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  • Mucronulatol

    Mucronulatol

    Mucronulatol
    产品编号 CFN95386
    CAS编号 20878-98-2
    分子式 = 分子量 C17H18O5 = 302.3
    产品纯度 >=98%
    物理属性 Powder
    化合物类型 Flavonoids
    植物来源 The herbs of Lotus corniculatus L.
    ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用
    提供自定义包装
    产品名称 产品编号 CAS编号 包装 QQ客服
    Mucronulatol CFN95386 20878-98-2 1mg QQ客服:2159513211
    Mucronulatol CFN95386 20878-98-2 5mg QQ客服:2159513211
    Mucronulatol CFN95386 20878-98-2 10mg QQ客服:2159513211
    Mucronulatol CFN95386 20878-98-2 20mg QQ客服:2159513211
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    ChemFaces的产品在许多优秀和顶级科学期刊中被引用

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.
    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.
    IF=12.804(2019)

    PMID: 30417089
    我们的产品现已经出口到下面的研究机构与大学,并且还在增涨
  • Hamdard University (India)
  • University of Toronto (Canada)
  • Helmholtz Zentrum München (Germany)
  • Charles Sturt University (Denmark)
  • University of Eastern Finland (Finland)
  • Universiti Putra Malaysia(UPM) (Malaysia)
  • Yale University (USA)
  • National Cancer Center Research Institute (Japan)
  • Mendel University in Brno (Czech Republic)
  • University of Queensland (Australia)
  • Charles University in Prague (Czech Republic)
  • Korea Food Research Institute(KFRI) (Korea)
  • Heinrich-Heine-University Düsseldorf (Germany)
  • Michigan State University (USA)
  • More...
  • 国外学术期刊发表的引用ChemFaces产品的部分文献
  • Evid Based Complement Alternat Med.2018, 2018:4259603
  • Pharmacological Reports2020, 1-9
  • Antioxidants (Basel).2020, 9(4):284.
  • Biochem Biophys Res Commun.2019, 518(4):732-738
  • Int J Mol Sci.2017, 18(5)
  • Toxins (Basel).2020, 12(4):210.
  • J Appl Microbiol.2022, 132(2):949-963.
  • Plant Growth Regulation2020, 90(2):383-392
  • J of Health Science and Alternative Medicine2019, 1(1)
  • Korean Journal of Pharmacognosy2019, 50(4):285-290
  • iScience.2020, 23(2):100849.
  • J Nat Prod.2022, doi: 10.1021
  • Chem Biol Interact.2016, 260:168-175
  • Food Research International2020, 108987
  • Appl. Sci.2021, 11(19),9343.
  • Korean J. Medicinal Crop Sci.2022, 30(2):124-133
  • Evid Based Complement Alternat Med.2017, 2017:1583185
  • Biomed Pharmacother.2021, 139:111585.
  • Int J Biol Macromol.2020, 161:1230-1239.
  • Biochem Biophys Res Commun.2020, 522(1):40-46
  • Food Res Int.2017, 96:40-45
  • Journal of Oil Palm Research2019, 31(2):238-247
  • PLoS One.2017, 12(3):e0173585
  • ...
  • 生物活性
    Description: Mucronulatol has anticancer,antiangiogenic activity. Mucronulatol exhibits markedly potent inhibition of yeast α-glucosidase.
    In vitro:
    Nat Prod Res . 2021 Dec;35(24):5879-5882.
    Exploring natural compounds for the management of non-small cell lung cancer[Pubmed: 32722994]
    A growing incidence of drug resistance and tumour proliferation in non-small cell lung cancer escalates the urge for potential lead molecules. The plant-derived natural compounds have played a pivotal role in potential therapeutic agents owing to its versatility and low toxicity over the past decades. In this study, we have executed an in-silico based screening of 1574 natural compounds against the β-catenin via an integrated pharmacophore approach. Further investigation revealed that Mucronulatol and 7,4'-dihydroxyhomoisoflavanone possess a higher Glide score (-4.748 and -3.943 kcal/mol), binding affinity (-44.763 and -41.883 kcal/mol) alongside drug-likeness property than the iCRT5. Moreover, these compounds are reported to have cytotoxicity against lung cancer cell lines with an IC50 value of 6.74 μM and 8.99 μM respectively. Furthermore, dynamic studies were employed to determine the structural stability and we hope that the lead molecules proposed in this study could effectively inhibit the β-catenin pathway associated with NSCLC.
