Info: Read More
  • 中药标准品生产商,产品定制服务
  • 补骨脂素

    Psoralen

    补骨脂素
    产品编号 CFN97142
    CAS编号 66-97-7
    分子式 = 分子量 C11H6O3 = 186.2
    产品纯度 >=98%
    物理属性 Powder
    化合物类型 Coumarins
    植物来源 The seeds of Psoralea corylifolia L.
    ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用
    提供自定义包装
    产品名称 产品编号 CAS编号 包装 QQ客服
    补骨脂素 CFN97142 66-97-7 10mg QQ客服:215959384
    补骨脂素 CFN97142 66-97-7 20mg QQ客服:215959384
    补骨脂素 CFN97142 66-97-7 50mg QQ客服:215959384
    补骨脂素 CFN97142 66-97-7 100mg QQ客服:215959384
    存储与注意事项
    1. 在您收到产品后请检查产品。如无问题,请将产品存入冰霜并且样品瓶保持密封,产品可以存放长达24个月(2-8摄氏度)。

    2. 只要有可能,产品溶解后,您应该在同一天应用于您的实验。 但是,如果您需要提前做预实验,或者需要全部溶解,我们建议您将溶液以等分试样的形式存放在-20℃的密封小瓶中。 通常,这些可用于长达两周。 使用前,打开样品瓶前,我们建议您将产品平衡至室温至少1小时。

    3. 需要更多关于溶解度,使用和处理的建议? 请发送电子邮件至:service@chemfaces.com
    订购流程
  • 1. 在线订购
  • 请联系我们QQ客服

  • 2. 电话订购
  • 请拨打电话:
    027-84237683 或 027-84237783

  • 3. 邮件或传真订购
  • 发送电子邮件到: manager@chemfaces.com 或
    发送传真到:027-84254680

  • 提供订购信息
  • 为了方便客户的订购,请需要订购ChemFaces产品的客户,在下单的时候请提供下列信息,以供我们快速为您建立发货信息。
  •  
  • 1. 产品编号(CAS No.或产品名称)
  • 2. 发货地址
  • 3. 联系方法 (联系人,电话)
  • 4. 开票抬头 (如果需要发票的客户)
  • 5. 发票地址(发货地址与发票地址不同)
  • 发货时间
    1. 付款方式为100%预付款客户,我们将在确认收到货款后当天或1-3个工作日发货。

    2. 付款方式为月结的客户,我们承诺在收到订单后当天或1-3个工作日内发货。

    3. 如果客户所需要的产品,需要重新生产,我们有权告知客户,交货时间需要延期。
    ChemFaces的产品在许多优秀和顶级科学期刊中被引用

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.
    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.
    IF=12.804(2019)

