三白脂素 B

Manassantin B

	产品编号	CFN70466
	CAS编号	88497-88-5
	分子式 = 分子量	C₄₁H₄₈O₁₁ = 716.8
	产品纯度	>=98%
	物理属性	Powder
	化合物类型	Lignans
	植物来源	The herbs of Saururus chinensis
ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用

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产品名称	产品编号	CAS编号	包装	QQ客服
三白脂素 B	CFN70466	88497-88-5	1mg	QQ客服：3257982914
三白脂素 B	CFN70466	88497-88-5	5mg	QQ客服：3257982914
三白脂素 B	CFN70466	88497-88-5	10mg	QQ客服：3257982914
三白脂素 B	CFN70466	88497-88-5	20mg	QQ客服：3257982914

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ChemFaces的产品在许多优秀和顶级科学期刊中被引用

Cell. 2018 Jan 11;172(1-2):249-261.e12.
doi: 10.1016/j.cell.2017.12.019.
IF=36.216(2019)

PMID: 29328914

Cell Metab. 2020 Mar 3;31(3):534-548.e5.
doi: 10.1016/j.cmet.2020.01.002.
IF=22.415(2019)

PMID: 32004475

Mol Cell. 2017 Nov 16;68(4):673-685.e6.
doi: 10.1016/j.molcel.2017.10.022.
IF=14.548(2019)

PMID: 29149595

ACS Nano. 2018 Apr 24;12(4): 3385-3396.
doi: 10.1021/acsnano.7b08969.
IF=13.903(2019)

PMID: 29553709

Nature Plants. 2016 Dec 22;3: 16206.
doi: 10.1038/nplants.2016.205.
IF=13.297(2019)

PMID: 28005066

Sci Adv. 2018 Oct 24;4(10): eaat6994.
doi: 10.1126/sciadv.aat6994.
IF=12.804(2019)

PMID: 30417089

Martin Luther University of Halle-Wittenberg (Germany)

The University of Newcastle (Australia)

Deutsches Krebsforschungszentrum (Germany)

University of Melbourne (Australia)

University of Wuerzburg (Germany)

University of Toulouse (France)

Imperial College London (United Kingdom)

Universidad Industrial de Santander (Colombia)

Texas A&M University (USA)

Kamphaengphet Rajabhat University (Thailand)

Kyoto University (Japan)

Univerzita Karlova v Praze (Czech Republic)

Instituto Politécnico de Bragan?a (Portugal)

Universidade do Porto (Portugal)

More...

Description:

Manassantin B is a potent inhibitor of NF-κB activation by the suppression of transciptional activity of RelA/p65 subunit of NF-κB. It also possesses anti-EBV lytic replication activity. Manassantin B inhibits interleukin-6-induced signal transducer and activator of transcription 3 activation in Hep3B cells, it has potential as a potent anti-inflammatory drug for use in pathological processes such as sepsis or acute lung injury. Manassantin B exerts antifibrotic activity in HSC-T6 cells, in part, via inhibition of cell proliferation and decrease of collagen production.

Targets:

NF-κB | p65 | EBV | TNF-α | Bcl-2 | p38 MAPK | JNK | ERK | IL Recepter | STAT

In vitro:

Journal of Natural Products,2013, 77(1):100-110.

Potential antiviral lignans from the roots of Saururus chinensis with activity against Epstein-Barr virus lytic replication.[Reference: WebLink]

Epstein-Barr virus (EBV) is a member of the γ-herpes virus subfamily and has been implicated in the pathogenesis of several human malignancies.
METHODS AND RESULTS:
Bioassay-guided fractionation was conducted on an EtOAc-soluble extract of the roots of Saururus chinensis and monitored using an EBV lytic replication assay. This led to the isolation of 19 new (1-19) and nine known (20-28) lignans. The absolute configurations of the new lignans were established by Mosher's ester, ECD, and computational methods. Eight lignans, including three sesquineolignans (19, 23, and 24) and five dineolignans (3, 4, 26, 27, and 28), exhibited inhibitory effects toward EBV lytic replication with EC50 values from 1.09 to 7.55 μM and SI values from 3.3 to 116.4. In particular, manassantin B (27) exhibited the most promising inhibition, with an EC50 of 1.72 μM, low cytotoxicity, CC50 > 200 μM, and SI > 116.4.
CONCLUSIONS:
This is the first study demonstrating that lignans possess anti-EBV lytic replication activity.

Natural Product Sciences, 2008, 14(2):118-121.

Antifibrotic activity of manassantin B from Saururus chinensis in HSC-T6 hepatic stellate cells.[Reference: WebLink]

METHODS AND RESULTS:
Manassantin B, a dilignan isolated from Saururus chinensis, significantly inhibited proliferation in HSC-T6 cells in concentration- and time-dependent manners. In addition, treatment of HSC-T6 cells with manassantin B changed cell morphology from flattened myofibroblastic membranous morphology, representing activation state, to slender shape, representing quiescent state. Furthermore, manassantin B effectively reduced collagen content in HSC-T6 cells.
CONCLUSIONS:
These results suggested that manassantin B exerted antifibrotic activity in HSC-T6 cells, in part, via inhibition of cell proliferation and decrease of collagen production.

	1 mg	5 mg	10 mg	20 mg	25 mg
1 mM	1.3951 mL	6.9754 mL	13.9509 mL	27.9018 mL	34.8772 mL
5 mM	0.279 mL	1.3951 mL	2.7902 mL	5.5804 mL	6.9754 mL
10 mM	0.1395 mL	0.6975 mL	1.3951 mL	2.7902 mL	3.4877 mL
50 mM	0.0279 mL	0.1395 mL	0.279 mL	0.558 mL	0.6975 mL
100 mM	0.014 mL	0.0698 mL	0.1395 mL	0.279 mL	0.3488 mL

产品名称	产品编号	CAS编号	分子式 = 分子量	位单	联系QQ
沉香四醇; Agarotetrol	CFN90875	69809-22-9	C₁₇H₁₈O₆ = 318.3	20mg	QQ客服：2056216494
Rubiayannone A; Rubiayannone A	CFN91049	517978-25-1	C₂₅H₂₆O₁₄ = 550.47	5mg	QQ客服：215959384
5-甲氧基劲直胺; 5-Methoxystrictamine	CFN97434	870995-64-5	C₂₁H₂₄N₂O₃ = 352.4	5mg	QQ客服：2056216494
小构树醇A; Kazinol A	CFN92431	99624-28-9	C₂₅H₃₀O₄ = 394.5	5mg	QQ客服：1413575084

三白脂素 B

Manassantin B

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