    Bioinformation . 2015 Feb 28;11(2):73-84.
    In silico pharmacokinetic and molecular docking studies of small molecules derived from Indigofera aspalathoides Vahl targeting receptor tyrosine kinases[Pubmed: 25848167]
    Angiogenesis is the formation of new blood vessels from preexisting vascular network that plays an important role in the tumor growth, invasion and metastasis. Anti-angiogenesis targeting tyrosine kinases such as vascular endothelial growth factor receptor 2 (VEGFR2) and platelet derived growth factor receptor β (PDGFRβ) constitutes a successful target for the treatment of cancer. In this work, molecular docking studies of three bioflavanoid such as indigocarpan, mucronulatol, indigocarpan diacetate and two diterpenes namely erythroxydiol X and Y derived from Indigofera aspalathoides as PDGFRβ and VEGFR2 inhibitors were performed using computational tools. The crystal structures of two target proteins were retrieved from PDB website. Among the five compounds investigated, indigocarpan exhibited potent binding energy ΔG = -7.04 kcal/mol with VEGFR2 and ΔG = -4.82 with PDGFRβ compared to commercially available anti-angiogenic drug sorafenib (positive control). Our results strongly suggested that indigocarpan is a potent angiogenesis inhibitor as ascertained by its potential interaction with VEGFR2 and PDGFRβ. This hypothesis provides a better insight to control metastasis by blocking angiogenesis.
    J Agric Food Chem. 2010 Sep 22;58(18):9988-9993.
    Yeast alpha-glucosidase inhibition by isoflavones from plants of Leguminosae as an in vitro alternative to acarbose[Pubmed: 20734984]
    In the course of searching for new classes of α-glucosidase inhibitors originated from natural resources, 11 kinds of isoflavones, i.e., medicarpin (1), formononetin (2), mucronulatol (3), (3R)-calussequinone (5), (3R)-5'-methoxyvestitol (6), tectorigenin (7), biochanin A (8), tuberosin (9), calycosin (10), daidzein (11), and genistein (12), as well as a flavone, liquritigenin (4), were isolated as active principles responsible for the yeast α-glucosidase inhibitory activity from two leguminous plant extracts, i.e., the heartwood extract of Dalbergia odorifera and the roots extract of Pueraria thunbergiana. Each components (1-12) demonstrated a significantly potent inhibition on yeast α-glucosidase in a dose dependent manner when the p-nitrophenyl-α-D-glucopyranoside was used as a substrate in vitro. The concentration required for 50% enzyme inhibition (IC50) were calculated as 2.93 mM (1), 0.51 mM (2), 3.52 mM (7) 0.35 mM (8), 3.52 mM (9), 0.85 mM (11), and 0.15 mM (12) when that of reference drug acarbose was evaluated as 9.11 mM, in vitro. However, isoflavone glycosides, i.e., puerarin (13), daidzin (14), formononetin-7-O-β-glucopyranoside (15), and genistin (16), exhibited a relatively poor inhibitory activity on yeast α-glucosidase as compared with the corresponding isoflavone (2, 11, 12), respectively.
    Bioorg Med Chem . 2008 May 15;16(10):5434-5440
    Cytotoxic constituents from Brazilian red propolis and their structure-activity relationship[Pubmed: 18440233]
