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  • Mucronulatol


    产品编号 CFN95386
    CAS编号 20878-98-2
    分子式 = 分子量 C17H18O5 = 302.3
    产品纯度 >=98%
    物理属性 Powder
    化合物类型 Flavonoids
    植物来源 The herbs of Lotus corniculatus L.
    产品名称 产品编号 CAS编号 包装 QQ客服
    Mucronulatol CFN95386 20878-98-2 1mg QQ客服:2159513211
    Mucronulatol CFN95386 20878-98-2 5mg QQ客服:2159513211
    Mucronulatol CFN95386 20878-98-2 10mg QQ客服:2159513211
    Mucronulatol CFN95386 20878-98-2 20mg QQ客服:2159513211
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    Cell. 2018 Jan 11;172(1-2):249-261.e12.
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    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
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    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.

    PMID: 30417089
  • University of Helsinki (Finland)
  • Vin?a Institute of Nuclear Sciences (Serbia)
  • Kyoto University (Japan)
  • Gyeongsang National University (Korea)
  • Uniwersytet Gdański (Poland)
  • Donald Danforth Plant Science Center (USA)
  • University of Stirling (United Kingdom)
  • University of Melbourne (Australia)
  • University of Hertfordshire (United Kingdom)
  • Heinrich-Heine-University Düsseldorf (Germany)
  • FORTH-IMBB (Greece)
  • University of Dicle (Turkey)
  • University of Sao Paulo (Brazil)
  • Rio de Janeiro State University (Brazil)
  • More...
  • 国外学术期刊发表的引用ChemFaces产品的部分文献
  • Sci Rep.2019, 9:19059
  • Inflammation2015, 38(1):445-55
  • Korean J of Pharmacognosy2020, 51,49-54.
  • Molecules.2021, 26(3):695.
  • Korean J. Food Preserv. 2021, 28(6):846-856.
  • J Nat Sc Biol Med2019, 10(2):149-156
  • Food Sci Nutr.2019, 8(1):246-256
  • Auburn University2015, 1-58
  • Chin J Pharm Anal.2019, 39(7):1217-1228
  • Nutrients.2020, 12(12):3638.
  • Primary and Industrial.2018, 52(11)
  • Molecules.2022, 27(5):1675
  • Cardiovasc Toxicol.2019, 19(4):297-305
  • Phytother Res.2019, 33(7):1784-1793
  • Korean Journal of Pharmacognosy2014, 113-120
  • J Pharmaceut Biomed2020, 178:112894
  • Tissue Cell.2022, 75:101728.
  • Plants (Basel).2021, 10(7):1376.
  • Cell.2018, 172(1-2):249-261
  • European Journal of Integrative Medicine2018, 20:165-172
  • The Journal of Agromedicine and Medical Sciences2018, 4(1)
  • J Chromatogr B Analyt Technol Biomed Life Sci.2018, 1080:27-36
  • Heliyon2020, 6(6):e04337.
  • ...
  • 生物活性
    Description: Mucronulatol has anticancer,antiangiogenic activity. Mucronulatol exhibits markedly potent inhibition of yeast α-glucosidase.
    In vitro:
    Nat Prod Res . 2021 Dec;35(24):5879-5882.
    Exploring natural compounds for the management of non-small cell lung cancer[Pubmed: 32722994]
    A growing incidence of drug resistance and tumour proliferation in non-small cell lung cancer escalates the urge for potential lead molecules. The plant-derived natural compounds have played a pivotal role in potential therapeutic agents owing to its versatility and low toxicity over the past decades. In this study, we have executed an in-silico based screening of 1574 natural compounds against the β-catenin via an integrated pharmacophore approach. Further investigation revealed that Mucronulatol and 7,4'-dihydroxyhomoisoflavanone possess a higher Glide score (-4.748 and -3.943 kcal/mol), binding affinity (-44.763 and -41.883 kcal/mol) alongside drug-likeness property than the iCRT5. Moreover, these compounds are reported to have cytotoxicity against lung cancer cell lines with an IC50 value of 6.74 μM and 8.99 μM respectively. Furthermore, dynamic studies were employed to determine the structural stability and we hope that the lead molecules proposed in this study could effectively inhibit the β-catenin pathway associated with NSCLC.
