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  • 赤芝酸A

    Lucidenic acid A

    赤芝酸A
    产品编号 CFN90574
    CAS编号 95311-94-7
    分子式 = 分子量 C27H38O6 = 458.59
    产品纯度 >=98%
    物理属性 Powder
    化合物类型 Triterpenoids
    植物来源 The fruit body of Ganoderma lucidum
    ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用
    提供自定义包装
    产品名称 产品编号 CAS编号 包装 QQ客服
    赤芝酸A CFN90574 95311-94-7 10mg QQ客服:215959384
    赤芝酸A CFN90574 95311-94-7 20mg QQ客服:215959384
    赤芝酸A CFN90574 95311-94-7 50mg QQ客服:215959384
    赤芝酸A CFN90574 95311-94-7 100mg QQ客服:215959384
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    ChemFaces的产品在许多优秀和顶级科学期刊中被引用

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.
    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.
    IF=12.804(2019)

    PMID: 30417089
    我们的产品现已经出口到下面的研究机构与大学,并且还在增涨
  • Universiti Putra Malaysia(UPM) (Malaysia)
  • University of Otago (New Zealand)
  • Imperial College London (United Kingdom)
  • University of Malaya (Malaysia)
  • Medical University of Gdansk (Poland)
  • Institute of Bioorganic Chemistry Polish Academy of Sciences (Poland)
  • Michigan State University (USA)
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  • Universidade de Franca (Brazil)
  • More...
  • 国外学术期刊发表的引用ChemFaces产品的部分文献
  • Phys Chem Chem Phys.2018, 20(23):15986-15994
  • Phytomedicine.2018, 47:48-57
  • Preprints2021, doi:10.20944
  • J Ethnopharmacol.2020, 260:112988.
  • BioResources J.2020, 15(3).
  • Biology (Basel).2020, 9(11):363.
  • Food Chem.2022, 373(Pt B):131364.
  • Oncotarget.2016, 8(51):88386-88400
  • Molecules.2019, 24(6):E1177
  • BMC Complement Altern Med.2018, 18(1):303
  • Institut Pasteur Korea2020, doi: 10.21203.
  • Molecules.2019, 24(22):E4022
  • Neurochem Int.2018, 121:114-124
  • J Nat Med.2020, 74(1):65-75
  • J Am Soc Mass Spectrom.2021, 32(5):1205-1214.
  • Molecules2021, 26(1),230
  • Sci Rep.2019, 9(1):18080
  • Nutrients.2021, 13(10):3414.
  • PLoS One.2018, 13(11):e0208055
  • Biomedicines.2020, 8(11):486.
  • Evid Based Complement Alternat Med.2016, 2016:1739760
  • Molecules.2020, 25(20):4851.
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  • ...
  • 生物活性
    Description: Lucidenic acid-A and -F are modulators of JNK and p38, respectively, they enhance LPS-induced immune responses in monocytic THP-1 cells possibly via the modulation of p38 and JNK MAPKs activation.Lucidenic acid A shows significant cytotoxic activity against Hep G2, Hep G2,2,15, and P-388 tumor cells.
    Targets: JNK | p38MAPK | MMP(e.g.TIMP)
    In vitro:
    Biochem Biophys Res Commun. 2011 Apr 29;408(1):18-24.
    Lucidenic acids-rich extract from antlered form of Ganoderma lucidum enhances TNFα induction in THP-1 monocytic cells possibly via its modulation of MAP kinases p38 and JNK.[Pubmed: 21453678]
    The Ganoderma lucidum (G. lucidum) is one of the oriental fungi that has been reported to have immunomodulatory properties. Although effect of β-glucans from G. lucidum has been well documented, little is known about how other major bioactive components, the triterpenes, contribute to the immunomodulatory function of G. lucidum.
    METHODS AND RESULTS:
