann Clin Microbiol Antimicrob. 2014 Sep 5;13(1):32.
    Antifungal activity of pomegranate peel extract and isolated compound punicalagin against dermatophytes.[Pubmed: 25260038]
    Dermatophyte species infect the epidermis and appendages, often with serious social and health-economic consequences. The hydroalcoholic extract of pomegranate fruit peel showed activity against the dermatophyte fungi Trichophyton mentagrophytes, T. rubrum, Microsporum canis and M. gypseum.
    METHODS AND RESULTS:
    Hydroalcoholic extract was prepared with pomegranate peels. This crude extract was fractionated and submitted to liquid-liquid partition, resulting in an active fraction which was fractionated in a Sephadex LH-20 column, followed by a Lobar column. The structure of the active compound was established with the use of spectroscopic methods. The crude extract of pomegranate fruit peel showed activity against the dermatophytes Trichophyton mentagrophytes, T. rubrum, Microsporum canis, and M. gypseum, with MICs values of 125 μg/ml and 250 μg/ml, respectively for each genus. Punicalagin was isolated and identified by spectroscopic analysis. The crude extract and punicalagin showed activity against the conidial and hyphal stages of the fungi. The cytotoxicity assay showed selectivity for fungal cells than for mammalian cells.
    CONCLUSIONS:
    These results indicated that the crude extract and punicalagin had a greater antifungal activity against T. rubrum, indicating that the pomegranate is a good target for study to obtain a new antidermatophyte medicine.
    Appl Environ Microbiol. 2014 Oct;80(19):6204-11.
    Punicalagin inhibits Salmonella virulence factors and has anti-quorum-sensing potential.[Pubmed: 25085489]
    Punicalagin, an essential component of pomegranate rind, has been demonstrated to possess antimicrobial activity against several food-borne pathogens, but its activity on the virulence of pathogens and its anti-quorum-sensing (anti-QS) potential have been rarely reported. This study investigated the efficacy of subinhibitory concentrations of Punicalagin on Salmonella virulence factors and QS systems.
    METHODS AND RESULTS:
    A broth microdilution method was used to determine the MICs of Punicalagin for 10 Salmonella strains. Motility assay and quantitative reverse transcription (RT)-PCR were performed to evaluate the effects of Punicalagin on the virulence attributes and QS-related genes of Salmonella. The MICs of Punicalagin for several Salmonella strains ranged from 250 to 1,000 μg/ml. Motility assays showed that Punicalagin, at 1/16× MIC and 1/32× MIC, significantly decreased bacterial swimming and swarming motility, which corresponded to downregulation of the motility-related genes (fliA, fliY, fljB, flhC, and fimD) in RT-PCR assays. RT-PCR also revealed that Punicalagin downregulated the expression of most of the selected genes involved in Salmonella virulence. Moreover, a QS inhibition assay indicated that Punicalagin dose dependently inhibited the production of violacein by Chromobacterium violaceum and repressed the expression of QS-related genes (sdiA and srgE) in Salmonella. In addition, Punicalagin significantly reduced Salmonella invasion of colonic cells (P<0.01) with no impact on adhesion.
    CONCLUSIONS:
    These findings suggest that Punicalagin has the potential to be developed as an alternative or supplemental agent for prevention of Salmonella infection.
    Antiviral Res . 2021 Jun;190:105075.
    Discovery of chebulagic acid and punicalagin as novel allosteric inhibitors of SARS-CoV-2 3CL pro[Pubmed: 33872675]
    Abstract The emerging SARS-CoV-2 infection is the cause of the global COVID-19 pandemic. To date, there are limited therapeutic options available to fight this disease. Here we examined the inhibitory abilities of two broad-spectrum antiviral natural products chebulagic acid (CHLA) and punicalagin (PUG) against SARS-CoV-2 viral replication. Both CHLA and PUG reduced virus-induced plaque formation in Vero-E6 monolayer at noncytotoxic concentrations, by targeting the enzymatic activity of viral 3-chymotrypsin-like cysteine protease (3CLpro) as allosteric regulators. Our study demonstrates the potential use of CHLA and PUG as novel COVID-19 therapies. Keywords: 3CLpro; Allosteric inhibitor; Chebulagic acid; Punicalagin; SARS-CoV-2.
    In vivo:
    Phytother Res. 2001 May;15(3):206-12.
    Antioxidant and hepatoprotective effects of punicalagin and punicalin on acetaminophen-induced liver damage in rats.[Pubmed: 11351354]
    Punicalagin and punicalin were isolated from the leaves of Terminalia catappa L., a Combretaceous plant distributed throughout tropical and subtropical beaches, which is used for the treatment of dermatitis and hepatitis. Our previous studies showed that both of these compounds exert antioxidative activity.
    METHODS AND RESULTS:
    In this study, the antihepatotoxic activity of Punicalagin and punicalin on acetaminophen-induced toxicity in the rat liver was evaluated. After evaluating the changes of several biochemical functions in serum, the levels of aspartate aminotransferase (AST) and alanine aminotransferase (ALT) were increased by acetaminophen administration and reduced by Punicalagin and punicalin. Histological changes around the hepatic central vein and oxidative damage induced by acetaminophen were also recovered by both compounds. The data show that both Punicalagin and punicalin exert antihepatotoxic activity, but treatment with larger doses enhanced liver damage.
