菜豆蛋白
Phaseollin
|
|
产品编号 |
CFN97946 |
| CAS编号 |
13401-40-6 |
| 分子式 = 分子量 |
C20H18O4 = 322.4 |
| 产品纯度 |
>=98% |
| 物理属性 |
Powder |
| 化合物类型 |
Flavonoids |
| 植物来源 |
The herbs of Erythrina addisoniae |
| ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用 |
|
| 产品名称 |
产品编号 |
CAS编号 |
包装 |
QQ客服 |
| 菜豆蛋白 |
CFN97946 |
13401-40-6 |
1mg |
QQ客服：1457312923 |
| 菜豆蛋白 |
CFN97946 |
13401-40-6 |
5mg |
QQ客服：1457312923 |
| 菜豆蛋白 |
CFN97946 |
13401-40-6 |
10mg |
QQ客服：1457312923 |
| 菜豆蛋白 |
CFN97946 |
13401-40-6 |
20mg |
QQ客服：1457312923 |
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ChemFaces的产品在许多优秀和顶级科学期刊中被引用
Cell. 2018 Jan 11;172(1-2):249-261.e12. doi: 10.1016/j.cell.2017.12.019.
IF=36.216(2019)PMID: 29328914
Cell Metab. 2020 Mar 3;31(3):534-548.e5. doi: 10.1016/j.cmet.2020.01.002.
IF=22.415(2019)PMID: 32004475
Mol Cell. 2017 Nov 16;68(4):673-685.e6. doi: 10.1016/j.molcel.2017.10.022.
IF=14.548(2019)PMID: 29149595
ACS Nano. 2018 Apr 24;12(4): 3385-3396. doi: 10.1021/acsnano.7b08969.
IF=13.903(2019)PMID: 29553709
Nature Plants. 2016 Dec 22;3: 16206. doi: 10.1038/nplants.2016.205.
IF=13.297(2019)PMID: 28005066
Sci Adv. 2018 Oct 24;4(10): eaat6994. doi: 10.1126/sciadv.aat6994.
IF=12.804(2019)PMID: 30417089
我们的产品现已经出口到下面的研究机构与大学，并且还在增涨
Aarhus University (Denmark)
Universidade da Beira Interior (Germany)
Subang Jaya Medical Centre (Malaysia)
Mendel University in Brno (Czech Republic)
The Vancouver Prostate Centre (VPC) (Canada)
Monash University Malaysia (Malaysia)
VIB Department of Plant Systems Biology, UGent (PSB) (Belgium)
University of Stirling (United Kingdom)
Chiang Mai University (Thailand)
University of Bordeaux (France)
Heinrich-Heine-University Düsseldorf (Germany)
Institute of Chinese Materia Medica (China)
Research Unit Molecular Epigenetics (MEG) (Germany)
University of Eastern Finland (Finland)
More...
国外学术期刊发表的引用ChemFaces产品的部分文献
| Description: |
Phaseollin and neorautenol may be responsible for the anticarcinogenic actions of the plant extract, may lead to new pharmacons to be used in cancer therapy.9-Aminoacridine and other DNA intercalators function as inducers of Phaseollin and phenylalanine ammonia lyase synthesis by reacting with the DNA template.The red kidney bean phytoalexins kievitone and phaseollin possess both estrogenic and antiestrogenic activities. |
| Targets: |
ERK | p65 | NF-kB | TNF-α | Estrogen receptor | Progestogen receptor |
| In vitro: |
| J Agric Food Chem. 2011 Jan 12;59(1):112-20. | | Estrogenic and antiestrogenic activities of phytoalexins from red kidney bean (Phaseolus vulgaris L.).[Pubmed: 21133423 ] |
METHODS AND RESULTS:
The phytoalexins kievitone and Phaseollin were isolated from A. sojae-treated red kidney bean extracts and analyzed for estrogenic activity using ERα and ERβ binding, ERE luciferase assays in MCF-7 and HEK 293 cells, and MCF-7 cell proliferation. Kievitone showed the highest relative binding affinity to ERα with kievitone (0.48%) > Phaseollin (0.21%), and Phaseollin showed the highest relative binding affinity to ERβ with Phaseollin (0.53%) > kievitone (0.42%). In an ERE luciferase assay in MCF-7 cells, kievitone displayed high ER transactivation at 10 μM; Phaseollin displayed low ER transactivation. Both kievitone and Phaseollin stimulated MCF-7 cell proliferation, with kievitone displaying agonist activity between 0.1 and 10 μM. Cotransfection reporter assays performed in HEK 293 demonstrated that Phaseollin selectively increased ERE transcriptional activity of ERβ and kievitone selectively increased ERE transcriptional activity of ERα. Although Phaseollin displayed attenuation of ER transactivation in the ERE luciferase assay in MCF-7 cells, both phytoalexins attenuated the effects of E2 in an MCF-7 cell colonial survival assay.
CONCLUSIONS:
This work provides evidence that the red kidney bean phytoalexins kievitone and Phaseollin possess both estrogenic and antiestrogenic activities. |
|
|
1 mg |
5 mg |
10 mg |
20 mg |
25 mg |
| 1 mM |
3.1017 mL |
15.5087 mL |
31.0174 mL |
62.0347 mL |
77.5434 mL |
| 5 mM |
0.6203 mL |
3.1017 mL |
6.2035 mL |
12.4069 mL |
15.5087 mL |
| 10 mM |
0.3102 mL |
1.5509 mL |
3.1017 mL |
6.2035 mL |
7.7543 mL |
| 50 mM |
0.062 mL |
0.3102 mL |
0.6203 mL |
1.2407 mL |
1.5509 mL |
| 100 mM |
0.031 mL |
0.1551 mL |
0.3102 mL |
0.6203 mL |
0.7754 mL |
* Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
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