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  • 原莪术烯醇

    Procurcumenol

    原莪术烯醇
    产品编号 CFN92647
    CAS编号 21698-40-8
    分子式 = 分子量 C15H22O2 = 234.3
    产品纯度 >=98%
    物理属性 Powder
    化合物类型 Sesquiterpenoids
    植物来源 The rhizomes of Curcuma phaeocaulis.
    ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用
    提供自定义包装
    产品名称 产品编号 CAS编号 包装 QQ客服
    原莪术烯醇 CFN92647 21698-40-8 1mg QQ客服:2056216494
    原莪术烯醇 CFN92647 21698-40-8 5mg QQ客服:2056216494
    原莪术烯醇 CFN92647 21698-40-8 10mg QQ客服:2056216494
    原莪术烯醇 CFN92647 21698-40-8 20mg QQ客服:2056216494
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    ChemFaces的产品在许多优秀和顶级科学期刊中被引用

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.
    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.
    IF=12.804(2019)

    PMID: 30417089
    我们的产品现已经出口到下面的研究机构与大学,并且还在增涨
  • University of Madras (India)
  • University of Wollongong (Australia)
  • Washington State University (USA)
  • University of Auckland (New Zealand)
  • University of Minnesota (USA)
  • Chungnam National University (Korea)
  • Periyar University (India)
  • Cornell University (USA)
  • The Australian National University (Australia)
  • University of Hertfordshire (United Kingdom)
  • Helmholtz Zentrum München (Germany)
  • University of Perugia (Italy)
  • University of Hawaii Cancer Center (USA)
  • Heinrich-Heine-University Düsseldorf (Germany)
  • More...
  • 国外学术期刊发表的引用ChemFaces产品的部分文献
  • Pharmacognosy Journal2019, 11(2): 369-373
  • Food Chem.2022, 378:131975.
  • Asian J of Pharmaceutical&Clinical 2018, 11(2)
  • Heliyon.2023, e12684.
  • J Cell Physiol.2021, 236(3):1950-1966.
  • Genes (Basel).2021, 12(7):1024.
  • CZECH MYCOLOGY2021, 73(1):1-19.
  • Evid Based Complement Alternat Med.2021, 2021:5585692.
  • Acta Pharm Sin B.2015, 5(4):323-9.
  • iScience.2023, 26(9):107602.
  • Neurochem Int.2018, 121:114-124
  • Molecules.2021, 26(16):4722.
  • Microchemical Journal2018, 137:168-173
  • Psychopharmacology (Berl).2020, 10.1007
  • Earth Environ. Sci. 2021, 905:012080.
  • FASEB J.2022, 36(7):e22387.
  • Cell.2022, 185(23):4298-4316.e21.
  • Appl. Sci. 2021, 11(23),11099.
  • Heliyon2022, 8(2):e08866.
  • Nutrients2023, 15(18), 4016.
  • Univerzita Karlova2022, 173245.
  • Appl Biochem Biotechnol.2020, 190(2):732-744
  • Biology (Basel).2020, 9(11):363.
  • ...
  • 生物活性
    Description: Procurcumenol is an inhibitor of Nitric Oxide. Procurcumenol and epicurcumenol have inhibitory effects on release of tumor necrosis factor-a (TNF-a).
    Targets: TNF-α | NO
    In vitro:
    J Nat Prod. 2013 Feb 22;76(2):223-9.
    Sesquiterpenes from the rhizomes of Curcuma heyneana.[Pubmed: 23387824]

