马卡因; 高丽槐素

Maackiain

	产品编号	CFN99746
	CAS编号	19908-48-6
	分子式 = 分子量	C₁₆H₁₂O₅ = 284.27
	产品纯度	>=98%
	物理属性	Powder
	化合物类型	Flavonoids
	植物来源	The flowers of Maackia amurensis Rupr.et Maxim.
ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用

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产品名称	产品编号	CAS编号	包装	QQ客服
马卡因; 高丽槐素	CFN99746	19908-48-6	10mg	QQ客服：2159513211
马卡因; 高丽槐素	CFN99746	19908-48-6	20mg	QQ客服：2159513211
马卡因; 高丽槐素	CFN99746	19908-48-6	50mg	QQ客服：2159513211
马卡因; 高丽槐素	CFN99746	19908-48-6	100mg	QQ客服：2159513211

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ChemFaces的产品在许多优秀和顶级科学期刊中被引用

Cell. 2018 Jan 11;172(1-2):249-261.e12.
doi: 10.1016/j.cell.2017.12.019.
IF=36.216(2019)

PMID: 29328914

Cell Metab. 2020 Mar 3;31(3):534-548.e5.
doi: 10.1016/j.cmet.2020.01.002.
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PMID: 32004475

Mol Cell. 2017 Nov 16;68(4):673-685.e6.
doi: 10.1016/j.molcel.2017.10.022.
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PMID: 29149595

ACS Nano. 2018 Apr 24;12(4): 3385-3396.
doi: 10.1021/acsnano.7b08969.
IF=13.903(2019)

PMID: 29553709

Nature Plants. 2016 Dec 22;3: 16206.
doi: 10.1038/nplants.2016.205.
IF=13.297(2019)

PMID: 28005066

Sci Adv. 2018 Oct 24;4(10): eaat6994.
doi: 10.1126/sciadv.aat6994.
IF=12.804(2019)

PMID: 30417089

Indian Institute of Science (India)

University of Wuerzburg (Germany)

Georgia Institute of Technology (USA)

Ateneo de Manila University (Philippines)

Shanghai Institute of Organic Chemistry (China)

Sanford Burnham Medical Research Institute (USA)

Colorado State University (USA)

Siksha O Anusandhan University (India)

University of Otago (New Zealand)

Sri Ramachandra University (India)

Wroclaw Medical University (Poland)

University of Bonn (Germany)

Kazusa DNA Research Institute (Japan)

Universidad de Antioquia (Colombia)

More...

Description:

Maackiain is an antimicrobial compound (phytoalexins), it has anticancer effects, it induces apoptosis and growth suppression. Maackiain also shows strong larvicidal activity (LC50 = 21.95 ± 1.34 ug/mL).

Targets:

Antifection

In vitro:

Exp Parasitol. 2015 Jun;153:160-4.

Extract of Bowdichia virgilioides and maackiain as larvicidal agent against Aedes aegypti mosquito.[Pubmed: 25819294]

METHODS AND RESULTS:
The larvicidal activities of extracts of three hardwood species (Hymenaea stigonorcapa, Anadenanthera colubrina and Bowdichia virgilioides) against 4th instar larvae of Aedes aegypti were evaluated using WHO guidelines. Extracts of H. stignocarpa and A. colubrina showed weak activity. The highest larvicidal effect was obtained with the cyclohexane extract of the heartwood of B. virgilioides, which caused 100% mortality at concentrations at 50 and 100 µg/mL. Fraction toluene/EtOAc (8:2) from this extract showed larvicidal activity (LC₅₀ = 34.90 ± 1.27 µg/mL). A mixture of two compounds identified as medicarpin and maackiain exhibited a very good larvicidal activity (sub-fraction 2, LC₅₀ = 17.5 ± 1.87 µg/mL) and maackiain showed to be a strong larvicidal compound (LC₅₀ = 21.95 ± 1.34 µg/mL).
CONCLUSIONS:
This result can be of value in the search for new natural larvicidal compounds from other hardwood plant extracts and presents the first report of B. virgilioides being used to control a mosquito vector.

