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  • 3-咔唑羧酸甲酯

    Methyl 3-carbazolecarboxylate

    3-咔唑羧酸甲酯
    产品编号 CFN97559
    CAS编号 97931-41-4
    分子式 = 分子量 C14H11NO2 = 225.2
    产品纯度 >=98%
    物理属性 Yellow powder
    化合物类型 Alkaloids
    植物来源 The herbs of Micromelum sp.
    ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用
    提供自定义包装
    产品名称 产品编号 CAS编号 包装 QQ客服
    3-咔唑羧酸甲酯 CFN97559 97931-41-4 1mg QQ客服:2159513211
    3-咔唑羧酸甲酯 CFN97559 97931-41-4 5mg QQ客服:2159513211
    3-咔唑羧酸甲酯 CFN97559 97931-41-4 10mg QQ客服:2159513211
    3-咔唑羧酸甲酯 CFN97559 97931-41-4 20mg QQ客服:2159513211
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    ChemFaces的产品在许多优秀和顶级科学期刊中被引用

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.
    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.
    IF=12.804(2019)

    PMID: 30417089
    我们的产品现已经出口到下面的研究机构与大学,并且还在增涨
  • Johannes Gutenberg University Mainz (JGU) (Germany)
  • Weizmann Institute of Science (Israel)
  • Max Rubner-Institut (MRI) (Germany)
  • Monash University (Australia)
  • Medizinische Universit?t Wien (Austria)
  • University of Wollongong (Australia)
  • Heinrich-Heine-University Düsseldorf (Germany)
  • Chiang Mai University (Thailand)
  • Wroclaw Medical University (Poland)
  • Worcester Polytechnic Institute (USA)
  • Max-Planck-Insitut (Germany)
  • Macau University of Science and Technology (China)
  • University of Minnesota (USA)
  • University of Bonn (Germany)
  • More...
  • 国外学术期刊发表的引用ChemFaces产品的部分文献
  • Tumour Biol.2015, 36(9):7027-34
  • Nutrients.2019, 12(1)
  • Elife.2021, 10:e68058.
  • Journal of Phytopathology2021, 169,Issue11-12.
  • In Vivo.2022, 36(3):1136-1143.
  • Biosci. Rep.2020, 10.1024
  • Inflammation.2015, 38(4):1502-16
  • Cells.2021, 10(11):2919.
  • Sci Rep.2021, 11(1):10931.
  • Nutrients.2020, 12(3):595.
  • J Ethnopharmacol.2019, 228:132-141
  • Front Aging Neurosci.2018, 10:269
  • Front Plant Sci.2017, 8:723
  • Cells.2021, 10(10):2633.
  • JMicrobiol Biotech Food Sci2021, e4289.
  • Molecules.2017, 22(6)
  • Nat Prod Commun.2014, 9(5):679-82
  • Molecules.2019, 24(10):E1930
  • Food Engineering Progress2019, 23(3)209-216
  • Lab Chip.2018, 18(6):971-978
  • J Ethnopharmacol.2017, 198:205-213
  • Exp Neurobiol.2018, 27(3):200-209
  • Korean J of Food Science&Technology 2017, 49(2):146-150
  • ...
  • 生物活性
    Description: Methyl 3-carbazolecarboxylate is a natural product from Micromelum sp.
    Targets: Immunology & Inflammation related
    In vitro:
    Planta Med. 2005 Mar;71(3):261-7.
    Anti-tuberculosis constituents from the stem bark of Micromelum hirsutum.[Pubmed: 15770548 ]

    METHODS AND RESULTS:
    Anti-TB bioassay-directed fractionation led to the isolation of six carbazole alkaloids, as well as the gamma-lactone derivative of oleic acid, from the CH (2)Cl (2) extract of the stem bark of Micromelum hirsutum. The carbazoles include the new micromeline ( 2) and five known alkaloids: lansine ( 3), 3-methylcarbazole ( 4), methyl carbazole-3-carboxylate ( Methyl 3-carbazolecarboxylate,5), 3-formylcarbazole ( 6), and 3-formyl-6-methoxycarbazole ( 7). Compound 1 was identified as the lactone derivative of oleic acid, (-)- Z-9-octadecene-4-olide, for which the trivial name micromolide ( 1) is suggested. It showed potent in vitro anti-TB activity against H37R v (MIC: 1.5 microg/mL), a selectivity index (SI) of 63, and exhibited activity against the Erdman strain of M. tuberculosis in a J774 mouse macrophage model (EC (90) : 5.6 microg/mL).
    CONCLUSIONS:
    Thus, 1 appears worthy of further evaluation as a potential new anti-TB agent. Isolates 2, 3, 6 and 7 had anti-TB MIC values between 14.3 and 42.3 microg/mL, while compounds 4 and 5 were considered inactive (MIC > 128 microg/mL). Structure elucidation and identification were based on spectroscopic analysis, including MS, 1D/2D NMR, and a full (1)H spin system analysis of 1.
    制备储备液(仅供参考)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 4.4405 mL 22.2025 mL 44.405 mL 88.8099 mL 111.0124 mL
    5 mM 0.8881 mL 4.4405 mL 8.881 mL 17.762 mL 22.2025 mL
    10 mM 0.444 mL 2.2202 mL 4.4405 mL 8.881 mL 11.1012 mL
    50 mM 0.0888 mL 0.444 mL 0.8881 mL 1.7762 mL 2.2202 mL
    100 mM 0.0444 mL 0.222 mL 0.444 mL 0.8881 mL 1.1101 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    部分图片展示
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    圆锥定A; Paniculidine A CFN97552 97399-93-4 C14H17NO2 = 231.3 5mg QQ客服:2159513211
    圆锥定B; Paniculidine B CFN97553 97399-94-5 C14H19NO2 = 233.3 5mg QQ客服:1413575084
    圆锥定C; Paniculidine C CFN97554 97399-95-6 C13H17NO = 203.3 5mg QQ客服:2056216494
    吲哚-3-丙烯酸甲酯; Indole-3-acrylic acid methyl ester CFN99899 19626-92-7 C12H11NO2 = 201.2 5mg QQ客服:1413575084
    3-吲哚乙酸; Indolelactic acid CFN95263 1821-52-9 C11H11NO3 = 205.2 20mg QQ客服:2159513211
    3-咔唑羧酸甲酯; Methyl 3-carbazolecarboxylate CFN97559 97931-41-4 C14H11NO2 = 225.2 5mg QQ客服:1413575084
    吲哚-3-甲酸; 1H-Indole-3-carboxylic acid CFN97256 771-50-6 C9H7NO2 = 161.2 1g QQ客服:1413575084
    吲哚-3-甲酸甲酯; Methyl 3-indolecarboxylate CFN97515 942-24-5 C10H9NO2 = 175.2 100mg QQ客服:2056216494
    2-(1H-Indole-3-carboxamido)benzoic acid; 2-(1H-Indole-3-carboxamido)benzoic acid CFN96192 171817-95-1 C16H12N2O3 = 280.3 5mg QQ客服:1413575084
    5-苄氧基吲哚-3-乙醛酰胺; Indole-3-glyoxylamide CFN96487 5548-10-7 C10H8N2O2 = 188.18 5mg QQ客服:215959384

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