    PMID: 30417089
    我们的产品现已经出口到下面的研究机构与大学,并且还在增涨
  • Seoul National University of Science and Technology (Korea)
  • National Chung Hsing University (Taiwan)
  • Sanford Burnham Prebys Medical Discovery Institute (USA)
  • University of Bordeaux (France)
  • Wageningen University (Netherlands)
  • University of Illinois (USA)
  • Korea Institute of Oriental Medicine (Korea)
  • Uniwersytet Medyczny w ?odzi (Poland)
  • S.N.D.T. Women's University (India)
  • Helmholtz Zentrum München (Germany)
  • Complutense University of Madrid (Spain)
  • The University of Newcastle (Australia)
  • Periyar University (India)
  • Shanghai Institute of Biochemistry and Cell Biology (China)
  • More...
  • 国外学术期刊发表的引用ChemFaces产品的部分文献
  • Pharmaceuticals (Basel).2021, 14(8):742.
  • Institute of Food Science & Technology2021, 18 December.
  • FEBS J.2022, 10.1111:febs.16676.
  • J Agric Food Chem.2021, 69(11):3496-3510.
  • Food Chem.2019, 278:683-691
  • 2023, 24(6):5769.Int J Mol Sci.
  • Int J Mol Sci.2020, 21(7):2530.
  • Journal of Functional Foods2021, 84:104581
  • Food Chem Toxicol.2023, 176:113785.
  • Universitat Stuttgart2022, opus-12200.
  • Foods.2021, 10(6):1378.
  • ScientificWorldJournal.2022, 2022:4806889.
  • J Nat Med.2022, 76(1):59-67.
  • Toxicological Research2020, doi: 10.1007.
  • J Neuroinflammation.2020, 17(1):75.
  • Anticancer Res.2014, 34(7):3505-9
  • Front Pharmacol.2021, 12:764297.
  • Anticancer Res.2020, 40(10):5529-5538.
  • Food Chem.2018, 262:78-85
  • Pharmaceuticals (Basel).2021, 14(7):633.
  • J Biotechnol.2020, 318:10-19.
  • Molecules.2021, 26(2):313.
  • ACS Omega2020, 5,33,20825-20830
  • ...
  • 生物活性
    Description: Psoralen is a naturally occurring furocoumarin that intercalates with DNA, inhibiting DNA synthesis and cell division. Psoralen has immunomodulatory properties on Th2 response in vitro, it can remit the degeneration of lumbar intervertebral disc induced by IL-1β to some extent, and affect the related factors of IL-1β signaling pathway. Psoralen may be feasible for reversing the multidrug resistance by inhibiting ABCB1 gene and protein expression. Psoralen ultraviolet A is an effective treatment for psoriasis.
    Targets: IL Receptor | HIV | EGFR | ABCB1 | GATA-3
    In vitro:
    Phytomedicine. 2014 Jun 15;21(7):970-7.
    Psoralen reverses docetaxel-induced multidrug resistance in A549/D16 human lung cancer cells lines.[Pubmed: 24703328]
    Chemotherapy is the recommended treatment for advanced-stage cancers. However, the emergence of multidrug resistance (MDR), the ability of cancer cells to become simultaneously resistant to different drugs, limits the efficacy of chemotherapy. Previous studies have shown that herbal medicine or natural food may be feasible for various cancers as potent chemopreventive drug. This study aims to explore the capablility of reversing the multidrug resistance of docetaxel (DOC)-resistant A549 cells (A549/D16) of psoralen and the underlying mechanisms.
    METHODS AND RESULTS:
    In this study, results showed that the cell viability of A549/D16 subline is decreased when treated with psoralen plus DOC, while psoralen has no effect on the cell proliferation on A549 and A549/D16 cells. Furthermore, mRNA and proteins levels of ABCB1 were decreased in the presence of psoralen, while decreased ABCB1 activity was also revealed by flow cytometry. Based on these results, we believe that psoralen may be feasible for reversing the multidrug resistance by inhibiting ABCB1 gene and protein expression.
    CONCLUSIONS:
    Such inhibition will lead to a decrease in ABCB1 activity and anti-cancer drug efflux, which eventually result in drug resistance reversal and therefore, sensitizing drug-resistant cells to death in combination with chemotherapeutic drugs.
    Pak J Pharm Sci. 2015 Mar;28(2 Suppl):667-70.
    Effects of psoralen on chondrocyte degeneration in lumbar intervertebral disc of rats.[Pubmed: 25796142]
    Discuss the internal mechanism of delaying degeneration of lumber intervertebral disc.
    METHODS AND RESULTS:
    The cartilage of lumbar intervertebral disc of SD rats was selected in vitro, then cultured by tissue explant method, and identified by HE staining, toluidine blue staining and immunofluorescence. The optimal concentration of psoralen was screened by cell proliferation assay and RT-PCR method. The cells in third generation with good growth situation is selected and placed in 6-well plate at concentration of 1×10(5)/well and its expression was tested. Compared to concentration of 0, the mRNA expression of Col2al (Collagen Ⅱ) secreted by was up regulated chondrocyte of lumbar intervertebral disc at the concentration of 12.5 and 25μM (P<0.0 or P<0.01). The aggrecan mRNA of psoralen group was higher than blank control group (P<0.01); compared with IL-1β induced group, the mRNA expression of Col2al was significantly increased but the mRNA expression of ADAMTS-5 was significantly decreased in psoralen group (P<0.01).
    CONCLUSIONS:
    These findings suggest that, psoralen can remit the degeneration of lumbar intervertebral disc induced by IL-1β to some extent, and affect the related factors of IL-1β signaling pathway.
