| In vitro: | 
				| Chem Biodivers. 2010 Jan;7(1):216-20.  |  | Benzophenones from Guignardia sp. IFB-E028, an endophyte on Hopea hainanensis.[Pubmed: 20087992 ] |   METHODS AND RESULTS: 
The first natural S-containing benzophenone dimer, named guignasulfide (3), was isolated from the culture of Guignardia sp. IFB-E028, an endophytic fungus residing in healthy leaves of Hopea hainanensis. Its structure was determined through correlative analyses of its MS, 1D- and 2D-NMR spectroscopic data. Two other known benzophenone derivatives, Monomethylsulochrin and rhizoctonic acid (1 and 2, resp.) were also isolated. 
 CONCLUSIONS: 
Guignasulfide (3) was more active against the human liver cancer cell line HepG2 (IC(50) value: 5.2+/-0.4 microM) than metabolites 1 and 2 (IC(50) values: 63.5+/-0.6 and 60.2+/-0.5 microM); compounds 1-3 showed also moderately inhibitory effects on the human bacterial pathogen Helicobacter pylori with MIC values of 28.9+/-0.1, 60.2+/-0.4, and 42.9+/-0.5 microM, respectively. |  | J Antibiot (Tokyo). 2006 Jun;59(6):362-5.  |  | A new diphenyl ether from marine-derived fungus Aspergillus sp. B-F-2.[Pubmed: 16915822 ] |   METHODS AND RESULTS: 
A new diphenyl ether dimethyl 2,3'-dimethylosoate (1) together with three known compounds Monomethylsulochrin (2), emodin (3), and questin (4) were isolated through bioassay-guided fractionations from the culture of a marine-derived fungus Aspergillus sp. B-F-2.  CONCLUSIONS: The structures of these compounds were determined by spectroscopic methods. Cytotoxicities of compounds 1 and 2 against K562 cell line were preliminarily evaluated by the MTT method and flow cytometry. |  
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