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  • (+)-南烛木树脂酚


    产品编号 CFN99488
    CAS编号 14464-90-5
    分子式 = 分子量 C22H28O8 = 420.5
    产品纯度 >=98%
    物理属性 Powder
    化合物类型 Lignans
    植物来源 The roots of Vitex negundo
    产品名称 产品编号 CAS编号 包装 QQ客服
    (+)-南烛木树脂酚 CFN99488 14464-90-5 1mg QQ客服:1413575084
    (+)-南烛木树脂酚 CFN99488 14464-90-5 5mg QQ客服:1413575084
    (+)-南烛木树脂酚 CFN99488 14464-90-5 10mg QQ客服:1413575084
    (+)-南烛木树脂酚 CFN99488 14464-90-5 20mg QQ客服:1413575084
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    Cell. 2018 Jan 11;172(1-2):249-261.e12.
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  • ...
  • 生物活性
    Description: Lyoniresinol has antioxidant effect, it shows robust anti-melanogenic activity, decreases tyrosinase activity and melanin biosynthesis in B16F10 cells by activating ERK signaling, which downregulated MITF, tyrosinase, but not TRP-1 and TRP-2 protein expression.
    Targets: ERK | TRP
    In vitro:
    Arch Pharm Res. 2005 Sep;28(9):1031-6.
    Antimicrobial property of (+)-lyoniresinol-3alpha-O-beta-D-glucopyranoside isolated from the root bark of Lycium chinense Miller against human pathogenic microorganisms.[Pubmed: 16212233]

    (+)-Lyoniresinol-3alpha-O-beta-D-glucopyranoside (1) was isolated from an ethyl acetate extract of the root bark from Lycium chinense Miller, and its structure was determined using 1D and 2D NMR spectroscopy including DEPT, HMQC, and HMBC. (+)-Lyoniresinol-3alpha-O-beta-D-glucopyranoside exhibited potent antimicrobial activity against antibiotic-resistant bacterial strains, methicillin-resistant Staphylococcus aureus (MRSA) isolated from patients, and human pathogenic fungi without having any hemolytic effect on human erythrocytes. In particular, compound 1 induced the accumulation of intracellular trehalose on C. albicans as stress response to the drug, and disrupted the dimorphic transition that forms pseudo-hyphae caused by the pathogenesis.
    This indicates that (+)-Lyoniresinol-3alpha-O-beta-D-glucopyranoside has excellent potential as a lead compound for the development of antibiotic agents.
    Mol Cell Biochem. 2013 Jan;373(1-2):211-6.
    Lyoniresinol inhibits melanogenic activity through the induction of microphthalmia-associated transcription factor and extracellular receptor kinase activation.[Pubmed: 23099844 ]
    Lyoniresinol was one of the eight lignans purified from methanol extract of Vitex negundo and was shown to have robust tyrosinase inhibitory capacity. However, the mechanism of its action is not known.
    Hence, the goal of the current study was to study the effects of Lyoniresinol on cytotoxicity and melanin content in murine B16F10 melanoma cells and to delineate the underlying mechanism of tyrosinase inhibition. Lyoniresinol was purified from methanol extract of Vitex negundo root and when tested in B16F10, cells showed robust anti-melanogenic activity. It caused the downregulation of microphthalmia-associated transcription factor (MITF) and tyrosinase steady state protein expression levels. Flow cytometry analysis of Lyoniresinol-treated cells showed that the latter activates extracellular receptor kinase (ERK) phosphorylation, which causes MITF protein degradation and suppression of tyrosinase activity. Lyoniresinol decreased tyrosinase activity and melanin biosynthesis in B16F10 cells by activating ERK signaling, which downregulated MITF, tyrosinase, but not TRP-1 and TRP-2 protein expression.
    Contingent to more vigorous in vitro and in vivo experiments, Lyoniresinol can perhaps be incorporated into clinical dermatologic use as a skin lightening agent.
    West African J. Med., 1994, 13(1):495-8.
    Changes in Lyoniresinol Content and Antioxidative Activity of Pickled Ume during the Seasoning Process[Reference: WebLink]
    Lyoniresinol content and antioxidative activity of commercially available seasoning pickled Ume was investigated.
    The seasoning pickled Ume with low salt concentration showed relatively low lyoniresinol content and antioxidative activity compared to products with high salt concentrations. This result indicates that excessive de-salt operation leads to decrease of a lyoniresinol content and antioxidative activity of flesh. Although remarkable decrease of lyoniresinol content and antioxidative activity of pickled Ume was observed in the early stage of seasoning process, re-extraction of lyoniresinol and antioxidative activity by osmotic pressure of seasoning liquid was thought to occur after two weeks and later.
    From the results obtained, we concluded that enough period seasoning by the seasoning liquid with enough osmotic pressure is necessary to produce the seasoning pickled Ume with rich nutritional function.
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 2.3781 mL 11.8906 mL 23.7812 mL 47.5624 mL 59.453 mL
    5 mM 0.4756 mL 2.3781 mL 4.7562 mL 9.5125 mL 11.8906 mL
    10 mM 0.2378 mL 1.1891 mL 2.3781 mL 4.7562 mL 5.9453 mL
    50 mM 0.0476 mL 0.2378 mL 0.4756 mL 0.9512 mL 1.1891 mL
    100 mM 0.0238 mL 0.1189 mL 0.2378 mL 0.4756 mL 0.5945 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    异橄榄树脂素; Cycloolivil CFN96185 3064-05-9 C20H24O7 = 376.4 5mg QQ客服:1413575084
    异落叶松脂素; Isolariciresinol CFN98915 548-29-8 C20H24O6 = 360.4 5mg QQ客服:2159513211
    9,9'-O-Isopropyllidene-isolariciresinol; 9,9'-O-Isopropyllidene-isolariciresinol CFN98276 252333-71-4 C23H28O6 = 400.5 5mg QQ客服:2056216494
    异落叶松脂素 9'-beta-D-吡喃木糖苷; Schizandriside CFN96693 71222-06-5 C25H32O10 = 492.52 5mg QQ客服:3257982914
    (-)-异落叶松脂素-9'-O-beta-D-吡喃葡萄糖苷; (-)-Isolariciresinol 9'-O-glucoside CFN89431 143236-04-8 C26H34O11 = 522.54 5mg QQ客服:1413575084
    Vitexdoin A; Vitexdoin A CFN96194 1186021-77-1 C19H18O6 = 342.4 5mg QQ客服:215959384
    7,8,9,9-四脱氢异落叶松树脂酚; 7,8,9,9-Tetradehydroisolariciresinol CFN99605 145918-59-8 C20H20O6 = 356.4 5mg QQ客服:1413575084
    Vitedoin A; Vitedoin A CFN96448 819861-40-0 C20H20O6 = 356.37 5mg QQ客服:1413575084
    (-)-5'-甲氧基异落叶松脂素-9'-O-beta-D-吡喃葡萄糖苷; (-)-5'-Methoxyisolariciresinol 3alpha-O-beta-glucopyranoside CFN95403 143236-03-7 C27H36O12 = 552.6 5mg QQ客服:1457312923
    (+)-南烛木树脂酚; (+)-Lyoniresinol CFN99488 14464-90-5 C22H28O8 = 420.5 5mg QQ客服:1457312923





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