    METHODS AND RESULTS:
    Four new germacranes [heyneanones A-D (1-4)], three new guaianes [4,10-epizedoarondiol (5), 15-hydroxyProcurcumenol (6), 12-hydroxycurcumenol (7)], and two new spirolactones [curcumanolides C (8) and D (9)] were isolated from the rhizomes of Curcuma heyneana together with 13 known sesquiterpenes and two known labdane-type diterpenes.
    CONCLUSIONS:
    Among the isolated compounds, heyneanone A (1), heyneanone C (3), 4,10-epizedoarondiol (5), Procurcumenol (16), aerugidiol (17), zerumin A (23), and (E)-15,16-bisnorlabda-8(17),11-dien-13-one (24) inhibited protein tyrosine phosphatase 1B (PTP1B) with IC(50) values of 42.5, 35.2, 35.1, 45.6, 35.7, 10.4, and 14.7 μM, respectively.
    ScientificWorldJournal. 2014;2014:321943.
    Cytotoxic constituents from the rhizomes of Curcuma zedoaria.[Pubmed: 25126594]
    Curcuma zedoaria also known as Temu putih is traditionally used in food preparations and treatment of various ailments including cancer.
    METHODS AND RESULTS:
    The cytotoxic activity of hexane, dichloromethane, ethyl acetate, methanol, and the methanol-soxhlet extracts of Curcuma zedoaria rhizomes was tested on two human cancer cell lines (Ca Ski and MCF-7) and a noncancer cell line (HUVEC) using MTT assay. Investigation on the chemical components in the hexane and dichloromethane fractions gave 19 compounds, namely, labda-8(17),12 diene-15,16 dial (1), dehydrocurdione (2), curcumenone (3), comosone II (4), curcumenol (5), Procurcumenol (6), germacrone (7), zerumbone epoxide (8), zederone (9), 9-isopropylidene-2,6-dimethyl-11-oxatricyclo[6.2.1.0(1,5)]undec-6-en-8-ol (10), furanodiene (11), germacrone-4,5-epoxide (12), calcaratarin A (13), isoProcurcumenol (14), germacrone-1,10-epoxide (15), zerumin A (16), curcumanolide A (17), curcuzedoalide (18), and gweicurculactone (19). Compounds (1-19) were evaluated for their antiproliferative effect using MTT assay against four cancer cell lines (Ca Ski, MCF-7, PC-3, and HT-29).
    制备储备液(仅供参考)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 4.268 mL 21.3402 mL 42.6803 mL 85.3606 mL 106.7008 mL
    5 mM 0.8536 mL 4.268 mL 8.5361 mL 17.0721 mL 21.3402 mL
    10 mM 0.4268 mL 2.134 mL 4.268 mL 8.5361 mL 10.6701 mL
    50 mM 0.0854 mL 0.4268 mL 0.8536 mL 1.7072 mL 2.134 mL
    100 mM 0.0427 mL 0.2134 mL 0.4268 mL 0.8536 mL 1.067 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    部分图片展示
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    新原莪述烯醇; Neoprocurcumenol CFN92789 102130-91-6 C15H22O2 = 234.3 5mg QQ客服:215959384
    窃衣醇酮; Torilolone CFN96368 13018-09-2 C15H24O3 = 252.4 5mg QQ客服:1413575084
    8-O-乙酰窃衣醇酮; 8-O-Acetyltorilolone CFN96792 20482-21-7 C17H26O4 = 294.39 5mg QQ客服:1457312923
    窃衣素; Torilin CFN96316 13018-10-5 C22H32O5 = 376.5 5mg QQ客服:3257982914
    1alpha-羟基窃衣素; 1alpha-Hydroxytorilin CFN96357 887147-75-3 C22H32O6 = 392.5 5mg QQ客服:1413575084
    1beta-羟基窃衣素; 1beta-Hydroxytorilin CFN96793 509078-16-4 C22H32O6 = 392.49 5mg QQ客服:1413575084
    苏葛三醇 6,9-二乙酸酯; Sugetriol 6,9-diacetate CFN96652 17928-63-1 C19H28O5 = 336.43 5mg QQ客服:215959384
    莪术醇; Curcumenol CFN92614 19431-84-6 C15H22O2 = 234.3 20mg QQ客服:1457312923
    异莪术醇; Isocurcumenol CFN92618 24063-71-6 C15H22O2 = 234.3 20mg QQ客服:2056216494
    莪术醇; 姜黄醇; Curcumol CFN99187 4871-97-0 C15H24O2 = 236.35 20mg QQ客服:2159513211

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