    Bioinformation . 2015 Feb 28;11(2):73-84.
    In silico pharmacokinetic and molecular docking studies of small molecules derived from Indigofera aspalathoides Vahl targeting receptor tyrosine kinases[Pubmed: 25848167]
    Angiogenesis is the formation of new blood vessels from preexisting vascular network that plays an important role in the tumor growth, invasion and metastasis. Anti-angiogenesis targeting tyrosine kinases such as vascular endothelial growth factor receptor 2 (VEGFR2) and platelet derived growth factor receptor β (PDGFRβ) constitutes a successful target for the treatment of cancer. In this work, molecular docking studies of three bioflavanoid such as indigocarpan, mucronulatol, indigocarpan diacetate and two diterpenes namely erythroxydiol X and Y derived from Indigofera aspalathoides as PDGFRβ and VEGFR2 inhibitors were performed using computational tools. The crystal structures of two target proteins were retrieved from PDB website. Among the five compounds investigated, indigocarpan exhibited potent binding energy ΔG = -7.04 kcal/mol with VEGFR2 and ΔG = -4.82 with PDGFRβ compared to commercially available anti-angiogenic drug sorafenib (positive control). Our results strongly suggested that indigocarpan is a potent angiogenesis inhibitor as ascertained by its potential interaction with VEGFR2 and PDGFRβ. This hypothesis provides a better insight to control metastasis by blocking angiogenesis.
    J Agric Food Chem. 2010 Sep 22;58(18):9988-9993.
    Yeast alpha-glucosidase inhibition by isoflavones from plants of Leguminosae as an in vitro alternative to acarbose[Pubmed: 20734984]
    In the course of searching for new classes of α-glucosidase inhibitors originated from natural resources, 11 kinds of isoflavones, i.e., medicarpin (1), formononetin (2), mucronulatol (3), (3R)-calussequinone (5), (3R)-5'-methoxyvestitol (6), tectorigenin (7), biochanin A (8), tuberosin (9), calycosin (10), daidzein (11), and genistein (12), as well as a flavone, liquritigenin (4), were isolated as active principles responsible for the yeast α-glucosidase inhibitory activity from two leguminous plant extracts, i.e., the heartwood extract of Dalbergia odorifera and the roots extract of Pueraria thunbergiana. Each components (1-12) demonstrated a significantly potent inhibition on yeast α-glucosidase in a dose dependent manner when the p-nitrophenyl-α-D-glucopyranoside was used as a substrate in vitro. The concentration required for 50% enzyme inhibition (IC50) were calculated as 2.93 mM (1), 0.51 mM (2), 3.52 mM (7) 0.35 mM (8), 3.52 mM (9), 0.85 mM (11), and 0.15 mM (12) when that of reference drug acarbose was evaluated as 9.11 mM, in vitro. However, isoflavone glycosides, i.e., puerarin (13), daidzin (14), formononetin-7-O-β-glucopyranoside (15), and genistin (16), exhibited a relatively poor inhibitory activity on yeast α-glucosidase as compared with the corresponding isoflavone (2, 11, 12), respectively.
