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  • 瓜子金皂苷XXXI

    Polygalasaponin XXXI

    瓜子金皂苷XXXI
    产品编号 CFN90728
    CAS编号 79103-90-5
    分子式 = 分子量 C75H112O36 = 1589.67
    产品纯度 >=98%
    物理属性 Powder
    化合物类型 Triterpenoids
    植物来源 The herbs of Polygala japonica Houtt.
    ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用
    提供自定义包装
    产品名称 产品编号 CAS编号 包装 QQ客服
    瓜子金皂苷XXXI CFN90728 79103-90-5 1mg QQ客服:215959384
    瓜子金皂苷XXXI CFN90728 79103-90-5 5mg QQ客服:215959384
    瓜子金皂苷XXXI CFN90728 79103-90-5 10mg QQ客服:215959384
    瓜子金皂苷XXXI CFN90728 79103-90-5 20mg QQ客服:215959384
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    ChemFaces的产品在许多优秀和顶级科学期刊中被引用

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.
    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.
    IF=12.804(2019)

    PMID: 30417089
    我们的产品现已经出口到下面的研究机构与大学,并且还在增涨
  • Universidad de Buenos Aires (Argentina)
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  • Universiti Kebangsaan Malaysia (Malaysia)
  • Heidelberg University (Germany)
  • Kazusa DNA Research Institute (Japan)
  • Aarhus University (Denmark)
  • Leibniz-Institut für Pflanzenbiochemie (IPB) (Germany)
  • Periyar University (India)
  • Chang Gung University (Taiwan)
  • Sri Ramachandra University (India)
  • Korea Institute of Oriental Medicine (Korea)
  • Shanghai University of TCM (China)
  • VIB Department of Plant Systems Biology, UGent (PSB) (Belgium)
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  • 国外学术期刊发表的引用ChemFaces产品的部分文献
  • Int J Mol Sci.2019, 20(3):E651
  • Phytochemistry.2021, 181:112539.
  • Drug Des Devel Ther.2020, 14:969-976.
  • J of Engineering Science&Technology2018, 13(9):2820-2828
  • Environ Toxicol.2023, 23929.
  • Cell.2022, 185(23):4298-4316.e21.
  • J of App. Res. on Med&Aromatic Plants2020, 100291.
  • Current Traditional Medicine, 2021, 7:326-335(10).
  • Environ Toxicol.2021, 36(9):1848-1856.
  • Food Res Int.2018, 106:909-919
  • Food Control2022, 132:108434.
  • Jour. of Stored Pro & Postharvest Res.2016, 7(3):32-36
  • Recent Pat Anticancer Drug Discov.2022, 17(4):416-426.
  • Biomed Pharmacother.2022, 145:112410.
  • Saf Health Work.2019, 10(2):196-204
  • Plant Cell Tiss Org2020, 1-16
  • J Plant Biotechnol.2023, 50:070-075.
  • Industrial Crops and Products2022, 188:115638
  • American Association for Anatomy2020, doi: 10.1002.
  • Int. J. Mol. Sci. 2022, 23(3),1696.
  • Trop J Nat Prod Res.2019, 3(1):6-9
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  • ...
  • 生物活性
    Description: Onjisaponin F(Polygalasaponin XXXI) acts non-competitively against cyclic AMP phosphodiesterase, like papaverine; it also exhibits a prolongation effect on hexobarbital sleeping time in mice. Intranasal vaccination with onjisaponin F(Polygalasaponin XXXI) can inhibit proliferation of mouse adapted influenza virus A/PR/8/34 in bronchoalveolar lavages of infected mice.
    Targets: cAMP
    In vivo:
    Acta Horticulturae, 2005 , 679 (679) :121-129.
    Intranasally and orally effective adjuvants from Chinese and Japanese medicinal herbs for nasal influenza vaccine[Reference: WebLink]
    Active substances from hot water extracts from 267 different Chinese and Japanese medicinal herbs were screened for mucosal adjuvant activity with influenza HA vaccine in mice. The extract from the root of Polygala tenuifolia was found to contain potent mucosal adjuvant activity.
    METHODS AND RESULTS:
    The active substances were purified and identified as onjisaponins A, E, F and G. Two inoculations of mice with onjisaponin F ((Polygalasaponin XXXI,1 μg) and influenza HA vaccine (1 μg) at 3 weeks intervals, significantly increased serum HI antibody and nasal anti-influenza virus IgA and IgG antibody titers after only 1 week over mice given HA vaccine alone after the secondary vaccination. Intranasal vaccination with onjisaponin F(Polygalasaponin XXXI) inhibited proliferation of mouse adapted influenza virus A/PR/8/34 in bronchoalveolar lavages of infected mice. Onjisaponins also showed adjuvant effect for intranasal vaccination of diphtheria-pertussis-tetanus (DPT) vaccine.
    CONCLUSIONS:
    Traditional Japanese herbal (Kampo) formulation, Sho-seiryu-to (Xiao-Qing-Long-Tang in Chinese) showed oral adjuvant activity for nasally administered influenza vaccine.
    制备储备液(仅供参考)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 0.6291 mL 3.1453 mL 6.2906 mL 12.5812 mL 15.7265 mL
    5 mM 0.1258 mL 0.6291 mL 1.2581 mL 2.5162 mL 3.1453 mL
    10 mM 0.0629 mL 0.3145 mL 0.6291 mL 1.2581 mL 1.5727 mL
    50 mM 0.0126 mL 0.0629 mL 0.1258 mL 0.2516 mL 0.3145 mL
    100 mM 0.0063 mL 0.0315 mL 0.0629 mL 0.1258 mL 0.1573 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    部分图片展示
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    虎掌草皂苷C; Huzhangoside C CFN95711 96315-52-5 C64H104O29 = 1337.5 20mg QQ客服:1413575084
    虎掌草皂甙D; Huzhangoside D CFN90384 96315-53-6 C64H104O30 = 1353.51 5mg QQ客服:3257982914
    灰毡毛忍冬皂苷B; 灰毡毛忍冬皂苷乙; Macranthoidin B CFN99148 136849-88-2 C65H106O32 = 1399.52 20mg QQ客服:2159513211
    桔梗皂苷D2; Platycodin D2 CFN93260 66663-90-9 C63H102O33 = 1387.5 5mg QQ客服:2159513211
    Platycoside E; Platycoside E CFN90786 237068-41-6 C69H112O38 = 1549.6 5mg QQ客服:3257982914
    青葙苷H; Celosin H CFN91669 1623405-28-6 C47H72O20 = 957.06 10mg QQ客服:3257982914
    青葙苷I; Celosin I CFN91061 1807732-38-2 C53H82O24 = 1103.2 10mg QQ客服:2056216494
    青葙苷J; Celosin J CFN91152 1623405-29-7 C58H90O28 = 1235.3 5mg QQ客服:215959384
    瓜子金皂苷XXXV; Polygalasaponin XXXV CFN95176 184479-28-5 C63H98O31 = 1351.5 5mg QQ客服:1457312923
    远志皂苷B; Onjisaponin B CFN90600 35906-36-6 C75H112O35 = 1573.69 5mg QQ客服:3257982914

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