Oncol Rep. 2004 Dec;12(6):1183-8.

Induction of apoptosis by maackiain and trifolirhizin (maackiain glycoside) isolated from sanzukon (Sophora Subprostrate Chen et T. Chen) in human promyelotic leukemia HL-60 cells.[Pubmed: 15547735]

METHODS AND RESULTS:
We have investigated the effects of maackiain and trifolirhizin (maackiain glycoside) isolated from sanzukon (Sophora Subprostrate Chen et T. Chen) on DNA of human promyelotic HL-60 leukemia cells. It was found that extent of induction of apoptosis by maackiain was larger than that by trifolirhizin in human leukemia HL-60 cells. Morphological changes showing apoptotic bodies were observed in the HL-60 cells treated with maackiain and trifolirhizin. The fragmentations of DNA by maackiain and trifolirhizin to oligonucleosomal-sized fragments that is a characteristic of apoptosis was observed to be concentration- and time-dependent in the HL-60 cells.
CONCLUSIONS:
The data of the present study show that the suppressions by maackiain and trifolrhizin of growth of the HL-60 cells result from the induction of apoptosis by these compounds, and that the extent of growth suppression and induction of apoptosis by maackiain was greater than that by the glycoside (trifolirhizin).

产品名称	产品编号	CAS编号	分子式 = 分子量	位单	联系QQ
苏木精; Hematoxylin	CFN96490	517-28-2	C₁₆H₁₄O₆ = 302.28	20mg	QQ客服：2159513211
3,9-二羟基紫檀碱; 3,9-Dihydroxypterocarpan	CFN97043	61135-91-9	C₁₅H₁₂O₄ = 256.3	5mg	QQ客服：1413575084
异美迪紫檀素; Isomedicarpin	CFN97226	74560-05-7	C₁₆H₁₄O₄ = 270.3	5mg	QQ客服：215959384
美迪紫檀素; Medicarpin	CFN98411	32383-76-9	C₁₆H₁₄O₄ = 270.3	10mg	QQ客服：215959384
美迪紫檀素-3-O-葡萄糖苷; Medicarpin 3-O-glucoside	CFN89498	52766-70-8	C₂₂H₂₄O₉ = 432.42	5mg	QQ客服：1413575084
Glycinol; Glycinol	CFN95122	69393-95-9	C₁₅H₁₂O₅ = 272.3	5mg	QQ客服：3257982914
6alpha-羟基美迪紫檀素; 6alpha-Hydroxymedicarpin	CFN96029	61135-92-0	C₁₆H₁₄O₅ = 286.3	5mg	QQ客服：3257982914
3,9-二甲氧基紫檀碱; 高紫檀素; Homopterocarpin	CFN97720	606-91-7	C₁₇H₁₆O₄ = 284.31	5mg	QQ客服：2056216494
(-)-Variabilin; (-)-Variabilin	CFN97945	370102-93-5	C₁₇H₁₆O₅ = 300.3	5mg	QQ客服：2056216494
3-羟基-9,10-二甲氧基紫檀烷; Methylnissolin	CFN90838	73340-41-7	C₁₇H₁₆O₅ = 300.3	10mg	QQ客服：2056216494

	1 mg	5 mg	10 mg	20 mg	25 mg
1 mM	3.5178 mL	17.5889 mL	35.1778 mL	70.3556 mL	87.9446 mL
5 mM	0.7036 mL	3.5178 mL	7.0356 mL	14.0711 mL	17.5889 mL
10 mM	0.3518 mL	1.7589 mL	3.5178 mL	7.0356 mL	8.7945 mL
50 mM	0.0704 mL	0.3518 mL	0.7036 mL	1.4071 mL	1.7589 mL
100 mM	0.0352 mL	0.1759 mL	0.3518 mL	0.7036 mL	0.8794 mL

马卡因; 高丽槐素

Maackiain

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