    Bioorg Med Chem . 2008 May 15;16(10):5434-5440
    Cytotoxic constituents from Brazilian red propolis and their structure-activity relationship[Pubmed: 18440233]
    Several classes of flavonoids [flavanoids (1-10), flavonol (11), isoflavones (12-18), isoflavanones (19-22), isoflavans (23-26), chalcones (27-30), auronol (31), pterocarpans (32-37), 2-arylbenzofuran (38), and neoflavonoid (39)] and lignans (40-42) isolated from the MeOH extract of Brazilian red propolis were investigated for their cytotoxic activity against a panel of six different cancer cell lines including murine colon 26-L5 carcinoma, murine B16-BL6 melanoma, murine Lewis lung carcinoma, human lung A549 adenocarcinoma, human cervix HeLa adenocarcinoma, and human HT-1080 fibrosarcoma cell lines. Based on the observed results, structure-activity relationships were discussed. Among the tested compounds, 7-hydroxy-6-methoxyflavanone (3) exhibited the most potent activity against B16-BL6 (IC(50), 6.66microM), LLC (IC(50), 9.29microM), A549 (IC(50), 8.63microM), and HT-1080 (IC(50), 7.94microM) cancer cell lines, and mucronulatol (26) against LLC (IC(50), 8.38microM) and A549 (IC(50), 9.9microM) cancer cell lines. These activity data were comparable to those of the clinically used anticancer drugs, 5-fluorouracil and doxorubicin, against the tested cell lines, suggesting that 3 and 26 are the good candidates for future anticancer drug development.
    Pharm Biol . 2000;38(3):229-234.
    Bioactive flavonoids from the black locust tree, robinia pseudoacacia[Pubmed: 21214467]
    Five flavonoids, acacetin ( 1 ), secundiflorol I ( 2 ), mucronulatol ( 3 ), isomucronulatol ( 4 ), and isovestitol ( 5 ) were isolated, with the fractionation being guided by the brine shrimp lethality test (BST), from the ethanolic extract of the whole plant of Robinia pseudoacacia (Fabaceae). The structures of 1 - 5 were identified by spectral analyses. Compounds 2 - 5 are, for the first time, reported from this species. Corrections have been made for the previous literature assignments of the 13 C NMR resonances of compounds 1 - 3 . Bioactivities in BST and cytotoxicities against a panel of six solid human tumor cell lines were determined, and 1 was significantly cytotoxic in the prostate cell line (PC-3).
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 3.308 mL 16.5399 mL 33.0797 mL 66.1594 mL 82.6993 mL
    5 mM 0.6616 mL 3.308 mL 6.6159 mL 13.2319 mL 16.5399 mL
    10 mM 0.3308 mL 1.654 mL 3.308 mL 6.6159 mL 8.2699 mL
    50 mM 0.0662 mL 0.3308 mL 0.6616 mL 1.3232 mL 1.654 mL
    100 mM 0.0331 mL 0.1654 mL 0.3308 mL 0.6616 mL 0.827 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    去甲基驴食草酚; Demethylvestitol CFN96183 65332-45-8 C15H14O4 = 258.3 5mg QQ客服:1413575084
    驴食草酚; Vestitol CFN98483 35878-41-2 C16H16O4 = 272.3 5mg QQ客服:2932563308
    Isosativan; Isosativan CFN97016 60102-29-6 C17H18O4 = 286.3 5mg QQ客服:215959384
    (-)-Sativan; (-)-Sativan CFN89475 41743-86-6 C17H18O4 = 286.32 5mg QQ客服:1148253675
    Sativan; Sativan CFN96501 71831-00-0 C17H18O4 = 286.32 5mg QQ客服:2159513211
    Mucronulatol; Mucronulatol CFN95386 20878-98-2 C17H18O5 = 302.3 5mg QQ客服:2159513211
    3',8-二羟基驴食草酚; 3',8-Dihydroxyvestitol CFN95384 122587-87-5 C16H16O6 = 304.3 5mg QQ客服:215959384
    光甘草定; Glabridin CFN99731 59870-68-7 C20H20O4 = 324.37 20mg QQ客服:2159513211
    Neorauflavane; Neorauflavane CFN97919 53734-74-0 C21H22O5 = 354.4 5mg QQ客服:2159513211
    Neorauflavene; Neorauflavene CFN97981 53734-75-1 C21H20O5 = 352.4 5mg QQ客服:2932563308





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