    Several classes of flavonoids [flavanoids (1-10), flavonol (11), isoflavones (12-18), isoflavanones (19-22), isoflavans (23-26), chalcones (27-30), auronol (31), pterocarpans (32-37), 2-arylbenzofuran (38), and neoflavonoid (39)] and lignans (40-42) isolated from the MeOH extract of Brazilian red propolis were investigated for their cytotoxic activity against a panel of six different cancer cell lines including murine colon 26-L5 carcinoma, murine B16-BL6 melanoma, murine Lewis lung carcinoma, human lung A549 adenocarcinoma, human cervix HeLa adenocarcinoma, and human HT-1080 fibrosarcoma cell lines. Based on the observed results, structure-activity relationships were discussed. Among the tested compounds, 7-hydroxy-6-methoxyflavanone (3) exhibited the most potent activity against B16-BL6 (IC(50), 6.66microM), LLC (IC(50), 9.29microM), A549 (IC(50), 8.63microM), and HT-1080 (IC(50), 7.94microM) cancer cell lines, and mucronulatol (26) against LLC (IC(50), 8.38microM) and A549 (IC(50), 9.9microM) cancer cell lines. These activity data were comparable to those of the clinically used anticancer drugs, 5-fluorouracil and doxorubicin, against the tested cell lines, suggesting that 3 and 26 are the good candidates for future anticancer drug development.
    Pharm Biol . 2000;38(3):229-234.
    Bioactive flavonoids from the black locust tree, robinia pseudoacacia[Pubmed: 21214467]
    Five flavonoids, acacetin ( 1 ), secundiflorol I ( 2 ), mucronulatol ( 3 ), isomucronulatol ( 4 ), and isovestitol ( 5 ) were isolated, with the fractionation being guided by the brine shrimp lethality test (BST), from the ethanolic extract of the whole plant of Robinia pseudoacacia (Fabaceae). The structures of 1 - 5 were identified by spectral analyses. Compounds 2 - 5 are, for the first time, reported from this species. Corrections have been made for the previous literature assignments of the 13 C NMR resonances of compounds 1 - 3 . Bioactivities in BST and cytotoxicities against a panel of six solid human tumor cell lines were determined, and 1 was significantly cytotoxic in the prostate cell line (PC-3).
    制备储备液(仅供参考)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 3.308 mL 16.5399 mL 33.0797 mL 66.1594 mL 82.6993 mL
    5 mM 0.6616 mL 3.308 mL 6.6159 mL 13.2319 mL 16.5399 mL
    10 mM 0.3308 mL 1.654 mL 3.308 mL 6.6159 mL 8.2699 mL
    50 mM 0.0662 mL 0.3308 mL 0.6616 mL 1.3232 mL 1.654 mL
    100 mM 0.0331 mL 0.1654 mL 0.3308 mL 0.6616 mL 0.827 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    部分图片展示
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    降香黄烃; Odoriflavene CFN91023 101153-41-7 C17H16O5 = 300.31 5mg QQ客服:2056216494
    Bidwillol A; Bidwillol A CFN97992 161099-42-9 C21H22O4 = 338.4 5mg QQ客服:2056216494
    Erythbidin A; Erythbidin A CFN96547 210050-83-2 C20H20O4 = 324.37 5mg QQ客服:1457312923
    光果甘草素; Glabrene CFN96402 60008-03-9 C20H18O4 = 322.4 5mg QQ客服:3257982914
    Dehydroglyasperin C; Dehydroglyasperin C CFN96483 199331-35-6 C21H22O5 = 354.4 5mg QQ客服:1457312923
    粗毛甘草素C; Glyasperin C CFN95065 142474-53-1 C21H24O5 = 356.4 5mg QQ客服:1457312923
    甘草西定; Licoricidin CFN96389 30508-27-1 C26H32O5 = 424.5 5mg QQ客服:1457312923
    甘草异黄烷甲; Licorisoflavan A CFN96372 129314-37-0 C27H34O5 = 438.6 5mg QQ客服:1413575084
    脱氢雌马酚; Phenoxodiol CFN91578 81267-65-4 C15H12O3 = 240.3 5mg QQ客服:215959384
    去甲基驴食草酚; Demethylvestitol CFN96183 65332-45-8 C15H14O4 = 258.3 5mg QQ客服:215959384

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