L-亮氨酸

L-Leucine

	产品编号	CFN94811
	CAS编号	61-90-5
	分子式 = 分子量	C₆H₁₃NO₂ = 131.2
	产品纯度	>=98%
	物理属性	Powder
	化合物类型	Alkaloids
	植物来源	The cultures of Corynebacterium glutamicum.
ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用

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产品名称	产品编号	CAS编号	包装	QQ客服
L-亮氨酸	CFN94811	61-90-5	10mg	QQ客服：3257982914
L-亮氨酸	CFN94811	61-90-5	20mg	QQ客服：3257982914
L-亮氨酸	CFN94811	61-90-5	50mg	QQ客服：3257982914
L-亮氨酸	CFN94811	61-90-5	100mg	QQ客服：3257982914

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ChemFaces的产品在许多优秀和顶级科学期刊中被引用

Cell. 2018 Jan 11;172(1-2):249-261.e12.
doi: 10.1016/j.cell.2017.12.019.
IF=36.216(2019)

PMID: 29328914

Cell Metab. 2020 Mar 3;31(3):534-548.e5.
doi: 10.1016/j.cmet.2020.01.002.
IF=22.415(2019)

PMID: 32004475

Mol Cell. 2017 Nov 16;68(4):673-685.e6.
doi: 10.1016/j.molcel.2017.10.022.
IF=14.548(2019)

PMID: 29149595

ACS Nano. 2018 Apr 24;12(4): 3385-3396.
doi: 10.1021/acsnano.7b08969.
IF=13.903(2019)

PMID: 29553709

Nature Plants. 2016 Dec 22;3: 16206.
doi: 10.1038/nplants.2016.205.
IF=13.297(2019)

PMID: 28005066

Sci Adv. 2018 Oct 24;4(10): eaat6994.
doi: 10.1126/sciadv.aat6994.
IF=12.804(2019)

PMID: 30417089

Universidad de La Salle (Mexico)

University of Maryland (USA)

Fraunhofer-Institut für Molekularbiologie und Angewandte ?kologie IME (Germany)

Institute of Pathophysiology Medical University of Vienna (Austria)

Universidade Católica Portuguesa (Portugal)

Universidad Veracuzana (Mexico)

University of Canterbury (New Zealand)

Heidelberg University (Germany)

Deutsches Krebsforschungszentrum (Germany)

Chang Gung University (Taiwan)

Uniwersytet Gdański (Poland)

Kyung Hee University (Korea)

Universite de Lille1 (France)

Guangzhou Institutes of Biomedicine and Health (China)

More...

Description:

L-Leucine is an essential amino acid for the human body, L-Leucine improves the anemia and developmental defects associated with Diamond-Blackfan anemia and del(5q) MDS by activating the mTOR pathway, and an excess of dietary l-leucine has been shown to retard the growth of rats fed low-protein diets or diets deficient in isoleucine.

Targets:

mTOR | p53

In vitro:

Blood. 2012 Sep 13;120(11):2214-24.

L-Leucine improves the anemia and developmental defects associated with Diamond-Blackfan anemia and del(5q) MDS by activating the mTOR pathway.[Pubmed: 22734070 ]

Haploinsufficiency of ribosomal proteins (RPs) has been proposed to be the common basis for the anemia observed in Diamond-Blackfan anemia (DBA) and myelodysplastic syndrome with loss of chromosome 5q [del(5q) MDS]. We have modeled DBA and del(5q) MDS in zebrafish using antisense morpholinos to rps19 and rps14, respectively, and have demonstrated that, as in humans, haploinsufficient levels of these proteins lead to a profound anemia.
METHODS AND RESULTS:
To address the hypothesis that RP loss results in impaired mRNA translation, we treated Rps19 and Rps14-deficient embryos with the amino acid L-Leucine, a known activator of mRNA translation. This resulted in a striking improvement of the anemia associated with RP loss. We confirmed our findings in primary human CD34⁺ cells, after shRNA knockdown of RPS19 and RPS14. Furthermore, we showed that loss of Rps19 or Rps14 activates the mTOR pathway, and this is accentuated by L-Leucine in both Rps19 and Rps14 morphants. This effect could be abrogated by rapamycin suggesting that mTOR signaling may be responsible for the improvement in anemia associated with L-Leucine.
CONCLUSIONS:
Our studies support the rationale for ongoing clinical trials of L-Leucine as a therapeutic agent for DBA, and potentially for patients with del(5q) MDS.

In vivo:

Arch Biochem Biophys. 1955 Jul;57(1):1-12.

L-Leucine, an isoleucine antagonist in the rat[Reference: WebLink]

METHODS AND RESULTS:
An excess of dietary L-Leucine has been shown to retard the growth of rats fed low-protein diets or diets deficient in isoleucine. The addition of isoleucine to such diets overcame, to a large extent, the growth-retarding action of an excess of L-Leucine.
CONCLUSIONS:
These observations suggest that an excess of dietary L-Leucine can act as an antimetabolite of isoleucine in the rat and can thereby increase the requirement of the rat for isoleucine.

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	1 mg	5 mg	10 mg	20 mg	25 mg
1 mM	7.622 mL	38.1098 mL	76.2195 mL	152.439 mL	190.5488 mL
5 mM	1.5244 mL	7.622 mL	15.2439 mL	30.4878 mL	38.1098 mL
10 mM	0.7622 mL	3.811 mL	7.622 mL	15.2439 mL	19.0549 mL
50 mM	0.1524 mL	0.7622 mL	1.5244 mL	3.0488 mL	3.811 mL
100 mM	0.0762 mL	0.3811 mL	0.7622 mL	1.5244 mL	1.9055 mL