    CONCLUSIONS:
    These results suggest that even if Punicalagin and punicalin have antioxidant activity at small doses, treatment with larger doses will possibly induce some cell toxicities.
    Biochem Biophys Res Commun. 2008 Jul 11;371(4):799-803.
    Immune-suppressive activity of punicalagin via inhibition of NFAT activation.[Pubmed: 18466764]
    Since T cell activation is central to the development of autoimmune diseases, we screened a natural product library comprising 1400 samples of medicinal herbal extracts, to identify compounds that suppress T cell activity.
    METHODS AND RESULTS:
    Punicalagin (PCG) isolated from the fruit of Punica granatum was identified as a potent immune suppressant, based on its inhibitory action on the activation of the nuclear factor of activated T cells (NFAT). PCG downregulated the mRNA and soluble protein expression of interleukin-2 from anti-CD3/anti-CD28-stimulated murine splenic CD4+ T cells and suppressed mixed leukocytes reaction (MLR) without exhibiting cytotoxicity to the cells. In vivo, the PCG treatment inhibited phorbol 12-myristate 13-acetate (PMA)-induced chronic ear edema in mice and decreased CD3+ T cell infiltration of the inflamed tissue.
    CONCLUSIONS:
    These results suggest that PCG could be a potential candidate for the therapeutics of various immune pathologies.
    Phytomedicine. 2012 Dec 15;20(1):67-70.
    Antiviral activity of punicalagin toward human enterovirus 71 in vitro and in vivo.[Pubmed: 23146421 ]
    Human enterovirus 71 is one of the major causative agents of hand, foot and mouth disease in children and has caused mortalities in large-scale outbreaks in the Asia-Pacific region in recent years. No vaccine or antiviral therapy is available currently in the clinic.
    METHODS AND RESULTS:
    In this work, we investigated the antiviral effect of punicalagin on enterovirus 71 both in vitro and in vivo. The results showed that punicalagin reduced the viral cytopathic effect on rhabdomyosarcoma cells with an IC₅₀) value of 15 μg/ml. Moreover, punicalagin treatment of mice challenged with a lethal dose of enterovirus 71 resulted in a reduction of mortality and relieved clinical symptoms by inhibiting viral replication.
    CONCLUSIONS:
    Our work suggested that punicalagin have the potential for further development as antiviral agents against enterovirus 71.
    制备储备液(仅供参考)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 0.9219 mL 4.6095 mL 9.219 mL 18.4379 mL 23.0474 mL
    5 mM 0.1844 mL 0.9219 mL 1.8438 mL 3.6876 mL 4.6095 mL
    10 mM 0.0922 mL 0.4609 mL 0.9219 mL 1.8438 mL 2.3047 mL
    50 mM 0.0184 mL 0.0922 mL 0.1844 mL 0.3688 mL 0.4609 mL
    100 mM 0.0092 mL 0.0461 mL 0.0922 mL 0.1844 mL 0.2305 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    部分图片展示
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    安石榴甙; 安石榴苷; Punicalagin CFN99938 65995-63-3 C48H28O30 = 1084.72 20mg QQ客服:2056216494
    诃子鞣质; Terchebulin CFN92297 132854-40-1 C48H28O30 = 1084.7 5mg QQ客服:1413575084
    鞣花酸-4-O-beta-D-吡喃木糖苷; Ellagic acid-4-O-beta-D-xylopyranoside CFN95618 139163-18-1 C19H14O12 = 434.3 5mg QQ客服:2056216494
    Eschweilenol C; Eschweilenol C CFN95363 211371-02-7 C20H16O12 = 448.3 10mg QQ客服:215959384
    3-甲基鞣花酸; 3-Methyl ellagic acid CFN70390 51768-38-8 C15H8O8 = 316.2 5mg QQ客服:3257982914
    鞣花酸-4-O-alpha-L-呋喃阿拉伯糖苷; Ellagic acid 4-O-alpha-L-arabinofuranoside CFN95613 358617-39-7 C19H14O12 = 434.3 5mg QQ客服:215959384
    蛇莓苷A; Ducheside A CFN99833 176665-78-4 C20H16O12 = 448.3 5mg QQ客服:1457312923
    3-O-甲基鞣花酸-4'-O-鼠李糖苷; 3-O-methylellagic acid 4'-O-alpha-L-rhamnopyranoside CFN95228 51768-39-9 C21H18O12 = 462.4 5mg QQ客服:2056216494
    3-O-甲基鞣花酸-3'-O-鼠李糖苷; 3-O-Methylellagic acid 3'-O-alpha-rhamnopyranoside CFN95375 352280-34-3 C21H18O12 = 462.4 5mg QQ客服:2159513211
    4,4'-O-二甲基鞣花酸; 4,4'-Di-O-methylellagic acid CFN92805 3374-77-4 C16H10O8 = 330.0 5mg QQ客服:3257982914

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