    Int J Mol Med . 2018 Jun;41(6):3727-3735.
    A novel psoralen derivative-MPFC enhances melanogenesis via activation of p38 MAPK and PKA signaling pathways in B16 cells[Pubmed: 29512683]
    Abstract As an active compound, psoralen is present in various Chinese herbal medicines and has exhibited significant activity in skin disease treatment. Its derivative 8-methoxypsoralan (8-MOP) is the most commonly used drug to induce repigmentation of vitiligo. In our previous screening assays, 4-methyl-6-phenyl-2H-furo[3,2-g]chromen-2-one (MPFC), a psoralen derivative, was identified as more effective tyrosinase and melanin activator than the positive control 8-MOP in consideration of low doses, as well as low toxicity. The overall purpose of this study was to characterize the melanogenic effect and mechanisms of MPFC in B16 cells. The melanin biosynthesis effects of MPFC were determined by examination of cellular melanin contents, tyrosinase activity assay, cyclic adenosinemonophosphate (cAMP) assay, and western blotting of MPFC-stimulated B16 mouse melanoma cells. Our results showed that MPFC enhanced both melanin synthesis and tyrosinase activity in a concentration-dependent manner as well as significantly activated the expression of melanogenic proteins such as tyrosinase, tyrosinase-related protein-1 and tyrosinase-related protein-2. Western blot analysis showed that MPFC increased the phosphorylation of p38 mitogen-activated protein kinase and cAMP response element-binding protein (CREB) as well as the expression of microphthalmia-associated transcription factor (MITF). Moreover, MPFC stimulated intracellular cAMP levels and induced tyrosinase activity and melanin synthesis were attenuated by H89, a protein kinase A inhibitor. These results indicated that MPFC-mediated activation of the p38 MAPK and the protein kinase A (PKA) pathway may shed light on a novel approach for an effective therapy for vitiligo.
    In vivo:
    Int J Nanomedicine. 2014 Jan 23;9:669-78.
    Evaluation of psoralen ethosomes for topical delivery in rats by using in vivo microdialysis.[Pubmed: 24489470]
    This study aimed to improve skin permeation and deposition of psoralen by using ethosomes and to investigate real-time drug release in the deep skin in rats.
    METHODS AND RESULTS:
    We used a uniform design method to evaluate the effects of different ethosome formulations on entrapment efficiency and drug skin deposition. Using in vitro and in vivo methods, we investigated skin penetration and release from psoralen-loaded ethosomes in comparison with an ethanol tincture. In in vitro studies, the use of ethosomes was associated with a 6.56-fold greater skin deposition of psoralen than that achieved with the use of the tincture. In vivo skin microdialysis showed that the peak concentration and area under the curve of psoralen from ethosomes were approximately 3.37 and 2.34 times higher, respectively, than those of psoralen from the tincture. Moreover, it revealed that the percutaneous permeability of ethosomes was greater when applied to the abdomen than when applied to the chest or scapulas.
    CONCLUSIONS:
    Enhanced permeation and skin deposition of psoralen delivered by ethosomes may help reduce toxicity and improve the efficacy of long-term psoralen treatment.
    制备储备液(仅供参考)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 5.3706 mL 26.8528 mL 53.7057 mL 107.4114 mL 134.2642 mL
    5 mM 1.0741 mL 5.3706 mL 10.7411 mL 21.4823 mL 26.8528 mL
    10 mM 0.5371 mL 2.6853 mL 5.3706 mL 10.7411 mL 13.4264 mL
    50 mM 0.1074 mL 0.5371 mL 1.0741 mL 2.1482 mL 2.6853 mL
    100 mM 0.0537 mL 0.2685 mL 0.5371 mL 1.0741 mL 1.3426 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    部分图片展示
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    香柑醇; 5-羟基-6,7-呋喃并香豆素; Bergaptol CFN98772 486-60-2 C11H6O4 = 202.2 20mg QQ客服:1457312923
    佛手苷内酯; Bergapten CFN98766 484-20-8 C12H8O4 = 216.2 20mg QQ客服:2056216494
    8-羟基佛手苷内酯; 8-Hydroxybergapten CFN90591 1603-47-0 C12H8O5 = 232.19 10mg QQ客服:2056216494
    异茴芹灵; Isopimpinellin CFN98752 482-27-9 C13H10O5 = 246.2 20mg QQ客服:1413575084
    Rivulobirin B; Rivulobirin B CFN99893 194145-29-4 C23H12O9 = 432.3 5mg QQ客服:1413575084
    三甲沙林; Trioxsalen CFN70355 3902-71-4 C14H12O3 = 228.2 5mg QQ客服:1457312923
    花椒毒酚,花椒毒醇; Xanthotoxol CFN98016 2009-24-7 C11H6O4 = 202.2 20mg QQ客服:2159513211
    花椒毒素; 8-甲氧基补骨脂素; Xanthotoxin CFN98372 298-81-7 C12H8O4 = 216.2 20mg QQ客服:1413575084
    佛手酚葡萄糖苷; Bergaptol-beta-glucopyranoside CFN95186 131623-13-7 C17H16O9 = 364.3 10mg QQ客服:2056216494
    8-羟基-5-O-beta-D-吡喃葡萄糖补骨脂素; 8-Hydroxy-5-O-beta-D-glucopyranosylpsoralen CFN98663 425680-98-4 C17H16O10 = 380.3 5mg QQ客服:1413575084

    信息支持


    公司简介
    订购流程
    付款方式
    退换货政策

    ChemFaces提供的产品仅用于科学研究使用,不用于诊断或治疗程序。

    联系方式


    电机:027-84237783
    传真:027-84254680
    在线QQ: 1413575084
    E-Mail:manager@chemfaces.com

    湖北省武汉沌口经济技术开区车城南路83号1号楼第三层厂房


    ChemFaces为科学家,科研人员与企业提供快速的产品递送。我们通过瑞士SGS ISO 9001:2008质量体系认证天然化合物与对照品的研发和生产