    Here, we showed that triterpenes-rich extract of antlered form of G. lucidum (G. lucidum AF) induces TNFα production in monocytic THP-1 cells. Furthermore, the extract also synergized with lipopolysaccharide (LPS) to induce TNFα production in THP-1 cells, suggesting an immunostimulatory role of triterpenes-rich extract of G. lucidum AF. Notably, the extract enhanced LPS-induced phosphorylation of p38 mitogen-activated protein kinase (MAPK), while it suppressed LPS-induced phosphorylation of c-Jun N-terminal kinase (JNK) MAPK. p38 Inhibitor suppressed TNFα production, while JNK inhibitor enhanced TNFα production, implying that synergistic effect of the extract may work by modulating p38 and JNK MAPKs. Moreover, we found that the triterpenes-rich extract of G. lucidum AF contains high amounts of lucidenic acids. Lucidenic acid-A, -F and -D(2), which seem to dominantly exist in the extract, were purified from the triterpenes-rich extract. We also identified Lucidenic acid-A and -F as modulators of JNK and p38, respectively.
    CONCLUSIONS:
    Thus, our data demonstrate that lucidenic acids-rich extract from G. lucidum AF enhances LPS-induced immune responses in monocytic THP-1 cells possibly via the modulation of p38 and JNK MAPKs activation.
    J. Nat.Prod., 2001, 64(64):1121-2.
    Two new triterpenoids, lucidenic acid N (1) and methyl lucidenate F (2), together with four known compounds, lucidenic acid A, lucidenolactone, lucidenic acid C, and ganoderic acid E, were isolated from the dried fruiting bodies of Ganoderma lucidum. Thei[Pubmed: 11520245]
    Two new triterpenoids, lucidenic acid N (1) and methyl lucidenate F (2), together with four known compounds, lucidenic acid A, lucidenolactone, lucidenic acid C, and ganoderic acid E, were isolated from the dried fruiting bodies of Ganoderma lucidum.
    METHODS AND RESULTS:
    Their structures were elucidated by spectral and chemical transformation studies. Among them, lucidenic acid N (1), lucidenic acid A, and ganoderic acid E showed significant cytotoxic activity against Hep G2, Hep G2,2,15, and P-388 tumor cells.
    制备储备液(仅供参考)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 2.1806 mL 10.903 mL 21.806 mL 43.6119 mL 54.5149 mL
    5 mM 0.4361 mL 2.1806 mL 4.3612 mL 8.7224 mL 10.903 mL
    10 mM 0.2181 mL 1.0903 mL 2.1806 mL 4.3612 mL 5.4515 mL
    50 mM 0.0436 mL 0.2181 mL 0.4361 mL 0.8722 mL 1.0903 mL
    100 mM 0.0218 mL 0.109 mL 0.2181 mL 0.4361 mL 0.5451 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    部分图片展示
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    灵芝酸G; Ganoderic acid G CFN90801 98665-22-6 C30H44O8 = 532.7 20mg QQ客服:1413575084
    20-羟基灵芝酸G; 20-Hydroxyganoderic acid G CFN91014 400604-12-8 C30H44O9 = 548.67 5mg QQ客服:3257982914
    灵芝酸N; Ganoderic acid N CFN90293 110241-19-5 C30H42O8 = 530.65 10mg QQ客服:1413575084
    灵芝烯酸A; Ganoderenic acid A CFN92236 100665-40-5 C30H42O7 = 514.7 10mg QQ客服:2056216494
    灵芝烯酸D; Ganoderenic acid D CFN90300 100665-43-8 C30H40O7 = 512.64 20mg QQ客服:215959384
    灵芝烯酸D甲酯; Methyl ganoderenate D CFN95572 748136-03-0 C31H42O7 = 526.7 5mg QQ客服:2159513211
    紫芝烯酸C; Ganosinensic acid C CFN95567 2231756-23-1 C30H40O7 = 512.6 5mg QQ客服:215959384
    灵芝烯酸E; Ganoderenic acid E CFN91024 110241-23-1 C30H40O8 = 528.63 5mg QQ客服:2159513211
    灵芝酸L; Ganoderic acid L CFN95022 102607-24-9 C30H46O8 = 534.7 5mg QQ客服:1457312923
    灵芝酸I; Ganoderic acid I CFN90740 98665-20-4 C30H44O8 = 532.67 5mg QQ客服:2056216494

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